Standard name Systematic name Name description Description
PRP8 YHR165C Component of U4/U6-U5 snRNP complex Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer
Visualize the interactome of PRP8
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.951 0.921 0.929
Mito NaN 0.063 0.263

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 468

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PRP8 6 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) physical 28 8 19 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Protein-peptide, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-fractionation, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Co-crystal Structure, Reconstituted Complex, Co-crystal Structure
AAR2 YBL074C Component of the U5 snRNP complex physical 17 6 10 Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Co-crystal Structure, Co-crystal Structure, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome physical 14 7 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex
CEF1 YMR213W Essential splicing factor physical 6 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Co-purification
CWC2 YDL209C Member of the NineTeen Complex (NTC) physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 6 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement
PRP16 YKR086W DEAH-box RNA helicase genetic 5 4 5 Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex physical 5 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PRP28 YDR243C Pre-mRNA splicing factor genetic 5 2 4 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
SPP382 YLR424W Essential protein that forms a dimer with Ntr2p physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SMB1 YER029C Core Sm protein Sm B physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SYF1 YDR416W Member of the NineTeen Complex (NTC) physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP3 YDR473C Splicing factor physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP19 YLL036C Splicing factor associated with the spliceosome physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS
LEA1 YPL213W Component of U2 snRNP complex physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
LIN1 YHR156C Non-essential component of U5 snRNP physical 4 2 4 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
SMD3 YLR147C Core Sm protein Sm D3 physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
LSM5 YER146W Lsm (Like Sm) protein physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 4 3 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
CLF1 YLR117C Member of the NineTeen Complex (NTC) physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP43 YGL120C RNA helicase in the DEAH-box family physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
LSM6 YDR378C Lsm (Like Sm) protein physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
LSM2 YBL026W Lsm (Like Sm) protein physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP31 YGR091W Splicing factor physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP4 YPR178W Splicing factor physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 3 3 3 Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect
CDC40 YDR364C Pre-mRNA splicing factor genetic 3 2 3 Synthetic Lethality, Synthetic Rescue, Synthetic Lethality
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 3 2 3 Synthetic Lethality, Synthetic Rescue, Synthetic Rescue
SLU7 YDR088C RNA splicing factor genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
LSM8 YJR022W Lsm (Like Sm) protein physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
SMD1 YGR074W Core Sm protein Sm D1 physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRP6 YBR055C Splicing factor physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CWC21 YDR482C Protein involved in RNA splicing by the spliceosome physical 3 3 2 Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
PRP40 YKL012W U1 snRNP protein involved in splicing physical 3 2 2 Two-hybrid, Two-hybrid, Reconstituted Complex
CWC23 YGL128C Component of a complex containing Cef1p physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SPP382 YLR424W Essential protein that forms a dimer with Ntr2p genetic 2 2 2 Dosage Rescue, Dosage Lethality
SLU7 YDR088C RNA splicing factor physical 2 2 2 Co-fractionation, Co-localization
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 2 2 2 Synthetic Rescue, Negative Genetic
NTR2 YKR022C Essential protein that forms a dimer with Ntr1p physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
PRP39 YML046W U1 snRNP protein involved in splicing physical 2 2 2 Two-hybrid, Reconstituted Complex
PRP16 YKR086W DEAH-box RNA helicase physical 2 2 2 Affinity Capture-MS, Co-localization
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
PRP9 YDL030W Subunit of the SF3a splicing factor complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RSE1 YML049C Protein involved in pre-mRNA splicing physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SMD2 YLR275W Core Sm protein Sm D2 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SPE1 YKL184W Ornithine decarboxylase genetic 2 1 2 Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 2 1 2 Negative Genetic, Negative Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 2 1 2 Negative Genetic, Negative Genetic
CEF1 YMR213W Essential splicing factor genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
ECM2 YBR065C Pre-mRNA splicing factor genetic 2 2 1 Synthetic Rescue, Positive Genetic
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
CWC21 YDR482C Protein involved in RNA splicing by the spliceosome genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
GBP2 YCL011C Poly(A+) RNA-binding protein genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
SWA2 YDR320C Auxilin-like protein involved in vesicular transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
HSP78 YDR258C Oligomeric mitochondrial matrix chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
ECM2 YBR065C Pre-mRNA splicing factor physical 1 1 1 Affinity Capture-MS
PRP45 YAL032C Protein required for pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
PRP46 YPL151C Member of the NineTeen Complex (NTC) physical 1 1 1 Affinity Capture-MS
SNT309 YPR101W Member of the NineTeen Complex (NTC) physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Two-hybrid
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Two-hybrid
UGA1 YGR019W Gamma-aminobutyrate (GABA) transaminase physical 1 1 1 Two-hybrid
UPC2 YDR213W Sterol regulatory element binding protein physical 1 1 1 Two-hybrid
SMX2 YFL017W-A Core Sm protein Sm G physical 1 1 1 Affinity Capture-MS
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 physical 1 1 1 Affinity Capture-MS
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
SME1 YOR159C Core Sm protein Sm E physical 1 1 1 Affinity Capture-MS
SMX3 YPR182W Core Sm protein Sm F physical 1 1 1 Affinity Capture-MS
YDL085C-A YDL085C-A Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SPP381 YBR152W mRNA splicing factor, component of U4/U6.U5 tri-snRNP physical 1 1 1 Affinity Capture-MS
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Reconstituted Complex
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Dosage Rescue
SMY2 YBR172C GYF domain protein physical 1 1 1 Affinity Capture-MS
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
YJU2 YKL095W Essential protein required for pre-mRNA splicing physical 1 1 1 Reconstituted Complex
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Protein-RNA
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Synthetic Lethality
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Synthetic Lethality
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Phenotypic Enhancement
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Phenotypic Enhancement
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TIM44 YIL022W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Positive Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Positive Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Positive Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Two-hybrid
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Synthetic Rescue
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase physical 1 1 1 Two-hybrid
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome physical 1 1 1 Affinity Capture-MS
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase physical 1 1 1 Two-hybrid
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly physical 1 1 1 Two-hybrid
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase physical 1 1 1 Affinity Capture-MS
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Negative Genetic
ECM5 YMR176W Subunit of the Snt2C complex physical 1 1 1 Two-hybrid
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM4 YER112W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
LSM7 YNL147W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
LUC7 YDL087C Essential protein associated with the U1 snRNP complex physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein physical 1 1 1 Affinity Capture-MS
PRP28 YDR243C Pre-mRNA splicing factor physical 1 1 1 Reconstituted Complex
PRP21 YJL203W Subunit of the SF3a splicing factor complex physical 1 1 1 Affinity Capture-MS
GPM1 YKL152C Tetrameric phosphoglycerate mutase physical 1 1 1 Two-hybrid
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 physical 1 1 1 Co-localization
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Dosage Lethality
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Positive Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Phenotypic Enhancement
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein genetic 1 1 1 Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Negative Genetic
MIG1 YGL035C Transcription factor involved in glucose repression physical 1 1 1 Two-hybrid
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
CKI1 YLR133W Choline kinase physical 1 1 1 Two-hybrid
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site physical 1 1 1 Two-hybrid
NBA1 YOL070C Protein involved in axial bud site selection genetic 1 1 1 Negative Genetic
ISY1 YJR050W Member of the NineTeen Complex (NTC) genetic 1 1 1 Synthetic Lethality
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Negative Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Synthetic Rescue
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Positive Genetic
KAR3 YPR141C Minus-end-directed microtubule motor physical 1 1 1 Two-hybrid
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Positive Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Negative Genetic
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes physical 1 1 1 Protein-peptide
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Negative Genetic
DJP1 YIR004W ER-associated chaperone involved in protein targeting physical 1 1 1 Two-hybrid
DPC29 YGR021W Putative mitochondrial protein of unknown function physical 1 1 1 Two-hybrid
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Synthetic Rescue
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
HUB1 YNR032C-A Ubiquitin-like protein modifier physical 1 1 1 Affinity Capture-Western
HUB1 YNR032C-A Ubiquitin-like protein modifier genetic 1 1 1 Synthetic Growth Defect
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Positive Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
FMP45 YDL222C Integral membrane protein localized to mitochondria physical 1 1 1 Affinity Capture-MS
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Positive Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
LCB4 YOR171C Sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
CUP1-1 YHR053C Metallothionein genetic 1 1 1 Synthetic Growth Defect
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Positive Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 1 1 1 Negative Genetic