GEnome-wide tool for Multi-scale Modeling
data Extraction and Representation
for Saccharomyces cerevisiae

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.

Standard name	Systematic name	Name description	Type	#Experiments	#Methods	#Publications	Evidence
RAD51	YER095W	Strand exchange protein	physical	43	5	32	Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-localization, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SRS2	YJL092W	DNA helicase and DNA-dependent ATPase	genetic	24	7	22	Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Dosage Lethality, Dosage Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Negative Genetic, Synthetic Rescue
RAD51	YER095W	Strand exchange protein	genetic	23	5	22	Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Positive Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Positive Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic, Phenotypic Suppression
SGS1	YMR190C	RecQ family nucleolar DNA helicase	genetic	23	6	18	Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Positive Genetic
REV3	YPL167C	Catalytic subunit of DNA polymerase zeta	genetic	22	6	16	Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
ELG1	YOR144C	Subunit of an alternative replication factor C complex	genetic	20	4	14	Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression, Phenotypic Suppression
YKU70	YMR284W	Subunit of the telomeric Ku complex (Yku70p-Yku80p)	genetic	19	6	18	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
RAD1	YPL022W	Single-stranded DNA endonuclease (with Rad10p)	genetic	18	4	17	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Positive Genetic
RAD27	YKL113C	5' to 3' exonuclease, 5' flap endonuclease	genetic	18	3	13	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RAD18	YCR066W	E3 ubiquitin ligase	genetic	17	7	14	Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Rescue
RAD59	YDL059C	Protein involved DNA double-strand break repair	physical	15	6	11	Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Co-localization, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, PCA, Affinity Capture-Western
RAD5	YLR032W	DNA helicase/Ubiquitin ligase	genetic	14	6	11	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Dosage Lethality, Phenotypic Suppression, Dosage Rescue
RFA1	YAR007C	Subunit of heterotrimeric Replication Protein A (RPA)	physical	13	5	10	Affinity Capture-MS, Two-hybrid, Two-hybrid, Co-localization, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
POL32	YJR043C	Third subunit of DNA polymerase delta	genetic	12	5	8	Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic
POL30	YBR088C	Proliferating cell nuclear antigen (PCNA)	genetic	11	5	11	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue
MRC1	YCL061C	S-phase checkpoint protein required for DNA replication	genetic	11	5	9	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect
POL3	YDL102W	Catalytic subunit of DNA polymerase delta	genetic	10	6	9	Phenotypic Suppression, Dosage Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD59	YDL059C	Protein involved DNA double-strand break repair	genetic	9	5	9	Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Phenotypic Enhancement
RFA1	YAR007C	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	9	5	8	Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement
RAD54	YGL163C	DNA-dependent ATPase that stimulates strand exchange	genetic	9	2	8	Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic, Positive Genetic
SIZ1	YDR409W	SUMO E3 ligase	genetic	9	4	7	Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
RRM3	YHR031C	DNA helicase involved in rDNA replication and Ty1 transposition	genetic	8	4	8	Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue
RAD50	YNL250W	Subunit of MRX complex with Mre11p and Xrs2p	genetic	8	4	8	Positive Genetic, Phenotypic Enhancement, Positive Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Positive Genetic
EST2	YLR318W	Reverse transcriptase subunit of the telomerase holoenzyme	genetic	8	3	8	Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
NUP60	YAR002W	FG-nucleoporin component of central core of the nuclear pore complex	genetic	8	3	7	Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD6	YGL058W	Ubiquitin-conjugating enzyme (E2)	genetic	8	3	7	Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
REV1	YOR346W	Deoxycytidyl transferase	genetic	8	3	7	Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
DUN1	YDL101C	Cell-cycle checkpoint S/T protein kinase	genetic	8	3	7	Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
NUP133	YKR082W	Subunit of Nup84p subcomplex of nuclear pore complex (NPC)	genetic	8	3	7	Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
DNA2	YHR164C	ATP-dependent 5'-flap endonuclease and DNA helicase	genetic	8	6	6	Synthetic Lethality, Dosage Rescue, Negative Genetic, Phenotypic Suppression, Dosage Rescue, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement
MUS81	YDR386W	Subunit of structure-specific Mms4p-Mus81p endonuclease	genetic	8	5	6	Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Positive Genetic, Negative Genetic
CTF18	YMR078C	Subunit of a complex with Ctf8p	genetic	8	4	6	Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality
CTF8	YHR191C	Subunit of a complex with Ctf18p	genetic	8	4	6	Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic
SLX8	YER116C	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex	genetic	7	5	7	Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Negative Genetic
DNL4	YOR005C	DNA ligase required for nonhomologous end-joining (NHEJ)	genetic	7	3	7	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Positive Genetic
RNH201	YNL072W	Ribonuclease H2 catalytic subunit	genetic	7	4	6	Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression
RTT109	YLL002W	Histone acetyltransferase	genetic	7	3	6	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect
CTF4	YPR135W	Chromatin-associated protein	genetic	7	2	6	Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RFA2	YNL312W	Subunit of heterotrimeric Replication Protein A (RPA)	physical	7	4	5	Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Affinity Capture-Western
DCC1	YCL016C	Subunit of a complex with Ctf8p and Ctf18p	genetic	7	3	5	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic
RPN10	YHR200W	Proteasome polyubiquitin receptor	genetic	7	2	5	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SKN7	YHR206W	Nuclear response regulator and transcription factor	genetic	7	2	5	Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RNH202	YDR279W	Ribonuclease H2 subunit	genetic	7	3	4	Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
DIA2	YOR080W	Origin-binding F-box protein	genetic	7	3	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
TEL1	YBL088C	Protein kinase primarily involved in telomere length regulation	genetic	6	4	6	Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
MSH2	YOL090W	Protein that binds to DNA mismatches	genetic	6	3	6	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
RAD3	YER171W	5' to 3' DNA helicase	genetic	6	3	6	Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Positive Genetic, Synthetic Lethality, Synthetic Lethality
YKU80	YMR106C	Subunit of telomeric Ku complex (Yku70p-Yku80p)	genetic	6	3	6	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
RAD52	YML032C	Protein involved in homologous recombination	physical	6	2	6	Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex
ASF1	YJL115W	Nucleosome assembly factor	genetic	6	4	5	Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
CLA4	YNL298W	Cdc42p-activated signal transducing kinase	genetic	6	3	5	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic
PMR1	YGL167C	High affinity Ca2+/Mn2+ P-type ATPase	genetic	6	3	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
MEC1	YBR136W	Genome integrity checkpoint protein and PI kinase superfamily member	genetic	5	4	5	Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement
CDC13	YDL220C	Single stranded DNA-binding protein found at TG1-3 telomere G-tails	genetic	5	4	5	Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
CDC73	YLR418C	Component of the Paf1p complex	genetic	5	3	5	Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression
PPH3	YDR075W	Catalytic subunit of protein phosphatase PP4 complex	genetic	5	3	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Positive Genetic, Negative Genetic
RTT107	YHR154W	BRCA1 C-terminal domain protein needed for recovery from DNA damage	genetic	5	3	5	Phenotypic Enhancement, Synthetic Growth Defect, Positive Genetic, Synthetic Growth Defect, Positive Genetic
TOP1	YOL006C	Topoisomerase I	genetic	5	3	5	Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
NUP84	YDL116W	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)	genetic	5	3	5	Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic, Synthetic Lethality
EST1	YLR233C	TLC1 RNA-associated factor involved in telomere length regulation	genetic	5	3	5	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DST1	YGL043W	General transcription elongation factor TFIIS	genetic	5	2	5	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SLX5	YDL013W	Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex	genetic	5	4	4	Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
APN1	YKL114C	Major apurinic/apyrimidinic endonuclease	genetic	5	4	4	Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
HHF1	YBR009C	Histone H4	genetic	5	3	4	Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
CDC9	YDL164C	DNA ligase I found in nucleus and mitochondria	genetic	5	3	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Suppression, Synthetic Lethality
TOF1	YNL273W	Subunit of a replication-pausing checkpoint complex	genetic	5	2	4	Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CIK1	YMR198W	Kinesin-associated protein	genetic	5	2	4	Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
LRS4	YDR439W	Nucleolar protein that forms a complex with Csm1p	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RFC5	YBR087W	Subunit of heteropentameric Replication factor C (RF-C)	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CMR1	YDL156W	Nuclear protein with role in transcription, protein quality control	genetic	5	3	3	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
MMS22	YLR320W	Subunit of E3 ubiquitin ligase complex involved in replication repair	genetic	5	2	3	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MPH1	YIR002C	3'-5' DNA helicase involved in error-free bypass of DNA lesions	genetic	4	4	4	Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
UMP1	YBR173C	Chaperone required for correct maturation of the 20S proteasome	genetic	4	4	4	Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
XRN1	YGL173C	Evolutionarily-conserved 5'-3' exonuclease	genetic	4	4	4	Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic
SIN3	YOL004W	Component of both the Rpd3S and Rpd3L histone deacetylase complexes	genetic	4	4	4	Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic
MRE11	YMR224C	Nuclease subunit of the MRX complex with Rad50p and Xrs2p	genetic	4	4	4	Phenotypic Suppression, Phenotypic Enhancement, Synthetic Lethality, Positive Genetic
PIF1	YML061C	DNA helicase, potent G-quadruplex DNA binder/unwinder	genetic	4	4	4	Synthetic Rescue, Phenotypic Suppression, Synthetic Lethality, Phenotypic Enhancement
POL2	YNL262W	Catalytic subunit of DNA polymerase (II) epsilon	genetic	4	3	4	Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
RAD9	YDR217C	DNA damage-dependent checkpoint protein	genetic	4	3	4	Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
DOA1	YKL213C	WD-repeat protein involved in ubiquitin-mediated protein degradation	genetic	4	2	4	Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
RFA2	YNL312W	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	4	2	4	Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
RAD55	YDR076W	Protein that stimulates strand exchange	genetic	4	2	4	Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic
SWD3	YBR175W	Essential subunit of the COMPASS (Set1C) complex	genetic	4	2	4	Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
REV7	YIL139C	Accessory subunit of DNA polymerase zeta	genetic	4	2	4	Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
WSS1	YHR134W	SUMO-ligase and SUMO-targeted metalloprotease	genetic	4	2	4	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
IRC5	YFR038W	Putative ATPase containing the DEAD/H helicase-related sequence motif	genetic	4	2	4	Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
PSY2	YNL201C	Subunit of protein phosphatase PP4 complex	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ROX1	YPR065W	Heme-dependent repressor of hypoxic genes	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	genetic	4	3	3	Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
POL1	YNL102W	Catalytic subunit of the DNA polymerase I alpha-primase complex	genetic	4	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RFA3	YJL173C	Subunit of heterotrimeric Replication Protein A (RPA)	physical	4	3	3	Two-hybrid, Affinity Capture-MS, Two-hybrid, Reconstituted Complex
UME6	YDR207C	Rpd3L histone deacetylase complex subunit	genetic	4	3	3	Positive Genetic, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect
CCS1	YMR038C	Copper chaperone for superoxide dismutase Sod1p	genetic	4	3	3	Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality
HRQ1	YDR291W	3'-5' DNA helicase of the conserved RecQ family	genetic	4	3	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic
NTG2	YOL043C	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase	genetic	4	3	3	Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
SRS2	YJL092W	DNA helicase and DNA-dependent ATPase	physical	4	2	3	Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid
RAD10	YML095C	Single-stranded DNA endonuclease (with Rad1p)	genetic	4	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
GET2	YER083C	Subunit of the GET complex	genetic	4	2	3	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
MMS1	YPR164W	Subunit of E3 ubiquitin ligase complex involved in replication repair	genetic	4	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MMS21	YEL019C	Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex	genetic	4	4	2	Positive Genetic, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect
CSM3	YMR048W	Replication fork associated factor	genetic	4	3	2	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic
ESA1	YOR244W	Catalytic subunit of the histone acetyltransferase complex (NuA4)	genetic	4	1	2	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
LSM1	YJL124C	Lsm (Like Sm) protein	genetic	3	3	3	Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
MLH1	YMR167W	Protein required for mismatch repair in mitosis and meiosis	genetic	3	3	3	Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue
ARP8	YOR141C	Nuclear actin-related protein involved in chromatin remodeling	genetic	3	3	3	Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic
SIR3	YLR442C	Silencing protein	genetic	3	3	3	Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
RSC2	YLR357W	Component of the RSC chromatin remodeling complex	genetic	3	3	3	Dosage Rescue, Synthetic Growth Defect, Phenotypic Suppression
RTT101	YJL047C	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex	genetic	3	3	3	Synthetic Growth Defect, Phenotypic Suppression, Positive Genetic
TOP3	YLR234W	DNA Topoisomerase III	genetic	3	3	3	Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic
MMS2	YGL087C	Ubiquitin-conjugating enzyme variant	genetic	3	3	3	Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect
GCR2	YNL199C	Transcriptional activator of genes involved in glycolysis	genetic	3	3	3	Synthetic Growth Defect, Positive Genetic, Negative Genetic
INO80	YGL150C	Nucleosome spacing factor	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
ORC2	YBR060C	Subunit of the origin recognition complex (ORC)	genetic	3	2	3	Synthetic Lethality, Negative Genetic, Negative Genetic
RAD57	YDR004W	Protein that stimulates strand exchange	genetic	3	2	3	Positive Genetic, Phenotypic Suppression, Positive Genetic
TDP1	YBR223C	Tyrosyl-DNA phosphodiesterase I	genetic	3	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
TRM2	YKR056W	tRNA methyltransferase	genetic	3	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue
SMC6	YLR383W	Subunit of the SMC5-SMC6 complex	genetic	3	2	3	Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
RMI1	YPL024W	Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex	genetic	3	2	3	Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect
VID22	YLR373C	G-quadruplex (G4) DNA binding protein	genetic	3	2	3	Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RML2	YEL050C	Mitochondrial ribosomal protein of the large subunit (L2)	genetic	3	2	3	Negative Genetic, Synthetic Growth Defect, Negative Genetic
SET1	YHR119W	Histone methyltransferase, subunit of the COMPASS (Set1C) complex	genetic	3	2	3	Negative Genetic, Synthetic Growth Defect, Negative Genetic
BUB2	YMR055C	Mitotic exit network regulator	genetic	3	2	3	Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CAC2	YML102W	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p	genetic	3	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
CLB2	YPR119W	B-type cyclin involved in cell cycle progression	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
CDC7	YDL017W	S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase)	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic
EXO1	YOR033C	5'-3' exonuclease and flap-endonuclease	genetic	3	2	3	Synthetic Lethality, Phenotypic Suppression, Synthetic Lethality
RAD2	YGR258C	Single-stranded DNA endonuclease	genetic	3	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
IRC19	YLL033W	Protein of unknown function	genetic	3	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
NPL3	YDR432W	RNA-binding protein	genetic	3	1	3	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	genetic	3	1	3	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
HDA1	YNL021W	Catalytic subunit of class II HDA1 histone deacetylase complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
HSL1	YKL101W	Nim1p-related protein kinase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
NHP10	YDL002C	Non-essential INO80 chromatin remodeling complex subunit	genetic	3	1	3	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
PRE9	YGR135W	Alpha 3 subunit of the 20S proteasome	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CDC5	YMR001C	Polo-like kinase required for mitotic exit	genetic	3	1	3	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
BUB1	YGR188C	Protein kinase involved in the cell cycle checkpoint into anaphase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
PSF1	YDR013W	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)	genetic	3	3	2	Phenotypic Enhancement, Phenotypic Suppression, Synthetic Lethality
POP2	YNR052C	Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	genetic	3	3	2	Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality
ULP1	YPL020C	Protease that specifically cleaves Smt3p protein conjugates	genetic	3	3	2	Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue
YCS4	YLR272C	Subunit of the condensin complex	genetic	3	3	2	Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue
YDJ1	YNL064C	Type I HSP40 co-chaperone	genetic	3	3	2	Negative Genetic, Synthetic Growth Defect, Synthetic Rescue
RPO21	YDL140C	RNA polymerase II largest subunit B220	genetic	3	3	2	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
BRE1	YDL074C	E3 ubiquitin ligase	genetic	3	2	2	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
HHF2	YNL030W	Histone H4	genetic	3	2	2	Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
SAW1	YAL027W	5'- and 3'-flap DNA binding protein	physical	3	2	2	Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
SMT3	YDR510W	Ubiquitin-like protein of the SUMO family	genetic	3	2	2	Synthetic Growth Defect, Negative Genetic, Negative Genetic
RPN5	YDL147W	Subunit of the CSN and 26S proteasome lid complexes	genetic	3	2	2	Synthetic Growth Defect, Negative Genetic, Negative Genetic
SWR1	YDR334W	Swi2/Snf2-related ATPase	genetic	3	2	2	Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
RNH203	YLR154C	Ribonuclease H2 subunit	genetic	3	2	2	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
NTG1	YAL015C	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase	genetic	3	2	2	Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
POL31	YJR006W	Subunit of DNA polymerase delta (polymerase III)	genetic	3	2	2	Synthetic Lethality, Negative Genetic, Negative Genetic
HUR1	YGL168W	Protein with a role in DNA repair	genetic	3	2	2	Synthetic Lethality, Negative Genetic, Negative Genetic
LGE1	YPL055C	Protein involved in histone H2B ubiquitination	genetic	3	2	2	Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
EAF1	YDR359C	Component of the NuA4 histone acetyltransferase complex	genetic	3	1	2	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
POL12	YBL035C	B subunit of DNA polymerase alpha-primase complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
RFC4	YOL094C	Subunit of heteropentameric Replication factor C (RF-C)	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
SFT2	YBL102W	Tetra-spanning membrane protein found mostly in the late Golgi	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
UBP14	YBR058C	Ubiquitin-specific protease	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
RPN11	YFR004W	Metalloprotease subunit of 19S regulatory particle	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
RPN12	YFR052W	Subunit of the 19S regulatory particle of the 26S proteasome lid	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
SIP4	YJL089W	C6 zinc cluster transcriptional activator	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
TSA1	YML028W	Thioredoxin peroxidase	genetic	3	1	2	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
RPT4	YOR259C	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
HOM6	YJR139C	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase)	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
EDS1	YBR033W	Putative zinc cluster protein, predicted to be a transcription factor	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
HHF1	YBR009C	Histone H4	physical	2	2	2	Affinity Capture-MS, Affinity Capture-Western
PRP4	YPR178W	Splicing factor	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
RFA3	YJL173C	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	2	2	2	Negative Genetic, Phenotypic Enhancement
UBC9	YDL064W	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway	physical	2	2	2	Biochemical Activity, Two-hybrid
SMT3	YDR510W	Ubiquitin-like protein of the SUMO family	physical	2	2	2	Affinity Capture-Western, Two-hybrid
RLF2	YPR018W	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1)	genetic	2	2	2	Phenotypic Enhancement, Synthetic Growth Defect
SIR2	YDL042C	Conserved NAD+ dependent histone deacetylase of the Sirtuin family	genetic	2	2	2	Phenotypic Enhancement, Phenotypic Suppression
SMC1	YFL008W	Subunit of the multiprotein cohesin complex	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
SMC5	YOL034W	Subunit of the SMC5-SMC6 complex	genetic	2	2	2	Synthetic Rescue, Negative Genetic
SOD1	YJR104C	Cytosolic copper-zinc superoxide dismutase	genetic	2	2	2	Negative Genetic, Synthetic Lethality
RTT105	YER104W	Chaperone for Replication Protein A complex (RPA)	genetic	2	2	2	Negative Genetic, Synthetic Growth Defect
SDS3	YIL084C	Component of the Rpd3L histone deacetylase complex	genetic	2	2	2	Negative Genetic, Synthetic Growth Defect
XRS2	YDR369C	FHA domain-containing component of the Mre11 complex	genetic	2	2	2	Positive Genetic, Synthetic Growth Defect
RNA14	YMR061W	Component of the cleavage and polyadenylation factor I (CF I)	genetic	2	2	2	Negative Genetic, Synthetic Growth Defect
TIF6	YPR016C	Constituent of 66S pre-ribosomal particles	genetic	2	2	2	Positive Genetic, Negative Genetic
SWI6	YLR182W	Transcription cofactor	genetic	2	2	2	Negative Genetic, Synthetic Lethality
YEN1	YER041W	Holliday junction resolvase	genetic	2	2	2	Synthetic Rescue, Synthetic Lethality
RNR4	YGR180C	Ribonucleotide-diphosphate reductase (RNR) small subunit	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SEN1	YLR430W	ATP-dependent 5' to 3' RNA/DNA and DNA helicase	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
RIM11	YMR139W	Protein kinase	genetic	2	2	2	Phenotypic Enhancement, Phenotypic Suppression
RCO1	YMR075W	Essential component of the Rpd3S histone deacetylase complex	genetic	2	2	2	Positive Genetic, Negative Genetic
RFC1	YOR217W	Subunit of heteropentameric Replication factor C (RF-C)	genetic	2	2	2	Synthetic Lethality, Negative Genetic
RNH1	YMR234W	Ribonuclease H1	genetic	2	2	2	Synthetic Lethality, Phenotypic Suppression
SAE2	YGL175C	Endonuclease required for telomere elongation	genetic	2	2	2	Phenotypic Suppression, Negative Genetic
UBP12	YJL197W	Ubiquitin-specific protease	genetic	2	2	2	Negative Genetic, Phenotypic Suppression
PGD1	YGL025C	Subunit of the RNA polymerase II mediator complex	genetic	2	2	2	Synthetic Rescue, Negative Genetic
CSN9	YDR179C	Subunit of the Cop9 signalosome	genetic	2	2	2	Positive Genetic, Negative Genetic
NUP120	YKL057C	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)	genetic	2	2	2	Synthetic Lethality, Negative Genetic
PIN4	YBL051C	Protein involved in G2/M phase progression and response to DNA damage	genetic	2	2	2	Phenotypic Enhancement, Synthetic Growth Defect
MAG1	YER142C	3-methyl-adenine DNA glycosylase	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
HHT1	YBR010W	Histone H3	genetic	2	2	2	Synthetic Growth Defect, Synthetic Rescue
DBF2	YGR092W	Ser/Thr kinase involved in transcription and stress response	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
CDH1	YGL003C	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
RAD4	YER162C	Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2	genetic	2	2	2	Synthetic Growth Defect, Positive Genetic
NFI1	YOR156C	SUMO E3 ligase	genetic	2	2	2	Synthetic Growth Defect, Phenotypic Suppression
DBF4	YDR052C	Regulatory subunit of Cdc7p-Dbf4p kinase complex	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
PUP1	YOR157C	Beta 2 subunit of the 20S proteasome	genetic	2	2	2	Synthetic Rescue, Negative Genetic
KAP120	YPL125W	Karyopherin responsible for the nuclear import of Rpf1p	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
PUP2	YGR253C	Alpha 5 subunit of the 20S proteasome	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
BUD31	YCR063W	Component of the SF3b subcomplex of the U2 snRNP	genetic	2	1	2	Positive Genetic, Positive Genetic
CKS1	YBR135W	Cyclin-dependent protein kinase regulatory subunit and adaptor	genetic	2	1	2	Negative Genetic, Negative Genetic
MPH1	YIR002C	3'-5' DNA helicase involved in error-free bypass of DNA lesions	physical	2	1	2	Affinity Capture-MS, Affinity Capture-MS
MSH6	YDR097C	Protein required for mismatch repair in mitosis and meiosis	physical	2	1	2	Affinity Capture-MS, Affinity Capture-MS
PAC10	YGR078C	Part of the heteromeric co-chaperone GimC/prefoldin complex	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
REC102	YLR329W	Protein involved in early stages of meiotic recombination	genetic	2	1	2	Synthetic Rescue, Synthetic Rescue
REC107	YJR021C	Protein involved in early stages of meiotic recombination	genetic	2	1	2	Synthetic Rescue, Synthetic Rescue
RPN6	YDL097C	Essential, non-ATPase regulatory subunit of the 26S proteasome lid	genetic	2	1	2	Negative Genetic, Negative Genetic
UBP6	YFR010W	Ubiquitin-specific protease	genetic	2	1	2	Negative Genetic, Negative Genetic
SAP30	YMR263W	Component of Rpd3L histone deacetylase complex	genetic	2	1	2	Negative Genetic, Negative Genetic
SEC22	YLR268W	R-SNARE protein	genetic	2	1	2	Negative Genetic, Negative Genetic
VMA1	YDL185W	Subunit A of the V1 peripheral membrane domain of V-ATPase	genetic	2	1	2	Negative Genetic, Negative Genetic
RPT2	YDL007W	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	2	1	2	Negative Genetic, Negative Genetic
YFR057W	YFR057W	Putative protein of unknown function	genetic	2	1	2	Negative Genetic, Negative Genetic
SLX4	YLR135W	Endonuclease involved in processing DNA	genetic	2	1	2	Negative Genetic, Negative Genetic
RTS1	YOR014W	B-type regulatory subunit of protein phosphatase 2A (PP2A)	genetic	2	1	2	Negative Genetic, Negative Genetic
BSP1	YPR171W	Adapter that links synaptojanins to the cortical actin cytoskeleton	genetic	2	1	2	Negative Genetic, Negative Genetic
ATG9	YDL149W	Transmembrane protein involved in forming Cvt and autophagic vesicles	genetic	2	1	2	Negative Genetic, Negative Genetic
LTE1	YAL024C	Protein similar to GDP/GTP exchange factors	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
BRE2	YLR015W	Subunit of COMPASS (Set1C) complex	genetic	2	1	2	Negative Genetic, Negative Genetic
IRA2	YOL081W	GTPase-activating protein	genetic	2	1	2	Negative Genetic, Negative Genetic
BFA1	YJR053W	Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p	genetic	2	1	2	Negative Genetic, Negative Genetic
RAD14	YMR201C	Subunit of Nucleotide Excision Repair Factor 1 (NEF1)	genetic	2	1	2	Phenotypic Enhancement, Phenotypic Enhancement
PAP2	YOL115W	Non-canonical poly(A) polymerase	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
BIM1	YER016W	Microtubule plus end-tracking protein	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
PRI1	YIR008C	Subunit of DNA primase	genetic	2	1	2	Negative Genetic, Negative Genetic
ERG5	YMR015C	C-22 sterol desaturase	genetic	2	1	2	Negative Genetic, Negative Genetic
PGU1	YJR153W	Endo-polygalacturonase	genetic	2	1	2	Negative Genetic, Negative Genetic
HYR1	YIR037W	Glutathione peroxidase	genetic	2	1	2	Negative Genetic, Negative Genetic
ERG3	YLR056W	C-5 sterol desaturase	genetic	2	1	2	Negative Genetic, Negative Genetic
ARD1	YHR013C	Subunit of protein N-terminal acetyltransferase NatA	genetic	2	2	1	Synthetic Lethality, Synthetic Growth Defect
SLX5	YDL013W	Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex	physical	2	2	1	Biochemical Activity, Reconstituted Complex
RAD55	YDR076W	Protein that stimulates strand exchange	physical	2	2	1	Two-hybrid, Reconstituted Complex
STN1	YDR082W	Telomere end-binding and capping protein	genetic	2	2	1	Synthetic Lethality, Phenotypic Enhancement
RPA190	YOR341W	RNA polymerase I largest subunit A190	genetic	2	2	1	Phenotypic Suppression, Synthetic Rescue
CSM2	YIL132C	Subunit of the Shu complex (aka PCSS complex)	genetic	2	2	1	Positive Genetic, Negative Genetic
CSM1	YCR086W	Nucleolar protein that mediates homolog segregation during meiosis I	genetic	2	2	1	Synthetic Lethality, Synthetic Growth Defect
MPS1	YDL028C	Dual-specificity kinase	physical	2	2	1	Biochemical Activity, Affinity Capture-Western
OGG1	YML060W	Nuclear and mitochondrial glycosylase/lyase	genetic	2	2	1	Phenotypic Suppression, Synthetic Growth Defect
ALG14	YBR070C	Component of UDP-GlcNAc transferase	genetic	2	2	1	Negative Genetic, Positive Genetic
CDC48	YDL126C	AAA ATPase with protein-unfoldase activity	physical	2	1	1	Affinity Capture-Western, Affinity Capture-Western
PRE10	YOR362C	Alpha 7 subunit of the 20S proteasome	genetic	2	1	1	Negative Genetic, Negative Genetic
PRE2	YPR103W	Beta 5 subunit of the 20S proteasome	genetic	2	1	1	Negative Genetic, Negative Genetic
PDC1	YLR044C	Major of three pyruvate decarboxylase isozymes	genetic	2	1	1	Negative Genetic, Negative Genetic
UFD1	YGR048W	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase	physical	2	1	1	Affinity Capture-Western, Affinity Capture-Western
RPN4	YDL020C	Transcription factor that stimulates expression of proteasome genes	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
SOV1	YMR066W	Mitochondrial protein of unknown function	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
NAT1	YDL040C	Subunit of protein N-terminal acetyltransferase NatA	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
GET1	YGL020C	Subunit of the GET complex	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
CDC20	YGL116W	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	2	1	1	Synthetic Lethality, Synthetic Lethality
MCM4	YPR019W	Essential helicase component of heterohexameric MCM2-7 complexes	physical	2	1	1	Affinity Capture-Western, Affinity Capture-Western
CSM2	YIL132C	Subunit of the Shu complex (aka PCSS complex)	physical	2	1	1	Two-hybrid, Two-hybrid
NPT1	YOR209C	Nicotinate phosphoribosyltransferase	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
DFR1	YOR236W	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis	genetic	2	1	1	Negative Genetic, Negative Genetic
FKH1	YIL131C	Forkhead family transcription factor	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
MED2	YDL005C	Subunit of the RNA polymerase II mediator complex	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
XBP1	YIL101C	Transcriptional repressor	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
YAP1	YML007W	Basic leucine zipper (bZIP) transcription factor	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
REB1	YBR049C	RNA polymerase I enhancer binding protein	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	regulation	1	1	1	protein kinase assay evidence
MED4	YOR174W	Subunit of the RNA polymerase II mediator complex	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
CAD1	YDR423C	AP-1-like basic leucine zipper (bZIP) transcriptional activator	regulation	1	1	1	DNA to cDNA expression microarray evidence
DSN1	YIR010W	Essential component of the outer kinetochore MIND complex	physical	1	1	1	Affinity Capture-MS
DED81	YHR019C	Cytosolic asparaginyl-tRNA synthetase	genetic	1	1	1	Positive Genetic
LEO1	YOR123C	Component of the Paf1 complex	genetic	1	1	1	Phenotypic Suppression
MTW1	YAL034W-A	Essential component of the MIND kinetochore complex	physical	1	1	1	Co-localization
CKA1	YIL035C	Alpha catalytic subunit of casein kinase 2 (CK2)	genetic	1	1	1	Positive Genetic
CKB2	YOR039W	Beta' regulatory subunit of casein kinase 2 (CK2)	genetic	1	1	1	Phenotypic Enhancement
NSE3	YDR288W	Component of the SMC5-SMC6 complex	genetic	1	1	1	Positive Genetic
PRP19	YLL036C	Splicing factor associated with the spliceosome	genetic	1	1	1	Synthetic Rescue
BRR2	YER172C	RNA-dependent ATPase RNA helicase (DEIH box)	genetic	1	1	1	Positive Genetic
NSE4	YDL105W	Component of the SMC5-SMC6 complex	genetic	1	1	1	Positive Genetic
CDC42	YLR229C	Small rho-like GTPase	genetic	1	1	1	Negative Genetic
MRT4	YKL009W	Protein involved in mRNA turnover and ribosome assembly	genetic	1	1	1	Positive Genetic
PAT1	YCR077C	Deadenylation-dependent mRNA-decapping factor	genetic	1	1	1	Synthetic Growth Defect
LSM3	YLR438C-A	Lsm (Like Sm) protein	genetic	1	1	1	Negative Genetic
LSM6	YDR378C	Lsm (Like Sm) protein	genetic	1	1	1	Synthetic Growth Defect
CDC48	YDL126C	AAA ATPase with protein-unfoldase activity	genetic	1	1	1	Negative Genetic
HPR1	YDR138W	Subunit of THO/TREX complexes	genetic	1	1	1	Synthetic Growth Defect
NUT1	YGL151W	Component of the RNA polymerase II mediator complex	genetic	1	1	1	Positive Genetic
PRE7	YBL041W	Beta 6 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	physical	1	1	1	Affinity Capture-RNA
NAB2	YGL122C	Nuclear polyadenylated RNA-binding protein	physical	1	1	1	Affinity Capture-RNA
BDF1	YLR399C	BET family transcriptional regulator	genetic	1	1	1	Synthetic Growth Defect
BET2	YPR176C	Beta subunit of Type II geranylgeranyltransferase	genetic	1	1	1	Negative Genetic
BEM2	YER155C	Rho GTPase activating protein (RhoGAP)	genetic	1	1	1	Negative Genetic
CDC14	YFR028C	Protein phosphatase required for mitotic exit	genetic	1	1	1	Synthetic Rescue
CDC45	YLR103C	DNA replication initiation factor	genetic	1	1	1	Synthetic Lethality
ERG26	YGL001C	C-3 sterol dehydrogenase	genetic	1	1	1	Negative Genetic
CEG1	YGL130W	Guanylyltransferase involved in mRNA 5' capping	genetic	1	1	1	Negative Genetic
CTK1	YKL139W	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I)	genetic	1	1	1	Synthetic Lethality
CDC23	YHR166C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	genetic	1	1	1	Negative Genetic
DHH1	YDL160C	Cytoplasmic DEAD-box helicase and mRNA decapping activator	physical	1	1	1	Affinity Capture-RNA
HRP1	YOL123W	Subunit of cleavage factor I	genetic	1	1	1	Negative Genetic
HHF2	YNL030W	Histone H4	physical	1	1	1	Affinity Capture-MS
ISW1	YBR245C	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers	physical	1	1	1	Affinity Capture-RNA
ISW2	YOR304W	ATP-dependent DNA translocase involved in chromatin remodeling	genetic	1	1	1	Synthetic Growth Defect
END3	YNL084C	EH domain-containing protein involved in endocytosis	genetic	1	1	1	Phenotypic Suppression
LAS17	YOR181W	Actin assembly factor	genetic	1	1	1	Negative Genetic
LSM7	YNL147W	Lsm (Like Sm) protein	genetic	1	1	1	Synthetic Lethality
FAB1	YFR019W	1-phosphatidylinositol-3-phosphate 5-kinase	genetic	1	1	1	Negative Genetic
MRP17	YKL003C	Mitochondrial ribosomal protein of the small subunit	genetic	1	1	1	Synthetic Growth Defect
GEP3	YOR205C	Protein required for mitochondrial ribosome small subunit biogenesis	genetic	1	1	1	Synthetic Growth Defect
MGM101	YJR144W	Protein with a role in mitochondrial DNA recombinational repair	genetic	1	1	1	Synthetic Lethality
MSH3	YCR092C	Mismatch repair protein	genetic	1	1	1	Phenotypic Enhancement
CMR1	YDL156W	Nuclear protein with role in transcription, protein quality control	physical	1	1	1	Affinity Capture-MS
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	genetic	1	1	1	Negative Genetic
FAS2	YPL231W	Alpha subunit of fatty acid synthetase	genetic	1	1	1	Negative Genetic
GIM3	YNL153C	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Synthetic Growth Defect
GIM5	YML094W	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Synthetic Growth Defect
MGS1	YNL218W	Protein with DNA-dependent ATPase and ssDNA annealing activities	genetic	1	1	1	Dosage Rescue
POP7	YBR167C	Subunit of RNase MRP, nuclear RNase P and telomerase	genetic	1	1	1	Positive Genetic
HSP82	YPL240C	Hsp90 chaperone	physical	1	1	1	Affinity Capture-MS
EST3	YIL009C-A	Component of the telomerase holoenzyme	genetic	1	1	1	Phenotypic Enhancement
PRE4	YFR050C	Beta 7 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
HTA1	YDR225W	Histone H2A	genetic	1	1	1	Phenotypic Suppression
DAM1	YGR113W	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	1	1	1	Positive Genetic
PAA1	YDR071C	Polyamine acetyltransferase	genetic	1	1	1	Positive Genetic
NAB3	YPL190C	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p)	genetic	1	1	1	Negative Genetic
PUB1	YNL016W	Poly (A)+ RNA-binding protein	physical	1	1	1	Affinity Capture-MS
MIR1	YJR077C	Mitochondrial phosphate carrier	genetic	1	1	1	Positive Genetic
RAD23	YEL037C	Protein with ubiquitin-like N terminus	genetic	1	1	1	Phenotypic Enhancement
MET18	YIL128W	Component of cytosolic iron-sulfur protein assembly (CIA) machinery	genetic	1	1	1	Negative Genetic
RAD52	YML032C	Protein involved in homologous recombination	genetic	1	1	1	Phenotypic Suppression
RDH54	YBR073W	DNA-dependent ATPase	physical	1	1	1	Co-localization
RDH54	YBR073W	DNA-dependent ATPase	genetic	1	1	1	Negative Genetic
RAD9	YDR217C	DNA damage-dependent checkpoint protein	physical	1	1	1	Co-localization
RIM1	YCR028C-A	ssDNA-binding protein essential for mitochondrial genome maintenance	physical	1	1	1	Affinity Capture-MS
SIZ1	YDR409W	SUMO E3 ligase	physical	1	1	1	Biochemical Activity
SLX8	YER116C	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex	physical	1	1	1	Biochemical Activity
SGV1	YPR161C	Cyclin (Bur2p)-dependent protein kinase	physical	1	1	1	Affinity Capture-MS
SGV1	YPR161C	Cyclin (Bur2p)-dependent protein kinase	genetic	1	1	1	Synthetic Growth Defect
WHI3	YNL197C	RNA binding protein that modulates mRNA stability	physical	1	1	1	Affinity Capture-RNA
UBC9	YDL064W	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway	genetic	1	1	1	Synthetic Rescue
SSB2	YNL209W	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone	physical	1	1	1	Co-purification
RAD57	YDR004W	Protein that stimulates strand exchange	physical	1	1	1	Reconstituted Complex
RTC1	YOL138C	Subunit of SEACAT, a subcomplex of the SEA complex	physical	1	1	1	Affinity Capture-MS
RET1	YOR207C	Second-largest subunit of RNA polymerase III	physical	1	1	1	Affinity Capture-MS
SIT4	YDL047W	Ceramide-activated, type 2A-related serine-threonine phosphatase	genetic	1	1	1	Synthetic Lethality
SPO13	YHR014W	Meiotic regulator	genetic	1	1	1	Phenotypic Enhancement
RAD7	YJR052W	Nucleotide excision repair (NER) protein	genetic	1	1	1	Phenotypic Enhancement
SIR4	YDR227W	SIR protein involved in assembly of silent chromatin domains	genetic	1	1	1	Phenotypic Enhancement
TPP1	YMR156C	DNA 3'-phosphatase	genetic	1	1	1	Synthetic Lethality
SPO11	YHL022C	Meiosis-specific protein required for meiotic recombination	genetic	1	1	1	Synthetic Rescue
REC104	YHR157W	Protein involved in early stages of meiotic recombination	genetic	1	1	1	Synthetic Rescue
RKM4	YDR257C	Ribosomal lysine methyltransferase	genetic	1	1	1	Synthetic Rescue
SMC2	YFR031C	Subunit of the condensin complex	genetic	1	1	1	Synthetic Growth Defect
RSC30	YHR056C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Synthetic Growth Defect
RSC1	YGR056W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Dosage Rescue
SFH1	YLR321C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Dosage Rescue
VPS21	YOR089C	Endosomal Rab family GTPase	genetic	1	1	1	Negative Genetic
SSN2	YDR443C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
VPS8	YAL002W	Membrane-binding component of the CORVET complex	genetic	1	1	1	Negative Genetic
RTT103	YDR289C	Protein involved in transcription termination by RNA polymerase II	genetic	1	1	1	Synthetic Growth Defect
TGS1	YPL157W	Trimethyl guanosine synthase, conserved nucleolar methyl transferase	genetic	1	1	1	Negative Genetic
VMA6	YLR447C	Subunit d of the V0 integral membrane domain of V-ATPase	genetic	1	1	1	Synthetic Lethality
SNT309	YPR101W	Member of the NineTeen Complex (NTC)	genetic	1	1	1	Negative Genetic
YEF3	YLR249W	Translation elongation factor 3	genetic	1	1	1	Positive Genetic
SUP35	YDR172W	Translation termination factor eRF3	genetic	1	1	1	Positive Genetic
TRL1	YJL087C	tRNA ligase	genetic	1	1	1	Positive Genetic
SQT1	YIR012W	Specific assembly chaperone for ribosomal protein Rpl10p	genetic	1	1	1	Positive Genetic
TEF4	YKL081W	Gamma subunit of translational elongation factor eEF1B	genetic	1	1	1	Positive Genetic
WHI5	YOR083W	Repressor of G1 transcription	genetic	1	1	1	Positive Genetic
TRA1	YHR099W	Subunit of SAGA and NuA4 histone acetyltransferase complexes	genetic	1	1	1	Synthetic Growth Defect
VPS75	YNL246W	NAP family histone chaperone	genetic	1	1	1	Synthetic Growth Defect
VMA9	YCL005W-A	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex	genetic	1	1	1	Negative Genetic
RSC4	YKR008W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Negative Genetic
YNR071C	YNR071C	Putative aldose 1-epimerase	genetic	1	1	1	Negative Genetic
SKI8	YGL213C	Ski complex component and WD-repeat protein	genetic	1	1	1	Synthetic Rescue
SUA5	YGL169W	Protein involved in threonylcarbamoyl adenosine biosynthesis	genetic	1	1	1	Synthetic Growth Defect
YKE2	YLR200W	Subunit of the heterohexameric Gim/prefoldin protein complex	genetic	1	1	1	Synthetic Growth Defect
RAD53	YPL153C	DNA damage response kinase	genetic	1	1	1	Synthetic Growth Defect
SLA2	YNL243W	Adaptor protein that links actin to clathrin and endocytosis	genetic	1	1	1	Synthetic Growth Defect
SOH1	YGL127C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Synthetic Growth Defect
STP22	YCL008C	Component of the ESCRT-I complex	genetic	1	1	1	Synthetic Growth Defect
VAC7	YNL054W	Integral vacuolar membrane protein	genetic	1	1	1	Synthetic Growth Defect
VPS15	YBR097W	Serine/threonine protein kinase involved in vacuolar protein sorting	genetic	1	1	1	Synthetic Growth Defect
VPS34	YLR240W	Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate	genetic	1	1	1	Synthetic Growth Defect
YAP1	YML007W	Basic leucine zipper (bZIP) transcription factor	genetic	1	1	1	Synthetic Growth Defect
RMD9	YGL107C	Mitochondrial protein that controls mitochondrial gene expression	genetic	1	1	1	Synthetic Growth Defect
RFX1	YLR176C	Major transcriptional repressor of DNA-damage-regulated genes	genetic	1	1	1	Phenotypic Suppression
SIS2	YKR072C	Negative regulatory subunit of protein phosphatase 1 (Ppz1p)	genetic	1	1	1	Dosage Growth Defect
STM1	YLR150W	Protein required for optimal translation under nutrient stress	genetic	1	1	1	Dosage Rescue
ULP2	YIL031W	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins	genetic	1	1	1	Synthetic Lethality
ZRT1	YGL255W	High-affinity zinc transporter of the plasma membrane	genetic	1	1	1	Phenotypic Suppression
RIM101	YHL027W	Cys2His2 zinc-finger transcriptional repressor	genetic	1	1	1	Negative Genetic
SOK2	YMR016C	Nuclear protein that negatively regulates pseudohyphal differentiation	genetic	1	1	1	Negative Genetic
SLT2	YHR030C	Serine/threonine MAP kinase	genetic	1	1	1	Negative Genetic
SMK1	YPR054W	Middle sporulation-specific mitogen-activated protein kinase (MAPK)	genetic	1	1	1	Positive Genetic
RDS1	YCR106W	Putative zinc cluster transcription factor	genetic	1	1	1	Positive Genetic
ULS1	YOR191W	Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL)	genetic	1	1	1	Synthetic Growth Defect
SML1	YML058W	Ribonucleotide reductase inhibitor	genetic	1	1	1	Synthetic Rescue
VPH2	YKL119C	Integral membrane protein required for V-ATPase function	genetic	1	1	1	Negative Genetic
SCS7	YMR272C	Sphingolipid alpha-hydroxylase	genetic	1	1	1	Negative Genetic
VMA11	YPL234C	Vacuolar ATPase V0 domain subunit c'	genetic	1	1	1	Negative Genetic
YGL193C	YGL193C	Haploid-specific gene repressed by a1-alpha2	genetic	1	1	1	Synthetic Growth Defect
RPD3	YNL330C	Histone deacetylase, component of both the Rpd3S and Rpd3L complexes	genetic	1	1	1	Synthetic Growth Defect
TBF1	YPL128C	Telobox-containing general regulatory factor	genetic	1	1	1	Synthetic Growth Defect
TAF1	YGR274C	TFIID subunit, involved in RNA pol II transcription initiation	genetic	1	1	1	Synthetic Lethality
SRB8	YCR081W	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Phenotypic Suppression
RRP6	YOR001W	Nuclear exosome exonuclease component	genetic	1	1	1	Phenotypic Suppression
UAF30	YOR295W	Subunit of UAF (upstream activation factor) complex	genetic	1	1	1	Synthetic Lethality
TOP2	YNL088W	Topoisomerase II	genetic	1	1	1	Synthetic Growth Defect
RPB2	YOR151C	RNA polymerase II second largest subunit B150	genetic	1	1	1	Synthetic Growth Defect
RPB9	YGL070C	RNA polymerase II subunit B12.6	genetic	1	1	1	Synthetic Growth Defect
SPT16	YGL207W	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p)	genetic	1	1	1	Synthetic Growth Defect
TFB1	YDR311W	Subunit of TFIIH and nucleotide excision repair factor 3 complexes	genetic	1	1	1	Positive Genetic
SPC105	YGL093W	Subunit of a kinetochore-microtubule binding complex	genetic	1	1	1	Positive Genetic
RIB2	YOL066C	Bifunctional DRAP deaminase tRNA:pseudouridine synthase	genetic	1	1	1	Positive Genetic
YRA1	YDR381W	Nuclear polyadenylated RNA-binding protein	genetic	1	1	1	Negative Genetic
TUB2	YFL037W	Beta-tubulin	genetic	1	1	1	Negative Genetic
SCL1	YGL011C	Alpha 1 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
RFC2	YJR068W	Subunit of heteropentameric Replication factor C (RF-C)	genetic	1	1	1	Negative Genetic
RSC58	YLR033W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Negative Genetic
RPS15	YOL040C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
RPT5	YOR117W	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	1	1	1	Negative Genetic
RPN8	YOR261C	Essential non-ATPase regulatory subunit of the 26S proteasome	genetic	1	1	1	Negative Genetic
RPN1	YHR027C	Non-ATPase base subunit of the 19S RP of the 26S proteasome	genetic	1	1	1	Negative Genetic
SRV2	YNL138W	CAP (cyclase-associated protein)	genetic	1	1	1	Negative Genetic
RPN7	YPR108W	Essential non-ATPase regulatory subunit of the 26S proteasome	genetic	1	1	1	Negative Genetic
YBP1	YBR216C	Protein involved in cellular response to oxidative stress	genetic	1	1	1	Negative Genetic
SEH1	YGL100W	Subunit of the Nup84 nuclear pore and SEACAT subcomplexes	genetic	1	1	1	Negative Genetic
TIM21	YGR033C	Nonessential component of the TIM23 complex	genetic	1	1	1	Negative Genetic
TRX2	YGR209C	Cytoplasmic thioredoxin isoenzyme	genetic	1	1	1	Negative Genetic
RPL16A	YIL133C	Ribosomal 60S subunit protein L16A	genetic	1	1	1	Negative Genetic
RPS22A	YJL190C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
YJR124C	YJR124C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SEI1	YLR404W	Seipin involved in lipid droplet (LD) assembly	genetic	1	1	1	Negative Genetic
YKL075C	YKL075C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VMA13	YPR036W	Subunit H of the V1 peripheral membrane domain of V-ATPase	genetic	1	1	1	Negative Genetic
YNG2	YHR090C	Subunit of NuA4, an essential histone acetyltransferase complex	genetic	1	1	1	Negative Genetic
SCH9	YHR205W	AGC family protein kinase	genetic	1	1	1	Negative Genetic
RXT2	YBR095C	Component of the histone deacetylase Rpd3L complex	genetic	1	1	1	Negative Genetic
SIW14	YNL032W	Inositol phosphatase involved in inositol pyrophosphate metabolism	genetic	1	1	1	Positive Genetic
SSK2	YNR031C	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway	genetic	1	1	1	Negative Genetic
YMR226C	YMR226C	NADP(+)-dependent serine dehydrogenase and carbonyl reductase	genetic	1	1	1	Positive Genetic
RRD2	YPL152W	Peptidyl-prolyl cis/trans-isomerase	genetic	1	1	1	Negative Genetic
RPC40	YPR110C	RNA polymerase subunit AC40	genetic	1	1	1	Negative Genetic
YVH1	YIR026C	Dual specificity protein phosphatase	genetic	1	1	1	Negative Genetic
RRD1	YIL153W	Peptidyl-prolyl cis/trans-isomerase	genetic	1	1	1	Negative Genetic
RCK1	YGL158W	Protein kinase involved in oxidative stress response	genetic	1	1	1	Positive Genetic
VAC14	YLR386W	Enzyme regulator	genetic	1	1	1	Positive Genetic
RPS10A	YOR293W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
SKY1	YMR216C	SR protein kinase (SRPK)	genetic	1	1	1	Positive Genetic
RIM20	YOR275C	Protein involved in proteolytic activation of Rim101p	genetic	1	1	1	Negative Genetic
RSC8	YFR037C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Negative Genetic
RAS2	YNL098C	GTP-binding protein	genetic	1	1	1	Negative Genetic
SWD1	YAR003W	Subunit of the COMPASS (Set1C) complex	genetic	1	1	1	Negative Genetic
SEC7	YDR170C	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors	genetic	1	1	1	Negative Genetic
SUM1	YDR310C	Transcriptional repressor that regulates middle-sporulation genes	genetic	1	1	1	Positive Genetic
SPC3	YLR066W	Subunit of signal peptidase complex	genetic	1	1	1	Positive Genetic
SRN2	YLR119W	Component of the ESCRT-I complex	genetic	1	1	1	Negative Genetic
RIM21	YNL294C	pH sensor molecule, component of the RIM101 pathway	genetic	1	1	1	Negative Genetic
SHU1	YHL006C	Component of Shu complex (aka PCSS complex)	genetic	1	1	1	Positive Genetic
RAD61	YDR014W	Subunit of a complex that inhibits sister chromatid cohesion	genetic	1	1	1	Negative Genetic
UBP10	YNL186W	Ubiquitin-specific protease, deubiquitinates Ub-protein moieties	genetic	1	1	1	Phenotypic Suppression
PHO23	YNL097C	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Negative Genetic
PUP3	YER094C	Beta 3 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
CDC6	YJL194W	Essential ATP-binding protein required for DNA replication	genetic	1	1	1	Synthetic Lethality
PPH21	YDL134C	Catalytic subunit of protein phosphatase 2A, PP2A	genetic	1	1	1	Negative Genetic
ANP1	YEL036C	Subunit of the alpha-1,6 mannosyltransferase complex	genetic	1	1	1	Positive Genetic
CDC25	YLR310C	Membrane bound guanine nucleotide exchange factor	genetic	1	1	1	Negative Genetic
BUR2	YLR226W	Cyclin for the Sgv1p (Bur1p) protein kinase	physical	1	1	1	Affinity Capture-MS
PTC1	YDL006W	Type 2C protein phosphatase (PP2C)	genetic	1	1	1	Positive Genetic
HEM13	YDR044W	Coproporphyrinogen III oxidase	genetic	1	1	1	Negative Genetic
BCK1	YJL095W	MAPKKK acting in the protein kinase C signaling pathway	genetic	1	1	1	Synthetic Growth Defect
FDH1	YOR388C	NAD(+)-dependent formate dehydrogenase	genetic	1	1	1	Negative Genetic
DIA4	YHR011W	Probable mitochondrial seryl-tRNA synthetase	genetic	1	1	1	Synthetic Lethality
LSM12	YHR121W	Protein of unknown function that may function in RNA processing	physical	1	1	1	Affinity Capture-MS
FPR3	YML074C	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase)	genetic	1	1	1	Synthetic Rescue
ADR1	YDR216W	Carbon source-responsive zinc-finger transcription factor	genetic	1	1	1	Positive Genetic
CAF20	YOR276W	Phosphoprotein of the mRNA cap-binding complex	physical	1	1	1	Affinity Capture-RNA
ASA1	YPR085C	Subunit of the ASTRA complex, involved in chromatin remodeling	genetic	1	1	1	Negative Genetic
HTB1	YDR224C	Histone H2B	genetic	1	1	1	Phenotypic Enhancement
CNA1	YLR433C	Calcineurin A	genetic	1	1	1	Positive Genetic
PBS2	YJL128C	MAP kinase kinase of the HOG signaling pathway	genetic	1	1	1	Negative Genetic
CHK1	YBR274W	Serine/threonine kinase and DNA damage checkpoint effector	genetic	1	1	1	Phenotypic Enhancement
CYC8	YBR112C	General transcriptional co-repressor	genetic	1	1	1	Negative Genetic
DDC1	YPL194W	DNA damage checkpoint protein	physical	1	1	1	Co-localization
PBR1	YNL181W	Putative oxidoreductase	genetic	1	1	1	Positive Genetic
DMC1	YER179W	Meiosis-specific recombinase required for double-strand break repair	genetic	1	1	1	Phenotypic Enhancement
ELM1	YKL048C	Serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
PSK2	YOL045W	PAS-domain containing serine/threonine protein kinase	genetic	1	1	1	Positive Genetic
GRS1	YBR121C	Cytoplasmic and mitochondrial glycyl-tRNA synthase	genetic	1	1	1	Positive Genetic
HIR1	YBL008W	Subunit of the HIR complex	genetic	1	1	1	Negative Genetic
RAD24	YER173W	Checkpoint protein	genetic	1	1	1	Phenotypic Suppression
ARE1	YCR048W	Acyl-CoA:sterol acyltransferase	genetic	1	1	1	Negative Genetic
HIR2	YOR038C	Subunit of HIR nucleosome assembly complex	genetic	1	1	1	Negative Genetic
ISU1	YPL135W	Conserved protein of the mitochondrial matrix	genetic	1	1	1	Negative Genetic
HHO1	YPL127C	Histone H1, linker histone with roles in meiosis and sporulation	genetic	1	1	1	Synthetic Rescue
DPB11	YJL090C	DNA replication initiation protein	genetic	1	1	1	Positive Genetic
BUD9	YGR041W	Protein involved in bud-site selection	genetic	1	1	1	Positive Genetic
MER1	YNL210W	mRNA-binding protein required for meiosis-specific mRNA splicing	genetic	1	1	1	Synthetic Rescue
ELC1	YPL046C	Elongin C, conserved among eukaryotes	genetic	1	1	1	Synthetic Growth Defect
MCK1	YNL307C	Dual-specificity ser/thr and tyrosine protein kinase	genetic	1	1	1	Negative Genetic
PTC2	YER089C	Type 2C protein phosphatase (PP2C)	genetic	1	1	1	Negative Genetic
EAP1	YKL204W	eIF4E-associated protein, competes with eIF4G for binding to eIF4E	genetic	1	1	1	Negative Genetic
BUB3	YOR026W	Kinetochore checkpoint WD40 repeat protein	genetic	1	1	1	Synthetic Growth Defect
MUS81	YDR386W	Subunit of structure-specific Mms4p-Mus81p endonuclease	physical	1	1	1	Reconstituted Complex
MMS4	YBR098W	Subunit of structure-specific Mms4p-Mus81p endonuclease	physical	1	1	1	Reconstituted Complex
MMS4	YBR098W	Subunit of structure-specific Mms4p-Mus81p endonuclease	genetic	1	1	1	Positive Genetic
ALD5	YER073W	Mitochondrial aldehyde dehydrogenase	physical	1	1	1	Affinity Capture-MS
MEC3	YLR288C	DNA damage and meiotic pachytene checkpoint protein	genetic	1	1	1	Phenotypic Enhancement
EXO70	YJL085W	Subunit of the exocyst complex	genetic	1	1	1	Negative Genetic
CIN5	YOR028C	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family	genetic	1	1	1	Positive Genetic
POL4	YCR014C	DNA polymerase IV	genetic	1	1	1	Phenotypic Enhancement
BIR1	YJR089W	Subunit of chromosomal passenger complex (CPC)	genetic	1	1	1	Negative Genetic
PSO2	YMR137C	Nuclease required for DNA single- and double-strand break repair	genetic	1	1	1	Synthetic Growth Defect
NBP2	YDR162C	Protein involved in the HOG (high osmolarity glycerol) pathway	genetic	1	1	1	Positive Genetic
CTK3	YML112W	Gamma subunit of C-terminal domain kinase I	genetic	1	1	1	Synthetic Lethality
MTQ2	YDR140W	S-adenosylmethionine-dependent methyltransferase	genetic	1	1	1	Synthetic Growth Defect
AFT1	YGL071W	Transcription factor involved in iron utilization and homeostasis	genetic	1	1	1	Synthetic Rescue
GRX5	YPL059W	Glutathione-dependent oxidoreductase	genetic	1	1	1	Synthetic Growth Defect
HST3	YOR025W	Sirtuin, histone H3 deacetylase	genetic	1	1	1	Synthetic Lethality
LST7	YGR057C	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p	genetic	1	1	1	Negative Genetic
MSH5	YDL154W	Protein of the MutS family	genetic	1	1	1	Phenotypic Enhancement
PKC1	YBL105C	Protein serine/threonine kinase	genetic	1	1	1	Phenotypic Suppression
IME1	YJR094C	Master regulator of meiosis that is active only during meiotic events	genetic	1	1	1	Synthetic Rescue
PPA2	YMR267W	Mitochondrial inorganic pyrophosphatase	genetic	1	1	1	Negative Genetic
CHA4	YLR098C	DNA binding transcriptional activator	genetic	1	1	1	Negative Genetic
GPI16	YHR188C	Subunit of the glycosylphosphatidylinositol transamidase complex	genetic	1	1	1	Negative Genetic
APC11	YDL008W	Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
IPL1	YPL209C	Aurora kinase of chromosomal passenger complex	physical	1	1	1	Biochemical Activity
DOC1	YGL240W	Processivity factor	genetic	1	1	1	Negative Genetic
CDC21	YOR074C	Thymidylate synthase	genetic	1	1	1	Negative Genetic
IES2	YNL215W	Protein that associates with the INO80 chromatin remodeling complex	genetic	1	1	1	Synthetic Growth Defect
IES6	YEL044W	Component of the INO80 chromatin remodeling complex	genetic	1	1	1	Synthetic Growth Defect
CSE4	YKL049C	Centromeric histone H3-like protein	genetic	1	1	1	Negative Genetic
CLB5	YPR120C	B-type cyclin involved in DNA replication during S phase	genetic	1	1	1	Positive Genetic
CTK2	YJL006C	Beta subunit of C-terminal domain kinase I (CTDK-I)	genetic	1	1	1	Synthetic Lethality
GIM4	YEL003W	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Synthetic Growth Defect
KAR3	YPR141C	Minus-end-directed microtubule motor	genetic	1	1	1	Synthetic Lethality
MDM12	YOL009C	Mitochondrial outer membrane protein, ERMES complex subunit	genetic	1	1	1	Synthetic Growth Defect
OST3	YOR085W	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Positive Genetic
PAN1	YIR006C	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p	genetic	1	1	1	Positive Genetic
GAL4	YPL248C	DNA-binding transcription factor required for activating GAL genes	genetic	1	1	1	Negative Genetic
NUP170	YBL079W	Subunit of inner ring of nuclear pore complex (NPC)	genetic	1	1	1	Negative Genetic
MPT5	YGL178W	mRNA-binding protein of the PUF family	physical	1	1	1	Affinity Capture-RNA
CSG2	YBR036C	Endoplasmic reticulum membrane protein	genetic	1	1	1	Negative Genetic
ESC2	YDR363W	Sumo-like domain protein	genetic	1	1	1	Phenotypic Suppression
DOT1	YDR440W	Nucleosomal histone H3-Lys79 methylase	genetic	1	1	1	Synthetic Rescue
HMT1	YBR034C	Nuclear SAM-dependent mono- and asymmetric methyltransferase	physical	1	1	1	Affinity Capture-MS
MEI4	YER044C-A	Meiosis-specific protein involved in forming DSBs	genetic	1	1	1	Synthetic Rescue
MET31	YPL038W	Zinc-finger DNA-binding transcription factor	genetic	1	1	1	Positive Genetic
MKK1	YOR231W	MAPKK involved in the protein kinase C signaling pathway	genetic	1	1	1	Positive Genetic
MRI1	YPR118W	5'-methylthioribose-1-phosphate isomerase	genetic	1	1	1	Negative Genetic
HHT2	YNL031C	Histone H3	physical	1	1	1	Affinity Capture-Western
HHT2	YNL031C	Histone H3	genetic	1	1	1	Synthetic Growth Defect
APN2	YBL019W	Class II abasic (AP) endonuclease involved in repair of DNA damage	genetic	1	1	1	Synthetic Lethality
ASH1	YKL185W	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Positive Genetic
MID1	YNL291C	Stretch-activated Ca2+-permeable cation channel	genetic	1	1	1	Synthetic Growth Defect
MON2	YNL297C	Protein with a role in endocytosis and vacuole integrity	genetic	1	1	1	Synthetic Growth Defect
MOG1	YJR074W	Conserved nuclear protein that interacts with GTP-Gsp1p	genetic	1	1	1	Negative Genetic
CCC1	YLR220W	Vacuolar Fe2+/Mn2+ transporter	genetic	1	1	1	Negative Genetic
GEF1	YJR040W	Voltage-gated chloride channel	genetic	1	1	1	Positive Genetic
KTR2	YKR061W	Mannosyltransferase involved in N-linked protein glycosylation	genetic	1	1	1	Synthetic Growth Defect
ORC6	YHR118C	Subunit of the origin recognition complex (ORC)	genetic	1	1	1	Synthetic Lethality
MSS11	YMR164C	Transcription factor	genetic	1	1	1	Positive Genetic
PSY3	YLR376C	Component of Shu complex (aka PCSS complex)	physical	1	1	1	Reconstituted Complex
PSY3	YLR376C	Component of Shu complex (aka PCSS complex)	genetic	1	1	1	Negative Genetic
DIC1	YLR348C	Mitochondrial dicarboxylate carrier	genetic	1	1	1	Negative Genetic
NFS1	YCL017C	Cysteine desulfurase involved in iron-sulfur cluster biogenesis	genetic	1	1	1	Negative Genetic
KCS1	YDR017C	Inositol hexakisphosphate and inositol heptakisphosphate kinase	genetic	1	1	1	Negative Genetic
RAD30	YDR419W	DNA polymerase eta	genetic	1	1	1	Synthetic Growth Defect
PDC2	YDR081C	Transcription factor for thiamine-regulated genes	genetic	1	1	1	Negative Genetic
GRX4	YER174C	Glutathione-dependent oxidoreductase and glutathione S-transferase	genetic	1	1	1	Negative Genetic
CUL3	YGR003W	Ubiquitin-protein ligase	genetic	1	1	1	Negative Genetic
NDT80	YHR124W	Meiosis-specific transcription factor	genetic	1	1	1	Phenotypic Suppression
IRC8	YJL051W	Bud tip localized protein of unknown function	genetic	1	1	1	Synthetic Growth Defect
CTP1	YBR291C	Mitochondrial inner membrane citrate transporter	genetic	1	1	1	Positive Genetic
NAM2	YLR382C	Mitochondrial leucyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
IRC25	YLR021W	Component of a heterodimeric Poc4p-Irc25p chaperone	genetic	1	1	1	Negative Genetic
MSS18	YPR134W	Nuclear encoded protein needed for splicing of mitochondrial intron	genetic	1	1	1	Positive Genetic
PMS1	YNL082W	ATP-binding protein required for mismatch repair	genetic	1	1	1	Phenotypic Enhancement
GSH1	YJL101C	Gamma glutamylcysteine synthetase	genetic	1	1	1	Synthetic Growth Defect
HST4	YDR191W	NAD(+)-dependent protein deacetylase	genetic	1	1	1	Synthetic Lethality
PUF2	YPR042C	PUF family mRNA-binding protein	physical	1	1	1	Affinity Capture-RNA
NEJ1	YLR265C	DNA end-binding protein required for nonhomologous end joining (NHEJ)	genetic	1	1	1	Phenotypic Enhancement
DDP1	YOR163W	Diadenosine and diphosphoinositol polyphosphate phosphatase	genetic	1	1	1	Negative Genetic
PRX1	YBL064C	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity	genetic	1	1	1	Negative Genetic
MTM1	YGR257C	Mitochondrial protein of the mitochondrial carrier family	genetic	1	1	1	Negative Genetic
DER1	YBR201W	ER membrane protein that promotes export of misfolded polypeptides	genetic	1	1	1	Negative Genetic
PHD1	YKL043W	Transcriptional activator that enhances pseudohyphal growth	genetic	1	1	1	Positive Genetic
MET7	YOR241W	Folylpolyglutamate synthetase	genetic	1	1	1	Negative Genetic
LDB18	YLL049W	Component of the dynactin complex	genetic	1	1	1	Negative Genetic
FCY2	YER056C	Purine-cytosine permease	genetic	1	1	1	Phenotypic Suppression
LGE1	YPL055C	Protein involved in histone H2B ubiquitination	physical	1	1	1	Affinity Capture-MS
MDM32	YOR147W	Mitochondrial inner membrane protein with similarity to Mdm31p	genetic	1	1	1	Negative Genetic
HER2	YMR293C	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex	genetic	1	1	1	Negative Genetic
PIN2	YOR104W	Exomer-dependent cargo protein	genetic	1	1	1	Negative Genetic
KRE1	YNL322C	Cell wall glycoprotein involved in beta-glucan assembly	genetic	1	1	1	Positive Genetic
BUD16	YEL029C	Putative pyridoxal kinase	genetic	1	1	1	Phenotypic Suppression
OPI3	YJR073C	Methylene-fatty-acyl-phospholipid synthase	genetic	1	1	1	Negative Genetic
LMO1	YLL007C	Homolog of mammalian ELMO (Engulfment and celL MOtility)	genetic	1	1	1	Negative Genetic
IRC15	YPL017C	Microtubule associated protein	genetic	1	1	1	Negative Genetic
AGP1	YCL025C	Broad-specificity, low-affinity amino acid permease	genetic	1	1	1	Positive Genetic
MMM1	YLL006W	ER integral membrane protein, ERMES complex subunit	physical	1	1	1	Affinity Capture-MS
AIM10	YER087W	Protein with similarity to tRNA synthetases	genetic	1	1	1	Synthetic Growth Defect
POF1	YCL047C	Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT)	genetic	1	1	1	Negative Genetic
NGL1	YOL042W	Putative endonuclease	genetic	1	1	1	Negative Genetic
PGA3	YML125C	Putative cytochrome b5 reductase, localized to the plasma membrane	genetic	1	1	1	Negative Genetic
PPM1	YDR435C	Carboxyl methyltransferase	genetic	1	1	1	Negative Genetic
HNT3	YOR258W	DNA 5' AMP hydrolase involved in DNA repair	genetic	1	1	1	Synthetic Rescue
PAU10	YDR542W	Protein of unknown function	genetic	1	1	1	Negative Genetic
PAU24	YBR301W	Cell wall mannoprotein	genetic	1	1	1	Negative Genetic