Standard name Systematic name Name description Description
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR
Visualize the interactome of YCF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nuc Periphery 0.067 0.066 0.297
Nucleus 0.058 0.094 NaN
Vac/Vac Memb 0.893 0.858 0.798
Mito NaN NaN 0.052
Nucleolus NaN NaN 0.057

GFP localization & abundance

GFP localization GFP abundance
vacuolar membrane 396

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YCF1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1168 (glutathione transport), r_0964 (reduced glutathione via ABC system)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 7 3 6 Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect
BPT1 YLL015W ABC type transmembrane transporter of MRP/CFTR family genetic 3 1 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase genetic 3 3 2 Phenotypic Enhancement, Phenotypic Suppression, Dosage Rescue
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 2 2 2 PCA, Affinity Capture-Western
ADH1 YOL086C Alcohol dehydrogenase physical 2 2 1 Affinity Capture-Western, PCA
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization physical 2 2 1 Affinity Capture-Western, PCA
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 2 2 1 PCA, FRET
RAS2 YNL098C GTP-binding protein physical 2 2 1 Affinity Capture-Western, PCA
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity physical 2 2 1 PCA, Affinity Capture-Western
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
BMH1 YER177W 14-3-3 protein, major isoform physical 2 1 1 PCA, PCA
GTS1 YGL181W Protein involved in Arf3p regulation and in transcription regulation physical 2 1 1 Two-hybrid, Two-hybrid
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform physical 2 1 1 PCA, PCA
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-Western
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-Western
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-Western
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 PCA
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 PCA
PAB1 YER165W Poly(A) binding protein physical 1 1 1 PCA
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 PCA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase physical 1 1 1 PCA
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Dosage Rescue
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase physical 1 1 1 PCA
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
FAS2 YPL231W Alpha subunit of fatty acid synthetase physical 1 1 1 PCA
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
PGK1 YCR012W 3-phosphoglycerate kinase physical 1 1 1 PCA
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 PCA
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
GPM1 YKL152C Tetrameric phosphoglycerate mutase physical 1 1 1 PCA
NUM1 YDR150W Protein required for nuclear migration physical 1 1 1 PCA
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Dosage Rescue
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
EFB1 YAL003W Translation elongation factor 1 beta physical 1 1 1 PCA
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 PCA
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel genetic 1 1 1 Dosage Rescue
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
VMA10 YHR039C-A Subunit G of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes physical 1 1 1 Affinity Capture-Western
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) physical 1 1 1 PCA
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Dosage Rescue
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
AHP1 YLR109W Thiol-specific peroxiredoxin genetic 1 1 1 Dosage Rescue
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase physical 1 1 1 PCA
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Rescue
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) physical 1 1 1 PCA
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor physical 1 1 1 PCA
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase physical 1 1 1 PCA
LSM8 YJR022W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p physical 1 1 1 PCA
YBT1 YLL048C Transporter of the ATP-binding cassette (ABC) family genetic 1 1 1 Phenotypic Enhancement
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE physical 1 1 1 Affinity Capture-Western
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex physical 1 1 1 Reconstituted Complex
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Positive Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
CDC19 YAL038W Pyruvate kinase physical 1 1 1 PCA
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 PCA
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
TIF3 YPR163C Translation initiation factor eIF-4B physical 1 1 1 PCA
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 PCA
SNU13 YEL026W RNA binding protein physical 1 1 1 PCA
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Dosage Rescue
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Rescue
HOB2 YPR117W Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
KIN4 YOR233W Serine/threonine protein kinase physical 1 1 1 PCA
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 1 1 1 PCA
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Dosage Rescue
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Dosage Rescue
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Synthetic Rescue
ARR1 YPR199C Transcriptional activator of the basic leucine zipper (bZIP) family genetic 1 1 1 Synthetic Growth Defect
FRE4 YNR060W Ferric reductase genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Dosage Rescue
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-Western
YNL208W YNL208W Protein of unknown function physical 1 1 1 PCA
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter physical 1 1 1 Affinity Capture-Western
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 1 1 1 Dosage Rescue
TMA7 YLR262C-A Protein of unknown function that associates with ribosomes physical 1 1 1 PCA
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic