AHA1 |
YDR214W |
Co-chaperone that binds Hsp82p and activates its ATPase activity |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
SBA1 |
YKL117W |
Co-chaperone that binds and regulates Hsp90 family chaperones |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
BNI1 |
YNL271C |
Formin |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
SHE1 |
YBL031W |
Mitotic spindle protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SPO71 |
YDR104C |
Meiosis-specific protein required for prospore membrane morphogenesis |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPS30B |
YOR182C |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
APC9 |
YLR102C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
STP1 |
YDR463W |
Transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
CYC8 |
YBR112C |
General transcriptional co-repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATG3 |
YNR007C |
E2-like enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
BGL2 |
YGR282C |
Endo-beta-1,3-glucanase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VPH1 |
YOR270C |
Subunit a of the vacuolar-ATPase V0 domain |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
NAS6 |
YGR232W |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SIP1 |
YDR422C |
One of three alternate beta-subunits of the Snf1p kinase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SKS1 |
YPL026C |
Putative serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
YCK3 |
YER123W |
Palmitoylated vacuolar membrane-localized casein kinase I isoform |
physical |
1 |
1 |
1 |
Reconstituted Complex |
YPL150W |
YPL150W |
Protein kinase of unknown cellular role |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ENT3 |
YJR125C |
Protein containing an N-terminal epsin-like domain |
physical |
1 |
1 |
1 |
Reconstituted Complex |
TIF4631 |
YGR162W |
Translation initiation factor eIF4G and scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MSB2 |
YGR014W |
Mucin family member involved in various signaling pathways |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GLK1 |
YCL040W |
Glucokinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YDL199C |
YDL199C |
Putative transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
PMT5 |
YDL093W |
Protein O-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
THI3 |
YDL080C |
Regulatory protein that binds Pdc2p and Thi2p transcription factors |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
HIM1 |
YDR317W |
Protein of unknown function involved in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
YFT2 |
YDR319C |
Protein needed for ER membrane biosynthesis in response to ER stress |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS74 |
YDR372C |
Golgi PI4K effector, PtdIns4P sensor, and retention receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ROG3 |
YFR022W |
Alpha-arrestin involved in ubiquitin-dependent endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCY1 |
YGL083W |
Putative kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPC1 |
YGL080W |
Highly conserved subunit of mitochondrial pyruvate carrier (MPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR122W |
YGR122W |
Protein that may be involved in pH regulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR283C |
YGR283C |
Putative methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIL024C |
YIL024C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS21B |
YJL136C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA2 |
YJL130C |
Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTK2 |
YJR059W |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA1 |
YKL216W |
Dihydroorotate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA4 |
YLR420W |
Dihydroorotase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PML39 |
YML107C |
Protein required for nuclear retention of unspliced pre-mRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA5 |
YML106W |
Major orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAT2 |
YMR136W |
Protein containing GATA family zinc finger motifs |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HRB1 |
YNL004W |
Poly(A+) RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO12 |
YHR152W |
Nucleolar protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MOB1 |
YIL106W |
Component of the mitotic exit network |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
IZH2 |
YOL002C |
Plasma membrane receptor for plant antifungal osmotin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
POP4 |
YBR257W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Positive Genetic |
RSM22 |
YKL155C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
GLN4 |
YOR168W |
Glutamine tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAK5 |
YBR142W |
Essential nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Negative Genetic |
MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC4 |
YLR086W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PFY1 |
YOR122C |
Profilin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA190 |
YOR341W |
RNA polymerase I largest subunit A190 |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
1 |
1 |
1 |
Positive Genetic |
APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRN1 |
YBL097W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CPS1 |
YJL172W |
Vacuolar carboxypeptidase S |
genetic |
1 |
1 |
1 |
Negative Genetic |
BNS1 |
YGR230W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CPR5 |
YDR304C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCV1 |
YFR012W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM32 |
YER176W |
DNA dependent ATPase/DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |