Standard name Systematic name Name description Description
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role
Visualize the interactome of DUN1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 48

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.237 NaN 0.065
Nucleus 0.914 0.890 0.858
Vac/Vac Memb NaN 0.099 NaN
Cytoplasm NaN NaN 0.084

GFP localization & abundance

GFP localization GFP abundance
nucleus 3480

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DUN1 8 0 0 1 1

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 15 5 12 Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
SML1 YML058W Ribonucleotide reductase inhibitor genetic 14 5 13 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 9 4 8 Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 9 3 8 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 9 2 8 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD53 YPL153C DNA damage response kinase physical 9 5 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Protein-peptide, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 8 2 8 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SML1 YML058W Ribonucleotide reductase inhibitor physical 8 3 7 Affinity Capture-MS, Two-hybrid, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
RAD52 YML032C Protein involved in homologous recombination genetic 8 3 7 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 7 2 7 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 7 2 7 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 7 2 7 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 7 2 7 Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 7 5 6 Dosage Rescue, Synthetic Lethality, Dosage Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression
RAD24 YER173W Checkpoint protein genetic 7 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 3 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic, Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 6 3 6 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 6 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 6 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 6 4 5 Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 6 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 6 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 5 4 5 Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect
BLM10 YFL007W Proteasome activator genetic 5 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 5 2 5 Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 5 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 5 4 4 Dosage Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
PDS1 YDR113C Securin genetic 5 4 4 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 5 3 4 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 5 3 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Dosage Lethality, Dosage Lethality
DIA2 YOR080W Origin-binding F-box protein genetic 5 2 4 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 5 3 3 Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 5 3 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 5 2 3 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
UBX7 YBR273C UBX (ubiquitin regulatory X) domain-containing protein genetic 4 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
YJL027C YJL027C Putative protein of unknown function genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Phenotypic Enhancement
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 4 3 2 Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
RTT109 YLL002W Histone acetyltransferase genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 2 3 Synthetic Rescue, Negative Genetic, Synthetic Rescue
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase physical 3 3 2 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity
TSA1 YML028W Thioredoxin peroxidase genetic 3 3 2 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 3 3 2 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
SAE2 YGL175C Endonuclease required for telomere elongation genetic 3 2 2 Dosage Lethality, Dosage Lethality, Synthetic Growth Defect
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 3 2 2 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 2 2 Dosage Lethality, Phenotypic Suppression
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PLB2 YMR006C Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 2 2 2 Positive Genetic, Dosage Lethality
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 2 2 2 Synthetic Rescue, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 2 2 2 Synthetic Growth Defect, Dosage Lethality
FKH2 YNL068C Forkhead family transcription factor genetic 2 2 2 Negative Genetic, Positive Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 2 2 Dosage Lethality, Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 2 2 2 Dosage Growth Defect, Negative Genetic
MSH1 YHR120W DNA-binding protein of the mitochondria genetic 2 2 2 Phenotypic Suppression, Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 1 2 Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 1 2 Negative Genetic, Negative Genetic
AHA1 YDR214W Co-chaperone that binds Hsp82p and activates its ATPase activity physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RAD24 YER173W Checkpoint protein physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RAD28 YDR030C Protein involved in DNA repair physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
SAE2 YGL175C Endonuclease required for telomere elongation physical 2 2 1 Affinity Capture-MS, Protein-peptide
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
FET3 YMR058W Ferro-O2-oxidoreductase genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
BRE1 YDL074C E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FIR1 YER032W Protein involved in 3' mRNA processing genetic 2 1 1 Dosage Lethality, Dosage Lethality
PBP2 YBR233W RNA binding protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
NDD1 YOR372C Transcriptional activator essential for nuclear division genetic 2 1 1 Dosage Lethality, Dosage Lethality
ECM22 YLR228C Sterol regulatory element binding protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 2 1 1 Dosage Lethality, Dosage Lethality
KSP1 YHR082C Serine/threonine protein kinase genetic 2 1 1 Dosage Lethality, Dosage Lethality
RDH54 YBR073W DNA-dependent ATPase genetic 2 1 1 Dosage Lethality, Dosage Lethality
YPR015C YPR015C Putative zinc finger transcription factor genetic 2 1 1 Dosage Lethality, Dosage Lethality
YLH47 YPR125W Mitochondrial inner membrane protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 2 1 1 Dosage Lethality, Dosage Lethality
MSN5 YDR335W Karyopherin genetic 2 1 1 Dosage Lethality, Dosage Lethality
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 2 1 1 Dosage Lethality, Dosage Lethality
MRH4 YGL064C Mitochondrial ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 1 Dosage Lethality, Dosage Lethality
MFG1 YDL233W Regulator of filamentous growth genetic 2 1 1 Dosage Lethality, Dosage Lethality
SIP4 YJL089W C6 zinc cluster transcriptional activator genetic 2 1 1 Dosage Lethality, Dosage Lethality
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 2 1 1 Dosage Lethality, Dosage Lethality
CTF4 YPR135W Chromatin-associated protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ALY1 YKR021W Alpha arrestin, substrate of calcineurin genetic 2 1 1 Dosage Lethality, Dosage Lethality
ALK2 YBL009W Atypical protein kinase genetic 2 1 1 Dosage Lethality, Dosage Lethality
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 protein kinase assay evidence
DIF1 YLR437C Protein that regulates nuclear import of Rnr2p and Rnr4p regulation 1 1 1 qualitative western immunoblotting evidence
SML1 YML058W Ribonucleotide reductase inhibitor regulation 1 1 1 protein kinase assay evidence
PDS1 YDR113C Securin regulation 1 1 1 qualitative western immunoblotting evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Positive Genetic
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Positive Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Dosage Lethality
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Dosage Lethality
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Dosage Growth Defect
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Biochemical Activity
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Positive Genetic
DRE2 YKR071C Component of the cytosolic Fe-S protein assembly (CIA) machinery genetic 1 1 1 Phenotypic Suppression
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 1 1 1 Dosage Lethality
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Growth Defect
YJU2 YKL095W Essential protein required for pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) physical 1 1 1 Affinity Capture-MS
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Synthetic Lethality
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
RAD9 YDR217C DNA damage-dependent checkpoint protein physical 1 1 1 Affinity Capture-MS
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase physical 1 1 1 Affinity Capture-MS
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Dosage Lethality
PGM2 YMR105C Phosphoglucomutase physical 1 1 1 Affinity Capture-MS
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) physical 1 1 1 Affinity Capture-MS
TOP2 YNL088W Topoisomerase II physical 1 1 1 Affinity Capture-MS
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Two-hybrid
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex physical 1 1 1 Two-hybrid
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 1 1 1 Biochemical Activity
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation physical 1 1 1 Biochemical Activity
PCK1 YKR097W Phosphoenolpyruvate carboxykinase physical 1 1 1 Biochemical Activity
PFS1 YHR185C Sporulation protein required for prospore membrane formation physical 1 1 1 Biochemical Activity
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase physical 1 1 1 Biochemical Activity
VHR2 YER064C Non-essential nuclear protein physical 1 1 1 Biochemical Activity
YLR001C YLR001C Putative protein of unknown function physical 1 1 1 Biochemical Activity
YGR038C-A YGR038C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Biochemical Activity
YJR056C YJR056C Protein of unknown function physical 1 1 1 Biochemical Activity
YER079W YER079W Putative protein of unknown function physical 1 1 1 Biochemical Activity
GTT3 YEL017W Protein of unknown function may be involved in glutathione metabolism physical 1 1 1 Biochemical Activity
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase physical 1 1 1 Biochemical Activity
SPS1 YDR523C STE20-family GCKIII protein kinase physical 1 1 1 Biochemical Activity
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Biochemical Activity
YML083C YML083C Protein of unknown function physical 1 1 1 Biochemical Activity
KAR9 YPL269W Spindle positioning factor physical 1 1 1 Two-hybrid
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-MS
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Affinity Capture-MS
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 1 1 1 Affinity Capture-MS
YCP4 YCR004C Protein of unknown function physical 1 1 1 Affinity Capture-MS
YGR130C YGR130C Component of the eisosome with unknown function physical 1 1 1 Affinity Capture-MS
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly physical 1 1 1 Affinity Capture-MS
SEG1 YMR086W Component of eisosome required for proper eisosome assembly physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-Western
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-Western
PIL1 YGR086C Eisosome core component genetic 1 1 1 Dosage Growth Defect
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) physical 1 1 1 Co-purification
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 PCA
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Phenotypic Enhancement
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Synthetic Growth Defect
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Phenotypic Enhancement
HHT2 YNL031C Histone H3 genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
HOP1 YIL072W Meiosis-specific protein required for chromosome synapsis genetic 1 1 1 Positive Genetic
HRK1 YOR267C Protein kinase genetic 1 1 1 Positive Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Positive Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Positive Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Positive Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Lethality
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Phenotypic Suppression
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Synthetic Growth Defect
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Synthetic Growth Defect
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Growth Defect
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Synthetic Growth Defect
RIB4 YOL143C Lumazine synthase (DMRL synthase) genetic 1 1 1 Synthetic Growth Defect
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Growth Defect
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Synthetic Growth Defect
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Synthetic Growth Defect
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Growth Defect
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Synthetic Growth Defect
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Dosage Rescue
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Positive Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
MBP1 YDL056W Transcription factor genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
KCC4 YCL024W Protein kinase of the bud neck involved in the septin checkpoint genetic 1 1 1 Negative Genetic
ISR1 YPR106W Predicted protein kinase genetic 1 1 1 Negative Genetic
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor genetic 1 1 1 Negative Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Negative Genetic
FKH1 YIL131C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Dosage Lethality
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Dosage Lethality
SVL3 YPL032C Protein of unknown function genetic 1 1 1 Dosage Lethality
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Dosage Lethality
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Dosage Lethality
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Dosage Lethality
ITT1 YML068W Protein that modulates the efficiency of translation termination genetic 1 1 1 Dosage Lethality
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III genetic 1 1 1 Dosage Lethality
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA genetic 1 1 1 Dosage Lethality
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Dosage Lethality
RTC3 YHR087W Protein of unknown function involved in RNA metabolism genetic 1 1 1 Dosage Lethality
NPR1 YNL183C Protein kinase genetic 1 1 1 Dosage Lethality
MCY1 YGR012W Putative cysteine synthase genetic 1 1 1 Dosage Lethality
SPR6 YER115C Protein of unknown function genetic 1 1 1 Dosage Lethality
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Dosage Lethality
LSC1 YOR142W Alpha subunit of succinyl-CoA ligase genetic 1 1 1 Dosage Lethality
TMA16 YOR252W Protein of unknown function that associates with ribosomes genetic 1 1 1 Dosage Lethality
YNR048W YNR048W Potential noncatalytic subunit for phospholipid translocase Dnf3p genetic 1 1 1 Dosage Lethality
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 1 1 1 Dosage Lethality
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair genetic 1 1 1 Dosage Lethality
RCR1 YBR005W Plasma membrane (PM) ubiquitin ligase-substrate adaptor genetic 1 1 1 Dosage Lethality
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Dosage Lethality
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Dosage Lethality
SHQ1 YIL104C Chaperone protein genetic 1 1 1 Dosage Lethality
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Dosage Lethality
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Dosage Lethality
PML1 YLR016C Subunit of the RES complex genetic 1 1 1 Dosage Lethality
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis genetic 1 1 1 Dosage Lethality
YSY6 YBR162W-A Protein of unknown function genetic 1 1 1 Dosage Lethality
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 1 1 1 Dosage Lethality
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Dosage Lethality
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Dosage Lethality
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Dosage Lethality
TIR1 YER011W Cell wall mannoprotein genetic 1 1 1 Dosage Lethality
MCR1 YKL150W Mitochondrial NADH-cytochrome b5 reductase genetic 1 1 1 Dosage Lethality
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
ILT1 YDR090C Protein of unknown function genetic 1 1 1 Dosage Lethality
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 1 1 1 Dosage Lethality
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Dosage Lethality
STF2 YGR008C Protein involved in resistance to desiccation stress genetic 1 1 1 Dosage Lethality
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Dosage Lethality
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Dosage Lethality
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Dosage Lethality
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Dosage Lethality
PRM2 YIL037C Pheromone-regulated protein genetic 1 1 1 Dosage Lethality
PEX3 YDR329C Peroxisomal membrane protein (PMP) genetic 1 1 1 Dosage Lethality
YLR126C YLR126C Putative glutamine amidotransferase genetic 1 1 1 Dosage Lethality
PET123 YOR158W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Dosage Lethality
HUL4 YJR036C Protein with similarity to hect domain E3 ubiquitin-protein ligases genetic 1 1 1 Dosage Lethality
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Dosage Lethality
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Dosage Lethality
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Dosage Lethality
EFG1 YGR271C-A Ribosome biogenesis factor required for maturation of 18S rRNA genetic 1 1 1 Dosage Lethality
YML020W YML020W Putative protein of unknown function genetic 1 1 1 Dosage Lethality
YIG1 YPL201C Protein that interacts with glycerol 3-phosphatase genetic 1 1 1 Dosage Lethality
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Dosage Lethality
MEF1 YLR069C Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Dosage Lethality
SDS23 YGL056C Protein involved in cell separation during budding genetic 1 1 1 Dosage Lethality
HUA1 YGR268C Cytoplasmic protein containing a zinc finger domain genetic 1 1 1 Dosage Lethality
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Dosage Lethality
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Dosage Lethality
TOS4 YLR183C Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Synthetic Growth Defect
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Synthetic Rescue
HAP4 YKL109W Transcription factor genetic 1 1 1 Dosage Lethality
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Dosage Lethality
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Dosage Lethality
MSB1 YOR188W Protein of unknown function genetic 1 1 1 Dosage Lethality
PUS1 YPL212C tRNA:pseudouridine synthase genetic 1 1 1 Dosage Lethality
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p genetic 1 1 1 Dosage Lethality
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Dosage Lethality
PEX21 YGR239C Peroxin required for peroxisomal matrix protein targeting genetic 1 1 1 Dosage Lethality
SPO21 YOL091W Component of the meiotic outer plaque of the spindle pole body genetic 1 1 1 Dosage Lethality
PPM2 YOL141W AdoMet-dependent tRNA methyltransferase genetic 1 1 1 Dosage Lethality
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Dosage Lethality
YPR063C YPR063C ER-localized protein of unknown function genetic 1 1 1 Dosage Lethality
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Dosage Lethality
MRPL16 YBL038W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
RRP46 YGR095C Exosome non-catalytic core component genetic 1 1 1 Dosage Lethality
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Dosage Lethality
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Dosage Lethality
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Dosage Lethality
YHL009W-A YHL009W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol genetic 1 1 1 Dosage Lethality
IMP4 YNL075W Component of the SSU processome genetic 1 1 1 Dosage Lethality
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway genetic 1 1 1 Dosage Lethality
RCK1 YGL158W Protein kinase involved in oxidative stress response genetic 1 1 1 Dosage Lethality
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Dosage Lethality
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p genetic 1 1 1 Dosage Lethality
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Dosage Lethality
YHR210C YHR210C Putative aldose 1-epimerase superfamily protein genetic 1 1 1 Dosage Lethality
LYS1 YIR034C Saccharopine dehydrogenase (NAD+, L-lysine-forming) genetic 1 1 1 Dosage Lethality
RMD5 YDR255C Component of GID Complex that confers ubiquitin ligase (U3) activity genetic 1 1 1 Dosage Lethality
YER187W YER187W Putative protein of unknown function genetic 1 1 1 Dosage Lethality
GTO3 YMR251W Omega class glutathione transferase genetic 1 1 1 Dosage Lethality
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Dosage Lethality
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Dosage Lethality
IFH1 YLR223C Coactivator, regulates transcription of ribosomal protein (RP) genes genetic 1 1 1 Dosage Lethality
GOT1 YMR292W Homodimeric protein that is packaged into COPII vesicles genetic 1 1 1 Dosage Lethality
VMA10 YHR039C-A Subunit G of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Dosage Lethality
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Dosage Lethality
PHA2 YNL316C Prephenate dehydratase genetic 1 1 1 Dosage Lethality
GIS3 YLR094C Protein of unknown function genetic 1 1 1 Dosage Lethality
RPL14B YHL001W Ribosomal 60S subunit protein L14B genetic 1 1 1 Dosage Lethality
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Dosage Lethality
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Dosage Lethality
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Dosage Lethality
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Dosage Lethality
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Dosage Lethality
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Dosage Lethality
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Dosage Lethality
SDH7 YDR511W Mitochondrial protein involved in assembly of succinate dehydrogenase genetic 1 1 1 Dosage Lethality
FDC1 YDR539W Ferulic acid decarboxylase genetic 1 1 1 Dosage Lethality
YDR182W-A YDR182W-A Putative protein of unknown function genetic 1 1 1 Dosage Lethality
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Dosage Lethality
MTF2 YDL044C Mitochondrial protein that interacts with mitochondrial RNA polymerase genetic 1 1 1 Dosage Lethality
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Dosage Lethality
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Dosage Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Synthetic Lethality
NBP35 YGL091C Essential cytoplasmic iron-sulfur cluster binding protein genetic 1 1 1 Dosage Growth Defect
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Dosage Growth Defect
SYH1 YPL105C Protein of unknown function that influences nuclear pore distribution genetic 1 1 1 Dosage Growth Defect
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Dosage Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Dosage Growth Defect
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Dosage Growth Defect
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Positive Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
RTR1 YER139C Dual specificity protein phosphatase genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
YHI9 YHR029C Protein of unknown function genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 1 1 1 Negative Genetic
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Phenotypic Suppression
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Phenotypic Suppression
GRX5 YPL059W Glutathione-dependent oxidoreductase genetic 1 1 1 Phenotypic Suppression
IBA57 YJR122W Protein involved in incorporating iron-sulfur clusters into proteins genetic 1 1 1 Phenotypic Suppression
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
MSF1 YPR047W Mitochondrial phenylalanyl-tRNA synthetase genetic 1 1 1 Positive Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Growth Defect
GRX3 YDR098C Glutathione-dependent oxidoreductase genetic 1 1 1 Phenotypic Suppression
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase genetic 1 1 1 Phenotypic Suppression
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Phenotypic Suppression
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Phenotypic Suppression
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Phenotypic Suppression
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Phenotypic Enhancement
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Synthetic Growth Defect
AGX1 YFL030W Alanine:glyoxylate aminotransferase (AGT) physical 1 1 1 Affinity Capture-MS
ARG4 YHR018C Argininosuccinate lyase genetic 1 1 1 Dosage Lethality
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV physical 1 1 1 Affinity Capture-MS
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Biochemical Activity
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis genetic 1 1 1 Dosage Growth Defect
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Synthetic Growth Defect
CTR1 YPR124W High-affinity copper transporter of plasma membrane genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Phenotypic Suppression
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Negative Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Dosage Lethality
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 1 1 1 Affinity Capture-MS
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Positive Genetic
CHA4 YLR098C DNA binding transcriptional activator physical 1 1 1 Biochemical Activity
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Synthetic Lethality
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) genetic 1 1 1 Dosage Lethality
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Phenotypic Suppression
ATS1 YAL020C Protein required for modification of wobble nucleosides in tRNA genetic 1 1 1 Dosage Growth Defect
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Synthetic Growth Defect
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 1 1 1 Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation physical 1 1 1 Biochemical Activity
CUS2 YNL286W Putative checkpoint factor in transcription genetic 1 1 1 Dosage Lethality
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Dosage Lethality
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Positive Genetic
BOP3 YNL042W Protein of unknown function genetic 1 1 1 Dosage Lethality
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Dosage Lethality
ASG7 YJL170C Protein that regulates signaling from G protein beta subunit Ste4p genetic 1 1 1 Dosage Lethality
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Dosage Lethality
BIO2 YGR286C Biotin synthase genetic 1 1 1 Dosage Lethality
CUP9 YPL177C Homeodomain-containing transcriptional repressor physical 1 1 1 Biochemical Activity
ALR2 YFL050C Probable Mg(2+) transporter genetic 1 1 1 Dosage Lethality
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase physical 1 1 1 Biochemical Activity
DIF1 YLR437C Protein that regulates nuclear import of Rnr2p and Rnr4p physical 1 1 1 Biochemical Activity
COQ8 YGL119W ATPase required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Dosage Lethality
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Synthetic Lethality
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Dosage Rescue
CMC1 YKL137W Copper-binding protein of the mitochondrial intermembrane space genetic 1 1 1 Dosage Lethality
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Dosage Lethality
BIO4 YNR057C Dethiobiotin synthetase genetic 1 1 1 Dosage Lethality