Standard name Systematic name Name description Description
TOM40 YMR203W Component of the TOM (translocase of outer membrane) complex Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions
Visualize the interactome of TOM40
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TOM40 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 27 6 24 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Reconstituted Complex, Affinity Capture-MS
TOM20 YGR082W Component of the TOM (translocase of outer membrane) complex physical 12 3 11 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-fractionation, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex physical 8 2 8 Affinity Capture-Western, Co-fractionation, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SAM35 YHR083W Component of the sorting and assembly machinery (SAM) complex physical 7 2 4 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TIM23 YNR017W Essential component of the TIM23 complex physical 6 4 6 Co-purification, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 5 3 4 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
MIC60 YKR016W Component of the MICOS complex physical 5 3 3 Affinity Capture-Western, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-Western
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 4 3 4 Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Affinity Capture-MS
TOM5 YPR133W-A Component of the TOM (translocase of outer membrane) complex physical 4 2 4 Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western
TIM50 YPL063W Essential component of the TIM23 complex physical 3 3 3 Affinity Capture-MS, Co-fractionation, Reconstituted Complex
MDM10 YAL010C Subunit of both the ERMES and the SAM complex physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex physical 3 2 3 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
RPM2 YML091C Protein subunit of mitochondrial RNase P genetic 3 1 3 Dosage Rescue, Dosage Rescue, Dosage Rescue
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
TIM10 YHR005C-A Essential protein of the mitochondrial intermembrane space physical 2 2 2 Co-purification, Reconstituted Complex
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
TOM6 YOR045W Component of the TOM (translocase of outer membrane) complex genetic 2 2 1 Dosage Rescue, Synthetic Lethality
UGO1 YDR470C Outer membrane component of the mitochondrial fusion machinery physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-Western
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 1 1 1 Dosage Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Biochemical Activity
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
PTC5 YOR090C Mitochondrial type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Synthetic Lethality
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
PET191 YJR034W Protein required for assembly of cytochrome c oxidase physical 1 1 1 Affinity Capture-Western
PRR1 YKL116C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
TOM5 YPR133W-A Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Synthetic Growth Defect
YNK1 YKL067W Nucleoside diphosphate kinase physical 1 1 1 Reconstituted Complex
TOM40 YMR203W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Reconstituted Complex
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Growth Defect
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
TOM6 YOR045W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Affinity Capture-Western
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
XDJ1 YLR090W Chaperone with a role in facilitating mitochondrial protein import physical 1 1 1 Affinity Capture-Western
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
KTI11 YBL071W-A Zn-ribbon protein that co-purifies with Dph1 and Dph2 physical 1 1 1 Affinity Capture-MS
MIX17 YMR002W Mitochondrial intermembrane space protein physical 1 1 1 Affinity Capture-Western
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TIM21 YGR033C Nonessential component of the TIM23 complex physical 1 1 1 Affinity Capture-Western
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
PEX3 YDR329C Peroxisomal membrane protein (PMP) physical 1 1 1 PCA
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
POR2 YIL114C Putative mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-Western
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-Western
TAZ1 YPR140W Lyso-phosphatidylcholine acyltransferase physical 1 1 1 Reconstituted Complex
SCM4 YGR049W Mitochondrial outer membrane protein of unknown function physical 1 1 1 Affinity Capture-Western
SYM1 YLR251W Protein required for ethanol metabolism physical 1 1 1 Reconstituted Complex