Standard name Systematic name Name description Description
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1
Visualize the interactome of PAF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.063 NaN NaN
Nucleolus 0.595 0.496 0.420
Nucleus 0.848 0.809 0.739

GFP localization & abundance

GFP localization GFP abundance
nucleus 1040

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PAF1 31 1 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 20 4 12 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure
CDC73 YLR418C Component of the Paf1p complex physical 18 2 14 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 18 4 13 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
LEO1 YOR123C Component of the Paf1 complex physical 14 5 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 8 1 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 6 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 5 4 3 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 4 3 4 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Rescue
RRP6 YOR001W Nuclear exosome exonuclease component genetic 3 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 2 2 Dosage Rescue, Synthetic Lethality, Synthetic Lethality
HPR1 YDR138W Subunit of THO/TREX complexes physical 3 1 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SLT2 YHR030C Serine/threonine MAP kinase physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
BRF1 YGR246C TFIIIB B-related factor physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit physical 2 2 2 Affinity Capture-Western, Co-purification
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Synthetic Lethality, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 2 2 Synthetic Lethality, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 2 2 Synthetic Lethality, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 2 2 2 Synthetic Lethality, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 2 2 2 Affinity Capture-MS, Biochemical Activity
IKI3 YLR384C Subunit of Elongator complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 2 2 PCA, Affinity Capture-MS
ELP2 YGR200C Subunit of Elongator complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
HHT1 YBR010W Histone H3 genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RPB4 YJL140W RNA polymerase II subunit B32 genetic 2 2 1 Synthetic Lethality, Dosage Rescue
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 2 2 1 Affinity Capture-MS, Biochemical Activity
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GRE2 YOL151W 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARE2 YNR019W Acyl-CoA:sterol acyltransferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST26 YBR042C Acyltransferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HPM1 YIL110W AdoMet-dependent methyltransferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARN1 YHL040C ARN family transporter for siderophore-iron chelates regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ATG40 YOR152C Autophagy receptor with a role in endoplasmic reticulum degradation regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ATG7 YHR171W Autophagy-related protein and dual specificity member of the E1 family regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PEX14 YGL153W Central component of the peroxisomal importomer complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HOS1 YPR068C Class I histone deacetylase (HDAC) family member regulation 1 1 1 chromatin immunoprecipitation-chip evidence
VPS36 YLR417W Component of the ESCRT-II complex regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ATG10 YLL042C Conserved E2-like conjugating enzyme regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
TRS33 YOR115C Core component of TRAPP complexes I, II and IV regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SGN1 YIR001C Cytoplasmic RNA-binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
EMW1 YNL313C Essential conserved protein with a role in cell wall integrity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIT1 YEL065W Ferrioxamine B transporter regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HXT10 YFL011W Hexose transporter regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
HSP82 YPL240C Hsp90 chaperone regulation 1 1 1 chromatin immunoprecipitation-chip evidence
EMP46 YLR080W Integral membrane component of ER-derived COPII-coated vesicles regulation 1 1 1 chromatin immunoprecipitation-chip evidence
EMP65 YER140W Integral membrane protein of the ER regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane regulation 1 1 1 northern blot evidence
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
MFA1 YDR461W Mating pheromone a-factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ODC2 YOR222W Mitochondrial inner membrane transporter regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ATR1 YML116W Multidrug efflux pump of the major facilitator superfamily regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NTH1 YDR001C Neutral trehalase, degrades trehalose regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SNF7 YLR025W One of four subunits of the ESCRT-III complex regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ATG36 YJL185C Pex3p interacting protein, required for pexophagy regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
TRP1 YDR007W Phosphoribosylanthranilate isomerase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC5 YMR001C Polo-like kinase required for mitotic exit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TDA4 YJR116W Protein distantly similar to ceramide synthases, Lag1p and Lac1p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PNS1 YOR161C Protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YRB2 YIL063C Protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AIM17 YHL021C Protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SYM1 YLR251W Protein required for ethanol metabolism regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ATG1 YGL180W Protein serine/threonine kinase regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
MRX4 YPL168W Protein that associates with mitochondrial ribosome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPL2 YHR136C Protein with similarity to cyclin-dependent kinase inhibitors regulation 1 1 1 northern blot evidence
FMP27 YLR454W Protein with structural similarity to lipid transport protein Vps13p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AAD3 YCR107W Putative aryl-alcohol dehydrogenase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MMT1 YMR177W Putative metal transporter involved in mitochondrial iron accumulation regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YGR210C YGR210C Putative protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YOR338W YOR338W Putative protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
USV1 YPL230W Putative transcription factor containing a C2H2 zinc finger regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AIM44 YPL158C Regulator of Cdc42p and Rho1p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ILV6 YCL009C Regulatory subunit of acetolactate synthase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
VTC3 YPL019C Regulatory subunit of the vacuolar transporter chaperone (VTC) complex regulation 1 1 1 northern blot evidence
PHO5 YBR093C Repressible acid phosphatase regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
DBF20 YPR111W Ser/Thr kinase involved in late nuclear division regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SSH4 YKL124W Specificity factor required for Rsp5p-dependent ubiquitination regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HOS4 YIL112W Subunit of the Set3 complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
WTM1 YOR230W Transcriptional modulator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ATG39 YLR312C Transmembrane receptor with a role in nucleophagy regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
WWM1 YFL010C WW domain containing protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 1 1 1 Reconstituted Complex
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Synthetic Rescue
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Synthetic Rescue
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Rescue
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Rescue
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Affinity Capture-Western
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Enhancement
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RBG1 YAL036C Member of the DRG family of GTP-binding proteins physical 1 1 1 Affinity Capture-MS
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Protein-RNA
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Protein-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex physical 1 1 1 Affinity Capture-Luminescence
SPT6 YGR116W Nucleosome remodeling protein physical 1 1 1 Affinity Capture-Western
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Synthetic Lethality
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 1 1 1 Reconstituted Complex
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Dosage Rescue
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Lethality
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Lethality
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Lethality
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Synthetic Lethality
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Synthetic Lethality
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Positive Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Positive Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
RTT106 YNL206C Histone chaperone genetic 1 1 1 Synthetic Growth Defect
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Growth Defect
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Synthetic Lethality
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Synthetic Growth Defect
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Synthetic Rescue
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Synthetic Rescue
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Synthetic Rescue
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Lethality
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Lethality
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Synthetic Rescue
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Phenotypic Enhancement
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Phenotypic Enhancement
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Enhancement
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Phenotypic Enhancement
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Positive Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Protein-RNA
BRE1 YDL074C E3 ubiquitin ligase physical 1 1 1 Reconstituted Complex
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Lethality
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 1 1 1 Affinity Capture-Luminescence
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Synthetic Lethality
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 Reconstituted Complex
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-Western
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 1 1 1 Phenotypic Suppression
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
MBP1 YDL056W Transcription factor genetic 1 1 1 Dosage Rescue
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-Western
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 1 1 1 Co-localization
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Phenotypic Suppression
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 1 1 1 Synthetic Growth Defect
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex physical 1 1 1 Two-hybrid
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
HTB1 YDR224C Histone H2B genetic 1 1 1 Phenotypic Suppression
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-Western
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Phenotypic Suppression
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Synthetic Lethality
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Rescue
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Synthetic Rescue
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Synthetic Growth Defect
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Synthetic Lethality
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Phenotypic Enhancement
CDC19 YAL038W Pyruvate kinase physical 1 1 1 Protein-RNA
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Rescue
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
AYT1 YLL063C Acetyltransferase physical 1 1 1 Affinity Capture-MS
GLO4 YOR040W Mitochondrial glyoxalase II physical 1 1 1 Affinity Capture-MS
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Synthetic Growth Defect
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Positive Genetic