Standard name Systematic name Name description Description
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner
Visualize the interactome of VMA1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.202 NaN 0.075
Nucleolus 0.064 NaN 0.086
Nucleus 0.073 NaN NaN
Vac/Vac Memb 0.716 NaN 0.862
Mito NaN NaN 0.052

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
VMA1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1086 (V-ATPase, vacuole), r_1085 (V-ATPase, Golgi)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase physical 13 6 11 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Co-fractionation, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Co-purification
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 13 5 10 Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 7 4 7 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Co-purification
VMA10 YHR039C-A Subunit G of the V1 peripheral membrane domain of V-ATPase physical 7 4 7 Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) physical 6 4 6 Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase physical 5 4 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Protein-peptide, Co-purification
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase physical 5 3 5 Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Co-purification
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase physical 4 4 4 Affinity Capture-Western, Affinity Capture-MS, Protein-peptide, Reconstituted Complex
TLG2 YOL018C Syntaxin-like t-SNARE genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase physical 3 3 3 Affinity Capture-Western, Reconstituted Complex, Co-purification
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 3 3 3 Two-hybrid, Affinity Capture-Western, Co-purification
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 3 2 3 Negative Genetic, Positive Genetic, Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 3 2 3 Affinity Capture-RNA, Affinity Capture-MS, Affinity Capture-RNA
YPT6 YLR262C Rab family GTPase genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SYS1 YJL004C Integral membrane protein of the Golgi genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD3 YER171W 5' to 3' DNA helicase physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 2 2 Negative Genetic, Synthetic Lethality
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' physical 2 2 2 Affinity Capture-Western, Co-purification
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 2 2 2 Negative Genetic, Synthetic Lethality
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 2 2 Positive Genetic, Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 2 1 2 Negative Genetic, Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 2 1 2 Negative Genetic, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 1 2 Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
IMD3 YLR432W Inosine monophosphate dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 2 1 2 Negative Genetic, Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 1 2 Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 2 1 2 Negative Genetic, Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein genetic 2 1 2 Negative Genetic, Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 2 1 2 Negative Genetic, Negative Genetic
PIL1 YGR086C Eisosome core component genetic 2 1 2 Negative Genetic, Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 2 1 2 Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 2 1 2 Negative Genetic, Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 2 1 2 Positive Genetic, Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 2 1 2 Negative Genetic, Negative Genetic
YSY6 YBR162W-A Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
YBR225W YBR225W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 2 1 2 Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 2 1 2 Positive Genetic, Positive Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
YAP1801 YHR161C Protein of the AP180 family, involved in clathrin cage assembly genetic 2 1 2 Negative Genetic, Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
YJR015W YJR015W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YKL222C YKL222C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 2 1 2 Negative Genetic, Negative Genetic
VTA1 YLR181C Multivesicular body (MVB) protein genetic 2 1 2 Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 2 Negative Genetic, Negative Genetic
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
YOL036W YOL036W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YOL013W-A YOL013W-A Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 2 1 2 Positive Genetic, Positive Genetic
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 2 1 2 Negative Genetic, Negative Genetic
YPR096C YPR096C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 2 1 2 Positive Genetic, Positive Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
AIP1 YMR092C Actin cortical patch component genetic 2 1 2 Negative Genetic, Negative Genetic
UBI4 YLL039C Ubiquitin genetic 2 1 2 Negative Genetic, Negative Genetic
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 2 1 2 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 2 Negative Genetic, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 1 2 Negative Genetic, Negative Genetic
FPK1 YNR047W Ser/Thr protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 2 1 2 Positive Genetic, Positive Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 1 2 Positive Genetic, Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 1 2 Negative Genetic, Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 2 1 2 Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 2 1 2 Negative Genetic, Negative Genetic
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p genetic 2 1 2 Negative Genetic, Negative Genetic
GNP1 YDR508C Broad specificity amino acid permease genetic 2 1 2 Negative Genetic, Negative Genetic
MVP1 YMR004W Protein required for sorting proteins to the vacuole genetic 2 1 2 Negative Genetic, Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 2 1 2 Negative Genetic, Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 2 1 2 Negative Genetic, Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
MDR1 YGR100W Cytoplasmic GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 2 1 2 Negative Genetic, Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 2 1 2 Positive Genetic, Positive Genetic
ATG8 YBL078C Ub-like protein genetic 2 1 2 Negative Genetic, Negative Genetic
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway genetic 2 1 2 Negative Genetic, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Negative Genetic, Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 2 1 2 Negative Genetic, Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 2 1 2 Negative Genetic, Negative Genetic
GAL10 YBR019C UDP-glucose-4-epimerase genetic 2 1 2 Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Negative Genetic, Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 2 1 2 Negative Genetic, Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 2 1 2 Positive Genetic, Positive Genetic
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 2 1 2 Negative Genetic, Negative Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 2 1 2 Negative Genetic, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 2 1 2 Negative Genetic, Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 2 1 2 Negative Genetic, Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 2 1 2 Negative Genetic, Negative Genetic
ERF2 YLR246W Subunit of a palmitoyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
STB5 YHR178W Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
MMT2 YPL224C Putative metal transporter involved in mitochondrial iron accumulation genetic 2 1 2 Negative Genetic, Negative Genetic
RTN1 YDR233C Reticulon protein genetic 2 1 2 Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex genetic 2 1 2 Negative Genetic, Negative Genetic
HAM1 YJR069C Nucleoside triphosphate pyrophosphohydrolase genetic 2 1 2 Negative Genetic, Negative Genetic
PEX1 YKL197C AAA-peroxin genetic 2 1 2 Positive Genetic, Positive Genetic
GLO4 YOR040W Mitochondrial glyoxalase II genetic 2 1 2 Positive Genetic, Positive Genetic
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 2 1 2 Negative Genetic, Negative Genetic
DDR48 YMR173W DNA damage-responsive protein genetic 2 1 2 Negative Genetic, Negative Genetic
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 2 1 2 Negative Genetic, Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 2 1 2 Negative Genetic, Negative Genetic
FIG2 YCR089W Cell wall adhesin, expressed specifically during mating genetic 2 1 2 Negative Genetic, Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
MRP35 YNL122C Mitochondrial ribosomal protein of the large subunit genetic 2 1 2 Negative Genetic, Negative Genetic
FTR1 YER145C High affinity iron permease genetic 2 1 2 Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
AQY3 YFL054C Putative channel-like protein genetic 2 1 2 Negative Genetic, Negative Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 2 1 2 Positive Genetic, Positive Genetic
TRP3 YKL211C Indole-3-glycerol-phosphate synthase genetic 2 1 2 Negative Genetic, Negative Genetic
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 2 1 2 Negative Genetic, Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 2 1 2 Negative Genetic, Negative Genetic
SKG1 YKR100C Transmembrane protein with a role in cell wall polymer composition genetic 2 1 2 Positive Genetic, Positive Genetic
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 2 1 2 Negative Genetic, Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 2 1 2 Negative Genetic, Negative Genetic
UGA2 YBR006W Succinate semialdehyde dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
TWF1 YGR080W Twinfilin genetic 2 1 2 Negative Genetic, Negative Genetic
SHR5 YOL110W Palmitoyltransferase subunit genetic 2 1 2 Negative Genetic, Negative Genetic
MTC2 YKL098W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
ATO2 YNR002C Putative transmembrane protein involved in export of ammonia genetic 2 1 2 Negative Genetic, Negative Genetic
GRE2 YOL151W 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase genetic 2 1 2 Negative Genetic, Negative Genetic
MYG1 YER156C Protein involved in mitochondrial function genetic 2 1 2 Negative Genetic, Negative Genetic
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
MCH4 YOL119C Protein with similarity to mammalian monocarboxylate permeases genetic 2 1 2 Negative Genetic, Negative Genetic
DLT1 YMR126C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p genetic 2 1 2 Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 2 1 2 Negative Genetic, Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 2 1 2 Negative Genetic, Negative Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 2 1 2 Negative Genetic, Negative Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 2 1 2 Positive Genetic, Positive Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
BNA4 YBL098W Kynurenine 3-monooxygenase genetic 2 1 2 Negative Genetic, Negative Genetic
PAN6 YIL145C Pantothenate synthase genetic 2 1 2 Negative Genetic, Negative Genetic
AIF1 YNR074C Mitochondrial cell death effector genetic 2 1 2 Negative Genetic, Negative Genetic
PHO3 YBR092C Constitutively expressed acid phosphatase similar to Pho5p genetic 2 1 2 Positive Genetic, Positive Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 2 1 2 Negative Genetic, Negative Genetic
MME1 YMR166C Transporter of the mitochondrial inner membrane that exports magnesium genetic 2 1 2 Positive Genetic, Positive Genetic
HPM1 YIL110W AdoMet-dependent methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 2 1 2 Negative Genetic, Negative Genetic
MAY24 YPR153W Peripheral ER membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
MTC6 YHR151C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RNP1 YLL046C Ribonucleoprotein that contains two RNA recognition motifs (RRM) genetic 2 1 2 Negative Genetic, Negative Genetic
TMN3 YER113C Protein with a role in cellular adhesion and filamentous growth genetic 2 1 2 Negative Genetic, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
ADH1 YOL086C Alcohol dehydrogenase genetic 1 1 1 Phenotypic Enhancement
EMW1 YNL313C Essential conserved protein with a role in cell wall integrity physical 1 1 1 Affinity Capture-MS
UTP13 YLR222C Nucleolar protein physical 1 1 1 Affinity Capture-MS
UTP18 YJL069C Small-subunit processome protein involved in pre-18S rRNA maturation physical 1 1 1 Affinity Capture-MS
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase physical 1 1 1 Affinity Capture-RNA
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 1 1 1 Affinity Capture-MS
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Lethality
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
AIM21 YIR003W Subunit of a complex that associates with actin filaments genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
SDA1 YGR245C Protein required for actin organization and passage through Start genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication physical 1 1 1 Affinity Capture-MS
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
KCC4 YCL024W Protein kinase of the bud neck involved in the septin checkpoint genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Positive Genetic
SWH1 YAR042W Protein similar to mammalian oxysterol-binding protein genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex physical 1 1 1 Affinity Capture-MS
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation physical 1 1 1 Affinity Capture-MS
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Growth Defect
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery physical 1 1 1 Affinity Capture-MS
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex physical 1 1 1 Affinity Capture-MS
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase physical 1 1 1 Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Synthetic Growth Defect
PRP11 YDL043C Subunit of the SF3a splicing factor complex physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Positive Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Positive Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein physical 1 1 1 Affinity Capture-MS
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Synthetic Lethality
YPK2 YMR104C AGC-type S/T protein kinase physical 1 1 1 Affinity Capture-MS
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Rescue
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase physical 1 1 1 Affinity Capture-Western
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Phenotypic Suppression
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
YEL023C YEL023C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
XDJ1 YLR090W Chaperone with a role in facilitating mitochondrial protein import physical 1 1 1 Affinity Capture-MS
YIG1 YPL201C Protein that interacts with glycerol 3-phosphatase physical 1 1 1 Affinity Capture-MS
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis physical 1 1 1 Affinity Capture-MS
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
VMA16 YHR026W Subunit c'' of the vacuolar ATPase physical 1 1 1 Co-purification
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex physical 1 1 1 Co-purification
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Dosage Lethality
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Synthetic Lethality
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Lethality
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Lethality
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Lethality
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Synthetic Growth Defect
YPT7 YML001W Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes genetic 1 1 1 Synthetic Growth Defect
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
YGL081W YGL081W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
YNL095C YNL095C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
YKL091C YKL091C Putative phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Positive Genetic
YPQ1 YOL092W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Positive Genetic
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
YKL063C YKL063C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLR053C YLR053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Negative Genetic
YOR238W YOR238W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Phenotypic Suppression
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Synthetic Growth Defect
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) physical 1 1 1 Affinity Capture-MS
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Negative Genetic
BNA3 YJL060W Kynurenine aminotransferase genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface genetic 1 1 1 Negative Genetic
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 1 1 1 Positive Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 1 1 1 Positive Genetic
IRA2 YOL081W GTPase-activating protein physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Negative Genetic
ATG29 YPL166W Autophagy-specific protein genetic 1 1 1 Negative Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Synthetic Growth Defect
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Synthetic Lethality
CNB1 YKL190W Calcineurin B genetic 1 1 1 Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Positive Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p physical 1 1 1 Affinity Capture-MS
PTC5 YOR090C Mitochondrial type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Synthetic Lethality
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Lethality
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Positive Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription physical 1 1 1 Affinity Capture-MS
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Negative Genetic
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 1 1 1 Affinity Capture-Western
ELM1 YKL048C Serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-MS
DOG1 YHR044C 2-deoxyglucose-6-phosphate phosphatase genetic 1 1 1 Positive Genetic
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex physical 1 1 1 Affinity Capture-MS
HMG2 YLR450W HMG-CoA reductase genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 1 1 1 Affinity Capture-MS
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
MIC19 YFR011C Component of the MICOS complex genetic 1 1 1 Negative Genetic
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 1 1 1 Negative Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair physical 1 1 1 Affinity Capture-MS
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Negative Genetic
APE2 YKL157W Aminopeptidase yscII genetic 1 1 1 Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
NTA1 YJR062C Amidase physical 1 1 1 Affinity Capture-MS
SIR3 YLR442C Silencing protein physical 1 1 1 Affinity Capture-MS
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Positive Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Growth Defect
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 1 1 1 Synthetic Rescue
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
NIF3 YGL221C Protein of unknown function genetic 1 1 1 Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Affinity Capture-MS
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Synthetic Growth Defect
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Synthetic Growth Defect
SNA3 YJL151C Protein involved in efficient MVB sorting of proteins to the vacuole genetic 1 1 1 Negative Genetic
PRM9 YAR031W Pheromone-regulated protein genetic 1 1 1 Negative Genetic
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance physical 1 1 1 Affinity Capture-MS
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 1 1 1 Synthetic Growth Defect
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Positive Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 1 1 1 Negative Genetic
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Synthetic Growth Defect
ELO3 YLR372W Elongase genetic 1 1 1 Synthetic Growth Defect
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
MYO3 YKL129C One of two type I myosins genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion genetic 1 1 1 Synthetic Rescue
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Lethality
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Growth Defect
EMP46 YLR080W Integral membrane component of ER-derived COPII-coated vesicles genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
PDR17 YNL264C Phosphatidylinositol transfer protein (PITP) physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
DAL80 YKR034W Negative regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Synthetic Growth Defect
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Growth Defect
OSH3 YHR073W Member of an oxysterol-binding protein family genetic 1 1 1 Positive Genetic
SRO77 YBL106C Protein with roles in exocytosis and cation homeostasis genetic 1 1 1 Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MNT4 YNR059W Putative alpha-1,3-mannosyltransferase genetic 1 1 1 Negative Genetic
ENT5 YDR153C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
ATG10 YLL042C Conserved E2-like conjugating enzyme genetic 1 1 1 Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane physical 1 1 1 Co-fractionation
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Phenotypic Suppression
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Synthetic Growth Defect
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Affinity Capture-MS
NDJ1 YOL104C Protein that regulates meiotic SPB cohesion and telomere clustering genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
MIG2 YGL209W Zinc finger transcriptional repressor genetic 1 1 1 Negative Genetic
CPR5 YDR304C Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER physical 1 1 1 Affinity Capture-MS
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
RAD34 YDR314C Protein involved in nucleotide excision repair (NER) genetic 1 1 1 Negative Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
UBP2 YOR124C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Growth Defect
VID24 YBR105C GID Complex regulatory subunit physical 1 1 1 Affinity Capture-MS
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell genetic 1 1 1 Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Positive Genetic
SSE2 YBR169C Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family genetic 1 1 1 Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Positive Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Synthetic Growth Defect
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
KRE28 YDR532C Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TUB3 YML124C Alpha-tubulin physical 1 1 1 Affinity Capture-MS
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Positive Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Negative Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SCH9 YHR205W AGC family protein kinase physical 1 1 1 Affinity Capture-Western
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Synthetic Growth Defect
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 1 1 1 Negative Genetic
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Synthetic Growth Defect
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Synthetic Lethality
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Lethality
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Negative Genetic
PIS1 YPR113W Phosphatidylinositol synthase physical 1 1 1 Affinity Capture-MS
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
HNT2 YDR305C Dinucleoside triphosphate hydrolase genetic 1 1 1 Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 1 1 1 Negative Genetic
MSP1 YGR028W Highly-conserved N-terminally anchored AAA-ATPase genetic 1 1 1 Negative Genetic
TAE1 YBR261C AdoMet-dependent proline methyltransferase genetic 1 1 1 Negative Genetic
SRY1 YKL218C 3-hydroxyaspartate dehydratase genetic 1 1 1 Positive Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Positive Genetic
COS10 YNR075W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
CCW14 YLR390W-A Covalently linked cell wall glycoprotein genetic 1 1 1 Negative Genetic
FSF1 YOR271C Putative protein genetic 1 1 1 Negative Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
APT2 YDR441C Potential adenine phosphoribosyltransferase genetic 1 1 1 Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
IRC20 YLR247C E3 ubiquitin ligase and putative helicase genetic 1 1 1 Negative Genetic
DSD1 YGL196W D-serine dehydratase (aka D-serine ammonia-lyase) genetic 1 1 1 Negative Genetic
ALE1 YOR175C Broad-specificity lysophospholipid acyltransferase genetic 1 1 1 Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
GAS2 YLR343W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 1 1 1 Negative Genetic
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Negative Genetic
MRX11 YPL041C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
FRE7 YOL152W Putative ferric reductase with similarity to Fre2p genetic 1 1 1 Negative Genetic
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Negative Genetic
SPO22 YIL073C Meiosis-specific protein essential for chromosome synapsis genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
RKM3 YBR030W Ribosomal lysine methyltransferase genetic 1 1 1 Negative Genetic
SRL4 YPL033C Protein of unknown function genetic 1 1 1 Negative Genetic
SOA1 YIL166C Sulfonate and inorganic sulfur transporter genetic 1 1 1 Negative Genetic
PAU5 YFL020C Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic