Standard name Systematic name Name description Description
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life
Visualize the interactome of SPT5
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.589 0.554 0.640
Nucleus 0.856 0.847 0.823

GFP localization & abundance

GFP localization GFP abundance
nucleus 2340

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SPT5 9 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 17 5 13 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Co-purification, Reconstituted Complex, Affinity Capture-Western
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 16 3 12 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PSY2 YNL201C Subunit of protein phosphatase PP4 complex physical 8 2 6 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPB7 YDR404C RNA polymerase II subunit B16 physical 7 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 6 3 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western
PSY4 YBL046W Regulatory subunit of protein phosphatase PP4 physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 5 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 5 3 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 4 3 4 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue
RPB4 YJL140W RNA polymerase II subunit B32 physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
DST1 YGL043W General transcription elongation factor TFIIS genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
RPB11 YOL005C RNA polymerase II subunit B12.5 physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 4 4 3 Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 4 3 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-localization
SPT6 YGR116W Nucleosome remodeling protein physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPA49 YNL248C RNA polymerase I subunit A49 genetic 4 3 2 Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement
SUB1 YMR039C Transcriptional regulator genetic 4 4 1 Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 3 2 3 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 3 2 3 Synthetic Lethality, Dosage Rescue, Synthetic Lethality
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SUB1 YMR039C Transcriptional regulator physical 3 3 2 Affinity Capture-MS, Affinity Capture-Western, Co-localization
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 3 2 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
ABD1 YBR236C Methyltransferase physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CDC73 YLR418C Component of the Paf1p complex physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPA49 YNL248C RNA polymerase I subunit A49 physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
NHP6A YPR052C High-mobility group (HMG) protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
RPB5 YBR154C RNA polymerase subunit ABC27 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRP40 YKL012W U1 snRNP protein involved in splicing physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
RPO26 YPR187W RNA polymerase subunit ABC23 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
UFO1 YML088W F-box receptor protein physical 2 2 1 Affinity Capture-MS, Reconstituted Complex
TEN1 YLR010C Protein that regulates telomeric length physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
TEN1 YLR010C Protein that regulates telomeric length genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Positive Genetic, Negative Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 2 2 1 Dosage Rescue, Synthetic Rescue
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 1 Negative Genetic, Positive Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
PRP8 YHR165C Component of U4/U6-U5 snRNP complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
MPS3 YJL019W Nuclear envelope protein genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation regulation 1 1 1 protein kinase assay evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Growth Defect
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Synthetic Rescue
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
LEO1 YOR123C Component of the Paf1 complex physical 1 1 1 Affinity Capture-MS
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Synthetic Rescue
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Synthetic Rescue
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Growth Defect
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing physical 1 1 1 Affinity Capture-MS
IKI3 YLR384C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase physical 1 1 1 Affinity Capture-MS
NOP2 YNL061W rRNA m5C methyltransferase physical 1 1 1 Affinity Capture-MS
NOP7 YGR103W Component of several different pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
NSA1 YGL111W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
LOC1 YFR001W Nucleolar protein involved in the asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly physical 1 1 1 Affinity Capture-MS
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
HCA4 YJL033W DEAD box RNA helicase physical 1 1 1 Affinity Capture-MS
MTR4 YJL050W RNA duplex-sensing translocase physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
RPA34 YJL148W RNA polymerase I subunit A34.5 physical 1 1 1 Reconstituted Complex
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Synthetic Rescue
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPA43 YOR340C RNA polymerase I subunit A43 physical 1 1 1 Two-hybrid
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Lethality
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RLI1 YDR091C Essential Fe-S protein physical 1 1 1 Affinity Capture-MS
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Dosage Rescue
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Dosage Rescue
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
PUF6 YDR496C Pumilio-homology domain protein physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Proximity Label-MS
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family physical 1 1 1 Affinity Capture-MS
RIX1 YHR197W Component of the Rix1 complex and possibly pre-replicative complexes physical 1 1 1 Affinity Capture-MS
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Synthetic Lethality
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Phenotypic Enhancement
GCN2 YDR283C Protein kinase physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 genetic 1 1 1 Phenotypic Suppression
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Reconstituted Complex
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 1 1 1 Affinity Capture-MS
NHP6B YBR089C-A High-mobility group (HMG) protein physical 1 1 1 Affinity Capture-MS
NHP6B YBR089C-A High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
PAP1 YKR002W Poly(A) polymerase physical 1 1 1 Affinity Capture-MS
LEA1 YPL213W Component of U2 snRNP complex physical 1 1 1 Affinity Capture-Western
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Affinity Capture-MS
NOP14 YDL148C Nucleolar protein physical 1 1 1 Affinity Capture-MS
RAI1 YGL246C Nuclear decapping endonuclease physical 1 1 1 Affinity Capture-MS
REF2 YDR195W RNA-binding protein physical 1 1 1 Affinity Capture-MS
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
RPB9 YGL070C RNA polymerase II subunit B12.6 physical 1 1 1 Affinity Capture-MS
RPB8 YOR224C RNA polymerase subunit ABC14.5 physical 1 1 1 Affinity Capture-MS
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation physical 1 1 1 Affinity Capture-MS
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Affinity Capture-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex physical 1 1 1 Affinity Capture-MS
SPN1 YPR133C Protein involved in RNA polymerase II transcription physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-MS
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
TIF5 YPR041W Translation initiation factor eIF5 physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Synthetic Lethality
SUA7 YPR086W Transcription factor TFIIB physical 1 1 1 Affinity Capture-MS
SVL3 YPL032C Protein of unknown function physical 1 1 1 Affinity Capture-MS
THO1 YER063W Conserved nuclear RNA-binding protein physical 1 1 1 Affinity Capture-MS
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase physical 1 1 1 Affinity Capture-MS
YGR054W YGR054W Eukaryotic initiation factor eIF2A physical 1 1 1 Affinity Capture-MS
TMA22 YJR014W Protein of unknown function physical 1 1 1 Affinity Capture-MS
TIF3 YPR163C Translation initiation factor eIF-4B physical 1 1 1 Affinity Capture-MS
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family physical 1 1 1 Affinity Capture-MS
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Co-purification
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Affinity Capture-MS
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Affinity Capture-MS
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-MS
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Affinity Capture-MS
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TRM112 YNR046W Protein involved in methylation of tRNA, rRNA, and translation factors physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
STN1 YDR082W Telomere end-binding and capping protein physical 1 1 1 Affinity Capture-MS
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) physical 1 1 1 Affinity Capture-MS
MCM2 YBL023C Protein involved in DNA replication physical 1 1 1 Affinity Capture-MS
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) physical 1 1 1 Affinity Capture-MS
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
ROK1 YGL171W RNA-dependent ATPase physical 1 1 1 Affinity Capture-MS
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
BBC1 YJL020C Protein possibly involved in assembly of actin patches physical 1 1 1 Affinity Capture-MS
FIN1 YDR130C Spindle pole body-related intermediate filament protein physical 1 1 1 Affinity Capture-Western
HEL2 YDR266C RING finger ubiquitin ligase (E3) physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
NPA3 YJR072C Member of the conserved GPN-loop GTPase family physical 1 1 1 Affinity Capture-MS
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Biochemical Activity
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Suppression
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Growth Defect
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Synthetic Growth Defect
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-MS
MAP2 YBL091C Methionine aminopeptidase physical 1 1 1 Affinity Capture-MS
ASR1 YPR093C Ubiquitin ligase that modifies and regulates RNA Pol II physical 1 1 1 Affinity Capture-MS
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-MS
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 PCA
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes physical 1 1 1 Affinity Capture-MS
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes physical 1 1 1 Affinity Capture-MS
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes genetic 1 1 1 Synthetic Growth Defect
AMD1 YML035C AMP deaminase physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping physical 1 1 1 Affinity Capture-MS
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Synthetic Lethality
CRP1 YHR146W Protein that binds to cruciform DNA structures physical 1 1 1 Affinity Capture-MS
NHP6A YPR052C High-mobility group (HMG) protein physical 1 1 1 Affinity Capture-MS
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III physical 1 1 1 Affinity Capture-MS
SMC2 YFR031C Subunit of the condensin complex physical 1 1 1 Affinity Capture-MS
JIP5 YPR169W Protein required for biogenesis of the large ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
RRN3 YKL125W Protein required for transcription of rDNA by RNA polymerase I physical 1 1 1 Reconstituted Complex
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Synthetic Growth Defect
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
PDP3 YLR455W Component of the NuA3b histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
JHD2 YJR119C JmjC domain family histone demethylase physical 1 1 1 Affinity Capture-MS
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Synthetic Lethality
CUZ1 YNL155W Protein with a role in the ubiquitin-proteasome pathway physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RTR1 YER139C Dual specificity protein phosphatase physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
RTT106 YNL206C Histone chaperone genetic 1 1 1 Synthetic Growth Defect
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
PMC1 YGL006W Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination physical 1 1 1 Affinity Capture-MS
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect