ARO9 |
YHR137W |
Aromatic aminotransferase II |
genetic |
5 |
3 |
4 |
Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
ALT1 |
YLR089C |
Alanine transaminase (glutamic pyruvic transaminase) |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ADH3 |
YMR083W |
Mitochondrial alcohol dehydrogenase isozyme III |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
HOM6 |
YJR139C |
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
YMC2 |
YBR104W |
Putative mitochondrial inner membrane transporter |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MCX1 |
YBR227C |
Non-proteolytic ATPase of the AAA family |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
CTP1 |
YBR291C |
Mitochondrial inner membrane citrate transporter |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ARO8 |
YGL202W |
Aromatic aminotransferase I |
physical |
2 |
2 |
2 |
Co-purification, Co-crystal Structure |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-RNA |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
KGD2 |
YDR148C |
Dihydrolipoyl transsuccinylase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SER2 |
YGR208W |
Phosphoserine phosphatase of the phosphoglycerate pathway |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MSA2 |
YKR077W |
Putative transcriptional activator |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
RTG1 |
YOL067C |
Transcription factor (bHLH) involved in interorganelle communication |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ENV7 |
YPL236C |
Vacuolar membrane protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ARO10 |
YDR380W |
Phenylpyruvate decarboxylase |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
YHM2 |
YMR241W |
Citrate and oxoglutarate carrier protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
AAT2 |
YLR027C |
Cytosolic aspartate aminotransferase involved in nitrogen metabolism |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ACO2 |
YJL200C |
Putative mitochondrial aconitase isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALG5 |
YPL227C |
UDP-glucose:dolichyl-phosphate glucosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMD1 |
YGR074W |
Core Sm protein Sm D1 |
physical |
1 |
1 |
1 |
Two-hybrid |
RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SPS1 |
YDR523C |
STE20-family GCKIII protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOM1 |
YDR457W |
E3 ubiquitin ligase of the hect-domain class |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PTC7 |
YHR076W |
Type 2C serine/threonine protein phosphatase (PP2C) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
COQ8 |
YGL119W |
ATPase required for ubiquinone biosynthesis and respiratory growth |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TIF4631 |
YGR162W |
Translation initiation factor eIF4G and scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TFC6 |
YDR362C |
Subunit of RNA polymerase III transcription initiation factor complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GEM1 |
YAL048C |
Outer mitochondrial membrane GTPase, subunit of the ERMES complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ERV15 |
YBR210W |
Protein involved in export of proteins from the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
RHB1 |
YCR027C |
Putative Rheb-related GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
YFH1 |
YDL120W |
Mitochondrial matrix iron chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBX3 |
YDL091C |
Clathrin-coated vesicle component, regulator of endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGD1 |
YLR336C |
Essential nuclear protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
LUG1 |
YLR352W |
Protein of unknown function with similarity to F-box proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
KES1 |
YPL145C |
Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHR020W |
YHR020W |
Prolyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Positive Genetic |
IDH2 |
YOR136W |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTR2 |
YKR093W |
Integral membrane peptide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
MET7 |
YOR241W |
Folylpolyglutamate synthetase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Positive Genetic |
TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Positive Genetic |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL10 |
YLR075W |
Ribosomal 60S subunit protein L10 |
genetic |
1 |
1 |
1 |
Positive Genetic |
YBL008W-A |
YBL008W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
ECM2 |
YBR065C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
GCV1 |
YDR019C |
T subunit of the mitochondrial glycine decarboxylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
GPR1 |
YDL035C |
Plasma membrane G protein coupled receptor (GPCR) |
genetic |
1 |
1 |
1 |
Positive Genetic |
HSE1 |
YHL002W |
Subunit of the endosomal Vps27p-Hse1p complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
JEM1 |
YJL073W |
DnaJ-like chaperone required for nuclear membrane fusion during mating |
genetic |
1 |
1 |
1 |
Positive Genetic |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPI11 |
YDR302W |
ER membrane protein involved in a late step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRS31 |
YDR472W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BET1 |
YIL004C |
Type II membrane protein required for vesicular transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHS1 |
YJL097W |
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAK11 |
YKL021C |
Protein involved in an early step of 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA6 |
YKL024C |
Uridylate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE8 |
YML092C |
Alpha 2 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC29 |
YPL124W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
TFB4 |
YPR056W |
Subunit of TFIIH complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
MIS1 |
YBR084W |
Mitochondrial C1-tetrahydrofolate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MBA1 |
YBR185C |
Membrane-associated mitochondrial ribosome receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMA35 |
YCR100C |
Protein involved in protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX9 |
YDL067C |
Subunit VIIa of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
LYS20 |
YDL182W |
Homocitrate synthase isozyme and functions in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
COI1 |
YDR381C-A |
Mitochondrial assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIP1 |
YEL024W |
Ubiquinol-cytochrome-c reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FCY2 |
YER056C |
Purine-cytosine permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPR6 |
YER115C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTR1 |
YER139C |
Dual specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISC10 |
YER180C |
Meiosis-specific MAPK inhibitor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRX19 |
YDL183C |
Protein that may form an active mitochondrial KHE system |
genetic |
1 |
1 |
1 |
Negative Genetic |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
FRE7 |
YOL152W |
Putative ferric reductase with similarity to Fre2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA22 |
YHR060W |
Protein that is required for vacuolar H+-ATPase (V-ATPase) function |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX23 |
YHR116W |
Protein that functions in mitochondrial copper homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPL2 |
YHR136C |
Protein with similarity to cyclin-dependent kinase inhibitors |
genetic |
1 |
1 |
1 |
Negative Genetic |
PKP1 |
YIL042C |
Mitochondrial protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO22 |
YIL073C |
Meiosis-specific protein essential for chromosome synapsis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIL092W |
YIL092W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
MGM101 |
YJR144W |
Protein with a role in mitochondrial DNA recombinational repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
LHS1 |
YKL073W |
Molecular chaperone of the endoplasmic reticulum lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSR2 |
YLR019W |
Putative plasma membrane phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDD1 |
YLR245C |
Cytidine deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RCF1 |
YML030W |
Cytochrome c oxidase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO84 |
YML123C |
High-affinity inorganic phosphate (Pi) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX14 |
YML129C |
Mitochondrial cytochrome c oxidase (complex IV) assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MGR3 |
YMR115W |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL24 |
YMR193W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RCE1 |
YMR274C |
Type II CAAX prenyl protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNL040W |
YNL040W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
POR1 |
YNL055C |
Mitochondrial porin (voltage-dependent anion channel) |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNL146W |
YNL146W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL10 |
YNL284C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO91 |
YNR013C |
Low-affinity vacuolar phosphate transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
CRT10 |
YOL063C |
Protein required for the degradation of mutant 25S rRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIG1 |
YPL049C |
MAP kinase-responsive inhibitor of the Ste12p transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
LEE1 |
YPL054W |
Zinc-finger protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YER152C |
YER152C |
Protein with 2-aminoadipate transaminase activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BNA3 |
YJL060W |
Kynurenine aminotransferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
BAT2 |
YJR148W |
Cytosolic branched-chain amino acid (BCAA) aminotransferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
AIM22 |
YJL046W |
Lipoate-protein ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
APS1 |
YLR170C |
Small subunit of the clathrin-associated adaptor complex AP-1 |
genetic |
1 |
1 |
1 |
Positive Genetic |
ALO1 |
YML086C |
D-Arabinono-1,4-lactone oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |