Standard name Systematic name Name description Description
PRE8 YML092C Alpha 2 subunit of the 20S proteasome Alpha 2 subunit of the 20S proteasome
Visualize the interactome of PRE8
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.211 0.152 0.240
Nucleus 0.947 0.788 0.747
Cytoplasm NaN 0.068 NaN
Vac/Vac Memb NaN 0.053 NaN

GFP localization & abundance

GFP localization GFP abundance
nucleus 7060

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PRE8 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 12 3 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 10 4 8 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Co-purification
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome physical 9 2 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-MS, Affinity Capture-MS
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome physical 7 3 7 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-MS
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 6 2 5 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 5 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
PUP1 YOR157C Beta 2 subunit of the 20S proteasome physical 4 2 4 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
PUP3 YER094C Beta 3 subunit of the 20S proteasome physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ECM29 YHL030W Scaffold protein physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
PRE7 YBL041W Beta 6 subunit of the 20S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE4 YFR050C Beta 7 subunit of the 20S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
PRE3 YJL001W Beta 1 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BLM10 YFL007W Proteasome activator physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 2 1 1 Negative Genetic, Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 2 1 1 Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPN2 YIL075C Subunit of the 26S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis physical 1 1 1 Affinity Capture-MS
VAC14 YLR386W Enzyme regulator physical 1 1 1 Two-hybrid
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Reconstituted Complex
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p genetic 1 1 1 Dosage Rescue
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Dosage Rescue
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Positive Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Positive Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Positive Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Positive Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
RBA50 YDR527W Protein involved in transcription genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
SHQ1 YIL104C Chaperone protein genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SOK1 YDR006C Protein of unknown function genetic 1 1 1 Negative Genetic
SAP1 YER047C Putative ATPase of the AAA family genetic 1 1 1 Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VPS501 YKR078W Vacuolar SNX-BAR protein genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
PUT7 YLR283W Regulator of mitochondrial proline metabolism genetic 1 1 1 Negative Genetic
SWC7 YLR385C Protein of unknown function genetic 1 1 1 Negative Genetic
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Negative Genetic
YNL046W YNL046W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL115C YNL115C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
TRM10 YOL093W tRNA methyltransferase genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Affinity Capture-MS
EST3 YIL009C-A Component of the telomerase holoenzyme physical 1 1 1 Affinity Capture-MS
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Positive Genetic
BDH2 YAL061W Putative medium-chain alcohol dehydrogenase with similarity to BDH1 genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 1 1 1 Negative Genetic
APP1 YNL094W Phosphatidate phosphatase, converts phosphatidate to diacylglycerol genetic 1 1 1 Negative Genetic
CMK1 YFR014C Calmodulin-dependent protein kinase genetic 1 1 1 Positive Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
NUP49 YGL172W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Two-hybrid
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Positive Genetic
PBA1 YLR199C Protein involved in 20S proteasome assembly physical 1 1 1 Affinity Capture-MS
FUB1 YCR076C Proteasome-binding protein physical 1 1 1 Affinity Capture-MS
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes physical 1 1 1 Affinity Capture-MS
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
CTL1 YMR180C RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
LAA2 YBL010C Clathrin adaptor (adaptin) accessory protein genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Negative Genetic
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex physical 1 1 1 Reconstituted Complex
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network physical 1 1 1 Proximity Label-MS
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Affinity Capture-MS
PLB3 YOL011W Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
ARO8 YGL202W Aromatic aminotransferase I genetic 1 1 1 Negative Genetic
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
ALD4 YOR374W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Rescue
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Negative Genetic
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Positive Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
PIG1 YLR273C Putative targeting subunit for type-1 protein phosphatase Glc7p genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
CAB2 YIL083C Phosphopantothenoylcysteine synthetase (PPCS) genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic