RAD18 |
YCR066W |
E3 ubiquitin ligase |
physical |
28 |
7 |
17 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Far Western, Far Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Far Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Co-purification, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Two-hybrid |
UBR1 |
YGR184C |
E3 ubiquitin ligase (N-recognin) |
physical |
14 |
4 |
10 |
Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
physical |
13 |
5 |
9 |
Affinity Capture-MS, Co-localization, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
10 |
3 |
9 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
8 |
3 |
7 |
Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
8 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
8 |
2 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
physical |
7 |
4 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
UBA1 |
YKL210W |
Ubiquitin activating enzyme (E1) |
physical |
6 |
3 |
6 |
Affinity Capture-MS, Biochemical Activity, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
6 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
6 |
2 |
5 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
6 |
1 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
6 |
2 |
2 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
5 |
2 |
5 |
Negative Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
5 |
2 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect |
RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect |
SWC3 |
YAL011W |
Protein of unknown function |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Positive Genetic |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
4 |
2 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Negative Genetic, Synthetic Lethality |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
3 |
3 |
3 |
Positive Genetic, Synthetic Growth Defect, Phenotypic Enhancement |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
UBP6 |
YFR010W |
Ubiquitin-specific protease |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression |
RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
CSF1 |
YLR087C |
Protein with structural similarity to lipid transport protein Vps13p |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
3 |
1 |
3 |
Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Lethality, Synthetic Lethality |
YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
CCS1 |
YMR038C |
Copper chaperone for superoxide dismutase Sod1p |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Lethality, Synthetic Lethality |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
physical |
3 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
3 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
CSE2 |
YNR010W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
SPF1 |
YEL031W |
P-type ATPase, ion transporter of the ER membrane |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
YPT6 |
YLR262C |
Rab family GTPase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Suppression |
SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
GCR2 |
YNL199C |
Transcriptional activator of genes involved in glycolysis |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
CDC26 |
YFR036W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
CTK2 |
YJL006C |
Beta subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
HTB2 |
YBL002W |
Histone H2B |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
IES1 |
YFL013C |
Subunit of the INO80 chromatin remodeling complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RAD10 |
YML095C |
Single-stranded DNA endonuclease (with Rad1p) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HOM6 |
YJR139C |
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
YNG1 |
YOR064C |
Subunit of the NuA3 histone acetyltransferase complex |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
SAS4 |
YDR181C |
Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTR1 |
YER139C |
Dual specificity protein phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VPS9 |
YML097C |
Guanine nucleotide exchange factor (GEF) and ubiquitin receptor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YML096W |
YML096W |
Putative protein with similarity to asparagine synthetases |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YML020W |
YML020W |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MMR1 |
YLR190W |
Phosphorylated protein of the mitochondrial outer membrane |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
BUD16 |
YEL029C |
Putative pyridoxal kinase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Enhancement |
RNH203 |
YLR154C |
Ribonuclease H2 subunit |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
RIF2 |
YLR453C |
Protein that binds to the Rap1p C-terminus |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Phenotypic Suppression |
CLN3 |
YAL040C |
G1 cyclin involved in cell cycle progression |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Growth Defect |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
EPL1 |
YFL024C |
Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
ADA2 |
YDR448W |
Transcription coactivator |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
ACS2 |
YLR153C |
Acetyl-coA synthetase isoform |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
2 |
1 |
1 |
Synthetic Rescue, Synthetic Rescue |
SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
TAF9 |
YMR236W |
Subunit (17 kDa) of TFIID and SAGA complexes |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
HHT1 |
YBR010W |
Histone H3 |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
ARN1 |
YHL040C |
ARN family transporter for siderophore-iron chelates |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
PHO81 |
YGR233C |
Cyclin-dependent kinase (CDK) inhibitor |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
PHO84 |
YML123C |
High-affinity inorganic phosphate (Pi) transporter |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
PHO5 |
YBR093C |
Repressible acid phosphatase |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CDC40 |
YDR364C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Positive Genetic |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Co-purification |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX6 |
YHR051W |
Subunit VI of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
END3 |
YNL084C |
EH domain-containing protein involved in endocytosis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MDM10 |
YAL010C |
Subunit of both the ERMES and the SAM complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IMG1 |
YCR046C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
IMG2 |
YCR071C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL16 |
YBL038W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL7 |
YDR237W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL9 |
YGR220C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRP51 |
YPL118W |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CCM1 |
YGR150C |
Mitochondrial 15S rRNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GEP3 |
YOR205C |
Protein required for mitochondrial ribosome small subunit biogenesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPS16 |
YPL013C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
INO80 |
YGL150C |
Nucleosome spacing factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PEP3 |
YLR148W |
Component of CORVET membrane tethering complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD3 |
YER171W |
5' to 3' DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSL1 |
YIR009W |
U2B component of U2 snRNP |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HFI1 |
YPL254W |
Adaptor protein required for structural integrity of the SAGA complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
DIA4 |
YHR011W |
Probable mitochondrial seryl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HTB1 |
YDR224C |
Histone H2B |
physical |
1 |
1 |
1 |
Biochemical Activity |
PST2 |
YDR032C |
FMN-dependent NAD(P)H:quinone oxidoreductase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Dosage Rescue |
PRS3 |
YHL011C |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC37 |
YDR168W |
Essential Hsp90p co-chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SWD2 |
YKL018W |
Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SPB4 |
YFL002C |
Putative ATP-dependent RNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBI4 |
YLL039C |
Ubiquitin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
physical |
1 |
1 |
1 |
Reconstituted Complex |
UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SIT4 |
YDL047W |
Ceramide-activated, type 2A-related serine-threonine phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SET2 |
YJL168C |
Histone methyltransferase with a role in transcriptional elongation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RPB9 |
YGL070C |
RNA polymerase II subunit B12.6 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SPT8 |
YLR055C |
Subunit of the SAGA transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS21 |
YOR089C |
Endosomal Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIR1 |
YKR101W |
Protein involved in silencing at mating-type loci HML and HMR |
genetic |
1 |
1 |
1 |
Negative Genetic |
VIK1 |
YPL253C |
Protein that forms a kinesin-14 heterodimeric motor with Kar3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAM37 |
YMR060C |
Component of the Sorting and Assembly Machinery (SAM) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOR338W |
YOR338W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TSA2 |
YDR453C |
Stress inducible cytoplasmic thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
STO1 |
YMR125W |
Large subunit of the nuclear mRNA cap-binding protein complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
RXT3 |
YDL076C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
YJR124C |
YJR124C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAS2 |
YMR127C |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS68 |
YOL129W |
Vacuolar membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RKR1 |
YMR247C |
RING domain E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TDP1 |
YBR223C |
Tyrosyl-DNA phosphodiesterase I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
WSC2 |
YNL283C |
Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway |
genetic |
1 |
1 |
1 |
Dosage Rescue |
RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RGP1 |
YDR137W |
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIM13 |
YMR154C |
Calpain-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RML2 |
YEL050C |
Mitochondrial ribosomal protein of the large subunit (L2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS52 |
YDR484W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SCS3 |
YGL126W |
Protein required for normal ER membrane biosynthesis in response to ER |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
STB2 |
YMR053C |
Protein that interacts with Sin3p in a two-hybrid assay |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UBP14 |
YBR058C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA22 |
YHR060W |
Protein that is required for vacuolar H+-ATPase (V-ATPase) function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS16 |
YPL045W |
Subunit of the HOPS and the CORVET complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS25 |
YJR102C |
Component of the ESCRT-II complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS36 |
YLR417W |
Component of the ESCRT-II complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YDR114C |
YDR114C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWA2 |
YDR320C |
Auxilin-like protein involved in vesicular transport |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RSM18 |
YER050C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SHE2 |
YKL130C |
RNA-binding protein that binds specific mRNAs and interacts with She3p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SOV1 |
YMR066W |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRB5 |
YGR104C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TIM18 |
YOR297C |
Component of the mitochondrial TIM22 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA2 |
YBR127C |
Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA5 |
YKL080W |
Subunit C of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA7 |
YGR020C |
Subunit F of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPH2 |
YKL119C |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS33 |
YLR396C |
ATP-binding protein that is a subunit of the HOPS and CORVET complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA16 |
YHR026W |
Subunit c'' of the vacuolar ATPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RSM25 |
YIL093C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SGO1 |
YOR073W |
Component of the spindle checkpoint |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ZUO1 |
YGR285C |
Ribosome-associated chaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
UBP10 |
YNL186W |
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RFS1 |
YBR052C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
YOR1 |
YGR281W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSM4 |
YIL030C |
Membrane-embedded ubiquitin-protein ligase and retrotranslocase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPH1 |
YOR270C |
Subunit a of the vacuolar-ATPase V0 domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MAG1 |
YER142C |
3-methyl-adenine DNA glycosylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MSS116 |
YDR194C |
Mitochondrial transcription elongation factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CTR1 |
YPR124W |
High-affinity copper transporter of plasma membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
PPZ1 |
YML016C |
Serine/threonine protein phosphatase Z, isoform of Ppz2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Dosage Rescue |
CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CHZ1 |
YER030W |
Histone chaperone for Htz1p/H2A-H2B dimer |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PSO2 |
YMR137C |
Nuclease required for DNA single- and double-strand break repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CTK3 |
YML112W |
Gamma subunit of C-terminal domain kinase I |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PRS1 |
YKL181W |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GRX5 |
YPL059W |
Glutathione-dependent oxidoreductase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
physical |
1 |
1 |
1 |
Biochemical Activity |
MTF1 |
YMR228W |
Mitochondrial RNA polymerase specificity factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PIR5 |
YJL160C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
CEP3 |
YMR168C |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CRP1 |
YHR146W |
Protein that binds to cruciform DNA structures |
genetic |
1 |
1 |
1 |
Negative Genetic |
NHP6A |
YPR052C |
High-mobility group (HMG) protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
IES6 |
YEL044W |
Component of the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MDM12 |
YOL009C |
Mitochondrial outer membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MGM1 |
YOR211C |
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PET123 |
YOR158W |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GAL4 |
YPL248C |
DNA-binding transcription factor required for activating GAL genes |
physical |
1 |
1 |
1 |
Co-localization |
NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
FBP1 |
YLR377C |
Fructose-1,6-bisphosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD2 |
YGR258C |
Single-stranded DNA endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CAT8 |
YMR280C |
Zinc cluster transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAC1 |
YMR021C |
Copper-sensing transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MTF2 |
YDL044C |
Mitochondrial protein that interacts with mitochondrial RNA polymerase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CHS5 |
YLR330W |
Component of the exomer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MATALPHA2 |
YCR039C |
Homeobox-domain protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
HHT2 |
YNL031C |
Histone H3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MON2 |
YNL297C |
Protein with a role in endocytosis and vacuole integrity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MDM31 |
YHR194W |
Mitochondrial protein that may have a role in phospholipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CUE4 |
YML101C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HEM14 |
YER014W |
Protoporphyrinogen oxidase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PAH1 |
YMR165C |
Mg2+-dependent phosphatidate (PA) phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
LYS20 |
YDL182W |
Homocitrate synthase isozyme and functions in DNA repair |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD30 |
YDR419W |
DNA polymerase eta |
physical |
1 |
1 |
1 |
Protein-peptide |
HTD2 |
YHR067W |
Mitochondrial 3-hydroxyacyl-thioester dehydratase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MTG1 |
YMR097C |
Putative GTPase peripheral to the mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
COQ6 |
YGR255C |
Flavin-dependent monooxygenase involved in ubiquinone biosynthesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NPT1 |
YOR209C |
Nicotinate phosphoribosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL32 |
YCR003W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PEX32 |
YBR168W |
Peroxisomal integral membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MUB1 |
YMR100W |
MYND domain-containing protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ALT1 |
YLR089C |
Alanine transaminase (glutamic pyruvic transaminase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
OGG1 |
YML060W |
Nuclear and mitochondrial glycosylase/lyase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
IRC19 |
YLL033W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ACL4 |
YDR161W |
Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GUA1 |
YMR217W |
GMP synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MSK1 |
YNL073W |
Mitochondrial lysine-tRNA synthetase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MTM1 |
YGR257C |
Mitochondrial protein of the mitochondrial carrier family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ILM1 |
YJR118C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MDM32 |
YOR147W |
Mitochondrial inner membrane protein with similarity to Mdm31p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CEM1 |
YER061C |
Mitochondrial beta-keto-acyl synthase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MSN1 |
YOL116W |
Transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NCS2 |
YNL119W |
Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
GTF1 |
YGR102C |
Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL33 |
YMR286W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MSC1 |
YML128C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MCT1 |
YOR221C |
Predicted malonyl-CoA:ACP transferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL37 |
YBR268W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
AIM10 |
YER087W |
Protein with similarity to tRNA synthetases |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
QRI5 |
YLR204W |
Mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |