Standard name Systematic name Name description Description
DMA2 YNL116W Ubiquitin-protein ligase (E3) Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication
Visualize the interactome of DMA2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 160

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.965 0.973 0.974
Mito 0.063 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DMA2 2 2 2 3 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 10 5 10 Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 4 3 3 Synthetic Lethality, Dosage Lethality, Negative Genetic, Synthetic Lethality
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 3 3 2 Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression
BNI1 YNL271C Formin genetic 3 3 2 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 3 3 2 Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression
ELM1 YKL048C Serine/threonine protein kinase genetic 3 3 2 Synthetic Lethality, Synthetic Rescue, Dosage Growth Defect
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement
DMA1 YHR115C Ubiquitin-protein ligase (E3) physical 3 2 2 Affinity Capture-MS, Biochemical Activity, Biochemical Activity
UBC13 YDR092W E2 ubiquitin-conjugating enzyme physical 2 2 2 Two-hybrid, Reconstituted Complex
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 2 2 2 Dosage Lethality, Synthetic Rescue
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 2 2 2 Synthetic Lethality, Dosage Growth Defect
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex physical 2 2 2 Affinity Capture-Western, Two-hybrid
DMA2 YNL116W Ubiquitin-protein ligase (E3) physical 2 1 2 Biochemical Activity, Biochemical Activity
NCE101 YJL205C Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 2 1 2 Negative Genetic, Negative Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 2 1 2 Negative Genetic, Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation physical 2 2 1 Affinity Capture-MS, Protein-peptide
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 2 2 1 Synthetic Rescue, Synthetic Lethality
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
BUB2 YMR055C Mitotic exit network regulator genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
SKP2 YNL311C F-box protein of unknown function physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RSF2 YJR127C Zinc-finger protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes regulation 1 1 1 DNA to cDNA expression microarray evidence
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein regulation 1 1 1 qualitative western immunoblotting evidence
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Phenotypic Suppression
BNI1 YNL271C Formin physical 1 1 1 Affinity Capture-Western
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Lethality
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Positive Genetic
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor physical 1 1 1 Two-hybrid
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Positive Genetic
CIR2 YOR356W Putative ortholog of human ETF-dH genetic 1 1 1 Positive Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Dosage Lethality
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter physical 1 1 1 Affinity Capture-MS
GDE1 YPL110C Glycerophosphocholine (GroPCho) phosphodiesterase physical 1 1 1 Affinity Capture-MS
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) physical 1 1 1 Affinity Capture-MS
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Two-hybrid
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase physical 1 1 1 Biochemical Activity
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 1 1 1 Biochemical Activity
MPS1 YDL028C Dual-specificity kinase physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
ERR1 YOR393W Putative phosphopyruvate hydratase physical 1 1 1 PCA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SHS1 YDL225W Component of the septin ring that is required for cytokinesis physical 1 1 1 Biochemical Activity
UBC5 YDR059C Ubiquitin-conjugating enzyme physical 1 1 1 Two-hybrid
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Synthetic Rescue
POG1 YIL122W DNA-binding transcriptional activator physical 1 1 1 Two-hybrid
POG1 YIL122W DNA-binding transcriptional activator genetic 1 1 1 Dosage Growth Defect
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Reconstituted Complex
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Rescue
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Synthetic Lethality
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein physical 1 1 1 Affinity Capture-Western
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein genetic 1 1 1 Synthetic Lethality
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Affinity Capture-Western
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-Western
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Synthetic Rescue
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MSK1 YNL073W Mitochondrial lysine-tRNA synthetase genetic 1 1 1 Negative Genetic
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Positive Genetic
SRY1 YKL218C 3-hydroxyaspartate dehydratase genetic 1 1 1 Negative Genetic
UFD4 YKL010C Ubiquitin-protein ligase (E3) genetic 1 1 1 Phenotypic Suppression
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Synthetic Lethality
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Positive Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Positive Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Positive Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Negative Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation genetic 1 1 1 Dosage Lethality
VHS2 YIL135C Regulator of septin dynamics genetic 1 1 1 Dosage Rescue
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Positive Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Positive Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Positive Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Positive Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Positive Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
YDR415C YDR415C Putative aminopeptidase genetic 1 1 1 Positive Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Positive Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
MEP1 YGR121C Ammonium permease genetic 1 1 1 Positive Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Positive Genetic
NGL1 YOL042W Putative endonuclease genetic 1 1 1 Positive Genetic
YOL162W YOL162W Putative protein of unknown function genetic 1 1 1 Positive Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Positive Genetic
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Positive Genetic
DSE3 YOR264W Daughter cell-specific protein, may help establish daughter fate genetic 1 1 1 Positive Genetic
YOR292C YOR292C Putative protein of unknown function genetic 1 1 1 Positive Genetic
YOR296W YOR296W Putative protein of unknown function genetic 1 1 1 Positive Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Positive Genetic
SLY41 YOR307C Protein involved in ER-to-Golgi transport genetic 1 1 1 Positive Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Positive Genetic
YOR381W-A YOR381W-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk genetic 1 1 1 Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase genetic 1 1 1 Negative Genetic
MRX14 YDR115W Putative mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SND1 YDR186C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
MCY1 YGR012W Putative cysteine synthase genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
YKR005C YKR005C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Synthetic Growth Defect
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Synthetic Growth Defect
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
HBT1 YDL223C Shmoo tip protein, substrate of Hub1p ubiquitin-like protein genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Synthetic Rescue
SYP1 YCR030C Negative regulator of WASP-Arp23 complex genetic 1 1 1 Synthetic Rescue
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Synthetic Rescue
COS111 YBR203W Protein required for antifungal drug ciclopirox olamine resistance genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Lethality
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Synthetic Rescue
ARG81 YML099C Zinc finger transcription factor involved in arginine-responsive genes genetic 1 1 1 Positive Genetic
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Positive Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Positive Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 1 1 1 Phenotypic Suppression
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Phenotypic Suppression
BNR1 YIL159W Formin physical 1 1 1 Affinity Capture-Western
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
AGP2 YBR132C Plasma membrane regulator of polyamine and carnitine transport genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 1 1 1 Positive Genetic
CHA1 YCL064C Catabolic L-serine (L-threonine) deaminase genetic 1 1 1 Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 1 1 1 Negative Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Dosage Rescue
AST2 YER101C Lipid raft associated protein genetic 1 1 1 Negative Genetic
COS12 YGL263W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Positive Genetic
COX16 YJL003W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
ALG8 YOR067C Glucosyl transferase genetic 1 1 1 Positive Genetic