Standard name Systematic name Name description Description
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
Visualize the interactome of HCS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.996 0.987 0.98

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 1040

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HCS1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 2 2 Phenotypic Suppression, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Positive Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Negative Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
DUG1 YFR044C Cys-Gly metallo-di-peptidase genetic 1 1 1 Negative Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles genetic 1 1 1 Positive Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 1 1 1 Negative Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Positive Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Negative Genetic
FPK1 YNR047W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
FUB1 YCR076C Proteasome-binding protein genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
ECM19 YLR390W Protein of unknown function genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Positive Genetic
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis physical 1 1 1 Two-hybrid
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 1 1 1 Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Positive Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Positive Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Positive Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Positive Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Positive Genetic
YJR098C YJR098C Putative protein of unknown function genetic 1 1 1 Positive Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Positive Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Positive Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Positive Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Positive Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Positive Genetic
MET6 YER091C Cobalamin-independent methionine synthase genetic 1 1 1 Positive Genetic
MET13 YGL125W Major isozyme of methylenetetrahydrofolate reductase genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Positive Genetic
SMT1 YJL147C Translational repressor of the mitochondrial ATP6/8 mRNA genetic 1 1 1 Positive Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Positive Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Positive Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Positive Genetic
SNU13 YEL026W RNA binding protein genetic 1 1 1 Negative Genetic
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Negative Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
YDR210W YDR210W Predicted tail-anchored plasma membrane protein genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Negative Genetic
SXM1 YDR395W Nuclear transport factor (karyopherin) genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
IRC4 YDR540C Protein similar to bacterial secreted DfsB proteins genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SPO13 YHR014W Meiotic regulator genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
YIL092W YIL092W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIR042C YIR042C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 1 1 1 Negative Genetic
RPS18B YML026C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
IOC4 YMR044W Member of a complex (Isw1b) with Isw1p and Ioc2p genetic 1 1 1 Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
MRPL44 YMR225C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
PBI2 YNL015W Cytosolic inhibitor of vacuolar proteinase B (PRB1) genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
HUT1 YPL244C Protein with a role in UDP-galactose transport to the Golgi lumen genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
ICT1 YLR099C Lysophosphatidic acid acyltransferase genetic 1 1 1 Negative Genetic
RPL18B YNL301C Ribosomal 60S subunit protein L18B genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YOR034C-A YOR034C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPL077C YPL077C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPR172W YPR172W Protein of unknown function genetic 1 1 1 Negative Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
DPC29 YGR021W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Positive Genetic
FCY1 YPR062W Cytosine deaminase genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
CWH43 YCR017C GPI lipid remodelase genetic 1 1 1 Negative Genetic
ALO1 YML086C D-Arabinono-1,4-lactone oxidase genetic 1 1 1 Positive Genetic
AIM6 YDL237W Protein of unknown function genetic 1 1 1 Negative Genetic