CDC45 |
YLR103C |
DNA replication initiation factor |
physical |
27 |
5 |
24 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
MCM2 |
YBL023C |
Protein involved in DNA replication |
physical |
27 |
7 |
22 |
Co-localization, Co-localization, Co-fractionation, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
MCM6 |
YGL201C |
Protein involved in DNA replication |
physical |
21 |
6 |
18 |
Co-localization, Co-purification, Reconstituted Complex, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
20 |
7 |
17 |
Co-localization, Co-purification, Co-purification, Reconstituted Complex, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
MCM3 |
YEL032W |
Protein involved in DNA replication |
physical |
19 |
5 |
18 |
Co-localization, Co-localization, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
CTF4 |
YPR135W |
Chromatin-associated protein |
physical |
16 |
3 |
15 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
15 |
3 |
14 |
Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
13 |
4 |
11 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
physical |
13 |
5 |
9 |
Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-purification, Co-localization, Affinity Capture-Western |
PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
11 |
3 |
11 |
Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
11 |
3 |
10 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
physical |
10 |
4 |
9 |
Biochemical Activity, Biochemical Activity, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Two-hybrid, Affinity Capture-Western |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
physical |
9 |
3 |
8 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western |
CSM3 |
YMR048W |
Replication fork associated factor |
physical |
8 |
2 |
8 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
physical |
8 |
2 |
7 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
PSF3 |
YOL146W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
7 |
3 |
7 |
Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
7 |
5 |
6 |
Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic, Negative Genetic |
TAH11 |
YJR046W |
DNA replication licensing factor |
physical |
7 |
3 |
6 |
Reconstituted Complex, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
6 |
2 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
6 |
4 |
4 |
Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Growth Defect |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
physical |
6 |
2 |
4 |
Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-fractionation, Reconstituted Complex, Reconstituted Complex |
MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
5 |
4 |
5 |
Phenotypic Enhancement, Synthetic Lethality, Dosage Growth Defect, Negative Genetic, Synthetic Lethality |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
5 |
4 |
4 |
Phenotypic Enhancement, Synthetic Lethality, Dosage Growth Defect, Negative Genetic, Negative Genetic |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
5 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
HHF1 |
YBR009C |
Histone H4 |
physical |
4 |
1 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
HHT1 |
YBR010W |
Histone H3 |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
SLD2 |
YKL108W |
Single-stranded DNA origin-binding and annealing protein |
physical |
3 |
2 |
2 |
Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
DPB2 |
YPR175W |
Second largest subunit of DNA polymerase II (DNA polymerase epsilon) |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Enhancement |
HTA1 |
YDR225W |
Histone H2A |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
HTA2 |
YBL003C |
Histone H2A |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
HTB1 |
YDR224C |
Histone H2B |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
TOP1 |
YOL006C |
Topoisomerase I |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
PRI1 |
YIR008C |
Subunit of DNA primase |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-MS |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Synthetic Rescue |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Rescue |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IPI3 |
YNL182C |
Component of the Rix1 complex and pre-replicative complexes (pre-RCs) |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RAD52 |
YML032C |
Protein involved in homologous recombination |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
regulation |
1 |
1 |
1 |
quantitative mass spectrometry evidence |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
regulation |
1 |
1 |
1 |
qualitative western immunoblotting evidence |
ADH1 |
YOL086C |
Alcohol dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DBP7 |
YKR024C |
Putative ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ARP2 |
YDL029W |
Essential component of the Arp2/3 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Dosage Lethality |
DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
EMG1 |
YLR186W |
Methyltransferase for rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HRT1 |
YOL133W |
RING-H2 domain core subunit of multiple ubiquitin ligase complexes |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTB2 |
YBL002W |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ENO2 |
YHR174W |
Enolase II, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD21 |
YOR078W |
Component of small ribosomal subunit (SSU) processosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
GPM1 |
YKL152C |
Tetrameric phosphoglycerate mutase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HOG1 |
YLR113W |
Mitogen-activated protein kinase involved in osmoregulation |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
DIA2 |
YOR080W |
Origin-binding F-box protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SAN1 |
YDR143C |
Ubiquitin-protein ligase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SKY1 |
YMR216C |
SR protein kinase (SRPK) |
physical |
1 |
1 |
1 |
Biochemical Activity |
TPK1 |
YJL164C |
cAMP-dependent protein kinase catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
physical |
1 |
1 |
1 |
Co-localization |
TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRI2 |
YKL045W |
Subunit of DNA primase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MRK1 |
YDL079C |
Glycogen synthase kinase 3 (GSK-3) homolog |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
RTK1 |
YDL025C |
Putative protein kinase, potentially phosphorylated by Cdc28p |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SPB4 |
YFL002C |
Putative ATP-dependent RNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
physical |
1 |
1 |
1 |
Co-purification |
RVB2 |
YPL235W |
ATP-dependent DNA helicase, also known as reptin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PMP1 |
YCR024C-A |
Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
TIF4631 |
YGR162W |
Translation initiation factor eIF4G and scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YEF3 |
YLR249W |
Translation elongation factor 3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS5 |
YJR123W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PSA1 |
YDL055C |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PGK1 |
YCR012W |
3-phosphoglycerate kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL21A |
YBR191W |
Ribosomal 60S subunit protein L21A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD53 |
YPL153C |
DNA damage response kinase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
TRA1 |
YHR099W |
Subunit of SAGA and NuA4 histone acetyltransferase complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT5 |
YML010W |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UFD1 |
YGR048W |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MLH3 |
YPL164C |
Protein involved in DNA mismatch repair and meiotic recombination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS12 |
YOR369C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS13 |
YDR064W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS18A |
YDR450W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MTQ2 |
YDR140W |
S-adenosylmethionine-dependent methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD51 |
YER095W |
Strand exchange protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Positive Genetic |
PMS1 |
YNL082W |
ATP-binding protein required for mismatch repair |
genetic |
1 |
1 |
1 |
Positive Genetic |
MKT1 |
YNL085W |
Protein similar to nucleases that forms a complex with Pbp1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
PCF11 |
YDR228C |
mRNA 3' end processing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
UTP5 |
YDR398W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA7 |
YBL039C |
Major CTP synthase isozyme (see also URA8) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
PMT3 |
YOR321W |
Protein O-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NHP6B |
YBR089C-A |
High-mobility group (HMG) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
YEL076C |
YEL076C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMA2 |
YML066C |
Meiosis-specific prospore membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNL162W-A |
YNL162W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
physical |
1 |
1 |
1 |
Biochemical Activity |
ATG1 |
YGL180W |
Protein serine/threonine kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CDC19 |
YAL038W |
Pyruvate kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MCA1 |
YOR197W |
Ca2+-dependent cysteine protease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BET4 |
YJL031C |
Alpha subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
BAP3 |
YDR046C |
Amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLB6 |
YGR109C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIT2 |
YDR402C |
N-formyltyrosine oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Negative Genetic |