| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
55 |
6 |
47 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
12 |
5 |
11 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
12 |
5 |
10 |
Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic |
| YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
11 |
6 |
9 |
Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect |
| SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
9 |
6 |
9 |
Dosage Growth Defect, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
9 |
4 |
7 |
Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
9 |
5 |
6 |
Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Positive Genetic, Negative Genetic |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
8 |
5 |
7 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
8 |
2 |
7 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
physical |
7 |
3 |
7 |
Affinity Capture-Western, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
6 |
4 |
6 |
Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
6 |
4 |
6 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect |
| RIF2 |
YLR453C |
Protein that binds to the Rap1p C-terminus |
genetic |
6 |
4 |
6 |
Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
6 |
4 |
4 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect |
| EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
5 |
4 |
4 |
Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
5 |
3 |
4 |
Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
5 |
3 |
4 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression |
| SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
5 |
3 |
4 |
Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
physical |
5 |
1 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
4 |
4 |
4 |
Dosage Lethality, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect |
| RAD24 |
YER173W |
Checkpoint protein |
genetic |
4 |
3 |
4 |
Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
| RAD17 |
YOR368W |
Checkpoint protein |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
4 |
1 |
3 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
4 |
3 |
2 |
Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue |
| LCD1 |
YDR499W |
Essential protein required for the DNA integrity checkpoint pathways |
genetic |
3 |
3 |
3 |
Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
3 |
3 |
3 |
Dosage Lethality, Synthetic Growth Defect, Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
physical |
3 |
2 |
3 |
Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western |
| RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
3 |
1 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
3 |
3 |
2 |
Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression |
| ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-Western |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Suppression |
| RIF2 |
YLR453C |
Protein that binds to the Rap1p C-terminus |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
physical |
2 |
1 |
2 |
Co-crystal Structure, Co-crystal Structure |
| HRI1 |
YLR301W |
Protein of unknown function that interacts with Sec72p and Hrr25p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PPT2 |
YPL148C |
Phosphopantetheine:protein transferase (PPTase) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HHF2 |
YNL030W |
Histone H4 |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Enhancement |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Growth Defect |
| NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Growth Defect |
| RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Synthetic Rescue |
| DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Synthetic Growth Defect |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| CSM2 |
YIL132C |
Subunit of the Shu complex (aka PCSS complex) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| SHU1 |
YHL006C |
Component of Shu complex (aka PCSS complex) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| PSY3 |
YLR376C |
Component of Shu complex (aka PCSS complex) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| SUA7 |
YPR086W |
Transcription factor TFIIB |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RAD53 |
YPL153C |
DNA damage response kinase |
regulation |
1 |
1 |
1 |
qualitative western immunoblotting evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CTR9 |
YOL145C |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA49 |
YNL248C |
RNA polymerase I subunit A49 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ARO1 |
YDR127W |
Pentafunctional arom protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ERG26 |
YGL001C |
C-3 sterol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| IST1 |
YNL265C |
Protein with positive role in the multivesicular body sorting pathway |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HDA3 |
YPR179C |
Subunit of HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LPD1 |
YFL018C |
Dihydrolipoamide dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDS3 |
YGL197W |
Putative component of the TOR regulatory pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SPO7 |
YAL009W |
Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MKS1 |
YNL076W |
Pleiotropic negative transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF7 |
YLR025W |
One of four subunits of the ESCRT-III complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| FUN30 |
YAL019W |
Snf2p family member with ATP-dependent chromatin remodeling activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
physical |
1 |
1 |
1 |
Biochemical Activity |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GDE1 |
YPL110C |
Glycerophosphocholine (GroPCho) phosphodiesterase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PDS1 |
YDR113C |
Securin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SGD1 |
YLR336C |
Essential nuclear protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DNL4 |
YOR005C |
DNA ligase required for nonhomologous end-joining (NHEJ) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ADE17 |
YMR120C |
Enzyme of 'de novo' purine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| EPT1 |
YHR123W |
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD26 |
YJR035W |
Protein involved in transcription-coupled nucleotide excision repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GCR2 |
YNL199C |
Transcriptional activator of genes involved in glycolysis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL4 |
YCR014C |
DNA polymerase IV |
physical |
1 |
1 |
1 |
Biochemical Activity |
| POL4 |
YCR014C |
DNA polymerase IV |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SIR3 |
YLR442C |
Silencing protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNF8 |
YPL002C |
Component of the ESCRT-II complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
physical |
1 |
1 |
1 |
Protein-peptide |
| SHU2 |
YDR078C |
Component of Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| KAR4 |
YCL055W |
Transcription factor required for response to pheromones |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MRX21 |
YPR011C |
Mitochondrial transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| IES4 |
YOR189W |
Component of the INO80 chromatiin remodeling complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SNF6 |
YHL025W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SWI3 |
YJL176C |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| VPS15 |
YBR097W |
Serine/threonine protein kinase involved in vacuolar protein sorting |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| VPS28 |
YPL065W |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ZIP1 |
YDR285W |
Transverse filament protein of the synaptonemal complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YMR046C |
YMR046C |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| VTC2 |
YFL004W |
Regulatory subunit of the vacuolar transporter chaperone (VTC) complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| UTP4 |
YDR324C |
Subunit of U3-containing 90S preribosome and SSU processome complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR273C |
YGR273C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUF1 |
YOR187W |
Mitochondrial translation elongation factor Tu (EF-Tu) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ESC2 |
YDR363W |
Sumo-like domain protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNF3 |
YDL194W |
Plasma membrane low glucose sensor, regulates glucose transport |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| ASH1 |
YKL185W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ERG5 |
YMR015C |
C-22 sterol desaturase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ECM21 |
YBL101C |
Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| PDP3 |
YLR455W |
Component of the NuA3b histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| LYS20 |
YDL182W |
Homocitrate synthase isozyme and functions in DNA repair |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SAT4 |
YCR008W |
Ser/Thr protein kinase involved in salt tolerance, nutrient response |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRPL17 |
YNL252C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GRE3 |
YHR104W |
Aldose reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RDH54 |
YBR073W |
DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CMK2 |
YOL016C |
Calmodulin-dependent protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PDE1 |
YGL248W |
Low-affinity cyclic AMP phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AAD14 |
YNL331C |
Putative aryl-alcohol dehydrogenase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ITR1 |
YDR497C |
Myo-inositol transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET8 |
YBR213W |
Bifunctional dehydrogenase and ferrochelatase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| PIR1 |
YKL164C |
O-glycosylated protein required for cell wall stability |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LMO1 |
YLL007C |
Homolog of mammalian ELMO (Engulfment and celL MOtility) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IRC21 |
YMR073C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MRX4 |
YPL168W |
Protein that associates with mitochondrial ribosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUL1 |
YBR294W |
High affinity sulfate permease of the SulP anion transporter family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUA5 |
YGL169W |
Protein involved in threonylcarbamoyl adenosine biosynthesis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
