Standard name Systematic name Name description Description
HEM25 YDL119C Mitochondrial glycine transporter Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
Visualize the interactome of HEM25
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.067 0.188 0.076
Mito 0.917 0.716 0.880
Vac/Vac Memb 0.100 0.135 NaN
ER NaN 0.057 NaN
Bud NaN NaN 0.067

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HEM25 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator genetic 4 4 2 Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Rescue, Positive Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 2 2 2 Dosage Growth Defect, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 2 1 2 Negative Genetic, Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 2 1 2 Negative Genetic, Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 2 1 2 Negative Genetic, Negative Genetic
MCX1 YBR227C Non-proteolytic ATPase of the AAA family genetic 2 1 2 Negative Genetic, Negative Genetic
SLX1 YBR228W Endonuclease involved in DNA recombination and repair genetic 2 1 2 Negative Genetic, Negative Genetic
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 2 1 2 Negative Genetic, Negative Genetic
HPT1 YDR399W Dimeric hypoxanthine-guanine phosphoribosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
IZH1 YDR492W Membrane protein involved in zinc ion homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 2 1 2 Negative Genetic, Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 2 1 2 Negative Genetic, Negative Genetic
YJL068C YJL068C Esterase that can function as an S-formylglutathione hydrolase genetic 2 1 2 Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 2 1 2 Negative Genetic, Negative Genetic
PTK1 YKL198C Putative serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 2 1 2 Negative Genetic, Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SFC1 YJR095W Mitochondrial succinate-fumarate transporter genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Negative Genetic
GLY1 YEL046C Threonine aldolase genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
ACH1 YBL015W Protein with CoA transferase activity genetic 1 1 1 Negative Genetic
GYP6 YJL044C GTPase-activating protein (GAP) for yeast Rab family member Ypt6p genetic 1 1 1 Negative Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
FUM1 YPL262W Fumarase genetic 1 1 1 Positive Genetic
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Positive Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
FUS2 YMR232W Cell fusion regulator genetic 1 1 1 Negative Genetic
CAT8 YMR280C Zinc cluster transcriptional activator genetic 1 1 1 Negative Genetic
HCH1 YNL281W Heat shock protein regulator genetic 1 1 1 Negative Genetic
BUD17 YNR027W Putative pyridoxal kinase genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Positive Genetic
AIM23 YJL131C Mitochondrial translation initiation factor 3 (IF3, mIF3) genetic 1 1 1 Negative Genetic
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Negative Genetic
CYC1 YJR048W Cytochrome c, isoform 1 genetic 1 1 1 Negative Genetic
EEB1 YPL095C Acyl-coenzymeA:ethanol O-acyltransferase genetic 1 1 1 Negative Genetic
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
GRX7 YBR014C Cis-golgi localized monothiol glutaredoxin genetic 1 1 1 Negative Genetic
ERG12 YMR208W Mevalonate kinase genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Positive Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Positive Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Positive Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Positive Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Synthetic Growth Defect
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Positive Genetic
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 1 1 1 Positive Genetic
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Positive Genetic
PAI3 YMR174C Cytoplasmic proteinase A (Pep4p) inhibitor genetic 1 1 1 Positive Genetic
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
PHO91 YNR013C Low-affinity vacuolar phosphate transporter genetic 1 1 1 Positive Genetic
TOM6 YOR045W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Positive Genetic
PRP45 YAL032C Protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
OLE1 YGL055W Delta(9) fatty acid desaturase genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RRP12 YPL012W Protein required for export of the ribosomal subunits genetic 1 1 1 Negative Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Negative Genetic
YBR200W-A YBR200W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 1 1 1 Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
PHO92 YDR374C Posttranscriptional regulator of phosphate and glucose metabolism genetic 1 1 1 Negative Genetic
PAD1 YDR538W Phenylacrylic acid decarboxylase genetic 1 1 1 Negative Genetic
TCA17 YEL048C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Negative Genetic
SWP82 YFL049W Member of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
TPN1 YGL186C Plasma membrane pyridoxine (vitamin B6) transporter genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHL012W YHL012W Putative UTP glucose-1-phosphate uridylyltransferase genetic 1 1 1 Negative Genetic
LEU5 YHR002W Mitochondrial carrier protein genetic 1 1 1 Negative Genetic
YHR022C-A YHR022C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR045W YHR045W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHK8 YHR048W Presumed antiporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
YJL193W YJL193W Putative protein of unknown function genetic 1 1 1 Negative Genetic
UTR1 YJR049C ATP-NADH kinase genetic 1 1 1 Negative Genetic
HOT13 YKL084W Zinc-binding mitochondrial intermembrane space (IMS) protein genetic 1 1 1 Negative Genetic
VBA5 YKR105C Plasma membrane protein of the Major Facilitator Superfamily (MFS) genetic 1 1 1 Negative Genetic
YLL066W-B YLL066W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
YLR419W YLR419W Putative helicase with limited sequence similarity to human Rb protein genetic 1 1 1 Negative Genetic
URA4 YLR420W Dihydroorotase genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
YML053C YML053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Negative Genetic
NGL2 YMR285C Protein involved in 5.8S rRNA processing genetic 1 1 1 Negative Genetic
YMR321C YMR321C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
MIC27 YNL100W Component of the MICOS complex genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
NGL1 YOL042W Putative endonuclease genetic 1 1 1 Negative Genetic
MCH4 YOL119C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
RDR1 YOR380W Transcriptional repressor involved in regulating multidrug resistance genetic 1 1 1 Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Positive Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family genetic 1 1 1 Phenotypic Enhancement
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Phenotypic Enhancement
ORT1 YOR130C Ornithine transporter of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
ERG8 YMR220W Phosphomevalonate kinase genetic 1 1 1 Negative Genetic
ADY2 YCR010C Acetate transporter required for normal sporulation genetic 1 1 1 Negative Genetic