Standard name Systematic name Name description Description
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
Visualize the interactome of HOM6
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.988 0.992 0.997

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 48900

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HOM6 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0547 (homoserine dehydrogenase (NADP)), r_0546 (homoserine dehydrogenase (NADH))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 8 3 5 Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Positive Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 7 3 6 Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Synthetic Rescue
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 5 2 4 Negative Genetic, Negative Genetic, Dosage Rescue, Negative Genetic, Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GNP1 YDR508C Broad specificity amino acid permease genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SEC13 YLR208W Structural component of 3 complexes genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ARO8 YGL202W Aromatic aminotransferase I genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GSH2 YOL049W Glutathione synthetase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TRM1 YDR120C tRNA methyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SOL4 YGR248W 6-phosphogluconolactonase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HXT4 YHR092C High-affinity glucose transporter genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEA4 YBL104C Subunit of SEACAT, a subcomplex of the SEA complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SLY41 YOR307C Protein involved in ER-to-Golgi transport genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
APL4 YPR029C Gamma-adaptin genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AFT2 YPL202C Iron-regulated transcriptional activator genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DAL1 YIR027C Allantoinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
ATP11 YNL315C Molecular chaperone genetic 2 2 2 Positive Genetic, Phenotypic Suppression
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) physical 2 2 2 Co-crystal Structure, Affinity Capture-MS
THR4 YCR053W Threonine synthase genetic 2 2 2 Synthetic Rescue, Positive Genetic
ERG8 YMR220W Phosphomevalonate kinase genetic 2 2 2 Negative Genetic, Positive Genetic
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 2 1 2 Negative Genetic, Negative Genetic
BAT1 YHR208W Mitochondrial branched-chain amino acid (BCAA) aminotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 2 1 2 Negative Genetic, Negative Genetic
ECM30 YLR436C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
HEL2 YDR266C RING finger ubiquitin ligase (E3) genetic 2 1 2 Negative Genetic, Negative Genetic
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 2 1 2 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 2 Negative Genetic, Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PXP1 YEL020C Peroxisomal matrix protein genetic 2 1 2 Negative Genetic, Negative Genetic
NUP157 YER105C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 2 1 2 Negative Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 2 Negative Genetic, Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 2 1 2 Negative Genetic, Negative Genetic
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 2 1 2 Negative Genetic, Negative Genetic
MRX19 YDL183C Protein that may form an active mitochondrial KHE system genetic 2 1 2 Negative Genetic, Negative Genetic
PAR32 YDL173W Low complexity protein genetic 2 1 2 Negative Genetic, Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 2 1 2 Negative Genetic, Negative Genetic
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p genetic 2 1 2 Negative Genetic, Negative Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 2 1 2 Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 1 2 Negative Genetic, Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 2 1 2 Negative Genetic, Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 2 1 2 Negative Genetic, Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 2 1 2 Negative Genetic, Negative Genetic
INP1 YMR204C Peripheral membrane protein of peroxisomes genetic 2 1 2 Negative Genetic, Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 2 1 2 Negative Genetic, Negative Genetic
YPL225W YPL225W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 2 1 2 Negative Genetic, Negative Genetic
TKL1 YPR074C Transketolase genetic 2 1 2 Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 2 Positive Genetic, Positive Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 1 2 Negative Genetic, Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 1 2 Negative Genetic, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 2 1 2 Negative Genetic, Negative Genetic
HTS1 YPR033C Cytoplasmic and mitochondrial histidine tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 2 1 2 Negative Genetic, Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
ART5 YGR068C Protein proposed to regulate endocytosis of plasma membrane proteins genetic 2 1 2 Negative Genetic, Negative Genetic
ATG33 YLR356W Mitochondrial mitophagy-specific protein genetic 2 1 2 Negative Genetic, Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation genetic 2 1 2 Negative Genetic, Negative Genetic
ASP1 YDR321W Cytosolic L-asparaginase, involved in asparagine catabolism genetic 2 1 2 Negative Genetic, Negative Genetic
HEM25 YDL119C Mitochondrial glycine transporter genetic 2 1 2 Negative Genetic, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
PHO85 YPL031C Cyclin-dependent kinase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 2 2 1 Positive Genetic, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 1 1 Negative Genetic, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 1 1 Positive Genetic, Positive Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Negative Genetic, Negative Genetic
VBA3 YCL069W Permease of basic amino acids in the vacuolar membrane genetic 2 1 1 Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 2 1 1 Negative Genetic, Negative Genetic
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 2 1 1 Negative Genetic, Negative Genetic
SVF1 YDR346C Protein with a potential role in cell survival pathways genetic 2 1 1 Negative Genetic, Negative Genetic
HPT1 YDR399W Dimeric hypoxanthine-guanine phosphoribosyltransferase genetic 2 1 1 Positive Genetic, Positive Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 2 1 1 Positive Genetic, Positive Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 2 1 1 Positive Genetic, Positive Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 1 Positive Genetic, Positive Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 2 1 1 Negative Genetic, Negative Genetic
RQT4 YKR023W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 2 1 1 Negative Genetic, Negative Genetic
REX2 YLR059C 3'-5' RNA exonuclease genetic 2 1 1 Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 1 Positive Genetic, Positive Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
RIT1 YMR283C Initiator methionine 2'-O-ribosyl phosphate transferase genetic 2 1 1 Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 2 1 1 Negative Genetic, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 2 1 1 Negative Genetic, Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 2 1 1 Negative Genetic, Negative Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
APS1 YLR170C Small subunit of the clathrin-associated adaptor complex AP-1 genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Positive Genetic
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
HCA4 YJL033W DEAD box RNA helicase genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
CEX1 YOR112W Component of nuclear aminoacylation-dependent tRNA export pathway genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Positive Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Positive Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
COX4 YGL187C Subunit IV of cytochrome c oxidase genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase genetic 1 1 1 Positive Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-MS
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Positive Genetic
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
FPR4 YLR449W Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Positive Genetic
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Positive Genetic
FDH1 YOR388C NAD(+)-dependent formate dehydrogenase genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Positive Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
ACH1 YBL015W Protein with CoA transferase activity genetic 1 1 1 Positive Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Positive Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 1 1 1 Negative Genetic
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Positive Genetic
ARP10 YDR106W Component of the dynactin complex genetic 1 1 1 Negative Genetic
DIP5 YPL265W Dicarboxylic amino acid permease genetic 1 1 1 Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Positive Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis genetic 1 1 1 Negative Genetic
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III genetic 1 1 1 Negative Genetic
HMF1 YER057C Member of the p14.5 protein family genetic 1 1 1 Negative Genetic
GPN3 YLR243W Putative GTPase with a role in biogenesis of RNA pol II and polIII genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
OTU1 YFL044C Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
VID24 YBR105C GID Complex regulatory subunit physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER physical 1 1 1 PCA
SKP1 YDR328C Evolutionarily conserved kinetochore protein genetic 1 1 1 Synthetic Growth Defect
PDI1 YCL043C Protein disulfide isomerase genetic 1 1 1 Synthetic Lethality
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
UTR4 YEL038W Protein with sequence similarity to acireductone synthases genetic 1 1 1 Negative Genetic
LSM4 YER112W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PTR3 YFR029W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
SAM35 YHR083W Component of the sorting and assembly machinery (SAM) complex genetic 1 1 1 Negative Genetic
UTR1 YJR049C ATP-NADH kinase genetic 1 1 1 Positive Genetic
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering genetic 1 1 1 Negative Genetic
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance genetic 1 1 1 Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
NCA3 YJL116C Protein involved in mitochondrion organization genetic 1 1 1 Positive Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
YBT1 YLL048C Transporter of the ATP-binding cassette (ABC) family genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Negative Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Negative Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
HRI1 YLR301W Protein of unknown function that interacts with Sec72p and Hrr25p genetic 1 1 1 Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
RFC3 YNL290W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
THR1 YHR025W Homoserine kinase genetic 1 1 1 Synthetic Rescue
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
SDH4 YDR178W Membrane anchor subunit of succinate dehydrogenase (SDH) genetic 1 1 1 Positive Genetic
MET14 YKL001C Adenylylsulfate kinase genetic 1 1 1 Positive Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
ODC1 YPL134C Mitochondrial inner membrane transporter genetic 1 1 1 Negative Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase genetic 1 1 1 Negative Genetic
ODC2 YOR222W Mitochondrial inner membrane transporter genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
NCP1 YHR042W NADP-cytochrome P450 reductase genetic 1 1 1 Positive Genetic
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 1 1 1 Negative Genetic
YNK1 YKL067W Nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
SDH3 YKL141W Subunit of succinate dehydrogenase and of TIM22 translocase genetic 1 1 1 Negative Genetic
VHT1 YGR065C High-affinity plasma membrane H+-biotin (vitamin H) symporter genetic 1 1 1 Negative Genetic
PIS1 YPR113W Phosphatidylinositol synthase genetic 1 1 1 Negative Genetic
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) genetic 1 1 1 Negative Genetic
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Negative Genetic
SER33 YIL074C 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase genetic 1 1 1 Phenotypic Suppression
TPO2 YGR138C Polyamine transporter of the major facilitator superfamily genetic 1 1 1 Phenotypic Suppression
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Phenotypic Suppression
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Phenotypic Suppression
PSY4 YBL046W Regulatory subunit of protein phosphatase PP4 genetic 1 1 1 Phenotypic Suppression
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Positive Genetic
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Positive Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
RBG2 YGR173W Protein with a role in translation genetic 1 1 1 Positive Genetic
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Positive Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Positive Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Positive Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Positive Genetic
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 1 1 1 Positive Genetic
PET111 YMR257C Mitochondrial translational activator specific for the COX2 mRNA genetic 1 1 1 Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
YOR032W-A YOR032W-A Protein of unknown function genetic 1 1 1 Positive Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase genetic 1 1 1 Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
YDR341C YDR341C Arginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
ISD11 YER048W-A Cysteine desulfurase (Nfs1p) activator genetic 1 1 1 Negative Genetic
UTP7 YER082C Nucleolar protein genetic 1 1 1 Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
YHR020W YHR020W Prolyl-tRNA synthetase genetic 1 1 1 Negative Genetic
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
RIX1 YHR197W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
LTO1 YNL260C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
IDI1 YPL117C Isopentenyl diphosphate:dimethylallyl diphosphate isomerase genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
SSA3 YBL075C ATPase involved in protein folding and the response to stress genetic 1 1 1 Negative Genetic
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
TKL2 YBR117C Transketolase genetic 1 1 1 Negative Genetic
PEX32 YBR168W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SED4 YCR067C Integral ER membrane protein that stimulates Sar1p GTPase activity genetic 1 1 1 Negative Genetic
TMA17 YDL110C Regulatory gamma subunit of fatty acid synthase (FAS) genetic 1 1 1 Negative Genetic
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Negative Genetic
PAU2 YEL049W Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
YAT2 YER024W Carnitine acetyltransferase genetic 1 1 1 Negative Genetic
TDA2 YER071C Subunit of a complex that associates with actin filaments genetic 1 1 1 Negative Genetic
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Negative Genetic
SHC1 YER096W Sporulation-specific activator of Chs3p (chitin synthase III) genetic 1 1 1 Negative Genetic
UBP9 YER098W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Negative Genetic
MAM1 YER106W Monopolin genetic 1 1 1 Negative Genetic
VFA1 YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting genetic 1 1 1 Negative Genetic
RTR1 YER139C Dual specificity protein phosphatase genetic 1 1 1 Negative Genetic
YER152C YER152C Protein with 2-aminoadipate transaminase activity genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family genetic 1 1 1 Negative Genetic
MPO1 YGL010W Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids genetic 1 1 1 Negative Genetic
PRM8 YGL053W Pheromone-regulated protein genetic 1 1 1 Negative Genetic
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Negative Genetic
PEX31 YGR004W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
MCO32 YGR053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
VPS62 YGR141W Vacuolar protein sorting (VPS) protein genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
SAY1 YGR263C Sterol deacetylase genetic 1 1 1 Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
LEU5 YHR002W Mitochondrial carrier protein genetic 1 1 1 Negative Genetic
IGO2 YHR132W-A Protein required for initiation of G0 program genetic 1 1 1 Negative Genetic
YHR140W YHR140W Endoplasmic reticulum protein genetic 1 1 1 Negative Genetic
TDA11 YHR159W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 1 1 1 Negative Genetic
YIL161W YIL161W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PRY3 YJL078C GPI-anchored cell wall protein involved in export of sterols genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
NDE1 YMR145C Mitochondrial external NADH dehydrogenase genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TVP38 YKR088C Integral membrane protein genetic 1 1 1 Negative Genetic
NFT1 YKR103W Putative transporter of the MRP subfamily genetic 1 1 1 Negative Genetic
YLL006W-A YLL006W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Negative Genetic
YLL053C YLL053C Putative protein genetic 1 1 1 Negative Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Negative Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
YPS1 YLR120C Aspartic protease genetic 1 1 1 Negative Genetic
TAG1 YLR173W Vacuolar membrane protein involved in termination of autophagy genetic 1 1 1 Negative Genetic
YLR345W YLR345W Similar to 6-phosphofructo-2-kinase enzymes genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
YMR242W-A YMR242W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
YMR315W YMR315W Protein with NADP(H) oxidoreductase activity genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Negative Genetic
YNL146C-A YNL146C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
RPL18B YNL301C Ribosomal 60S subunit protein L18B genetic 1 1 1 Negative Genetic
URK1 YNR012W Uridine/cytidine kinase genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
NGL1 YOL042W Putative endonuclease genetic 1 1 1 Negative Genetic
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Negative Genetic
PAU20 YOL161C Protein of unknown function genetic 1 1 1 Negative Genetic
RSB1 YOR049C Sphingoid long-chain base (LCB) efflux transporter genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
ISM1 YPL040C Mitochondrial isoleucyl-tRNA synthetase genetic 1 1 1 Negative Genetic
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family genetic 1 1 1 Negative Genetic
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
MRPL40 YPL173W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TYW1 YPL207W Iron-sulfur protein required for synthesis of wybutosine modified tRNA genetic 1 1 1 Negative Genetic
YPR084W YPR084W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Positive Genetic
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 1 1 1 Negative Genetic
GTO1 YGR154C Omega-class glutathione transferase genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Negative Genetic
ALD5 YER073W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
CRC1 YOR100C Mitochondrial inner membrane carnitine transporter genetic 1 1 1 Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
FZF1 YGL254W Transcription factor involved in sulfite metabolism genetic 1 1 1 Negative Genetic
CDD1 YLR245C Cytidine deaminase genetic 1 1 1 Negative Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Phenotypic Suppression
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Negative Genetic
AKR2 YOR034C Ankyrin repeat-containing protein genetic 1 1 1 Negative Genetic
ESL1 YIL151C hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Positive Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
DCD1 YHR144C Deoxycytidine monophosphate (dCMP) deaminase genetic 1 1 1 Negative Genetic
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Negative Genetic
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
DSE1 YER124C Daughter cell-specific protein genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Positive Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Phenotypic Suppression
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Positive Genetic
CUE4 YML101C Protein of unknown function genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
ANT1 YPR128C Peroxisomal adenine nucleotide transporter genetic 1 1 1 Negative Genetic
GAS5 YOL030W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 1 1 1 Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
CPR5 YDR304C Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER genetic 1 1 1 Negative Genetic
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
AZR1 YGR224W Plasma membrane transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
AST1 YBL069W Lipid raft associated protein genetic 1 1 1 Negative Genetic
HEM2 YGL040C Aminolevulinate dehydratase genetic 1 1 1 Negative Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
ARO7 YPR060C Chorismate mutase genetic 1 1 1 Positive Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
HAL9 YOL089C Putative transcription factor containing a zinc finger genetic 1 1 1 Negative Genetic
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall genetic 1 1 1 Positive Genetic
GPM3 YOL056W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Positive Genetic
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) genetic 1 1 1 Negative Genetic
GRS2 YPR081C Glycine-tRNA synthetase, not expressed under normal growth conditions genetic 1 1 1 Positive Genetic
CMI7 YIL002W-A Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
GLD1 YPR109W Component of Dsc E3 ligase complex in Golgi and endosomes genetic 1 1 1 Negative Genetic
ERG12 YMR208W Mevalonate kinase genetic 1 1 1 Negative Genetic
COS6 YGR295C Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Positive Genetic
FSH2 YMR222C Putative serine hydrolase that localizes to the cytoplasm genetic 1 1 1 Negative Genetic
FMT1 YBL013W Methionyl-tRNA formyltransferase genetic 1 1 1 Negative Genetic