CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
physical |
19 |
7 |
15 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-purification, PCA, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-MS |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
12 |
5 |
11 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-RNA, Co-purification, Affinity Capture-MS |
CAF40 |
YNL288W |
Component of the CCR4-NOT transcriptional complex |
physical |
12 |
3 |
11 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS |
NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
9 |
5 |
9 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS |
NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
9 |
4 |
9 |
Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
physical |
7 |
4 |
7 |
Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
physical |
7 |
4 |
7 |
Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure |
CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
6 |
4 |
6 |
Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
5 |
3 |
5 |
PCA, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA |
UBC5 |
YDR059C |
Ubiquitin-conjugating enzyme |
physical |
5 |
2 |
4 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex |
CAF130 |
YGR134W |
Subunit of the CCR4-NOT transcriptional regulatory complex |
physical |
4 |
3 |
4 |
Two-hybrid, Affinity Capture-MS, Co-purification, Affinity Capture-MS |
RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
physical |
4 |
3 |
2 |
Biochemical Activity, Co-fractionation, Affinity Capture-Western, Biochemical Activity |
CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Synthetic Lethality |
BUR2 |
YLR226W |
Cyclin for the Sgv1p (Bur1p) protein kinase |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect |
RKR1 |
YMR247C |
RING domain E3 ubiquitin ligase |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement |
CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
3 |
1 |
3 |
Dosage Rescue, Dosage Rescue, Dosage Rescue |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
3 |
3 |
2 |
Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic |
NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
3 |
2 |
2 |
Dosage Rescue, Synthetic Lethality, Synthetic Lethality |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
3 |
3 |
1 |
Dosage Lethality, Synthetic Lethality, Synthetic Rescue |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Growth Defect |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Biochemical Activity |
UBP6 |
YFR010W |
Ubiquitin-specific protease |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
JHD2 |
YJR119C |
JmjC domain family histone demethylase |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
ECM29 |
YHL030W |
Scaffold protein |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Phenotypic Suppression |
GAL11 |
YOL051W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
ARF1 |
YDL192W |
ADP-ribosylation factor |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
EGD1 |
YPL037C |
Subunit beta1 of the nascent polypeptide-associated complex (NAC) |
physical |
2 |
2 |
1 |
Two-hybrid, Affinity Capture-Western |
SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Biochemical Activity |
PSH1 |
YOL054W |
E3 ubiquitin ligase targeting centromere-binding protein Cse4p |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
YOR302W |
YOR302W |
CPA1 uORF |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
VMA11 |
YPL234C |
Vacuolar ATPase V0 domain subunit c' |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
RPN14 |
YGL004C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Rescue |
NAS6 |
YGR232W |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Rescue |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
physical |
2 |
1 |
1 |
Reconstituted Complex, Reconstituted Complex |
RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
physical |
2 |
1 |
1 |
Reconstituted Complex, Reconstituted Complex |
TAF9 |
YMR236W |
Subunit (17 kDa) of TFIID and SAGA complexes |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
JHD2 |
YJR119C |
JmjC domain family histone demethylase |
regulation |
1 |
1 |
1 |
ubiquitination assay evidence |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPN1 |
YPR133C |
Protein involved in RNA polymerase II transcription |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
NHP6A |
YPR052C |
High-mobility group (HMG) protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAF5 |
YEL018W |
Non-essential subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
LSM3 |
YLR438C-A |
Lsm (Like Sm) protein |
physical |
1 |
1 |
1 |
PCA |
MFT1 |
YML062C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM16 |
YMR128W |
Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FPR1 |
YNL135C |
Peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HRP1 |
YOL123W |
Subunit of cleavage factor I |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HRP1 |
YOL123W |
Subunit of cleavage factor I |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HSM3 |
YBR272C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ECM29 |
YHL030W |
Scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ADA2 |
YDR448W |
Transcription coactivator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
BLM10 |
YFL007W |
Proteasome activator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRO1 |
YPL084W |
Cytoplasmic class E vacuolar protein sorting (VPS) factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HEK2 |
YBL032W |
RNA binding protein involved in asymmetric localization of ASH1 mRNA |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
LTV1 |
YKL143W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATG17 |
YLR423C |
Scaffold protein responsible for phagophore assembly site organization |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
CAF120 |
YNL278W |
Part of the CCR4-NOT transcriptional regulatory complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CAF120 |
YNL278W |
Part of the CCR4-NOT transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GPD1 |
YDL022W |
NAD-dependent glycerol-3-phosphate dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
GUF1 |
YLR289W |
Mitochondrial matrix GTPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ATG7 |
YHR171W |
Autophagy-related protein and dual specificity member of the E1 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUL1 |
YMR275C |
Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HSL7 |
YBR133C |
Protein arginine N-methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HIR2 |
YOR038C |
Subunit of HIR nucleosome assembly complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
IGO1 |
YNL157W |
Protein required for initiation of G0 program |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
JSN1 |
YJR091C |
Member of the Puf family of RNA-binding proteins |
physical |
1 |
1 |
1 |
PCA |
JSN1 |
YJR091C |
Member of the Puf family of RNA-binding proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
BMT2 |
YBR141C |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IKI1 |
YHR187W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
physical |
1 |
1 |
1 |
PCA |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
physical |
1 |
1 |
1 |
PCA |
WHI3 |
YNL197C |
RNA binding protein that modulates mRNA stability |
physical |
1 |
1 |
1 |
PCA |
NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
physical |
1 |
1 |
1 |
PCA |
MTR4 |
YJL050W |
RNA duplex-sensing translocase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SKI6 |
YGR195W |
Exosome non-catalytic core component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RRP42 |
YDL111C |
Exosome non-catalytic core component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SMY2 |
YBR172C |
GYF domain protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SAN1 |
YDR143C |
Ubiquitin-protein ligase |
physical |
1 |
1 |
1 |
Two-hybrid |
SAM1 |
YLR180W |
S-adenosylmethionine synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SAM2 |
YDR502C |
S-adenosylmethionine synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPN8 |
YOR261C |
Essential non-ATPase regulatory subunit of the 26S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SCL1 |
YGL011C |
Alpha 1 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PRE6 |
YOL038W |
Alpha 4 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRE8 |
YML092C |
Alpha 2 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PUP2 |
YGR253C |
Alpha 5 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TMA108 |
YIL137C |
Ribosome-associated, nascent chain binding factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL16A |
YIL133C |
Ribosomal 60S subunit protein L16A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SCP160 |
YJL080C |
Essential RNA-binding G protein effector of mating response pathway |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TMA46 |
YOR091W |
Protein of unknown function that associates with translating ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT20 |
YOL148C |
Subunit of the SAGA transcriptional regulatory complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SPT20 |
YOL148C |
Subunit of the SAGA transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Biochemical Activity |
STL1 |
YDR536W |
Glycerol proton symporter of the plasma membrane |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPS7B |
YNL096C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
STE4 |
YOR212W |
G protein beta subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
STE11 |
YLR362W |
Signal transducing MEK kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NHP6A |
YPR052C |
High-mobility group (HMG) protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NHP6B |
YBR089C-A |
High-mobility group (HMG) protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA13 |
YPR036W |
Subunit H of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PIB1 |
YDR313C |
RING-type ubiquitin ligase of the endosomal and vacuolar membranes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
URE2 |
YNL229C |
Nitrogen catabolite repression transcriptional regulator |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RPA49 |
YNL248C |
RNA polymerase I subunit A49 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS38 |
YLR360W |
Part of a Vps34p phosphatidylinositol 3-kinase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VMA4 |
YOR332W |
Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MRT4 |
YKL009W |
Protein involved in mRNA turnover and ribosome assembly |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PPN1 |
YDR452W |
Dual endo- and exopolyphosphatase with a role in phosphate metabolism |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
YKR005C |
YKR005C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NNT1 |
YLR285W |
S-adenosylmethionine-dependent methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRX4 |
YPL168W |
Protein that associates with mitochondrial ribosome |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YMR085W |
YMR085W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUF1 |
YOR187W |
Mitochondrial translation elongation factor Tu (EF-Tu) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSS18 |
YPR134W |
Nuclear encoded protein needed for splicing of mitochondrial intron |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RBG2 |
YGR173W |
Protein with a role in translation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLH1 |
YGR271W |
Subunit of ribosome-associated quality control trigger complex (RQT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA34 |
YJL148W |
RNA polymerase I subunit A34.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP24 |
YMR268C |
Splicing factor that reanneals snRNPs during spliceosome recycling |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
POP7 |
YBR167C |
Subunit of RNase MRP, nuclear RNase P and telomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TIF2 |
YJL138C |
Translation initiation factor eIF4A |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOC4 |
YPR144C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NUP1 |
YOR098C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
TDA9 |
YML081W |
Transcription factor that regulates acetate production |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM101 |
YHL027W |
Cys2His2 zinc-finger transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL13B |
YMR142C |
Ribosomal 60S subunit protein L13B |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPL13A |
YDL082W |
Ribosomal 60S subunit protein L13A |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB4 |
YJL140W |
RNA polymerase II subunit B32 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NAS2 |
YIL007C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RAD26 |
YJR035W |
Protein involved in transcription-coupled nucleotide excision repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RPT2 |
YDL007W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
genetic |
1 |
1 |
1 |
Negative Genetic |
JHD2 |
YJR119C |
JmjC domain family histone demethylase |
physical |
1 |
1 |
1 |
Biochemical Activity |
AEP3 |
YPL005W |
Peripheral mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIS1 |
YDR096W |
Histone demethylase and transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
LOT5 |
YKL183W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ECM4 |
YKR076W |
S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MAK32 |
YCR019W |
Protein necessary for stability of L-A dsRNA-containing particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOD5 |
YOR274W |
Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase |
genetic |
1 |
1 |
1 |
Positive Genetic |