Standard name Systematic name Name description Description
URA4 YLR420W Dihydroorotase Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
Visualize the interactome of URA4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.986 0.98 0.97

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 12700

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
URA4 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0349 (dihydroorotase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 2 1 2 Negative Genetic, Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 2 1 2 Negative Genetic, Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 2 1 2 Negative Genetic, Negative Genetic
PHO13 YDL236W Conserved phosphatase acting as a metabolite repair enzyme physical 2 1 2 PCA, PCA
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 2 1 2 Negative Genetic, Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 2 1 1 Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 2 1 1 Negative Genetic, Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 2 1 1 Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 DNA to cDNA expression microarray evidence
BAS1 YKR099W Myb-related transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
PPR1 YLR014C Zinc finger transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways regulation 1 1 1 DNA to cDNA expression microarray evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Negative Genetic
APL1 YJR005W Beta-adaptin genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Positive Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
TFA1 YKL028W TFIIE large subunit genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
FDH1 YOR388C NAD(+)-dependent formate dehydrogenase genetic 1 1 1 Negative Genetic
ATP4 YPL078C Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Positive Genetic
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Positive Genetic
TOP2 YNL088W Topoisomerase II physical 1 1 1 PCA
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
MCX1 YBR227C Non-proteolytic ATPase of the AAA family genetic 1 1 1 Negative Genetic
EMI2 YDR516C Hexokinase expressed during growth with low glucose levels genetic 1 1 1 Negative Genetic
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Growth Defect
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Two-hybrid
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
QCR7 YDR529C Subunit 7 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Positive Genetic
GRX5 YPL059W Glutathione-dependent oxidoreductase genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
JSN1 YJR091C Member of the Puf family of RNA-binding proteins physical 1 1 1 Two-hybrid
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Positive Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RAX1 YOR301W Protein involved in establishing bud site selection genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
FUR1 YHR128W Uracil phosphoribosyltransferase genetic 1 1 1 Negative Genetic
PDR11 YIL013C ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
GAS5 YOL030W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Positive Genetic
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
COX7 YMR256C Subunit VII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Positive Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
MPH3 YJR160C Alpha-glucoside permease genetic 1 1 1 Positive Genetic
HEM25 YDL119C Mitochondrial glycine transporter genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
NIT2 YJL126W Nit protein genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Positive Genetic
LEU5 YHR002W Mitochondrial carrier protein genetic 1 1 1 Negative Genetic
ECM23 YPL021W Non-essential protein of unconfirmed function genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Positive Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Negative Genetic