Standard name Systematic name Name description Description
ADD66 YKL206C Protein involved in 20S proteasome assembly Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
Visualize the interactome of ADD66
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.899 0.964 0.985

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ADD66 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 6 2 5 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PBA1 YLR199C Protein involved in 20S proteasome assembly physical 5 4 4 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome physical 4 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 2 2 Negative Genetic, Positive Genetic
TMA17 YDL110C Regulatory gamma subunit of fatty acid synthase (FAS) genetic 2 1 2 Negative Genetic, Negative Genetic
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 2 1 2 Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 2 Positive Genetic, Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 2 Positive Genetic, Positive Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily physical 1 1 1 Affinity Capture-MS
PBA1 YLR199C Protein involved in 20S proteasome assembly genetic 1 1 1 Negative Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
TOS3 YGL179C Protein kinase physical 1 1 1 Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
PUP1 YOR157C Beta 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-Western
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome physical 1 1 1 Co-fractionation
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 1 1 1 Co-fractionation
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Biochemical Activity
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Rescue
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Positive Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Positive Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Positive Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Synthetic Growth Defect
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Positive Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
LTO1 YNL260C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Positive Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Positive Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Positive Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Positive Genetic
MRPL19 YNL185C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NOP7 YGR103W Component of several different pre-ribosomal particles genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
RRP3 YHR065C Protein involved in rRNA processing genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
YBL100W-C YBL100W-C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MRPL32 YCR003W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RSM28 YDR494W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
YEA4 YEL004W Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter genetic 1 1 1 Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Negative Genetic
YFL064C YFL064C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ULI1 YFR026C Protein of unknown function genetic 1 1 1 Negative Genetic
YGL242C YGL242C Protein of unknown function genetic 1 1 1 Negative Genetic
YIL161W YIL161W Putative protein of unknown function genetic 1 1 1 Negative Genetic
CBP1 YJL209W Mitochondrial protein, regulator of COB mRNA stability and translation genetic 1 1 1 Negative Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Negative Genetic
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A genetic 1 1 1 Negative Genetic
ATS1 YAL020C Protein required for modification of wobble nucleosides in tRNA genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
CLB3 YDL155W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
ALK1 YGL021W Atypical protein kinase genetic 1 1 1 Negative Genetic
EMC4 YGL231C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL26B YGR034W Ribosomal 60S subunit protein L26B genetic 1 1 1 Negative Genetic
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Negative Genetic
RPL24B YGR148C Ribosomal 60S subunit protein L24B genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
EFM1 YHL039W Lysine methyltransferase genetic 1 1 1 Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Negative Genetic
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
YJR098C YJR098C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
DAL80 YKR034W Negative regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
EXG1 YLR300W Major exo-1,3-beta-glucanase of the cell wall genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
PYP1 YNL010W Sugar alcohol phosphatase genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
YNL115C YNL115C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOL013W-A YOL013W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
LEU9 YOR108W Alpha-isopropylmalate synthase II (2-isopropylmalate synthase) genetic 1 1 1 Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
RFM1 YOR279C Component of the Sum1p-Rfm1p-Hst1p complex genetic 1 1 1 Negative Genetic
DBP1 YPL119C ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
MRI1 YPR118W 5'-methylthioribose-1-phosphate isomerase genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
COX19 YLL018C-A Protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
YLR225C YLR225C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPC2 YML055W Subunit of signal peptidase complex genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
PUL4 YNR063W Putative zinc-cluster transcription factor genetic 1 1 1 Negative Genetic
YPL113C YPL113C Glyoxylate reductase genetic 1 1 1 Negative Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Negative Genetic
YPR108W-A YPR108W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Positive Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Positive Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic