RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
10 |
2 |
10 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
RAD16 |
YBR114W |
Nucleotide excision repair (NER) protein |
genetic |
8 |
3 |
7 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
5 |
2 |
5 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
RPB9 |
YGL070C |
RNA polymerase II subunit B12.6 |
genetic |
4 |
2 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
HHF1 |
YBR009C |
Histone H4 |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression |
ELC1 |
YPL046C |
Elongin C, conserved among eukaryotes |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Positive Genetic |
END3 |
YNL084C |
EH domain-containing protein involved in endocytosis |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Phenotypic Enhancement |
SPT5 |
YML010W |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Rescue |
SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CTR9 |
YOL145C |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Positive Genetic |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC33 |
YOL139C |
Translation initiation factor eIF4E |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BDF1 |
YLR399C |
BET family transcriptional regulator |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
GDI1 |
YER136W |
GDP dissociation inhibitor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAM33 |
YIL070C |
Acidic protein of the mitochondrial matrix |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
physical |
1 |
1 |
1 |
Co-crystal Structure |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Negative Genetic |
PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
physical |
1 |
1 |
1 |
Two-hybrid |
IWR1 |
YDL115C |
RNA polymerase II transport factor, conserved from yeast to humans |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NUM1 |
YDR150W |
Protein required for nuclear migration |
physical |
1 |
1 |
1 |
Two-hybrid |
PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ACO1 |
YLR304C |
Aconitase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MDH1 |
YKL085W |
Mitochondrial malate dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ACH1 |
YBL015W |
Protein with CoA transferase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
GPP1 |
YIL053W |
Constitutively expressed DL-glycerol-3-phosphate phosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
CMK1 |
YFR014C |
Calmodulin-dependent protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ECM10 |
YEL030W |
Heat shock protein of the Hsp70 family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ELA1 |
YNL230C |
Elongin A |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
BUD32 |
YGR262C |
Protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
ADH4 |
YGL256W |
Alcohol dehydrogenase isoenzyme type IV |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ERG20 |
YJL167W |
Farnesyl pyrophosphate synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ADD66 |
YKL206C |
Protein involved in 20S proteasome assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTC7 |
YHR076W |
Type 2C serine/threonine protein phosphatase (PP2C) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MAG1 |
YER142C |
3-methyl-adenine DNA glycosylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
NTG1 |
YAL015C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MEH1 |
YKR007W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BIO3 |
YNR058W |
7,8-diamino-pelargonic acid aminotransferase (DAPA) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
1 |
1 |
1 |
Co-purification |
VMA1 |
YDL185W |
Subunit A of the V1 peripheral membrane domain of V-ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VMA1 |
YDL185W |
Subunit A of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC53 |
YFL045C |
Phosphomannomutase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TIF2 |
YJL138C |
Translation initiation factor eIF4A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YSP2 |
YDR326C |
Sterol-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TEF4 |
YKL081W |
Gamma subunit of translational elongation factor eEF1B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD3 |
YER171W |
5' to 3' DNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YMR226C |
YMR226C |
NADP(+)-dependent serine dehydrogenase and carbonyl reductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
physical |
1 |
1 |
1 |
Two-hybrid |
YPL216W |
YPL216W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC8 |
YFR037C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC11 |
YDR045C |
RNA polymerase III subunit C11 |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSF1 |
YHR066W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGO1 |
YOR073W |
Component of the spindle checkpoint |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
RGP1 |
YDR137W |
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
YML119W |
YML119W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPT6 |
YLR262C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RPC53 |
YDL150W |
RNA polymerase III subunit C53 |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDR124W |
YDR124W |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF5 |
YPR041W |
Translation initiation factor eIF5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIR1 |
YKR101W |
Protein involved in silencing at mating-type loci HML and HMR |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIR3 |
YLR442C |
Silencing protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SWD1 |
YAR003W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLM5 |
YCR024C |
Mitochondrial asparaginyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RSO55 |
YLR281C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR016W |
YGR016W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
THI4 |
YGR144W |
Thiazole synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR153W |
YGR153W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUC2 |
YIL162W |
Invertase |
genetic |
1 |
1 |
1 |
Negative Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRP3 |
YKL211C |
Indole-3-glycerol-phosphate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
USA1 |
YML029W |
Scaffold subunit of the Hrd1p ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSM19 |
YNR037C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRB4 |
YER022W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ADH6 |
YMR318C |
NADPH-dependent medium chain alcohol dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MMR1 |
YLR190W |
Phosphorylated protein of the mitochondrial outer membrane |
physical |
1 |
1 |
1 |
Two-hybrid |
CLG1 |
YGL215W |
Cyclin-like protein that interacts with Pho85p |
genetic |
1 |
1 |
1 |
Negative Genetic |
QCR6 |
YFR033C |
Subunit 6 of the ubiquinol cytochrome-c reductase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRF1 |
YGR246C |
TFIIIB B-related factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
KAR2 |
YJL034W |
ATPase involved in protein import into the ER |
physical |
1 |
1 |
1 |
Two-hybrid |
RAD2 |
YGR258C |
Single-stranded DNA endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
GFD2 |
YCL036W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
APN2 |
YBL019W |
Class II abasic (AP) endonuclease involved in repair of DNA damage |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
OSW7 |
YFR039C |
Protein involved in outer spore wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
KTR2 |
YKR061W |
Mannosyltransferase involved in N-linked protein glycosylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
GTB1 |
YDR221W |
Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p |
physical |
1 |
1 |
1 |
Two-hybrid |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CUL3 |
YGR003W |
Ubiquitin-protein ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
FMP46 |
YKR049C |
Putative redox protein containing a thioredoxin fold |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHB2 |
YGR231C |
Subunit of the prohibitin complex (Phb1p-Phb2p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
GEM1 |
YAL048C |
Outer mitochondrial membrane GTPase, subunit of the ERMES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPI17 |
YDR434W |
Transmembrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTG2 |
YOL043C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
DSC3 |
YOR223W |
Subunit of the DSC ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIT2 |
YOR382W |
Mannoprotein that is incorporated into the cell wall |
genetic |
1 |
1 |
1 |
Negative Genetic |
EDC1 |
YGL222C |
RNA-binding protein that activates mRNA decapping directly |
genetic |
1 |
1 |
1 |
Positive Genetic |
DSC2 |
YOL073C |
Multi-transmembrane subunit of the DSC ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDL2 |
YPL270W |
Mitochondrial inner membrane half-type ABC transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCT1 |
YOR221C |
Predicted malonyl-CoA:ACP transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LST4 |
YKL176C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
1 |
1 |
1 |
Negative Genetic |