Standard name Systematic name Name description Description
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication
Visualize the interactome of FKS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 18

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.115 0.263 0.115
Endosome 0.082 NaN NaN
Mito 0.104 NaN 0.328
Nucleus 0.060 0.062 0.115
Vac/Vac Memb 0.769 0.750 0.639

GFP localization & abundance

GFP localization GFP abundance
vacuole technical problem

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
FKS1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0005 (1,3-beta-glucan synthase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase genetic 16 6 12 Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Rescue
CHS7 YHR142W Protein of unknown function genetic 10 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 9 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 9 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 9 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 9 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 8 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Negative Genetic
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 7 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RLM1 YPL089C MADS-box transcription factor genetic 6 3 5 Synthetic Lethality, Dosage Rescue, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 6 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 6 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 5 3 4 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 5 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 5 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 5 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
CCH1 YGR217W Voltage-gated high-affinity calcium channel genetic 5 2 4 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 5 1 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
CHS5 YLR330W Component of the exomer complex genetic 5 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 4 2 4 Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Lethality
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 4 2 4 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 4 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 4 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CNA1 YLR433C Calcineurin A genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue
CMP2 YML057W Calcineurin A genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue
PHO85 YPL031C Cyclin-dependent kinase genetic 4 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MSN5 YDR335W Karyopherin genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Positive Genetic
FKS3 YMR306W Protein involved in spore wall assembly genetic 3 3 3 Synthetic Lethality, Dosage Rescue, Synthetic Rescue
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 3 3 3 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality
SNF1 YDR477W AMP-activated S/T protein kinase genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
SPA2 YLL021W Component of the polarisome genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
FIR1 YER032W Protein involved in 3' mRNA processing genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 3 2 2 Negative Genetic, Negative Genetic, Positive Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 3 2 2 Negative Genetic, Negative Genetic, Dosage Rescue
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
LDB18 YLL049W Component of the dynactin complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RHO2 YNL090W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FRK1 YPL141C Protein kinase of unknown cellular role genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ACK1 YDL203C Protein that functions in the cell wall integrity pathway genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 2 Negative Genetic, Positive Genetic
BNI1 YNL271C Formin genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 2 2 2 Co-purification, Co-fractionation
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 2 2 Synthetic Rescue, Positive Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
HBT1 YDL223C Shmoo tip protein, substrate of Hub1p ubiquitin-like protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
GNP1 YDR508C Broad specificity amino acid permease genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
YGL081W YGL081W Putative protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
PEX4 YGR133W Peroxisomal ubiquitin conjugating enzyme genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
NUC1 YJL208C Major mitochondrial nuclease genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
HIT1 YJR055W Protein involved in C/D snoRNP assembly genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
ILM1 YJR118C Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
QRI5 YLR204W Mitochondrial inner membrane protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
IRC21 YMR073C Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
TOP1 YOL006C Topoisomerase I genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
MRX11 YPL041C Protein that associates with mitochondrial ribosome genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
DOC1 YGL240W Processivity factor genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
AIM22 YJL046W Lipoate-protein ligase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
CUE3 YGL110C Subunit of ribosome-associated quality control trigger complex (RQT) genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
DFG16 YOR030W Probable multiple transmembrane protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
DSD1 YGL196W D-serine dehydratase (aka D-serine ammonia-lyase) genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ERP2 YAL007C Member of the p24 family involved in ER to Golgi transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SEC62 YPL094C Essential subunit of Sec63 complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 2 1 2 Dosage Rescue, Dosage Rescue
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 2 Negative Genetic, Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 2 1 2 Negative Genetic, Negative Genetic
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 2 1 2 Negative Genetic, Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 2 1 2 Negative Genetic, Negative Genetic
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 2 1 2 Negative Genetic, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 2 1 2 Positive Genetic, Positive Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 2 1 2 Positive Genetic, Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
CMD1 YBR109C Calmodulin genetic 2 1 2 Negative Genetic, Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Negative Genetic, Negative Genetic
EPO1 YMR124W Protein involved in septin-ER tethering genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
GAP1 YKR039W General amino acid permease physical 2 2 1 Two-hybrid, Affinity Capture-Western
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Negative Genetic, Positive Genetic
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly genetic 2 1 1 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 1 Positive Genetic, Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Negative Genetic, Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 2 1 1 Negative Genetic, Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 2 1 1 Negative Genetic, Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 2 1 1 Negative Genetic, Negative Genetic
RPI1 YIL119C Transcription factor, allelic differences between S288C and Sigma1278b genetic 2 1 1 Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 2 1 1 Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 2 1 1 Positive Genetic, Positive Genetic
TMA19 YKL056C Protein that associates with ribosomes genetic 2 1 1 Negative Genetic, Negative Genetic
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 2 1 1 Negative Genetic, Negative Genetic
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 2 1 1 Negative Genetic, Negative Genetic
IOC4 YMR044W Member of a complex (Isw1b) with Isw1p and Ioc2p genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Positive Genetic, Positive Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 1 1 Negative Genetic, Negative Genetic
GNA1 YFL017C Glucosamine-6-phosphate acetyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 2 1 1 Negative Genetic, Negative Genetic
SNF11 YDR073W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Negative Genetic, Negative Genetic
PAL1 YDR348C Protein of unknown function thought to be involved in endocytosis genetic 2 1 1 Negative Genetic, Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 1 Positive Genetic, Positive Genetic
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 2 1 1 Positive Genetic, Positive Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 northern blot evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Negative Genetic
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 1 1 1 Affinity Capture-MS
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Synthetic Growth Defect
APL1 YJR005W Beta-adaptin physical 1 1 1 Affinity Capture-MS
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
BOI2 YER114C Protein involved in polar growth physical 1 1 1 Two-hybrid
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase genetic 1 1 1 Positive Genetic
FTH1 YBR207W Putative high affinity iron transporter physical 1 1 1 Affinity Capture-MS
LCB2 YDR062W Component of serine palmitoyltransferase physical 1 1 1 Affinity Capture-MS
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 1 1 1 Affinity Capture-MS
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme physical 1 1 1 Affinity Capture-MS
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic physical 1 1 1 Affinity Capture-MS
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Synthetic Lethality
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) physical 1 1 1 Affinity Capture-MS
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase physical 1 1 1 Affinity Capture-MS
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) physical 1 1 1 Affinity Capture-MS
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Rescue
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Affinity Capture-MS
KIN2 YLR096W S/T protein kinase physical 1 1 1 Affinity Capture-MS
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Affinity Capture-MS
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Synthetic Growth Defect
PRK1 YIL095W Ser/Thr protein kinase physical 1 1 1 Affinity Capture-MS
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 1 1 1 Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Affinity Capture-MS
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II physical 1 1 1 Affinity Capture-MS
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting physical 1 1 1 Affinity Capture-MS
SEC13 YLR208W Structural component of 3 complexes physical 1 1 1 Affinity Capture-MS
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 1 1 1 Affinity Capture-MS
MDM34 YGL219C Mitochondrial component of the ERMES complex physical 1 1 1 Affinity Capture-MS
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-MS
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Positive Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER physical 1 1 1 PCA
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall physical 1 1 1 Affinity Capture-MS
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Synthetic Lethality
LRE1 YCL051W Protein involved in control of cell wall structure and stress response genetic 1 1 1 Dosage Rescue
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Dosage Rescue
MSB1 YOR188W Protein of unknown function genetic 1 1 1 Dosage Rescue
MTL1 YGR023W Putative plasma membrane sensor genetic 1 1 1 Dosage Rescue
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Dosage Rescue
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Dosage Rescue
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Synthetic Lethality
LRG1 YDL240W GTPase-activating protein (GAP) genetic 1 1 1 Synthetic Rescue
PXL1 YKR090W Protein that localizes to sites of polarized growth genetic 1 1 1 Synthetic Rescue
UTR2 YEL040W Chitin transglycosylase genetic 1 1 1 Synthetic Growth Defect
PLC1 YPL268W Phospholipase C genetic 1 1 1 Phenotypic Suppression
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Positive Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Positive Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Synthetic Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Positive Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
IZH3 YLR023C Membrane protein involved in zinc ion homeostasis genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Positive Genetic
SNO4 YMR322C Possible chaperone and cysteine protease genetic 1 1 1 Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Synthetic Growth Defect
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
PKH2 YOL100W Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
MYO1 YHR023W Type II myosin heavy chain genetic 1 1 1 Synthetic Lethality
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Positive Genetic
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Positive Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Positive Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Positive Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Positive Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Positive Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Positive Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Positive Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Positive Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Positive Genetic
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Positive Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Positive Genetic
SND1 YDR186C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Positive Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Positive Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Positive Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Positive Genetic
TYW3 YGL050W tRNA methyltransferase required for synthesis of wybutosine genetic 1 1 1 Positive Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Positive Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Positive Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Positive Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Positive Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Positive Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA genetic 1 1 1 Negative Genetic
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
SDA1 YGR245C Protein required for actin organization and passage through Start genetic 1 1 1 Negative Genetic
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor genetic 1 1 1 Negative Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Negative Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SME1 YOR159C Core Sm protein Sm E genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
RAM2 YKL019W Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
MRPL32 YCR003W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
NPP1 YCR026C Nucleotide pyrophosphatase/phosphodiesterase genetic 1 1 1 Negative Genetic
PRM7 YDL039C Pheromone-regulated protein genetic 1 1 1 Negative Genetic
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
YDL124W YDL124W NADPH-dependent alpha-keto amide reductase genetic 1 1 1 Negative Genetic
YDL177C YDL177C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
RPL12B YDR418W Ribosomal 60S subunit protein L12B genetic 1 1 1 Negative Genetic
GRH1 YDR517W Acetylated cis-Golgi protein, homolog of human GRASP65 genetic 1 1 1 Negative Genetic
IRC22 YEL001C Protein of unknown function genetic 1 1 1 Negative Genetic
PAU2 YEL049W Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Negative Genetic
MIC19 YFR011C Component of the MICOS complex genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Negative Genetic
SPR3 YGR059W Sporulation-specific homolog of the CDC3/10/11/12 family of genes genetic 1 1 1 Negative Genetic
MEP1 YGR121C Ammonium permease genetic 1 1 1 Negative Genetic
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RTT102 YGR275W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
TDA11 YHR159W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Negative Genetic
URA8 YJR103W Minor CTP synthase isozyme (see also URA7) genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
PTM1 YKL039W Protein of unknown function genetic 1 1 1 Negative Genetic
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 1 1 1 Negative Genetic
RCN1 YKL159C Protein involved in calcineurin regulation during calcium signaling genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 1 1 1 Negative Genetic
NAB6 YML117W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
YNL067W-B YNL067W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
MIC27 YNL100W Component of the MICOS complex genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
YNL320W YNL320W Putative protein of unknown function genetic 1 1 1 Negative Genetic
LRO1 YNR008W Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) genetic 1 1 1 Negative Genetic
YOL029C YOL029C Putative protein of unknown function genetic 1 1 1 Negative Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 1 1 1 Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
RCN2 YOR220W Protein of unknown function genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
MMT2 YPL224C Putative metal transporter involved in mitochondrial iron accumulation genetic 1 1 1 Negative Genetic
PBI1 YPL272C Putative protein of unknown function genetic 1 1 1 Negative Genetic
HSP32 YPL280W Possible chaperone and cysteine protease genetic 1 1 1 Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Lethality
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
YIP5 YGL161C Protein that interacts with Rab GTPases genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Positive Genetic
SNT2 YGL131C Subunit of Snt2C complex, RING finger ubiquitin ligase (E3) genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Positive Genetic
PRP8 YHR165C Component of U4/U6-U5 snRNP complex genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Phenotypic Suppression
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Affinity Capture-MS
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) physical 1 1 1 Affinity Capture-MS
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 1 1 1 PCA
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Phenotypic Enhancement
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway physical 1 1 1 Affinity Capture-MS
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Positive Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
CHS1 YNL192W Chitin synthase I genetic 1 1 1 Positive Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E physical 1 1 1 Affinity Capture-MS
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Negative Genetic
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p physical 1 1 1 Affinity Capture-MS
DAP1 YPL170W Heme-binding protein genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Affinity Capture-MS
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex physical 1 1 1 Affinity Capture-MS
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Positive Genetic
ATG27 YJL178C Type I membrane protein involved in autophagy and the Cvt pathway physical 1 1 1 Affinity Capture-MS
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Positive Genetic
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
ATG23 YLR431C Peripheral membrane protein required for autophagy and CVT physical 1 1 1 Affinity Capture-MS
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Negative Genetic
ERV41 YML067C Protein localized to COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Negative Genetic
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation physical 1 1 1 Affinity Capture-MS
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
ARK1 YNL020C Ser/Thr protein kinase physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Affinity Capture-MS
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 1 1 1 Negative Genetic
AIM45 YPR004C Putative ortholog of mammalian ETF-alpha genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase genetic 1 1 1 Positive Genetic
COI1 YDR381C-A Mitochondrial assembly factor genetic 1 1 1 Negative Genetic
CWH41 YGL027C Processing alpha glucosidase I genetic 1 1 1 Positive Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 1 1 1 Positive Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Positive Genetic
CRH1 YGR189C Chitin transglycosylase genetic 1 1 1 Synthetic Growth Defect
COQ4 YDR204W Protein with a role in ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
CIS3 YJL158C Mannose-containing glycoprotein constituent of the cell wall genetic 1 1 1 Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 1 1 1 Positive Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Positive Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Negative Genetic
DIE2 YGR227W Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase genetic 1 1 1 Positive Genetic
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic