BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
physical |
14 |
6 |
13 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Biochemical Activity, Two-hybrid, Two-hybrid, PCA, Affinity Capture-MS, PCA, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
RAS2 |
YNL098C |
GTP-binding protein |
genetic |
9 |
3 |
8 |
Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression |
YAK1 |
YJL141C |
Serine-threonine protein kinase |
physical |
8 |
4 |
4 |
Biochemical Activity, Two-hybrid, Two-hybrid, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity |
TPK2 |
YPL203W |
cAMP-dependent protein kinase catalytic subunit |
genetic |
7 |
4 |
7 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Lethality, Phenotypic Enhancement |
TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
7 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Suppression, Synthetic Lethality, Negative Genetic, Negative Genetic |
NTH1 |
YDR001C |
Neutral trehalase, degrades trehalose |
physical |
7 |
2 |
6 |
Biochemical Activity, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity |
CDC25 |
YLR310C |
Membrane bound guanine nucleotide exchange factor |
physical |
7 |
3 |
3 |
Affinity Capture-Western, Biochemical Activity, Two-hybrid, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity |
RAS1 |
YOR101W |
GTPase involved in G-protein signaling in adenylate cyclase activation |
genetic |
5 |
2 |
5 |
Synthetic Rescue, Dosage Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue |
TPK2 |
YPL203W |
cAMP-dependent protein kinase catalytic subunit |
physical |
5 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS |
CDC19 |
YAL038W |
Pyruvate kinase |
physical |
5 |
2 |
4 |
Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Biochemical Activity |
BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
4 |
4 |
4 |
Dosage Rescue, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement |
TPK1 |
YJL164C |
cAMP-dependent protein kinase catalytic subunit |
physical |
4 |
2 |
4 |
PCA, PCA, PCA, Biochemical Activity |
TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
physical |
4 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS |
TRM2 |
YKR056W |
tRNA methyltransferase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
FAR3 |
YMR052W |
Protein of unknown function |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
EDS1 |
YBR033W |
Putative zinc cluster protein, predicted to be a transcription factor |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PKH1 |
YDR490C |
Serine/threonine protein kinase |
physical |
4 |
3 |
2 |
Reconstituted Complex, Biochemical Activity, Biochemical Activity, Affinity Capture-Western |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
3 |
2 |
3 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
MDS3 |
YGL197W |
Putative component of the TOR regulatory pathway |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
VMA1 |
YDL185W |
Subunit A of the V1 peripheral membrane domain of V-ATPase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
YSA1 |
YBR111C |
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
YDL186W |
YDL186W |
Putative protein of unknown function |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
HBT1 |
YDL223C |
Shmoo tip protein, substrate of Hub1p ubiquitin-like protein |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
CKI1 |
YLR133W |
Choline kinase |
physical |
3 |
3 |
2 |
Biochemical Activity, Affinity Capture-Western, Two-hybrid |
CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Biochemical Activity, Biochemical Activity |
PYK2 |
YOR347C |
Pyruvate kinase |
physical |
3 |
2 |
2 |
Biochemical Activity, Reconstituted Complex, Biochemical Activity |
HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
physical |
2 |
2 |
2 |
Biochemical Activity, PCA |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
YMR196W |
YMR196W |
Putative protein of unknown function |
physical |
2 |
2 |
2 |
Biochemical Activity, Affinity Capture-MS |
YAK1 |
YJL141C |
Serine-threonine protein kinase |
genetic |
2 |
2 |
2 |
Dosage Rescue, Synthetic Rescue |
RIM15 |
YFL033C |
Protein kinase involved in cell proliferation in response to nutrients |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Two-hybrid |
GSF2 |
YML048W |
Endoplasmic reticulum (ER) localized integral membrane protein |
physical |
2 |
2 |
2 |
Biochemical Activity, Reconstituted Complex |
MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CYR1 |
YJL005W |
Adenylate cyclase |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
CDC25 |
YLR310C |
Membrane bound guanine nucleotide exchange factor |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TOM22 |
YNL131W |
Component of the TOM (Translocase of Outer Membrane) complex |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
SSO1 |
YPL232W |
Plasma membrane t-SNARE |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
TOM70 |
YNL121C |
Component of the TOM (translocase of outer membrane) complex |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
DOT6 |
YER088C |
Protein involved in rRNA and ribosome biogenesis |
physical |
2 |
2 |
1 |
Two-hybrid, Biochemical Activity |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
2 |
1 |
Dosage Rescue, Phenotypic Suppression |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
GEM1 |
YAL048C |
Outer mitochondrial membrane GTPase, subunit of the ERMES complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SUA7 |
YPR086W |
Transcription factor TFIIB |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
NEJ1 |
YLR265C |
DNA end-binding protein required for nonhomologous end joining (NHEJ) |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
physical |
1 |
1 |
1 |
Biochemical Activity |
LEO1 |
YOR123C |
Component of the Paf1 complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB2 |
YOR151C |
RNA polymerase II second largest subunit B150 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TFG1 |
YGR186W |
TFIIF (Transcription Factor II) largest subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SDS22 |
YKL193C |
Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p |
physical |
1 |
1 |
1 |
Biochemical Activity |
HSP60 |
YLR259C |
Tetradecameric mitochondrial chaperonin |
physical |
1 |
1 |
1 |
Biochemical Activity |
DRS1 |
YLL008W |
Nucleolar DEAD-box protein required for ribosome assembly and function |
physical |
1 |
1 |
1 |
Biochemical Activity |
HAS1 |
YMR290C |
ATP-dependent RNA helicase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ECM2 |
YBR065C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTR2 |
YKR022C |
Essential protein that forms a dimer with Ntr1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
physical |
1 |
1 |
1 |
Biochemical Activity |
ARC1 |
YGL105W |
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases |
physical |
1 |
1 |
1 |
Biochemical Activity |
NSR1 |
YGR159C |
Nucleolin, nucleolar protein that binds nuclear localization sequences |
physical |
1 |
1 |
1 |
Biochemical Activity |
RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
physical |
1 |
1 |
1 |
Biochemical Activity |
HCA4 |
YJL033W |
DEAD box RNA helicase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB4 |
YJL140W |
RNA polymerase II subunit B32 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPB7 |
YDR404C |
RNA polymerase II subunit B16 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPB7 |
YDR404C |
RNA polymerase II subunit B16 |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD11 |
YER025W |
Gamma subunit of the translation initiation factor eIF2 |
physical |
1 |
1 |
1 |
Reconstituted Complex |
RSC8 |
YFR037C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
physical |
1 |
1 |
1 |
Biochemical Activity |
NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
physical |
1 |
1 |
1 |
Biochemical Activity |
REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPN2 |
YIL075C |
Subunit of the 26S proteasome |
physical |
1 |
1 |
1 |
Biochemical Activity |
HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Biochemical Activity |
NIP1 |
YMR309C |
eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
1 |
1 |
1 |
Biochemical Activity |
SSD1 |
YDR293C |
Translational repressor |
physical |
1 |
1 |
1 |
Biochemical Activity |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
LHP1 |
YDL051W |
RNA binding protein required for maturation of tRNA and U6 snRNA |
physical |
1 |
1 |
1 |
Biochemical Activity |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
physical |
1 |
1 |
1 |
Biochemical Activity |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
physical |
1 |
1 |
1 |
Biochemical Activity |
BMH2 |
YDR099W |
14-3-3 protein, minor isoform |
genetic |
1 |
1 |
1 |
Dosage Rescue |
BOI2 |
YER114C |
Protein involved in polar growth |
physical |
1 |
1 |
1 |
Two-hybrid |
SDA1 |
YGR245C |
Protein required for actin organization and passage through Start |
genetic |
1 |
1 |
1 |
Negative Genetic |
IPI3 |
YNL182C |
Component of the Rix1 complex and pre-replicative complexes (pre-RCs) |
physical |
1 |
1 |
1 |
Biochemical Activity |
CNS1 |
YBR155W |
TPR-containing co-chaperone |
physical |
1 |
1 |
1 |
Biochemical Activity |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
physical |
1 |
1 |
1 |
Biochemical Activity |
BDF2 |
YDL070W |
Protein involved in transcription initiation |
physical |
1 |
1 |
1 |
Biochemical Activity |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MRPL10 |
YNL284C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUD3 |
YCL014W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
physical |
1 |
1 |
1 |
Biochemical Activity |
MRPL24 |
YMR193W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
GEP3 |
YOR205C |
Protein required for mitochondrial ribosome small subunit biogenesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Dosage Rescue |
MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Dosage Lethality |
ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
physical |
1 |
1 |
1 |
Biochemical Activity |
NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PFK1 |
YGR240C |
Alpha subunit of heterooctameric phosphofructokinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRP6 |
YBR055C |
Splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Biochemical Activity |
RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL6 |
YHR147C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPB10 |
YOR210W |
RNA polymerase subunit ABC10-beta |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
DBP2 |
YNL112W |
ATP-dependent RNA helicase of the DEAD-box protein family |
physical |
1 |
1 |
1 |
Biochemical Activity |
MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
physical |
1 |
1 |
1 |
Biochemical Activity |
SEC13 |
YLR208W |
Structural component of 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC62 |
YPL094C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOS4 |
YIL112W |
Subunit of the Set3 complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
AVT4 |
YNL101W |
Vacuolar transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
BSP1 |
YPR171W |
Adapter that links synaptojanins to the cortical actin cytoskeleton |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMD2 |
YLR275W |
Core Sm protein Sm D2 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SMX2 |
YFL017W-A |
Core Sm protein Sm G |
physical |
1 |
1 |
1 |
Biochemical Activity |
GAL83 |
YER027C |
One of three alternate beta-subunits of the Snf1 kinase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SCP160 |
YJL080C |
Essential RNA-binding G protein effector of mating response pathway |
physical |
1 |
1 |
1 |
Biochemical Activity |
SUI3 |
YPL237W |
Beta subunit of the translation initiation factor eIF2 |
physical |
1 |
1 |
1 |
Reconstituted Complex |
ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
physical |
1 |
1 |
1 |
Biochemical Activity |
TIF5 |
YPR041W |
Translation initiation factor eIF5 |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SPT5 |
YML010W |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOA1 |
YOR194C |
TFIIA large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGC1 |
YPR115W |
Putative regulator of the Fps1p glycerol channel |
physical |
1 |
1 |
1 |
Biochemical Activity |
TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
physical |
1 |
1 |
1 |
Biochemical Activity |
TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
physical |
1 |
1 |
1 |
Biochemical Activity |
CMS1 |
YLR003C |
Putative subunit of the 90S preribosome processome complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
LAP2 |
YNL045W |
Leucyl aminopeptidase yscIV with epoxide hydrolase activity |
physical |
1 |
1 |
1 |
Biochemical Activity |
NOB1 |
YOR056C |
Protein involved in proteasomal and 40S ribosomal subunit biogenesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
EDC3 |
YEL015W |
Non-essential conserved protein with a role in mRNA decapping |
physical |
1 |
1 |
1 |
Biochemical Activity |
GPH1 |
YPR160W |
Glycogen phosphorylase required for the mobilization of glycogen |
physical |
1 |
1 |
1 |
Biochemical Activity |
MSD1 |
YPL104W |
Mitochondrial aspartyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
physical |
1 |
1 |
1 |
Biochemical Activity |
FET4 |
YMR319C |
Low-affinity Fe(II) transporter of the plasma membrane |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IRA2 |
YOL081W |
GTPase-activating protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
VPS13 |
YLL040C |
Lipid transport protein involved in prospore membrane morphogenesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YPT53 |
YNL093W |
Stress-induced Rab family GTPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
URN1 |
YPR152C |
Protein of unknown function containing WW and FF domains |
physical |
1 |
1 |
1 |
Biochemical Activity |
YPL077C |
YPL077C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
YJL218W |
YJL218W |
Mitochondrial protein, putative acetyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YGR038C-A |
YGR038C-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
YDR239C |
YDR239C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
YHR214C-C |
YHR214C-C |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBP15 |
YMR304W |
Ubiquitin-specific protease involved in protein deubiquitination |
physical |
1 |
1 |
1 |
Biochemical Activity |
YPK3 |
YBR028C |
AGC kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBP10 |
YNL186W |
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties |
physical |
1 |
1 |
1 |
Biochemical Activity |
YBL055C |
YBL055C |
3'-->5' exonuclease and endonuclease with a possible role in apoptosis |
physical |
1 |
1 |
1 |
Biochemical Activity |
YRR1 |
YOR162C |
Zn2-Cys6 zinc-finger transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
YLR410W-A |
YLR410W-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
UTP7 |
YER082C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBP6 |
YFR010W |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBX4 |
YMR067C |
UBX domain-containing protein that interacts with Cdc48p |
physical |
1 |
1 |
1 |
Biochemical Activity |
VHS3 |
YOR054C |
Negative regulatory subunit of protein phosphatase 1 Ppz1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
YCR016W |
YCR016W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBP7 |
YIL156W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
physical |
1 |
1 |
1 |
Biochemical Activity |
WHI5 |
YOR083W |
Repressor of G1 transcription |
physical |
1 |
1 |
1 |
Biochemical Activity |
UBP9 |
YER098W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
physical |
1 |
1 |
1 |
Biochemical Activity |
TRM1 |
YDR120C |
tRNA methyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YML037C |
YML037C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
YPR137C-A |
YPR137C-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
YGR130C |
YGR130C |
Component of the eisosome with unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
YML045W-A |
YML045W-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
YPL257W-A |
YPL257W-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
YLR345W |
YLR345W |
Similar to 6-phosphofructo-2-kinase enzymes |
physical |
1 |
1 |
1 |
Biochemical Activity |
VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YHB1 |
YGR234W |
Nitric oxide oxidoreductase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YMR099C |
YMR099C |
Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase) |
physical |
1 |
1 |
1 |
Biochemical Activity |
YPT35 |
YHR105W |
Endosomal protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
UTR1 |
YJR049C |
ATP-NADH kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YER010C |
YER010C |
Bifunctional HMG aldolase/oxaloacetate decarboxylase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ZRG17 |
YNR039C |
Endoplasmic reticulum zinc transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
YGR266W |
YGR266W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
VHS2 |
YIL135C |
Regulator of septin dynamics |
physical |
1 |
1 |
1 |
Biochemical Activity |
YJL070C |
YJL070C |
Putative metallo-dependent hydrolase superfamily protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
TPO1 |
YLL028W |
Polyamine transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
Biochemical Activity |
YGR210C |
YGR210C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
YIG1 |
YPL201C |
Protein that interacts with glycerol 3-phosphatase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
WHI3 |
YNL197C |
RNA binding protein that modulates mRNA stability |
physical |
1 |
1 |
1 |
Biochemical Activity |
TSA1 |
YML028W |
Thioredoxin peroxidase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBP14 |
YBR058C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
XKS1 |
YGR194C |
Xylulokinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA13 |
YPR036W |
Subunit H of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RIM15 |
YFL033C |
Protein kinase involved in cell proliferation in response to nutrients |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FOL2 |
YGR267C |
GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
physical |
1 |
1 |
1 |
Biochemical Activity |
RTK1 |
YDL025C |
Putative protein kinase, potentially phosphorylated by Cdc28p |
physical |
1 |
1 |
1 |
Biochemical Activity |
KIN1 |
YDR122W |
S/T protein kinase |
physical |
1 |
1 |
1 |
PCA |
DPS1 |
YLL018C |
Aspartyl-tRNA synthetase, primarily cytoplasmic |
physical |
1 |
1 |
1 |
Biochemical Activity |
PBS2 |
YJL128C |
MAP kinase kinase of the HOG signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LCP5 |
YER127W |
Essential protein involved in maturation of 18S rRNA |
physical |
1 |
1 |
1 |
Biochemical Activity |
CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Positive Genetic |
SUI2 |
YJR007W |
Alpha subunit of the translation initiation factor eIF2 |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CBK1 |
YNL161W |
Serine/threonine protein kinase of the the RAM signaling network |
genetic |
1 |
1 |
1 |
Dosage Rescue |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
LAF1 |
YMR102C |
Sterol-binding beta-propeller protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
GIP2 |
YER054C |
Putative regulatory subunit of protein phosphatase Glc7p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PDS1 |
YDR113C |
Securin |
physical |
1 |
1 |
1 |
Biochemical Activity |
CAT5 |
YOR125C |
Protein required for ubiquinone (Coenzyme Q) biosynthesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARE2 |
YNR019W |
Acyl-CoA:sterol acyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
physical |
1 |
1 |
1 |
Biochemical Activity |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ERG20 |
YJL167W |
Farnesyl pyrophosphate synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADD66 |
YKL206C |
Protein involved in 20S proteasome assembly |
physical |
1 |
1 |
1 |
Biochemical Activity |
SHE3 |
YBR130C |
Protein adaptor between Myo4p and the She2p-mRNA complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
RAS2 |
YNL098C |
GTP-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
SLT2 |
YHR030C |
Serine/threonine MAP kinase |
physical |
1 |
1 |
1 |
PCA |
SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
KSS1 |
YGR040W |
Mitogen-activated protein kinase (MAPK) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
PGM1 |
YKL127W |
Phosphoglucomutase, minor isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
ICP55 |
YER078C |
Mitochondrial aminopeptidase |
physical |
1 |
1 |
1 |
Biochemical Activity |
NOP53 |
YPL146C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
physical |
1 |
1 |
1 |
Biochemical Activity |
SKT5 |
YBL061C |
Activator of Chs3p (chitin synthase III) during vegetative growth |
physical |
1 |
1 |
1 |
Biochemical Activity |
NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Biochemical Activity |
GCR2 |
YNL199C |
Transcriptional activator of genes involved in glycolysis |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOM2 |
YDR158W |
Aspartic beta semi-aldehyde dehydrogenase |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
IGO1 |
YNL157W |
Protein required for initiation of G0 program |
physical |
1 |
1 |
1 |
Biochemical Activity |
JJJ1 |
YNL227C |
Co-chaperone that stimulates the ATPase activity of Ssa1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
APL4 |
YPR029C |
Gamma-adaptin |
physical |
1 |
1 |
1 |
Biochemical Activity |
DCK1 |
YLR422W |
Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 |
genetic |
1 |
1 |
1 |
Positive Genetic |
FZF1 |
YGL254W |
Transcription factor involved in sulfite metabolism |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRS1 |
YKL181W |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
physical |
1 |
1 |
1 |
Biochemical Activity |
LAC1 |
YKL008C |
Ceramide synthase component |
physical |
1 |
1 |
1 |
Biochemical Activity |
ALR1 |
YOL130W |
Plasma membrane Mg(2+) transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
GZF3 |
YJL110C |
GATA zinc finger protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
GZF3 |
YJL110C |
GATA zinc finger protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALY2 |
YJL084C |
Alpha arrestin, Ub-ligase adaptor for Rsp5p |
physical |
1 |
1 |
1 |
Biochemical Activity |
DON1 |
YDR273W |
Meiosis-specific component of the spindle pole body |
physical |
1 |
1 |
1 |
Biochemical Activity |
AIM3 |
YBR108W |
Protein that inhibits barbed-end actin filament elongation |
physical |
1 |
1 |
1 |
Biochemical Activity |
RMD1 |
YDL001W |
Cytoplasmic protein required for sporulation |
physical |
1 |
1 |
1 |
Biochemical Activity |
NBA1 |
YOL070C |
Protein involved in axial bud site selection |
physical |
1 |
1 |
1 |
Biochemical Activity |
CHA4 |
YLR098C |
DNA binding transcriptional activator |
physical |
1 |
1 |
1 |
Biochemical Activity |
CHA4 |
YLR098C |
DNA binding transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
FMP16 |
YDR070C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
PEF1 |
YGR058W |
Penta-EF-hand protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
AKR2 |
YOR034C |
Ankyrin repeat-containing protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SER33 |
YIL074C |
3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRR1 |
YKL116C |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRR1 |
YKL116C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MGL2 |
YMR210W |
Monoacylglycerol and triacylglycerol lipase |
physical |
1 |
1 |
1 |
Biochemical Activity |
BLI1 |
YKL061W |
Subunit of the BLOC-1 complex involved in endosomal maturation |
physical |
1 |
1 |
1 |
Biochemical Activity |
DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Dosage Lethality |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SKO1 |
YNL167C |
Basic leucine zipper transcription factor of the ATF/CREB family |
physical |
1 |
1 |
1 |
Biochemical Activity |
TAF4 |
YMR005W |
TFIID subunit (48 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGT1 |
YKL038W |
Glucose-responsive transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
PHO4 |
YFR034C |
Basic helix-loop-helix (bHLH) transcription factor of the myc-family |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPS11A |
YDR025W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Biochemical Activity |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BNI5 |
YNL166C |
Linker protein responsible for recruitment of myosin to the bud neck |
physical |
1 |
1 |
1 |
Biochemical Activity |
MCM3 |
YEL032W |
Protein involved in DNA replication |
physical |
1 |
1 |
1 |
Biochemical Activity |
MTH1 |
YDR277C |
Negative regulator of the glucose-sensing signal transduction pathway |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NRG1 |
YDR043C |
Transcriptional repressor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIP5 |
YMR140W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOM40 |
YMR203W |
Component of the TOM (translocase of outer membrane) complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
DPH2 |
YKL191W |
Protein required for synthesis of diphthamide |
physical |
1 |
1 |
1 |
Biochemical Activity |
GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Dosage Rescue |
MBF1 |
YOR298C-A |
Transcriptional coactivator |
genetic |
1 |
1 |
1 |
Positive Genetic |
BAG7 |
YOR134W |
Rho GTPase activating protein (RhoGAP) |
physical |
1 |
1 |
1 |
Biochemical Activity |
GAP1 |
YKR039W |
General amino acid permease |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
physical |
1 |
1 |
1 |
Biochemical Activity |
SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
physical |
1 |
1 |
1 |
Biochemical Activity |
SCO1 |
YBR037C |
Copper-binding protein of mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUD6 |
YLR319C |
Actin- and formin-interacting protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
GPB2 |
YAL056W |
Multistep regulator of cAMP-PKA signaling |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GSY2 |
YLR258W |
Glycogen synthase |
physical |
1 |
1 |
1 |
Biochemical Activity |
GTS1 |
YGL181W |
Protein involved in Arf3p regulation and in transcription regulation |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
ALY1 |
YKR021W |
Alpha arrestin, substrate of calcineurin |
physical |
1 |
1 |
1 |
Biochemical Activity |
GIC2 |
YDR309C |
Rho-family GTPase interacting protein and Cdc42p effector |
physical |
1 |
1 |
1 |
Biochemical Activity |
GIC2 |
YDR309C |
Rho-family GTPase interacting protein and Cdc42p effector |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
NNK1 |
YKL171W |
Protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
RGA2 |
YDR379W |
GTPase-activating protein for polarity-establishment protein Cdc42p |
physical |
1 |
1 |
1 |
Biochemical Activity |
IVY1 |
YDR229W |
Phospholipid-binding protein that interacts with both Ypt7p and Vps33p |
physical |
1 |
1 |
1 |
Biochemical Activity |
HRI1 |
YLR301W |
Protein of unknown function that interacts with Sec72p and Hrr25p |
physical |
1 |
1 |
1 |
Biochemical Activity |
SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
physical |
1 |
1 |
1 |
Biochemical Activity |
OSH3 |
YHR073W |
Member of an oxysterol-binding protein family |
physical |
1 |
1 |
1 |
Biochemical Activity |
MGA1 |
YGR249W |
Protein similar to heat shock transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
AZF1 |
YOR113W |
Zinc-finger transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
GAT1 |
YFL021W |
Transcriptional activator of nitrogen catabolite repression genes |
genetic |
1 |
1 |
1 |
Dosage Rescue |
HSV2 |
YGR223C |
Phosphatidylinositol 3,5-bisphosphate-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
TIF3 |
YPR163C |
Translation initiation factor eIF-4B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
STM1 |
YLR150W |
Protein required for optimal translation under nutrient stress |
physical |
1 |
1 |
1 |
Biochemical Activity |
ENT5 |
YDR153C |
Protein containing an N-terminal epsin-like domain |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPL11A |
YPR102C |
Ribosomal 60S subunit protein L11A |
genetic |
1 |
1 |
1 |
Negative Genetic |
HBT1 |
YDL223C |
Shmoo tip protein, substrate of Hub1p ubiquitin-like protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
SRP101 |
YDR292C |
Signal recognition particle (SRP) receptor alpha subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
PXL1 |
YKR090W |
Protein that localizes to sites of polarized growth |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLO8 |
YER109C |
Transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
FOX2 |
YKR009C |
3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
physical |
1 |
1 |
1 |
Biochemical Activity |
IDS2 |
YJL146W |
Protein involved in modulation of Ime2p activity during meiosis |
physical |
1 |
1 |
1 |
Biochemical Activity |
HBS1 |
YKR084C |
GTPase with similarity to translation release factors |
physical |
1 |
1 |
1 |
Biochemical Activity |
BUG1 |
YDL099W |
Cis-golgi localized protein involved in ER to Golgi transport |
physical |
1 |
1 |
1 |
Biochemical Activity |
APM2 |
YHL019C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
FRA1 |
YLL029W |
Protein involved in negative regulation of iron regulon transcription |
physical |
1 |
1 |
1 |
Biochemical Activity |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CST26 |
YBR042C |
Acyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ESBP6 |
YNL125C |
Protein with similarity to monocarboxylate permeases |
physical |
1 |
1 |
1 |
Biochemical Activity |
STE7 |
YDL159W |
Signal transducing MAP kinase kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RPL40B |
YKR094C |
Ubiquitin-ribosomal 60S subunit protein L40B fusion protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
PAH1 |
YMR165C |
Mg2+-dependent phosphatidate (PA) phosphatase |
physical |
1 |
1 |
1 |
Biochemical Activity |
MAP1 |
YLR244C |
Methionine aminopeptidase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SAT4 |
YCR008W |
Ser/Thr protein kinase involved in salt tolerance, nutrient response |
physical |
1 |
1 |
1 |
Biochemical Activity |
SOL2 |
YCR073W-A |
Protein with a possible role in tRNA export |
physical |
1 |
1 |
1 |
Biochemical Activity |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHR1 |
YOR386W |
DNA photolyase involved in photoreactivation |
physical |
1 |
1 |
1 |
Biochemical Activity |
NTH1 |
YDR001C |
Neutral trehalase, degrades trehalose |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SOK1 |
YDR006C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Rescue |
AVT1 |
YJR001W |
Vacuolar transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPS10B |
YMR230W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PUF4 |
YGL014W |
Member of the PUF protein family |
physical |
1 |
1 |
1 |
Biochemical Activity |
GRX4 |
YER174C |
Glutathione-dependent oxidoreductase and glutathione S-transferase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
NPY1 |
YGL067W |
NADH diphosphatase (pyrophosphatase) |
physical |
1 |
1 |
1 |
Biochemical Activity |
MET12 |
YPL023C |
Protein with MTHFR activity in vitro |
physical |
1 |
1 |
1 |
Biochemical Activity |
PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RRP15 |
YPR143W |
Nucleolar protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
SAS10 |
YDL153C |
Subunit of U3-containing Small Subunit (SSU) processome complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
MBR1 |
YKL093W |
Protein involved in mitochondrial functions and stress response |
physical |
1 |
1 |
1 |
Biochemical Activity |
ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
physical |
1 |
1 |
1 |
Biochemical Activity |
CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
physical |
1 |
1 |
1 |
PCA |
SDO1 |
YLR022C |
Guanine nucleotide exchange factor (GEF) for Ria1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
ECM3 |
YOR092W |
Non-essential protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
CSH1 |
YBR161W |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RDS2 |
YPL133C |
Transcription factor involved in regulating gluconeogenesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
CYC7 |
YEL039C |
Cytochrome c isoform 2, expressed under hypoxic conditions |
physical |
1 |
1 |
1 |
Biochemical Activity |
PFK26 |
YIL107C |
6-phosphofructo-2-kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PHO13 |
YDL236W |
Conserved phosphatase acting as a metabolite repair enzyme |
physical |
1 |
1 |
1 |
Biochemical Activity |
STB3 |
YDR169C |
Ribosomal RNA processing element (RRPE)-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
PTH2 |
YBL057C |
One of two mitochondrially-localized peptidyl-tRNA hydrolases |
physical |
1 |
1 |
1 |
Biochemical Activity |
SYF2 |
YGR129W |
Member of the NineTeen Complex (NTC) |
physical |
1 |
1 |
1 |
Biochemical Activity |
RIM4 |
YHL024W |
Putative RNA-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
ARO3 |
YDR035W |
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
physical |
1 |
1 |
1 |
Biochemical Activity |
IGD1 |
YFR017C |
Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPS19B |
YNL302C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
ABP140 |
YOR239W |
AdoMet-dependent tRNA methyltransferase and actin binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
ALR2 |
YFL050C |
Probable Mg(2+) transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
ATG21 |
YPL100W |
Phosphoinositide binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
CMK2 |
YOL016C |
Calmodulin-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
AVT3 |
YKL146W |
Vacuolar transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
ADD37 |
YMR184W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
physical |
1 |
1 |
1 |
Biochemical Activity |
FPS1 |
YLL043W |
Aquaglyceroporin, plasma membrane channel |
physical |
1 |
1 |
1 |
Biochemical Activity |
CYC3 |
YAL039C |
Cytochrome c heme lyase (holocytochrome c synthase) |
physical |
1 |
1 |
1 |
Biochemical Activity |
IRC5 |
YFR038W |
Putative ATPase containing the DEAD/H helicase-related sequence motif |
physical |
1 |
1 |
1 |
Biochemical Activity |
MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
physical |
1 |
1 |
1 |
Biochemical Activity |
NGL3 |
YML118W |
3'-5' exonuclease specific for poly-A RNAs |
physical |
1 |
1 |
1 |
Biochemical Activity |
PHO91 |
YNR013C |
Low-affinity vacuolar phosphate transporter |
physical |
1 |
1 |
1 |
Biochemical Activity |
ENT4 |
YLL038C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
ICS2 |
YBR157C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
physical |
1 |
1 |
1 |
Biochemical Activity |
ISF1 |
YMR081C |
Serine-rich, hydrophilic protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
POX1 |
YGL205W |
Fatty-acyl coenzyme A oxidase |
physical |
1 |
1 |
1 |
Biochemical Activity |
NVJ2 |
YPR091C |
Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ) |
physical |
1 |
1 |
1 |
Biochemical Activity |
DGR2 |
YKL121W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
MNR2 |
YKL064W |
Vacuolar membrane protein required for magnesium homeostasis |
physical |
1 |
1 |
1 |
Biochemical Activity |
MLF3 |
YNL074C |
Serine-rich protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
RNH70 |
YGR276C |
3'-5' exoribonuclease |
physical |
1 |
1 |
1 |
Biochemical Activity |
RGD3 |
YHR182W |
GTPase activating protein (GAP) for Rho3p, involved in cell polarity g |
physical |
1 |
1 |
1 |
Biochemical Activity |
PIB2 |
YGL023C |
Phosphatidylinositol 3-phosphate binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
NEJ1 |
YLR265C |
DNA end-binding protein required for nonhomologous end joining (NHEJ) |
physical |
1 |
1 |
1 |
Biochemical Activity |
RUD3 |
YOR216C |
Golgi matrix protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
SSF2 |
YDR312W |
Protein required for ribosomal large subunit maturation |
physical |
1 |
1 |
1 |
Biochemical Activity |
TOM71 |
YHR117W |
Mitochondrial outer membrane protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
OTU2 |
YHL013C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
PGA2 |
YNL149C |
Essential protein required for maturation of Gas1p and Pho8p |
physical |
1 |
1 |
1 |
Biochemical Activity |
RNY1 |
YPL123C |
Vacuolar RNase of the T(2) family |
physical |
1 |
1 |
1 |
Biochemical Activity |
NMD4 |
YLR363C |
Protein that may be involved in nonsense-mediated mRNA decay |
physical |
1 |
1 |
1 |
Biochemical Activity |
RGM1 |
YMR182C |
Putative zinc finger DNA binding transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
SYG1 |
YIL047C |
Plasma membrane protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
TMA22 |
YJR014W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
SLZ1 |
YNL196C |
Sporulation-specific protein with a leucine zipper motif |
physical |
1 |
1 |
1 |
Biochemical Activity |
MPD1 |
YOR288C |
Member of the protein disulfide isomerase (PDI) family |
physical |
1 |
1 |
1 |
Biochemical Activity |
DIA1 |
YMR316W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
RKM4 |
YDR257C |
Ribosomal lysine methyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
STF2 |
YGR008C |
Protein involved in resistance to desiccation stress |
physical |
1 |
1 |
1 |
Biochemical Activity |
MIC26 |
YGR235C |
Component of the MICOS complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
SET5 |
YHR207C |
Methyltransferase involved in methylation of histone H4 Lys5, -8, -12 |
physical |
1 |
1 |
1 |
Biochemical Activity |
SKG1 |
YKR100C |
Transmembrane protein with a role in cell wall polymer composition |
physical |
1 |
1 |
1 |
Biochemical Activity |
TAG1 |
YLR173W |
Vacuolar membrane protein involved in termination of autophagy |
physical |
1 |
1 |
1 |
Biochemical Activity |
HUR1 |
YGL168W |
Protein with a role in DNA repair |
physical |
1 |
1 |
1 |
Biochemical Activity |
STR3 |
YGL184C |
Peroxisomal cystathionine beta-lyase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SNX41 |
YDR425W |
Sorting nexin |
physical |
1 |
1 |
1 |
Biochemical Activity |
LCL1 |
YPL056C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
TIP41 |
YPR040W |
Tap42p-interacting protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
PKP2 |
YGL059W |
Mitochondrial protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
QNS1 |
YHR074W |
Glutamine-dependent NAD(+) synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
CEM1 |
YER061C |
Mitochondrial beta-keto-acyl synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX23 |
YHR116W |
Protein that functions in mitochondrial copper homeostasis |
genetic |
1 |
1 |
1 |
Positive Genetic |
MDL2 |
YPL270W |
Mitochondrial inner membrane half-type ABC transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
CYT2 |
YKL087C |
Cytochrome c1 heme lyase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDE2 |
YOR360C |
High-affinity cyclic AMP phosphodiesterase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAT2 |
YOL020W |
High affinity tryptophan and tyrosine permease |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
TMA23 |
YMR269W |
Nucleolar protein implicated in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |