PCH2 |
YBR186W |
Hexameric ring ATPase that remodels chromosome axis protein Hop1p |
genetic |
8 |
4 |
7 |
Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement |
NUF2 |
YOL069W |
Component of the kinetochore-associated Ndc80 complex |
physical |
4 |
1 |
3 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid |
MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Dosage Rescue, Phenotypic Enhancement |
RED1 |
YLR263W |
Protein component of the synaptonemal complex axial elements |
genetic |
3 |
3 |
3 |
Dosage Rescue, Phenotypic Enhancement, Synthetic Rescue |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
CLB1 |
YGR108W |
B-type cyclin involved in cell cycle progression |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Phenotypic Suppression |
DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
CST9 |
YLR394W |
SUMO E3 ligase |
physical |
3 |
3 |
2 |
Affinity Capture-Western, Two-hybrid, Co-localization |
LCD1 |
YDR499W |
Essential protein required for the DNA integrity checkpoint pathways |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression |
SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
physical |
3 |
1 |
2 |
Two-hybrid, Two-hybrid, Two-hybrid |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Dosage Lethality |
CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Suppression |
SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
NDT80 |
YHR124W |
Meiosis-specific transcription factor |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
MPS3 |
YJL019W |
Nuclear envelope protein |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-MS |
ZAP1 |
YJL056C |
Zinc-regulated transcription factor |
regulation |
2 |
1 |
2 |
DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
ANP1 |
YEL036C |
Subunit of the alpha-1,6 mannosyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RHO2 |
YNL090W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
physical |
2 |
2 |
1 |
Two-hybrid, Reconstituted Complex |
NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
LAM4 |
YHR080C |
Sterol-binding protein that localizes to puncta in the cortical ER |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD11 |
YER025W |
Gamma subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRB4 |
YER022W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
APL3 |
YBL037W |
Alpha-adaptin |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
COX6 |
YHR051W |
Subunit VI of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
HTB2 |
YBL002W |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KIN3 |
YAR018C |
Nonessential serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
END3 |
YNL084C |
EH domain-containing protein involved in endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
physical |
1 |
1 |
1 |
Two-hybrid |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
1 |
1 |
1 |
Two-hybrid |
MSH4 |
YFL003C |
Protein involved in meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RIO2 |
YNL207W |
Essential serine kinase involved in the processing of 20S pre-rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HTB1 |
YDR224C |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DMC1 |
YER179W |
Meiosis-specific recombinase required for double-strand break repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MLH3 |
YPL164C |
Protein involved in DNA mismatch repair and meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
FHL1 |
YPR104C |
Regulator of ribosomal protein (RP) transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
ETP1 |
YHL010C |
Protein of unknown function required for growth on ethanol |
physical |
1 |
1 |
1 |
Two-hybrid |
FAR10 |
YLR238W |
Protein involved in recovery from arrest in response to pheromone |
physical |
1 |
1 |
1 |
Two-hybrid |
GYP5 |
YPL249C |
GTPase-activating protein (GAP) for yeast Rab family members |
physical |
1 |
1 |
1 |
Two-hybrid |
LHS1 |
YKL073W |
Molecular chaperone of the endoplasmic reticulum lumen |
physical |
1 |
1 |
1 |
Two-hybrid |
EPT1 |
YHR123W |
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
physical |
1 |
1 |
1 |
Biochemical Activity |
RED1 |
YLR263W |
Protein component of the synaptonemal complex axial elements |
physical |
1 |
1 |
1 |
Two-hybrid |
ECM11 |
YDR446W |
Meiosis-specific protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ATG1 |
YGL180W |
Protein serine/threonine kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAD3 |
YJL013C |
Subunit of spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MSH5 |
YDL154W |
Protein of the MutS family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SPC72 |
YAL047C |
Gamma-tubulin small complex (gamma-TuSC) receptor |
physical |
1 |
1 |
1 |
Two-hybrid |
CNL1 |
YDR357C |
Subunit of the BLOC-1 complex involved in endosomal maturation |
physical |
1 |
1 |
1 |
Two-hybrid |
BLI1 |
YKL061W |
Subunit of the BLOC-1 complex involved in endosomal maturation |
physical |
1 |
1 |
1 |
Two-hybrid |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
HOP1 |
YIL072W |
Meiosis-specific protein required for chromosome synapsis |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
physical |
1 |
1 |
1 |
Two-hybrid |
MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
physical |
1 |
1 |
1 |
Two-hybrid |
PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
physical |
1 |
1 |
1 |
Two-hybrid |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAS2 |
YMR127C |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SEC9 |
YGR009C |
t-SNARE protein required for secretory vesicle-plasma membrane fusion |
physical |
1 |
1 |
1 |
Two-hybrid |
TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
IMP1 |
YMR150C |
Catalytic subunit of mitochondrial inner membrane peptidase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NNF2 |
YGR089W |
Protein that exhibits physical and genetic interactions with Rpb8p |
physical |
1 |
1 |
1 |
Two-hybrid |
SPA2 |
YLL021W |
Component of the polarisome |
physical |
1 |
1 |
1 |
Two-hybrid |
VAC8 |
YEL013W |
Vacuole-specific Myo2p receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
REC8 |
YPR007C |
Meiosis-specific component of the sister chromatid cohesion complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
DID2 |
YKR035W-A |
Class E protein of the vacuolar protein-sorting (Vps) pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
RPL28 |
YGL103W |
Ribosomal 60S subunit protein L28 |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPM2 |
YIL138C |
Minor isoform of tropomyosin |
physical |
1 |
1 |
1 |
Two-hybrid |
MET4 |
YNL103W |
Leucine-zipper transcriptional activator |
physical |
1 |
1 |
1 |
Two-hybrid |
VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
physical |
1 |
1 |
1 |
Two-hybrid |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
RQC2 |
YPL009C |
Component of the Ribosome Quality Control (RQC) complex |
physical |
1 |
1 |
1 |
Two-hybrid |
SPR3 |
YGR059W |
Sporulation-specific homolog of the CDC3/10/11/12 family of genes |
physical |
1 |
1 |
1 |
Two-hybrid |
YTA6 |
YPL074W |
Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family |
physical |
1 |
1 |
1 |
Two-hybrid |
HEM4 |
YOR278W |
Uroporphyrinogen III synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO22 |
YIL073C |
Meiosis-specific protein essential for chromosome synapsis |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
YGL188C-A |
YGL188C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |