Standard name Systematic name Name description Description
CBK1 YNL161W Serine/threonine protein kinase of the the RAM signaling network Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
Visualize the interactome of CBK1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.152 0.160 0.155
Cell Periphery 0.440 0.249 0.262
Cort. Patches 0.424 0.320 0.296
Cytoplasm 0.352 0.544 0.519
Budsite NaN 0.059 0.078
ER NaN 0.071 NaN
SpindlePole NaN NaN 0.107

GFP localization & abundance

GFP localization GFP abundance
bud neck, cytoplasm 450

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CBK1 0 0 8 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MOB2 YFL034C-B Activator of Cbk1p kinase physical 12 5 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-crystal Structure, Co-crystal Structure, Two-hybrid, Co-purification
TAO3 YIL129C Component of the RAM signaling network physical 7 4 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, PCA, Two-hybrid
LRE1 YCL051W Protein involved in control of cell wall structure and stress response physical 7 5 4 Two-hybrid, Two-hybrid, PCA, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Co-localization
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis physical 6 3 6 Two-hybrid, Two-hybrid, Biochemical Activity, Affinity Capture-MS, Biochemical Activity, Biochemical Activity
SSD1 YDR293C Translational repressor genetic 6 4 5 Synthetic Rescue, Synthetic Rescue, Dosage Lethality, Synthetic Growth Defect, Dosage Lethality, Dosage Growth Defect
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 6 4 3 Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Protein-peptide, Affinity Capture-Western, Affinity Capture-Western
SSD1 YDR293C Translational repressor physical 5 4 4 Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Biochemical Activity, Reconstituted Complex
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 4 3 4 Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
CBK1 YNL161W Serine/threonine protein kinase of the the RAM signaling network physical 3 3 3 Two-hybrid, Reconstituted Complex, PCA
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity physical 3 2 3 Two-hybrid, Two-hybrid, Biochemical Activity
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 3 3 2 Two-hybrid, Affinity Capture-Western, Biochemical Activity
FIR1 YER032W Protein involved in 3' mRNA processing physical 3 3 2 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity
KIN2 YLR096W S/T protein kinase physical 3 2 2 Affinity Capture-MS, PCA, PCA
KIN1 YDR122W S/T protein kinase physical 3 2 2 Affinity Capture-MS, PCA, PCA
ARB1 YER036C ATPase of the ATP-binding cassette (ABC) family physical 2 2 2 Two-hybrid, Reconstituted Complex
TAO3 YIL129C Component of the RAM signaling network genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
YOL036W YOL036W Protein of unknown function physical 2 2 2 Two-hybrid, Affinity Capture-MS
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 2 2 2 Two-hybrid, Affinity Capture-MS
HYM1 YKL189W Component of the RAM signaling network genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
STE50 YCL032W Adaptor protein for various signaling pathways physical 2 1 2 Two-hybrid, Two-hybrid
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SIM1 YIL123W Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) genetic 2 1 2 Dosage Rescue, Dosage Rescue
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 2 1 2 Negative Genetic, Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis regulation 1 1 1 DNA to cDNA expression microarray evidence
FIR1 YER032W Protein involved in 3' mRNA processing regulation 1 1 1 protein kinase assay evidence
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Growth Defect
BOI2 YER114C Protein involved in polar growth physical 1 1 1 Two-hybrid
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 1 1 1 PCA
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone physical 1 1 1 Affinity Capture-MS
ECM10 YEL030W Heat shock protein of the Hsp70 family physical 1 1 1 Affinity Capture-MS
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
PRB1 YEL060C Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity physical 1 1 1 Affinity Capture-MS
GAL7 YBR018C Galactose-1-phosphate uridyl transferase physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
SEC28 YIL076W Epsilon-COP subunit of the coatomer physical 1 1 1 Affinity Capture-MS
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
LRE1 YCL051W Protein involved in control of cell wall structure and stress response genetic 1 1 1 Phenotypic Suppression
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Two-hybrid
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Synthetic Lethality
SOG2 YOR353C Key component of the RAM signaling network physical 1 1 1 Two-hybrid
SOG2 YOR353C Key component of the RAM signaling network genetic 1 1 1 Phenotypic Enhancement
STE5 YDR103W Pheromone-responsive MAPK scaffold protein physical 1 1 1 Two-hybrid
CLB3 YDL155W B-type cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
MOB1 YIL106W Component of the mitotic exit network physical 1 1 1 Two-hybrid
YIR016W YIR016W Putative protein of unknown function physical 1 1 1 Two-hybrid
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
LGE1 YPL055C Protein involved in histone H2B ubiquitination physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
FIN1 YDR130C Spindle pole body-related intermediate filament protein physical 1 1 1 Affinity Capture-Western
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Affinity Capture-MS
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E physical 1 1 1 Affinity Capture-MS
FIR1 YER032W Protein involved in 3' mRNA processing genetic 1 1 1 Phenotypic Enhancement
MRP8 YKL142W Protein of unknown function physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
ZRG8 YER033C Protein of unknown function physical 1 1 1 Affinity Capture-MS
ZRG8 YER033C Protein of unknown function genetic 1 1 1 Dosage Rescue
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase physical 1 1 1 PCA
HLR1 YDR528W Protein involved in regulation of cell wall composition and integrity physical 1 1 1 PCA
PAL1 YDR348C Protein of unknown function thought to be involved in endocytosis physical 1 1 1 PCA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 PCA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
SVL3 YPL032C Protein of unknown function physical 1 1 1 PCA
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
NBA1 YOL070C Protein involved in axial bud site selection physical 1 1 1 Reconstituted Complex
SNL1 YIL016W Ribosome-associated protein physical 1 1 1 Reconstituted Complex
SSE2 YBR169C Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family physical 1 1 1 Reconstituted Complex
TRZ1 YKR079C tRNA 3'-end processing endonuclease tRNase Z physical 1 1 1 Reconstituted Complex
WWM1 YFL010C WW domain containing protein of unknown function physical 1 1 1 Reconstituted Complex
MRX16 YDR132C Protein that associates with the large mitoribosomal subunit physical 1 1 1 Reconstituted Complex
RGI1 YER067W Protein involved in energy metabolism under respiratory conditions physical 1 1 1 Reconstituted Complex
YPT32 YGL210W Rab family GTPase involved in the exocytic pathway physical 1 1 1 Reconstituted Complex
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 1 1 1 Two-hybrid
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif physical 1 1 1 Two-hybrid
HYM1 YKL189W Component of the RAM signaling network physical 1 1 1 Two-hybrid
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 1 1 1 Affinity Capture-Western
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Dosage Rescue
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Growth Defect
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Dosage Rescue
SRL1 YOR247W Mannoprotein that exhibits a tight association with the cell wall genetic 1 1 1 Dosage Rescue
YPS1 YLR120C Aspartic protease genetic 1 1 1 Synthetic Growth Defect
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Synthetic Growth Defect
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Synthetic Growth Defect
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Growth Defect
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Synthetic Growth Defect
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Synthetic Growth Defect
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Phenotypic Enhancement
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Dosage Rescue
COG1 YGL223C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Lethality
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Lethality
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Synthetic Lethality
MNN1 YER001W Alpha-1,3-mannosyltransferase genetic 1 1 1 Dosage Rescue
MNN4 YKL201C Putative positive regulator of mannosylphosphate transferase Mnn6p genetic 1 1 1 Dosage Rescue
MNN9 YPL050C Subunit of Golgi mannosyltransferase complex genetic 1 1 1 Dosage Rescue
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Dosage Rescue
PMT3 YOR321W Protein O-mannosyltransferase genetic 1 1 1 Dosage Rescue
KTR1 YOR099W Alpha-1,2-mannosyltransferase genetic 1 1 1 Dosage Rescue
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
RPH1 YER169W JmjC domain-containing histone demethylase genetic 1 1 1 Dosage Rescue
MYO1 YHR023W Type II myosin heavy chain genetic 1 1 1 Phenotypic Suppression
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Synthetic Rescue
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Synthetic Growth Defect
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Dosage Rescue
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 1 1 1 Phenotypic Suppression
BNR1 YIL159W Formin genetic 1 1 1 Negative Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 1 1 1 Synthetic Growth Defect
AST1 YBL069W Lipid raft associated protein physical 1 1 1 Reconstituted Complex