Standard name Systematic name Name description Description
ARC18 YLR370C Subunit of the ARP2/3 complex Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches
Visualize the interactome of ARC18
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.051 0.118 0.105
Cell Periphery 0.077 0.087 0.263
Cort. Patches 0.603 0.559 0.671
ER 0.115 0.268 0.066
Golgi 0.346 0.173 0.645
Mito 0.231 0.079 NaN
Nucleolus 0.064 NaN NaN
Cytoplasm NaN 0.055 NaN

GFP localization & abundance

GFP localization GFP abundance
actin 1920

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ARC18 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ARP2 YDL029W Essential component of the Arp2/3 complex physical 13 4 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Affinity Capture-MS, Co-purification
ARP3 YJR065C Essential component of the Arp2/3 complex physical 8 3 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ARC15 YIL062C Subunit of the ARP2/3 complex physical 7 3 4 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, FRET
ARC19 YKL013C Subunit of the ARP2/3 complex physical 6 3 6 Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, PCA, PCA
ARC40 YBR234C Subunit of the ARP2/3 complex physical 6 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA
ARC35 YNR035C Subunit of the ARP2/3 complex physical 6 3 4 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ARC40 YBR234C Subunit of the ARP2/3 complex genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 2 1 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
LAS17 YOR181W Actin assembly factor physical 3 3 3 PCA, Affinity Capture-MS, Reconstituted Complex
JNM1 YMR294W Component of the yeast dynactin complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
BNR1 YIL159W Formin genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 2 2 Synthetic Haploinsufficiency, Negative Genetic, Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 3 2 2 Negative Genetic, Phenotypic Suppression, Phenotypic Suppression
GET2 YER083C Subunit of the GET complex genetic 3 2 2 Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Positive Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality
ILM1 YJR118C Protein of unknown function genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
COM2 YER130C Transcription factor that binds IME1 Upstream Activation Signal (UAS) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PRK1 YIL095W Ser/Thr protein kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SDD2 YMR074C Protein with homology to human PDCD5 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MYO5 YMR109W One of two type I myosin motors physical 2 2 2 Affinity Capture-Western, PCA
GET1 YGL020C Subunit of the GET complex genetic 2 2 2 Synthetic Lethality, Positive Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 2 1 2 Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 2 1 2 Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 2 1 2 Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
CHS7 YHR142W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 2 1 2 Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 1 2 Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 2 1 2 Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 2 1 2 Negative Genetic, Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 1 2 Negative Genetic, Negative Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 2 1 2 Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
MSO1 YNR049C Lipid-interacting protein in SNARE complex assembly machinery genetic 2 1 2 Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 2 1 2 Negative Genetic, Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 1 2 Negative Genetic, Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
RLM1 YPL089C MADS-box transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 2 1 2 Negative Genetic, Negative Genetic
SYT1 YPR095C Guanine nucleotide exchange factor (GEF) for Arf proteins genetic 2 1 2 Negative Genetic, Negative Genetic
CHS1 YNL192W Chitin synthase I genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
CHS5 YLR330W Component of the exomer complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 2 1 2 Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 2 1 2 Negative Genetic, Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 2 2 1 Positive Genetic, Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 2 2 1 Positive Genetic, Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SRV2 YNL138W CAP (cyclase-associated protein) genetic 2 1 1 Negative Genetic, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ELP3 YPL086C Subunit of Elongator complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PER1 YCR044C Protein of the endoplasmic reticulum genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PHO80 YOL001W Cyclin genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ARF1 YDL192W ADP-ribosylation factor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 1 Negative Genetic, Negative Genetic
CMD1 YBR109C Calmodulin genetic 2 1 1 Negative Genetic, Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 1 Negative Genetic, Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 2 1 1 Negative Genetic, Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 2 1 1 Negative Genetic, Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 2 1 1 Negative Genetic, Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 1 1 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG8 YOR067C Glucosyl transferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
JSN1 YJR091C Member of the Puf family of RNA-binding proteins physical 1 1 1 Co-localization
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Negative Genetic
VHR2 YER064C Non-essential nuclear protein physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 PCA
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 PCA
SRV2 YNL138W CAP (cyclase-associated protein) physical 1 1 1 PCA
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 1 1 1 PCA
ARC18 YLR370C Subunit of the ARP2/3 complex physical 1 1 1 PCA
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Reconstituted Complex
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
IRC20 YLR247C E3 ubiquitin ligase and putative helicase physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
BNI1 YNL271C Formin genetic 1 1 1 Positive Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity physical 1 1 1 PCA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SRB4 YER022W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Synthetic Lethality
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
PDI1 YCL043C Protein disulfide isomerase genetic 1 1 1 Synthetic Lethality
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
YGL242C YGL242C Protein of unknown function genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Negative Genetic
PRM2 YIL037C Pheromone-regulated protein genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
PBA1 YLR199C Protein involved in 20S proteasome assembly genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Lethality
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Lethality
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Lethality
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
YPT31 YER031C Rab family GTPase genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
CCH1 YGR217W Voltage-gated high-affinity calcium channel genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
CYC1 YJR048W Cytochrome c, isoform 1 genetic 1 1 1 Negative Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 1 1 1 Positive Genetic
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Positive Genetic
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Positive Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Positive Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Positive Genetic
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 1 1 1 Positive Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Positive Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Positive Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Positive Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Positive Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Positive Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Positive Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Positive Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
NPP1 YCR026C Nucleotide pyrophosphatase/phosphodiesterase genetic 1 1 1 Positive Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Positive Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Positive Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Positive Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
PHO91 YNR013C Low-affinity vacuolar phosphate transporter genetic 1 1 1 Positive Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Positive Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
HCA4 YJL033W DEAD box RNA helicase genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
LTO1 YNL260C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein genetic 1 1 1 Negative Genetic
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
NBP35 YGL091C Essential cytoplasmic iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 1 1 1 Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Negative Genetic
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
GAA1 YLR088W Subunit of the GPI:protein transamidase complex genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Negative Genetic
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi genetic 1 1 1 Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 1 1 1 Negative Genetic
YPT10 YBR264C Rab family GTP-binding protein genetic 1 1 1 Negative Genetic
UBX7 YBR273C UBX (ubiquitin regulatory X) domain-containing protein genetic 1 1 1 Negative Genetic
PRM7 YDL039C Pheromone-regulated protein genetic 1 1 1 Negative Genetic
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Negative Genetic
RSM24 YDR175C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 1 1 1 Negative Genetic
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis genetic 1 1 1 Negative Genetic
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Negative Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
GEP7 YGL057C Protein of unknown function genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Negative Genetic
PFK26 YIL107C 6-phosphofructo-2-kinase genetic 1 1 1 Negative Genetic
DAL3 YIR032C Ureidoglycolate lyase genetic 1 1 1 Negative Genetic
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
YNK1 YKL067W Nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
UFO1 YML088W F-box receptor protein genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
YNL194C YNL194C Integral membrane protein genetic 1 1 1 Negative Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
PUL4 YNR063W Putative zinc-cluster transcription factor genetic 1 1 1 Negative Genetic
YNR071C YNR071C Putative aldose 1-epimerase genetic 1 1 1 Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
RUP1 YOR138C Protein that regulates ubiquitination of Rsp5p genetic 1 1 1 Negative Genetic
DSE3 YOR264W Daughter cell-specific protein, may help establish daughter fate genetic 1 1 1 Negative Genetic
RDL2 YOR286W Protein with rhodanese activity genetic 1 1 1 Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Positive Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 1 1 1 Negative Genetic
ACO1 YLR304C Aconitase genetic 1 1 1 Negative Genetic
AIP1 YMR092C Actin cortical patch component genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
AIM45 YPR004C Putative ortholog of mammalian ETF-alpha genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
AQY3 YFL054C Putative channel-like protein genetic 1 1 1 Positive Genetic
ALO1 YML086C D-Arabinono-1,4-lactone oxidase genetic 1 1 1 Negative Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Negative Genetic