Standard name Systematic name Name description Description
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
Visualize the interactome of MKK1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.964 0.98 0.992

GFP localization & abundance

GFP localization GFP abundance
ambiguous 1040

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MKK1 2 0 0 4 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 17 5 13 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase physical 10 6 9 Biochemical Activity, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, PCA, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity, PCA, Affinity Capture-Western
SLT2 YHR030C Serine/threonine MAP kinase genetic 6 3 5 Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 6 3 5 Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 5 3 4 Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SVL3 YPL032C Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway physical 3 3 3 Two-hybrid, Affinity Capture-MS, PCA
SPA2 YLL021W Component of the polarisome physical 3 3 3 Two-hybrid, Co-localization, Affinity Capture-MS
PKC1 YBL105C Protein serine/threonine kinase genetic 3 3 3 Synthetic Rescue, Dosage Rescue, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 3 2 3 Synthetic Rescue, Positive Genetic, Positive Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 3 2 3 Dosage Rescue, Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
YBR287W YBR287W Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ATG22 YCL038C Vacuolar integral membrane protein required for efflux of amino acids genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YKR104W YKR104W Putative transporter of the MRP subfamily genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 3 3 1 Dosage Rescue, Synthetic Growth Defect, Synthetic Lethality
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 1 2 Positive Genetic, Positive Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 2 Negative Genetic, Negative Genetic
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
SDD1 YEL057C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SIP3 YNL257C Putative sterol transfer protein genetic 2 1 2 Negative Genetic, Negative Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Positive Genetic, Positive Genetic
YBR284W YBR284W Putative metallo-dependent hydrolase superfamily protein genetic 2 1 2 Negative Genetic, Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 2 1 2 Negative Genetic, Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 2 1 2 Negative Genetic, Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
STE11 YLR362W Signal transducing MEK kinase physical 2 2 1 Affinity Capture-Western, Biochemical Activity
SDP1 YIL113W Stress-inducible dual-specificity MAP kinase phosphatase genetic 2 2 1 Dosage Rescue, Synthetic Lethality
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PTC1 YDL006W Type 2C protein phosphatase (PP2C) regulation 1 1 1 qualitative western immunoblotting evidence
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function physical 1 1 1 Reconstituted Complex
AXL2 YIL140W Integral plasma membrane protein genetic 1 1 1 Negative Genetic
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 PCA
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
COX5A YNL052W Subunit Va of cytochrome c oxidase physical 1 1 1 Reconstituted Complex
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Reconstituted Complex
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Dosage Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ACK1 YDL203C Protein that functions in the cell wall integrity pathway genetic 1 1 1 Phenotypic Suppression
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
FAP7 YDL166C Essential NTPase required for small ribosome subunit synthesis physical 1 1 1 Biochemical Activity
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Dosage Growth Defect
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Rescue
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
FYV8 YGR196C Protein of unknown function physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
LPL1 YOR059C Phospholipase genetic 1 1 1 Negative Genetic
LAP2 YNL045W Leucyl aminopeptidase yscIV with epoxide hydrolase activity genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 PCA
CNB1 YKL190W Calcineurin B genetic 1 1 1 Dosage Rescue
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Positive Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Biochemical Activity
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-Western
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Dosage Growth Defect
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Dosage Growth Defect
FUB1 YCR076C Proteasome-binding protein genetic 1 1 1 Positive Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Dosage Growth Defect
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation physical 1 1 1 Reconstituted Complex
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 1 1 1 Reconstituted Complex
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Positive Genetic
BUD4 YJR092W Anillin-like protein involved in bud-site selection physical 1 1 1 Reconstituted Complex
CLC1 YGR167W Clathrin light chain physical 1 1 1 Reconstituted Complex
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Dosage Rescue
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Negative Genetic
DPC29 YGR021W Putative mitochondrial protein of unknown function physical 1 1 1 Reconstituted Complex
SPH1 YLR313C Protein involved in shmoo formation and bipolar bud site selection physical 1 1 1 Two-hybrid
REC104 YHR157W Protein involved in early stages of meiotic recombination physical 1 1 1 Biochemical Activity
VHR2 YER064C Non-essential nuclear protein physical 1 1 1 Biochemical Activity
YBR138C YBR138C Cytoplasmic protein of unknown function physical 1 1 1 Biochemical Activity
YML083C YML083C Protein of unknown function physical 1 1 1 Biochemical Activity
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Biochemical Activity
PUT3 YKL015W Transcriptional activator physical 1 1 1 Biochemical Activity
PKC1 YBL105C Protein serine/threonine kinase physical 1 1 1 Two-hybrid
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p physical 1 1 1 Affinity Capture-MS
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Dosage Rescue
RGD2 YFL047W GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p physical 1 1 1 Affinity Capture-Western
NTA1 YJR062C Amidase physical 1 1 1 Reconstituted Complex
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Reconstituted Complex
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 1 1 1 Reconstituted Complex
RTR1 YER139C Dual specificity protein phosphatase physical 1 1 1 Reconstituted Complex
WWM1 YFL010C WW domain containing protein of unknown function physical 1 1 1 Reconstituted Complex
PHO92 YDR374C Posttranscriptional regulator of phosphate and glucose metabolism physical 1 1 1 Reconstituted Complex
YIG1 YPL201C Protein that interacts with glycerol 3-phosphatase physical 1 1 1 Reconstituted Complex
YLR287C YLR287C Putative protein of unknown function physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects physical 1 1 1 Affinity Capture-Western
PTC1 YDL006W Type 2C protein phosphatase (PP2C) physical 1 1 1 Biochemical Activity
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Affinity Capture-Western
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Synthetic Rescue
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Phenotypic Suppression
MSG5 YNL053W Dual-specificity protein phosphatase genetic 1 1 1 Dosage Rescue
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Dosage Rescue
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Rescue
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 1 1 1 Synthetic Rescue
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Rescue
YPK2 YMR104C AGC-type S/T protein kinase genetic 1 1 1 Dosage Rescue
NRG1 YDR043C Transcriptional repressor genetic 1 1 1 Positive Genetic
UGA1 YGR019W Gamma-aminobutyrate (GABA) transaminase genetic 1 1 1 Negative Genetic
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Synthetic Lethality
YEF1 YEL041W ATP-NADH kinase genetic 1 1 1 Dosage Growth Defect
RQT4 YKR023W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Dosage Growth Defect
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
SEC13 YLR208W Structural component of 3 complexes genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 1 1 1 Negative Genetic
RPL2B YIL018W Ribosomal 60S subunit protein L2B genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Negative Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Dosage Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Positive Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Dosage Growth Defect
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin genetic 1 1 1 Negative Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic