Standard name Systematic name Name description Description
SAM2 YDR502C S-adenosylmethionine synthetase S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon
Visualize the interactome of SAM2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 92

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.996 0.991 0.996

GFP localization & abundance

GFP localization GFP abundance
ambiguous 22000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SAM2 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0726 (methionine adenosyltransferase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SAM1 YLR180W S-adenosylmethionine synthetase genetic 15 5 10 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
SAM1 YLR180W S-adenosylmethionine synthetase physical 5 4 4 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Co-fractionation, Affinity Capture-Western
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ABD1 YBR236C Methyltransferase genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
MET4 YNL103W Leucine-zipper transcriptional activator genetic 2 2 2 Synthetic Lethality, Dosage Rescue
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
LCB2 YDR062W Component of serine palmitoyltransferase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
ACS2 YLR153C Acetyl-coA synthetase isoform physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
OPI1 YHL020C Transcriptional regulator of a variety of genes regulation 1 1 1 DNA to cDNA expression microarray evidence
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RPL3 YOR063W Ribosomal 60S subunit protein L3 genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
KAP95 YLR347C Karyopherin beta physical 1 1 1 Affinity Capture-MS
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-MS
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 1 1 1 Negative Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Dosage Rescue
KGD1 YIL125W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
DBP8 YHR169W ATPase, putative RNA helicase of the DEAD-box family physical 1 1 1 Affinity Capture-MS
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p physical 1 1 1 Affinity Capture-MS
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 1 1 1 Positive Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
ERC1 YHR032W Member of the multi-drug and toxin extrusion (MATE) family genetic 1 1 1 Phenotypic Suppression
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance physical 1 1 1 Affinity Capture-MS
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CDC19 YAL038W Pyruvate kinase physical 1 1 1 Affinity Capture-MS
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade physical 1 1 1 Affinity Capture-MS
YLF2 YHL014C Protein of unknown function physical 1 1 1 Affinity Capture-MS
TSC13 YDL015C Enoyl reductase physical 1 1 1 Affinity Capture-MS
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 1 1 1 Affinity Capture-MS
SAM2 YDR502C S-adenosylmethionine synthetase physical 1 1 1 Two-hybrid
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
TOM6 YOR045W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Affinity Capture-MS
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
TFB4 YPR056W Subunit of TFIIH complex physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SNO4 YMR322C Possible chaperone and cysteine protease genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Positive Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
SPR6 YER115C Protein of unknown function genetic 1 1 1 Negative Genetic
YGL081W YGL081W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
YLR012C YLR012C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TMA10 YLR327C Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
YMR230W-A YMR230W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SUN4 YNL066W Cell wall protein related to glucanases localized in birth scars genetic 1 1 1 Negative Genetic
YOR034C-A YOR034C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p physical 1 1 1 Two-hybrid
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia physical 1 1 1 Affinity Capture-MS
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
FAT1 YBR041W Very long chain fatty acyl-CoA synthetase and fatty acid transporter genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
IRC8 YJL051W Bud tip localized protein of unknown function genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PDE1 YGL248W Low-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
HVG1 YER039C Protein of unknown function genetic 1 1 1 Negative Genetic
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Phenotypic Suppression
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Negative Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
PER1 YCR044C Protein of the endoplasmic reticulum physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic