Standard name Systematic name Name description Description
MDS3 YGL197W Putative component of the TOR regulatory pathway Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication
Visualize the interactome of MDS3
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.080 NaN NaN
Cytoplasm 0.986 0.966 0.97

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 396

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MDS3 0 2 0 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PMD1 YER132C Protein with an N-terminal kelch-like domain genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid
ILM1 YJR118C Protein of unknown function genetic 3 2 3 Negative Genetic, Positive Genetic, Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 3 3 1 Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 2 1 2 Negative Genetic, Negative Genetic
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YBR225W YBR225W Putative protein of unknown function physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 2 1 2 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
CLB3 YDL155W B-type cyclin involved in cell cycle progression physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 2 2 1 Phenotypic Enhancement, Synthetic Rescue
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 2 1 Synthetic Rescue, Dosage Rescue
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
HSP78 YDR258C Oligomeric mitochondrial matrix chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PPR1 YLR014C Zinc finger transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Positive Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
MMF1 YIL051C Mitochondrial protein required for transamination of isoleucine physical 1 1 1 Affinity Capture-MS
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
PEX13 YLR191W Peroxisomal importomer complex component physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 1 1 1 Affinity Capture-MS
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Affinity Capture-MS
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
RAD2 YGR258C Single-stranded DNA endonuclease genetic 1 1 1 Synthetic Growth Defect
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Synthetic Growth Defect
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) genetic 1 1 1 Synthetic Rescue
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Positive Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Positive Genetic
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network genetic 1 1 1 Negative Genetic
RME1 YGR044C Zinc finger protein involved in control of meiosis genetic 1 1 1 Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Positive Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Positive Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
SOG2 YOR353C Key component of the RAM signaling network genetic 1 1 1 Positive Genetic
YER079W YER079W Putative protein of unknown function genetic 1 1 1 Positive Genetic
PFA5 YDR459C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Positive Genetic
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Positive Genetic
YDR541C YDR541C Aldehyde reductase genetic 1 1 1 Positive Genetic
YER134C YER134C Magnesium-dependent acid phosphatase genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
PRP3 YDR473C Splicing factor genetic 1 1 1 Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 1 1 1 Negative Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Negative Genetic
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Negative Genetic
PAD1 YDR538W Phenylacrylic acid decarboxylase genetic 1 1 1 Negative Genetic
MET6 YER091C Cobalamin-independent methionine synthase genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
MMO1 YKL044W Protein of unknown function genetic 1 1 1 Negative Genetic
SPA2 YLL021W Component of the polarisome genetic 1 1 1 Negative Genetic
YLR287C YLR287C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 1 1 1 Negative Genetic
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 1 1 1 Negative Genetic
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Negative Genetic
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
FPK1 YNR047W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Positive Genetic
DAK2 YFL053W Dihydroxyacetone kinase genetic 1 1 1 Positive Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Affinity Capture-MS
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
HFL1 YKR051W Vacuole membrane protein that interacts with Atg8p genetic 1 1 1 Negative Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 1 1 1 Positive Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DAL82 YNL314W Positive regulator of allophanate inducible genes genetic 1 1 1 Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Positive Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
FBP1 YLR377C Fructose-1,6-bisphosphatase physical 1 1 1 Affinity Capture-MS
DBP1 YPL119C ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 Affinity Capture-MS
ARO80 YDR421W Zinc finger transcriptional activator of the Zn2Cys6 family genetic 1 1 1 Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
AQY3 YFL054C Putative channel-like protein genetic 1 1 1 Negative Genetic
CMR3 YPR013C Putative zinc finger protein genetic 1 1 1 Negative Genetic
DAP2 YHR028C Dipeptidyl aminopeptidase genetic 1 1 1 Negative Genetic
CIS3 YJL158C Mannose-containing glycoprotein constituent of the cell wall genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Positive Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
CSI2 YOL007C Protein of unknown function genetic 1 1 1 Negative Genetic
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells genetic 1 1 1 Negative Genetic
FIT1 YDR534C Mannoprotein that is incorporated into the cell wall genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
CUP1-2 YHR055C Metallothionein genetic 1 1 1 Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic