Standard name Systematic name Name description Description
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
Visualize the interactome of HSE1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.765 0.577 0.760
Mito 0.180 0.164 NaN
Nucleolus 0.143 0.082 0.089
SpindlePole 0.113 0.068 0.308
Vac/Vac Memb 0.152 0.214 NaN
Cort. Patches NaN 0.077 NaN
ER NaN 0.068 NaN
Golgi NaN 0.068 NaN
Peroxisome NaN NaN 0.226

GFP localization & abundance

GFP localization GFP abundance
endosome 358

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HSE1 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p physical 22 6 15 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, PCA, Affinity Capture-Western, Reconstituted Complex, PCA, Affinity Capture-Western, Affinity Capture-Western, PCA, PCA
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation physical 6 4 4 Two-hybrid, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions physical 5 3 3 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid
UBI4 YLL039C Ubiquitin physical 4 4 4 Affinity Capture-Western, Protein-peptide, Reconstituted Complex, Affinity Capture-MS
HUR1 YGL168W Protein with a role in DNA repair genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VTA1 YLR181C Multivesicular body (MVB) protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 3 3 2 Two-hybrid, Affinity Capture-Western, Reconstituted Complex
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 2 2 2 Positive Genetic, Phenotypic Enhancement
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome physical 2 1 2 Two-hybrid, Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi genetic 2 1 2 Negative Genetic, Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
YPT31 YER031C Rab family GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Negative Genetic, Negative Genetic
PTK1 YKL198C Putative serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 2 1 2 Negative Genetic, Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPL38 YLR325C Ribosomal 60S subunit protein L38 genetic 2 1 2 Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 2 1 2 Negative Genetic, Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 2 1 2 Positive Genetic, Positive Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 2 1 2 Negative Genetic, Negative Genetic
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 2 1 2 Negative Genetic, Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 2 1 2 Negative Genetic, Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 2 1 2 Positive Genetic, Positive Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 2 1 2 Negative Genetic, Negative Genetic
HUA1 YGR268C Cytoplasmic protein containing a zinc finger domain physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 2 2 1 Synthetic Rescue, Dosage Rescue
ERV14 YGL054C COPII-coated vesicle protein genetic 2 2 1 Negative Genetic, Positive Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 2 2 1 Negative Genetic, Positive Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 2 1 1 Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 1 1 Positive Genetic, Positive Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Positive Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Positive Genetic
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 1 1 1 Two-hybrid
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
ECM1 YAL059W Pre-ribosomal factor involved in 60S ribosomal protein subunit export genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Positive Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
HER1 YOR227W Protein of unknown function physical 1 1 1 Two-hybrid
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Two-hybrid
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Negative Genetic
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton physical 1 1 1 Two-hybrid
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Positive Genetic
LAP3 YNL239W Cysteine aminopeptidase with homocysteine-thiolactonase activity physical 1 1 1 Two-hybrid
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 Two-hybrid
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 Two-hybrid
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 1 1 1 Two-hybrid
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Two-hybrid
YAR009C YAR009C Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Two-hybrid
YEL023C YEL023C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
RUP1 YOR138C Protein that regulates ubiquitination of Rsp5p physical 1 1 1 Affinity Capture-Western
UBP2 YOR124C Ubiquitin-specific protease physical 1 1 1 Affinity Capture-Western
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex physical 1 1 1 PCA
LAS17 YOR181W Actin assembly factor physical 1 1 1 Two-hybrid
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone physical 1 1 1 Two-hybrid
RRP7 YCL031C Essential protein involved in rRNA processing and ribosome biogenesis physical 1 1 1 Two-hybrid
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Two-hybrid
YMR084W YMR084W Putative protein of unknown function physical 1 1 1 Two-hybrid
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component physical 1 1 1 Two-hybrid
MET31 YPL038W Zinc-finger DNA-binding transcription factor physical 1 1 1 Two-hybrid
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway physical 1 1 1 Two-hybrid
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Two-hybrid
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation physical 1 1 1 Two-hybrid
RRI2 YOL117W Subunit of the COP9 signalosome (CSN) complex physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation physical 1 1 1 Two-hybrid
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif physical 1 1 1 Two-hybrid
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SCD6 YPR129W Repressor of translation initiation physical 1 1 1 Two-hybrid
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Growth Defect
SDS23 YGL056C Protein involved in cell separation during budding genetic 1 1 1 Synthetic Growth Defect
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine genetic 1 1 1 Negative Genetic
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes genetic 1 1 1 Negative Genetic
SDS24 YBR214W Protein involved in cell separation during budding genetic 1 1 1 Synthetic Growth Defect
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Synthetic Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Synthetic Growth Defect
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
YER187W YER187W Putative protein of unknown function genetic 1 1 1 Positive Genetic
KEX1 YGL203C Cell death protease essential for hypochlorite-induced apoptosis genetic 1 1 1 Positive Genetic
RCH1 YMR034C Negative regulator of cytosolic calcium homeostasis genetic 1 1 1 Positive Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Positive Genetic
PAN6 YIL145C Pantothenate synthase genetic 1 1 1 Positive Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Positive Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RRG1 YDR065W Protein of unknown function genetic 1 1 1 Negative Genetic
RSM24 YDR175C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
RSM27 YGR215W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
YCR023C YCR023C Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Negative Genetic
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Negative Genetic
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 genetic 1 1 1 Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Negative Genetic
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Negative Genetic
POG1 YIL122W DNA-binding transcriptional activator genetic 1 1 1 Negative Genetic
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Negative Genetic
RPL17B YJL177W Ribosomal 60S subunit protein L17B genetic 1 1 1 Negative Genetic
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
MAG2 YLR427W Cytoplasmic protein of unknown function genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Negative Genetic
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family genetic 1 1 1 Negative Genetic
SAM4 YPL273W S-adenosylmethionine-homocysteine methyltransferase genetic 1 1 1 Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Negative Genetic
YML018C YML018C Protein of unknown function genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Negative Genetic
PET111 YMR257C Mitochondrial translational activator specific for the COX2 mRNA genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 1 1 1 Negative Genetic
RBD2 YPL246C Possible rhomboid protease genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Positive Genetic
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RRT2 YBR246W Methylesterase performing penultimate step of diphthamide biosynthesis genetic 1 1 1 Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Positive Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Positive Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Positive Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Positive Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Negative Genetic
YBP2 YGL060W Central kinetochore associated protein genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Negative Genetic
MEP1 YGR121C Ammonium permease genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
ISY1 YJR050W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
LAC1 YKL008C Ceramide synthase component genetic 1 1 1 Negative Genetic
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase genetic 1 1 1 Negative Genetic
SRP40 YKR092C Nucleolar serine-rich protein genetic 1 1 1 Negative Genetic
SSA2 YLL024C HSP70 family ATP-binding protein genetic 1 1 1 Negative Genetic
YCT1 YLL055W High-affinity cysteine-specific transporter genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Positive Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Positive Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Positive Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Negative Genetic
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Negative Genetic
TUL1 YKL034W Subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
MCP1 YOR228C Mitochondrial protein of unknown function involved in lipid homeostas genetic 1 1 1 Negative Genetic
PNT1 YOR266W Mitochondrial integral inner membrane protein genetic 1 1 1 Negative Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Negative Genetic
YIP5 YGL161C Protein that interacts with Rab GTPases genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization physical 1 1 1 Affinity Capture-MS
APP1 YNL094W Phosphatidate phosphatase, converts phosphatidate to diacylglycerol physical 1 1 1 Two-hybrid
CNB1 YKL190W Calcineurin B genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
CYC8 YBR112C General transcriptional co-repressor physical 1 1 1 Two-hybrid
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
COS111 YBR203W Protein required for antifungal drug ciclopirox olamine resistance genetic 1 1 1 Positive Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 1 1 1 Two-hybrid
ARE1 YCR048W Acyl-CoA:sterol acyltransferase physical 1 1 1 Two-hybrid
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
EXG1 YLR300W Major exo-1,3-beta-glucanase of the cell wall genetic 1 1 1 Negative Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
ARG81 YML099C Zinc finger transcription factor involved in arginine-responsive genes physical 1 1 1 Two-hybrid
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes physical 1 1 1 Two-hybrid
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation physical 1 1 1 Two-hybrid
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Positive Genetic
BRN1 YBL097W Subunit of the condensin complex physical 1 1 1 Affinity Capture-MS
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
BUD2 YKL092C GTPase activating factor for Rsr1p/Bud1p genetic 1 1 1 Negative Genetic
ACF2 YLR144C Intracellular beta-1,3-endoglucanase physical 1 1 1 Two-hybrid
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Synthetic Growth Defect
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Negative Genetic
FOX2 YKR009C 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase physical 1 1 1 Two-hybrid
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Positive Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
ADI1 YMR009W Acireductone dioxygenease involved in methionine salvage pathway genetic 1 1 1 Negative Genetic
ARO8 YGL202W Aromatic aminotransferase I genetic 1 1 1 Positive Genetic
HBS1 YKR084C GTPase with similarity to translation release factors genetic 1 1 1 Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
BNS1 YGR230W Protein of unknown function genetic 1 1 1 Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
GDA1 YEL042W Guanosine diphosphatase located in the Golgi genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Positive Genetic
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
ACB1 YGR037C Acyl-CoA-binding protein physical 1 1 1 Two-hybrid
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
CMR3 YPR013C Putative zinc finger protein genetic 1 1 1 Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 1 1 1 Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
FMP25 YLR077W Protein required for assembly of respiratory complex III genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
APA2 YDR530C Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
CIT3 YPR001W Dual specificity mitochondrial citrate and methylcitrate synthase genetic 1 1 1 Negative Genetic