Standard name Systematic name Name description Description
KIN4 YOR233W Serine/threonine protein kinase Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
Visualize the interactome of KIN4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 2

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.093 0.123 NaN
Cell Periphery 0.420 0.153 0.400
Cort. Patches 0.187 0.054 0.107
Cytoplasm 0.513 0.766 0.693
Mito NaN 0.054 NaN
SpindlePole NaN NaN 0.057

GFP localization & abundance

GFP localization GFP abundance
cell periphery 143

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
KIN4 0 0 0 2 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 12 7 8 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Dosage Rescue, Dosage Lethality, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
BUB2 YMR055C Mitotic exit network regulator genetic 7 2 7 Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
LTE1 YAL024C Protein similar to GDP/GTP exchange factors physical 7 4 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Co-localization
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 6 1 6 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p physical 6 3 5 Biochemical Activity, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
FRK1 YPL141C Protein kinase of unknown cellular role genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KAR9 YPL269W Spindle positioning factor genetic 5 3 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 4 2 3 Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SBE22 YHR103W Protein involved in bud growth genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 2 3 Positive Genetic, Positive Genetic, Synthetic Rescue
SPO12 YHR152W Nucleolar protein of unknown function genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
CMD1 YBR109C Calmodulin genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
OYE2 YHR179W Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YPT7 YML001W Rab family GTPase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DIA1 YMR316W Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CRS5 YOR031W Copper-binding metallothionein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
COA6 YMR244C-A Protein involved in cytochrome c oxidase (Complex IV) assembly genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ERJ5 YFR041C Type I membrane protein with a J domain genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 3 2 2 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
SUL1 YBR294W High affinity sulfate permease of the SulP anion transporter family genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 2 2 2 Synthetic Rescue, Dosage Growth Defect
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 2 2 2 Phenotypic Enhancement, Dosage Growth Defect
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 2 2 2 Synthetic Rescue, Synthetic Lethality
SLK19 YOR195W Kinetochore-associated protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
HEM25 YDL119C Mitochondrial glycine transporter genetic 2 2 2 Dosage Growth Defect, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 1 2 Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 2 Negative Genetic, Negative Genetic
AIM18 YHR198C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CLC1 YGR167W Clathrin light chain genetic 2 1 2 Negative Genetic, Negative Genetic
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 2 1 2 Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 2 1 2 Positive Genetic, Positive Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 2 1 2 Negative Genetic, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
YCR102C YCR102C Putative quinone oxidoreductase genetic 2 1 2 Negative Genetic, Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 2 1 2 Negative Genetic, Negative Genetic
MGA1 YGR249W Protein similar to heat shock transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 2 1 2 Negative Genetic, Negative Genetic
YJR096W YJR096W Xylose and arabinose reductase genetic 2 1 2 Negative Genetic, Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 1 Negative Genetic, Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ELM1 YKL048C Serine/threonine protein kinase regulation 1 1 1 protein kinase assay evidence
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing genetic 1 1 1 Negative Genetic
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function physical 1 1 1 Affinity Capture-MS
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Synthetic Rescue
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Dosage Growth Defect
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Dosage Growth Defect
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
GCN2 YDR283C Protein kinase genetic 1 1 1 Positive Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin physical 1 1 1 Biochemical Activity
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Dosage Growth Defect
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Positive Genetic
CSN9 YDR179C Subunit of the Cop9 signalosome physical 1 1 1 Biochemical Activity
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering physical 1 1 1 Biochemical Activity
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Positive Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Negative Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Phenotypic Suppression
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
ENV7 YPL236C Vacuolar membrane protein kinase genetic 1 1 1 Negative Genetic
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Phenotypic Suppression
ELM1 YKL048C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
GRX1 YCL035C Glutathione-dependent disulfide oxidoreductase genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Biochemical Activity
ARE1 YCR048W Acyl-CoA:sterol acyltransferase genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Negative Genetic
DLS1 YJL065C Subunit of ISW2/yCHRAC chromatin accessibility complex genetic 1 1 1 Negative Genetic
AVO2 YMR068W Component of a complex containing the Tor2p kinase and other proteins physical 1 1 1 Biochemical Activity
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Positive Genetic
GRC3 YLL035W Polynucleotide kinase present on rDNA genetic 1 1 1 Positive Genetic
BMT5 YIL096C Methyltransferase required for m3U2634 methylation of the 25S rRNA genetic 1 1 1 Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Dosage Growth Defect
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
CNM67 YNL225C Component of the spindle pole body outer plaque physical 1 1 1 Affinity Capture-MS
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 1 1 1 Synthetic Rescue
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation physical 1 1 1 Biochemical Activity
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
GDA1 YEL042W Guanosine diphosphatase located in the Golgi genetic 1 1 1 Negative Genetic
EXP1 YDL121C A cargo receptor protein for Pma1p genetic 1 1 1 Negative Genetic
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Positive Genetic
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 Affinity Capture-MS
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Negative Genetic
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
HOB2 YPR117W Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
UFD4 YKL010C Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-MS
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 1 1 1 Biochemical Activity
TOS1 YBR162C Covalently-bound cell wall protein of unknown function physical 1 1 1 Biochemical Activity
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase physical 1 1 1 Biochemical Activity
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Biochemical Activity
YRB1 YDR002W Ran GTPase binding protein physical 1 1 1 Biochemical Activity
YML096W YML096W Putative protein with similarity to asparagine synthetases physical 1 1 1 Biochemical Activity
SAS10 YDL153C Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Biochemical Activity
RNH70 YGR276C 3'-5' exoribonuclease physical 1 1 1 Biochemical Activity
SES1 YDR023W Cytosolic seryl-tRNA synthetase physical 1 1 1 Biochemical Activity
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase physical 1 1 1 Biochemical Activity
YML037C YML037C Putative protein of unknown function physical 1 1 1 Biochemical Activity
YML037C YML037C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YML083C YML083C Protein of unknown function physical 1 1 1 Biochemical Activity
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter physical 1 1 1 PCA
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter genetic 1 1 1 Dosage Rescue
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Affinity Capture-Western
LGE1 YPL055C Protein involved in histone H2B ubiquitination physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Affinity Capture-MS
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase physical 1 1 1 Reconstituted Complex
NBP1 YLR457C Spindle pole body (SPB) component physical 1 1 1 Affinity Capture-MS
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Affinity Capture-MS
SPC42 YKL042W Central plaque component of spindle pole body (SPB) physical 1 1 1 Affinity Capture-MS
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein physical 1 1 1 Affinity Capture-MS
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication physical 1 1 1 Affinity Capture-MS
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) physical 1 1 1 Two-hybrid
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Positive Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Growth Defect
YOR268C YOR268C Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
MEF1 YLR069C Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Dosage Growth Defect
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor genetic 1 1 1 Dosage Growth Defect
YDL129W YDL129W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Dosage Growth Defect
YDL186W YDL186W Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Dosage Growth Defect
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Dosage Growth Defect
SPS22 YCL048W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YPR172W YPR172W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
TFB3 YDR460W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Dosage Growth Defect
YHL009W-B YHL009W-B Retrotransposon TYA Gag and TYB Pol genes genetic 1 1 1 Dosage Growth Defect
PFK26 YIL107C 6-phosphofructo-2-kinase genetic 1 1 1 Dosage Growth Defect
YPR1 YDR368W NADPH-dependent aldo-keto reductase genetic 1 1 1 Dosage Growth Defect
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Dosage Growth Defect
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Growth Defect
SPS4 YOR313C Protein whose expression is induced during sporulation genetic 1 1 1 Dosage Growth Defect
RPL12A YEL054C Ribosomal 60S subunit protein L12A genetic 1 1 1 Dosage Growth Defect
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Dosage Growth Defect
MLC1 YGL106W Essential light chain for Myo1p genetic 1 1 1 Dosage Growth Defect
YGR027W-B YGR027W-B Retrotransposon TYA Gag and TYB Pol genes genetic 1 1 1 Dosage Growth Defect
SMN1 YHR202W Putative AMP hydrolase genetic 1 1 1 Dosage Growth Defect
NRT1 YOR071C High-affinity nicotinamide riboside transporter genetic 1 1 1 Dosage Growth Defect
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Dosage Growth Defect
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Dosage Growth Defect
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 1 1 1 Positive Genetic
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex genetic 1 1 1 Positive Genetic
YHR112C YHR112C Protein of unknown function genetic 1 1 1 Positive Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Positive Genetic
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
TCB2 YNL087W ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
SYT1 YPR095C Guanine nucleotide exchange factor (GEF) for Arf proteins genetic 1 1 1 Positive Genetic
TEF1 YPR080W Translational elongation factor EF-1 alpha genetic 1 1 1 Positive Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
UTP7 YER082C Nucleolar protein genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
MRX18 YBR056W Putative glycoside hydrolase of the mitochondrial intermembrane space genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RKM2 YDR198C Ribosomal protein lysine methyltransferase genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YEA4 YEL004W Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter genetic 1 1 1 Negative Genetic
OSW7 YFR039C Protein involved in outer spore wall assembly genetic 1 1 1 Negative Genetic
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
SPO22 YIL073C Meiosis-specific protein essential for chromosome synapsis genetic 1 1 1 Negative Genetic
MRS1 YIR021W Splicing protein genetic 1 1 1 Negative Genetic
YPS6 YIR039C Putative GPI-anchored aspartic protease genetic 1 1 1 Negative Genetic
PET191 YJR034W Protein required for assembly of cytochrome c oxidase genetic 1 1 1 Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
SKG1 YKR100C Transmembrane protein with a role in cell wall polymer composition genetic 1 1 1 Negative Genetic
MNL2 YLR057W Putative mannosidase involved in ER-associated protein degradation genetic 1 1 1 Negative Genetic
TRM12 YML005W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
UFO1 YML088W F-box receptor protein genetic 1 1 1 Negative Genetic
MDM1 YML104C PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs genetic 1 1 1 Negative Genetic
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
YBR225W YBR225W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
PET122 YER153C Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Negative Genetic
PEX31 YGR004W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 1 1 1 Negative Genetic
UBC12 YLR306W Enzyme that mediates the conjugation of Rub1p genetic 1 1 1 Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Phenotypic Suppression
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Phenotypic Suppression
NET1 YJL076W Core subunit of the RENT complex genetic 1 1 1 Phenotypic Suppression
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
ANY1 YMR010W Protein involved in phospholipid flippase function physical 1 1 1 Affinity Capture-MS
ISM1 YPL040C Mitochondrial isoleucyl-tRNA synthetase genetic 1 1 1 Dosage Growth Defect
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Negative Genetic
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Positive Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
GUT2 YIL155C Mitochondrial glycerol-3-phosphate dehydrogenase genetic 1 1 1 Negative Genetic
HVG1 YER039C Protein of unknown function genetic 1 1 1 Negative Genetic
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
DSE2 YHR143W Daughter cell-specific secreted protein with similarity to glucanases genetic 1 1 1 Negative Genetic
AGA2 YGL032C Adhesion subunit of a-agglutinin of a-cells genetic 1 1 1 Negative Genetic
FCY22 YER060W-A Putative purine-cytosine permease genetic 1 1 1 Dosage Growth Defect
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs genetic 1 1 1 Dosage Growth Defect
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
AFG1 YEL052W Protein that may act as a chaperone for cytochrome c oxidase subunits genetic 1 1 1 Negative Genetic
COS5 YJR161C Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
HMX1 YLR205C ER localized heme oxygenase genetic 1 1 1 Negative Genetic
ATG22 YCL038C Vacuolar integral membrane protein required for efflux of amino acids genetic 1 1 1 Negative Genetic
GAS2 YLR343W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
ALK2 YBL009W Atypical protein kinase physical 1 1 1 Affinity Capture-MS
FSH2 YMR222C Putative serine hydrolase that localizes to the cytoplasm genetic 1 1 1 Negative Genetic
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic