Standard name Systematic name Name description Description
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
Visualize the interactome of ERG9
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.759 0.861 0.740
ER 0.195 0.065 NaN
Mito 0.069 0.065 0.164
Vac/Vac Memb NaN NaN 0.093

GFP localization & abundance

GFP localization GFP abundance
ER 10800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ERG9 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1012 (squalene synthase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ERG3 YLR056W C-5 sterol desaturase genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 3 2 1 Positive Genetic, Negative Genetic, Negative Genetic
HMG1 YML075C HMG-CoA reductase genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
ERG8 YMR220W Phosphomevalonate kinase genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 2 Positive Genetic, Positive Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
CSH1 YBR161W Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 2 1 1 Negative Genetic, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 2 1 1 Negative Genetic, Negative Genetic
CMD1 YBR109C Calmodulin genetic 2 1 1 Negative Genetic, Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 1 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Positive Genetic, Positive Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 2 1 1 Negative Genetic, Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 2 1 1 Negative Genetic, Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 2 1 1 Negative Genetic, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 1 1 Negative Genetic, Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
SPL2 YHR136C Protein with similarity to cyclin-dependent kinase inhibitors genetic 2 1 1 Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 1 Negative Genetic, Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 1 1 Negative Genetic, Negative Genetic
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 2 1 1 Negative Genetic, Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 2 1 1 Negative Genetic, Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 2 1 1 Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 2 1 1 Negative Genetic, Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 2 1 1 Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 2 1 1 Negative Genetic, Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 2 1 1 Negative Genetic, Negative Genetic
RRN3 YKL125W Protein required for transcription of rDNA by RNA polymerase I genetic 2 1 1 Negative Genetic, Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 1 Negative Genetic, Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 2 1 1 Negative Genetic, Negative Genetic
PFY1 YOR122C Profilin genetic 2 1 1 Negative Genetic, Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 2 1 1 Negative Genetic, Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 1 1 Negative Genetic, Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 2 1 1 Negative Genetic, Negative Genetic
PAM17 YKR065C Constituent of the TIM23 complex genetic 2 1 1 Negative Genetic, Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP1 YLR256W Zinc finger transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
VHR2 YER064C Non-essential nuclear protein regulation 1 1 1 northern blot evidence
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
ADH1 YOL086C Alcohol dehydrogenase genetic 1 1 1 Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Positive Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Positive Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
ERG26 YGL001C C-3 sterol dehydrogenase physical 1 1 1 PCA
BNI1 YNL271C Formin genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Positive Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase genetic 1 1 1 Positive Genetic
CTO1 YCR015C Protein required for cold tolerance genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Positive Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase physical 1 1 1 PCA
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Positive Genetic
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase physical 1 1 1 PCA
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Negative Genetic
CCE1 YKL011C Mitochondrial cruciform cutting endonuclease genetic 1 1 1 Negative Genetic
CMG1 YLR271W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 1 1 1 PCA
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
ECM11 YDR446W Meiosis-specific protein genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Positive Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
ACO2 YJL200C Putative mitochondrial aconitase isozyme genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Positive Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
CST9 YLR394W SUMO E3 ligase genetic 1 1 1 Negative Genetic
EMP46 YLR080W Integral membrane component of ER-derived COPII-coated vesicles genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
ERG25 YGR060W C-4 methyl sterol oxidase physical 1 1 1 PCA
DJP1 YIR004W ER-associated chaperone involved in protein targeting genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
ERG28 YER044C Endoplasmic reticulum membrane protein physical 1 1 1 PCA
ASG1 YIL130W Zinc cluster protein proposed to be a transcriptional regulator genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
ACB1 YGR037C Acyl-CoA-binding protein genetic 1 1 1 Negative Genetic
ATG33 YLR356W Mitochondrial mitophagy-specific protein genetic 1 1 1 Positive Genetic
CUZ1 YNL155W Protein with a role in the ubiquitin-proteasome pathway physical 1 1 1 Affinity Capture-MS
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Negative Genetic
ENT4 YLL038C Protein of unknown function genetic 1 1 1 Negative Genetic
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 1 1 1 Negative Genetic
AAD4 YDL243C Putative aryl-alcohol dehydrogenase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
CWH43 YCR017C GPI lipid remodelase genetic 1 1 1 Negative Genetic
CRH1 YGR189C Chitin transglycosylase genetic 1 1 1 Negative Genetic
COA1 YIL157C Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase physical 1 1 1 PCA
CTS1 YLR286C Endochitinase genetic 1 1 1 Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 1 1 1 Positive Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
SAL1 YNL083W ADP/ATP transporter physical 1 1 1 PCA
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic physical 1 1 1 PCA
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
PLN1 YKR046C Perilipin, involved in formation and stability of lipid droplets physical 1 1 1 PCA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase physical 1 1 1 Affinity Capture-MS
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 1 1 1 Affinity Capture-MS
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
NFT1 YKR103W Putative transporter of the MRP subfamily physical 1 1 1 PCA
YKR104W YKR104W Putative transporter of the MRP subfamily physical 1 1 1 PCA
PDR10 YOR328W ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
RTN1 YDR233C Reticulon protein physical 1 1 1 Affinity Capture-MS
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Phenotypic Enhancement
SSU1 YPL092W Plasma membrane sulfite pump involved in sulfite metabolism genetic 1 1 1 Positive Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
LCB4 YOR171C Sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Positive Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Positive Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Positive Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Positive Genetic
TAM41 YGR046W Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) genetic 1 1 1 Positive Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Positive Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Positive Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Positive Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Positive Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Positive Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Positive Genetic
FUN26 YAL022C High affinity, broad selectivity, nucleoside/nucleobase transporter genetic 1 1 1 Positive Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Positive Genetic
YDL218W YDL218W Putative protein of unknown function genetic 1 1 1 Positive Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Positive Genetic
RIP1 YEL024W Ubiquinol-cytochrome-c reductase genetic 1 1 1 Positive Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Positive Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
GEP7 YGL057C Protein of unknown function genetic 1 1 1 Positive Genetic
SHY1 YGR112W Mitochondrial inner membrane protein required for complex IV assembly genetic 1 1 1 Positive Genetic
PAU12 YGR294W Protein of unknown function genetic 1 1 1 Positive Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Positive Genetic
NOP10 YHR072W-A Subunit of box H/ACA snoRNP complex genetic 1 1 1 Positive Genetic
YJL136W-A YJL136W-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Positive Genetic
PER33 YLR064W Protein that localizes to the endoplasmic reticulum genetic 1 1 1 Positive Genetic
YLR154C-H YLR154C-H Putative protein of unknown function genetic 1 1 1 Positive Genetic
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Positive Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Negative Genetic
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Negative Genetic
UTP4 YDR324C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase genetic 1 1 1 Negative Genetic
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Negative Genetic
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
NCA3 YJL116C Protein involved in mitochondrion organization genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
PDR8 YLR266C Transcription factor genetic 1 1 1 Negative Genetic
NMA1 YLR328W Nicotinic acid mononucleotide adenylyltransferase genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
TGL3 YMR313C Bifunctional triacylglycerol lipase and LPE acyltransferase genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
YAL063C-A YAL063C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
IAI11 YBL059W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YBL112C YBL112C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YBR071W YBR071W Protein of unknown function found in the cytoplasm and bud neck genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
YSW1 YBR148W Protein required for normal prospore membrane formation genetic 1 1 1 Negative Genetic
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
KTR4 YBR199W Glycosyltransferase involved in protein glycosylation genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
HMRA1 YCR097W Silenced copy of a1 at HMR genetic 1 1 1 Negative Genetic
MRX9 YDL027C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
YDR182W-A YDR182W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDR338C YDR338C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
LPP1 YDR503C Lipid phosphate phosphatase genetic 1 1 1 Negative Genetic
YDR524C-B YDR524C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
YEN1 YER041W Holliday junction resolvase genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
VPS73 YGL104C Mitochondrial protein genetic 1 1 1 Negative Genetic
TPN1 YGL186C Plasma membrane pyridoxine (vitamin B6) transporter genetic 1 1 1 Negative Genetic
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
YGR204C-A YGR204C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHL015W-A YHL015W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL055C YIL055C Putative protein of unknown function genetic 1 1 1 Negative Genetic
QDR2 YIL121W Plasma membrane transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Negative Genetic
IML2 YJL082W Protein required for clearance of inclusion bodies genetic 1 1 1 Negative Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
RPL17B YJL177W Ribosomal 60S subunit protein L17B genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
RPS14B YJL191W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PXP2 YJR111C Peroxisomal matrix protein with naturally active promoter genetic 1 1 1 Negative Genetic
IML1 YJR138W GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MNR2 YKL064W Vacuolar membrane protein required for magnesium homeostasis genetic 1 1 1 Negative Genetic
YKR005C YKR005C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SHB17 YKR043C Sedoheptulose bisphosphatase involved in riboneogenesis genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
OSW2 YLR054C Protein of unknown function reputedly involved in spore wall assembly genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SPO77 YLR341W Meiosis-specific protein of unknown function genetic 1 1 1 Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
HUG1 YML058W-A Ribonucleotide reductase inhibitor genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TRF5 YNL299W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
YPT11 YNL304W Rab GTPase genetic 1 1 1 Negative Genetic
PHO91 YNR013C Low-affinity vacuolar phosphate transporter genetic 1 1 1 Negative Genetic
RRT8 YOL048C Protein involved in spore wall assembly genetic 1 1 1 Negative Genetic
YOL097W-A YOL097W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
YOR293C-A YOR293C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR387C YOR387C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPL034W YPL034W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MUK1 YPL070W Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
YPR202W YPR202W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Dosage Rescue
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Synthetic Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Growth Defect
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Synthetic Growth Defect
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
AIM32 YML050W 2Fe-2S mitochondrial protein involved in redox quality control genetic 1 1 1 Negative Genetic
CQD2 YLR253W Mitochondrial protein involved in lipid homeostasis genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 1 1 1 Negative Genetic
ALP1 YNL270C Arginine transporter genetic 1 1 1 Negative Genetic