Standard name Systematic name Name description Description
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6
Visualize the interactome of NAS6
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.877 1.0 0.987

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 319

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
NAS6 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 14 6 11 Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Co-crystal Structure, PCA, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 12 3 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 9 4 6 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 9 3 6 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 8 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 7 4 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, Affinity Capture-Western
RPN10 YHR200W Proteasome polyubiquitin receptor physical 6 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 6 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 6 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 6 4 4 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 5 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPN2 YIL075C Subunit of the 26S proteasome physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PUF3 YLL013C Protein of the mitochondrial outer surface physical 4 1 4 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 4 3 3 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 4 3 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 3 2 Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 4 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 2 1 2 Negative Genetic, Negative Genetic
MNT2 YGL257C Mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
ECM29 YHL030W Scaffold protein genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity genetic 1 1 1 Phenotypic Suppression
SUI1 YNL244C Translation initiation factor eIF1 physical 1 1 1 Affinity Capture-MS
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Dosage Lethality
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Affinity Capture-MS
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
STE23 YLR389C Metalloprotease physical 1 1 1 Affinity Capture-MS
RPL9A YGL147C Ribosomal 60S subunit protein L9A physical 1 1 1 Affinity Capture-MS
RPL9B YNL067W Ribosomal 60S subunit protein L9B physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A physical 1 1 1 Affinity Capture-MS
RPL15B YMR121C Ribosomal 60S subunit protein L15B physical 1 1 1 Affinity Capture-MS
RRI2 YOL117W Subunit of the COP9 signalosome (CSN) complex physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RRB1 YMR131C Specific assembly chaperone for ribosomal protein Rpl3p genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SGN1 YIR001C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
YJU3 YKL094W Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters genetic 1 1 1 Negative Genetic
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
YEH2 YLR020C Steryl ester hydrolase genetic 1 1 1 Negative Genetic
YLR156C-A YLR156C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Dosage Rescue
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Positive Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Positive Genetic
EMI2 YDR516C Hexokinase expressed during growth with low glucose levels physical 1 1 1 Affinity Capture-MS
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
ECM31 YBR176W Ketopantoate hydroxymethyltransferase genetic 1 1 1 Negative Genetic
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
FMP23 YBR047W Putative protein of unknown function genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
FLO10 YKR102W Member of the FLO family of cell wall flocculation proteins genetic 1 1 1 Negative Genetic