Standard name Systematic name Name description Description
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
Visualize the interactome of TPK3
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.435 0.360 0.372
Nucleus 0.315 0.275 0.140
Vac/Vac Memb 0.500 0.557 0.491
Endosome NaN NaN 0.149

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 1590

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TPK3 1 0 0 6 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) physical 8 5 8 Affinity Capture-MS, Two-hybrid, Two-hybrid, Biochemical Activity, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 7 3 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Suppression, Synthetic Lethality, Negative Genetic, Negative Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit physical 7 3 5 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-MS
RAS2 YNL098C GTP-binding protein genetic 4 2 4 Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase genetic 3 2 3 Dosage Rescue, Dosage Rescue, Synthetic Rescue
YPK1 YKL126W S/T protein kinase genetic 3 1 3 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
PKH1 YDR490C Serine/threonine protein kinase physical 3 3 2 Affinity Capture-MS, Biochemical Activity, Affinity Capture-Western
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 2 2 Phenotypic Enhancement, Dosage Rescue
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 2 2 2 Dosage Rescue, Synthetic Rescue
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 2 2 2 Negative Genetic, Phenotypic Suppression
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p physical 2 2 2 Affinity Capture-MS, Biochemical Activity
MSN4 YKL062W Stress-responsive transcriptional activator genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
CAX4 YGR036C Dolichyl pyrophosphate (Dol-P-P) phosphatase genetic 2 2 2 Positive Genetic, Phenotypic Suppression
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
SDA1 YGR245C Protein required for actin organization and passage through Start genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 2 1 2 Negative Genetic, Negative Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 2 1 2 Negative Genetic, Negative Genetic
PRM7 YDL039C Pheromone-regulated protein genetic 2 1 2 Negative Genetic, Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
IDS2 YJL146W Protein involved in modulation of Ime2p activity during meiosis regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
CMR3 YPR013C Putative zinc finger protein genetic 2 1 1 Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing physical 1 1 1 Biochemical Activity
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 1 1 1 Two-hybrid
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
KAP123 YER110C Karyopherin beta genetic 1 1 1 Positive Genetic
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Biochemical Activity
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Reconstituted Complex
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase physical 1 1 1 Biochemical Activity
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Biochemical Activity
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Positive Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Positive Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Phenotypic Suppression
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Dosage Rescue
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Positive Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Phenotypic Suppression
ELP2 YGR200C Subunit of Elongator complex physical 1 1 1 Reconstituted Complex
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Negative Genetic
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Biochemical Activity
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor genetic 1 1 1 Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Phenotypic Enhancement
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Biochemical Activity
MAK5 YBR142W Essential nucleolar protein physical 1 1 1 Biochemical Activity
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Phenotypic Suppression
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Phenotypic Suppression
MRPL7 YDR237W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Biochemical Activity
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Dosage Lethality
INO80 YGL150C Nucleosome spacing factor genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Biochemical Activity
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Dosage Growth Defect
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Phenotypic Suppression
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Biochemical Activity
ADE57 YGL234W Bifunctional enzyme of 'de novo' purine nucleotide pathway physical 1 1 1 Affinity Capture-MS
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes physical 1 1 1 Biochemical Activity
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
RPP2B YDR382W Ribosomal protein P2 beta physical 1 1 1 Biochemical Activity
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Dosage Rescue
HRK1 YOR267C Protein kinase genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
SPP1 YPL138C Subunit of COMPASS (Set1C) physical 1 1 1 Biochemical Activity
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p genetic 1 1 1 Phenotypic Suppression
CMS1 YLR003C Putative subunit of the 90S preribosome processome complex physical 1 1 1 Reconstituted Complex
AKL1 YBR059C Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 1 1 1 Phenotypic Suppression
IRA2 YOL081W GTPase-activating protein physical 1 1 1 Biochemical Activity
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Synthetic Rescue
ATG29 YPL166W Autophagy-specific protein physical 1 1 1 Biochemical Activity
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SES1 YDR023W Cytosolic seryl-tRNA synthetase physical 1 1 1 Biochemical Activity
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 1 1 1 Negative Genetic
GIP2 YER054C Putative regulatory subunit of protein phosphatase Glc7p physical 1 1 1 Affinity Capture-MS
GDB1 YPR184W Glycogen debranching enzyme genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Biochemical Activity
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Biochemical Activity
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 1 1 1 Phenotypic Suppression
EMI2 YDR516C Hexokinase expressed during growth with low glucose levels genetic 1 1 1 Negative Genetic
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Biochemical Activity
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Phenotypic Suppression
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 1 1 1 Positive Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
NOP53 YPL146C Nucleolar protein physical 1 1 1 Biochemical Activity
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Affinity Capture-MS
YPT53 YNL093W Stress-induced Rab family GTPase physical 1 1 1 Affinity Capture-MS
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-MS
YHR033W YHR033W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Two-hybrid
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase physical 1 1 1 Biochemical Activity
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) physical 1 1 1 Biochemical Activity
VAM10 YOR068C Protein involved in vacuole morphogenesis physical 1 1 1 Biochemical Activity
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 1 1 1 Biochemical Activity
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p physical 1 1 1 Biochemical Activity
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex physical 1 1 1 Biochemical Activity
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Biochemical Activity
ZUO1 YGR285C Ribosome-associated chaperone physical 1 1 1 Biochemical Activity
TRX1 YLR043C Cytoplasmic thioredoxin isoenzyme physical 1 1 1 Biochemical Activity
YBR298C-A YBR298C-A Putative protein of unknown function physical 1 1 1 Biochemical Activity
YIF1 YNL263C Integral membrane protein physical 1 1 1 Biochemical Activity
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein physical 1 1 1 Reconstituted Complex
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Biochemical Activity
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Negative Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Synthetic Rescue
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Phenotypic Suppression
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Phenotypic Suppression
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 1 1 1 Phenotypic Suppression
TSR2 YLR435W Protein with a potential role in pre-rRNA processing genetic 1 1 1 Phenotypic Suppression
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Positive Genetic
YGL036W YGL036W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YPR084W YPR084W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 1 1 1 Negative Genetic
YDR169C-A YDR169C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPS6 YIR039C Putative GPI-anchored aspartic protease genetic 1 1 1 Negative Genetic
YJL043W YJL043W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Negative Genetic
YKE4 YIL023C Zinc transporter genetic 1 1 1 Negative Genetic
YIL067C YIL067C Uncharacterized protein of unknown function genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
YPL034W YPL034W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YMR084W YMR084W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Phenotypic Suppression
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
APE2 YKL157W Aminopeptidase yscII physical 1 1 1 Biochemical Activity
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase physical 1 1 1 Biochemical Activity
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Suppression
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Reconstituted Complex
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Biochemical Activity
GRX5 YPL059W Glutathione-dependent oxidoreductase genetic 1 1 1 Phenotypic Suppression
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway genetic 1 1 1 Phenotypic Suppression
PCL9 YDL179W Cyclin physical 1 1 1 Biochemical Activity
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
PFS1 YHR185C Sporulation protein required for prospore membrane formation physical 1 1 1 Biochemical Activity
IMA3 YIL172C Alpha-glucosidase physical 1 1 1 Biochemical Activity
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
FMP16 YDR070C Protein of unknown function genetic 1 1 1 Negative Genetic
PRR1 YKL116C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SWM2 YNR004W Protein with a role in snRNA and snoRNA cap trimethylation genetic 1 1 1 Phenotypic Suppression
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Dosage Lethality
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Reconstituted Complex
DOC1 YGL240W Processivity factor genetic 1 1 1 Dosage Lethality
PEX5 YDR244W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Phenotypic Suppression
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Synthetic Growth Defect
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
RGT1 YKL038W Glucose-responsive transcription factor physical 1 1 1 Biochemical Activity
APN1 YKL114C Major apurinic/apyrimidinic endonuclease physical 1 1 1 Biochemical Activity
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
MYO3 YKL129C One of two type I myosins genetic 1 1 1 Negative Genetic
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 1 1 1 Biochemical Activity
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Phenotypic Suppression
DPH1 YIL103W Protein required for synthesis of diphthamide genetic 1 1 1 Positive Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Phenotypic Suppression
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Biochemical Activity
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Biochemical Activity
BAG7 YOR134W Rho GTPase activating protein (RhoGAP) physical 1 1 1 Biochemical Activity
GAP1 YKR039W General amino acid permease physical 1 1 1 Reconstituted Complex
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Positive Genetic
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling physical 1 1 1 Reconstituted Complex
MET28 YIR017C bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex genetic 1 1 1 Negative Genetic
REC104 YHR157W Protein involved in early stages of meiotic recombination physical 1 1 1 Biochemical Activity
NNK1 YKL171W Protein kinase physical 1 1 1 Biochemical Activity
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p physical 1 1 1 Biochemical Activity
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
ETT1 YOR051C Nuclear protein that inhibits replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Co-fractionation
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase physical 1 1 1 Biochemical Activity
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
FLO8 YER109C Transcription factor genetic 1 1 1 Phenotypic Suppression
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 1 1 1 Phenotypic Suppression
MLS1 YNL117W Malate synthase, enzyme of the glyoxylate cycle physical 1 1 1 Biochemical Activity
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex physical 1 1 1 Biochemical Activity
HLR1 YDR528W Protein involved in regulation of cell wall composition and integrity genetic 1 1 1 Positive Genetic
AVT6 YER119C Vacuolar aspartate and glutamate exporter genetic 1 1 1 Negative Genetic
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Negative Genetic
MXR1 YER042W Methionine-S-sulfoxide reductase genetic 1 1 1 Negative Genetic
STE7 YDL159W Signal transducing MAP kinase kinase genetic 1 1 1 Phenotypic Suppression
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase physical 1 1 1 Biochemical Activity
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
NTH1 YDR001C Neutral trehalase, degrades trehalose physical 1 1 1 Biochemical Activity
NTH1 YDR001C Neutral trehalase, degrades trehalose genetic 1 1 1 Negative Genetic
SOK1 YDR006C Protein of unknown function genetic 1 1 1 Dosage Rescue
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
AVT1 YJR001W Vacuolar transporter physical 1 1 1 Biochemical Activity
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
FIG2 YCR089W Cell wall adhesin, expressed specifically during mating genetic 1 1 1 Negative Genetic
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Negative Genetic
RSM24 YDR175C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Phenotypic Suppression
RPP1A YDL081C Ribosomal stalk protein P1 alpha physical 1 1 1 Biochemical Activity
MBR1 YKL093W Protein involved in mitochondrial functions and stress response physical 1 1 1 Biochemical Activity
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) physical 1 1 1 Biochemical Activity
ALD2 YMR170C Cytoplasmic aldehyde dehydrogenase genetic 1 1 1 Phenotypic Suppression
CSH1 YBR161W Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Phenotypic Suppression
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel physical 1 1 1 Biochemical Activity
SYH1 YPL105C Protein of unknown function that influences nuclear pore distribution genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Positive Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase physical 1 1 1 Biochemical Activity
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Negative Genetic
NVJ3 YDR179W-A Protein with a potential role in tethering ER and vacuoles genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Phenotypic Suppression
DOS2 YDR068W Protein of unknown function physical 1 1 1 Biochemical Activity
IGD1 YFR017C Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity physical 1 1 1 Biochemical Activity
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Biochemical Activity
ALR2 YFL050C Probable Mg(2+) transporter genetic 1 1 1 Negative Genetic
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
ADD37 YMR184W Protein of unknown function physical 1 1 1 Biochemical Activity
GGC1 YDL198C Mitochondrial GTP/GDP transporter genetic 1 1 1 Phenotypic Suppression
INP54 YOL065C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
ISF1 YMR081C Serine-rich, hydrophilic protein physical 1 1 1 Biochemical Activity
MNR2 YKL064W Vacuolar membrane protein required for magnesium homeostasis physical 1 1 1 Biochemical Activity
RGD3 YHR182W GTPase activating protein (GAP) for Rho3p, involved in cell polarity g physical 1 1 1 Biochemical Activity
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
SUN4 YNL066W Cell wall protein related to glucanases localized in birth scars genetic 1 1 1 Negative Genetic
DAP2 YHR028C Dipeptidyl aminopeptidase physical 1 1 1 Biochemical Activity
TMA22 YJR014W Protein of unknown function physical 1 1 1 Biochemical Activity
STR3 YGL184C Peroxisomal cystathionine beta-lyase physical 1 1 1 Biochemical Activity
SNX41 YDR425W Sorting nexin physical 1 1 1 Biochemical Activity
LCL1 YPL056C Putative protein of unknown function physical 1 1 1 Biochemical Activity
ECM7 YLR443W Putative integral membrane protein with a role in calcium uptake physical 1 1 1 Biochemical Activity
MTG2 YHR168W Putative GTPase physical 1 1 1 Biochemical Activity
SIT1 YEL065W Ferrioxamine B transporter physical 1 1 1 Biochemical Activity
DDP1 YOR163W Diadenosine and diphosphoinositol polyphosphate phosphatase physical 1 1 1 Biochemical Activity
PNT1 YOR266W Mitochondrial integral inner membrane protein physical 1 1 1 Biochemical Activity
ERG24 YNL280C C-14 sterol reductase physical 1 1 1 Biochemical Activity
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase physical 1 1 1 Biochemical Activity
PDE1 YGL248W Low-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
TOS4 YLR183C Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Positive Genetic
PKP2 YGL059W Mitochondrial protein kinase physical 1 1 1 Biochemical Activity
SPS18 YNL204C Protein of unknown function, contains a putative zinc-binding domain genetic 1 1 1 Phenotypic Suppression
ALO1 YML086C D-Arabinono-1,4-lactone oxidase genetic 1 1 1 Negative Genetic
PFA3 YNL326C Palmitoyltransferase for Vac8p genetic 1 1 1 Phenotypic Suppression
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 1 1 1 Negative Genetic
ARO7 YPR060C Chorismate mutase genetic 1 1 1 Negative Genetic
MYG1 YER156C Protein involved in mitochondrial function genetic 1 1 1 Negative Genetic
MAL11 YGR289C High-affinity maltose transporter (alpha-glucoside transporter) genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Positive Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Negative Genetic
MCH4 YOL119C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Positive Genetic
PAN6 YIL145C Pantothenate synthase genetic 1 1 1 Negative Genetic
PUT1 YLR142W Proline oxidase genetic 1 1 1 Positive Genetic
RSM28 YDR494W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Negative Genetic
SDH7 YDR511W Mitochondrial protein involved in assembly of succinate dehydrogenase genetic 1 1 1 Negative Genetic
HNT3 YOR258W DNA 5' AMP hydrolase involved in DNA repair genetic 1 1 1 Phenotypic Suppression
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PUT7 YLR283W Regulator of mitochondrial proline metabolism genetic 1 1 1 Positive Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Phenotypic Suppression
SOP4 YJL192C ER-membrane protein genetic 1 1 1 Negative Genetic
MTC6 YHR151C Protein of unknown function genetic 1 1 1 Negative Genetic
SPR1 YOR190W Sporulation-specific exo-1,3-beta-glucanase genetic 1 1 1 Phenotypic Suppression