Standard name Systematic name Name description Description
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
Visualize the interactome of MLH3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MLH3 2 2 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis physical 20 6 12 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Co-crystal Structure, Two-hybrid
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 4 2 3 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
PMS1 YNL082W ATP-binding protein required for mismatch repair physical 3 2 1 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease physical 3 2 1 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex physical 1 1 1 Affinity Capture-MS
ARP3 YJR065C Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
AVO1 YOL078W Component of the membrane-bound TORC2 complex physical 1 1 1 Affinity Capture-MS
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly physical 1 1 1 Affinity Capture-MS
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KRS1 YDR037W Lysyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
GEA2 YEL022W Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) physical 1 1 1 Affinity Capture-MS
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Enhancement
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MLC1 YGL106W Essential light chain for Myo1p physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ physical 1 1 1 Affinity Capture-MS
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery physical 1 1 1 Affinity Capture-MS
ADE3 YGR204W Cytoplasmic trifunctional enzyme physical 1 1 1 Affinity Capture-MS
GLN1 YPR035W Glutamine synthetase (GS) physical 1 1 1 Affinity Capture-MS
LSP1 YPL004C Eisosome core component physical 1 1 1 Two-hybrid
FIN1 YDR130C Spindle pole body-related intermediate filament protein physical 1 1 1 Affinity Capture-MS
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Affinity Capture-Western
DCS1 YLR270W Non-essential hydrolase involved in mRNA decapping physical 1 1 1 Affinity Capture-MS
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
CAF120 YNL278W Part of the CCR4-NOT transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) physical 1 1 1 Affinity Capture-MS
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 1 1 1 Affinity Capture-Western
MSH5 YDL154W Protein of the MutS family physical 1 1 1 Reconstituted Complex
MSH5 YDL154W Protein of the MutS family genetic 1 1 1 Phenotypic Enhancement
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-Western
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
RPC34 YNR003C RNA polymerase III subunit C34 physical 1 1 1 Affinity Capture-MS
THI20 YOL055C Trifunctional enzyme of thiamine biosynthesis, degradation and salvage physical 1 1 1 Affinity Capture-MS
SIP18 YMR175W Phospholipid-binding hydrophilin physical 1 1 1 Affinity Capture-MS
RPO31 YOR116C RNA polymerase III largest subunit C160 physical 1 1 1 Affinity Capture-MS
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p physical 1 1 1 Affinity Capture-MS
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination physical 1 1 1 Affinity Capture-MS
PYC2 YBR218C Pyruvate carboxylase isoform physical 1 1 1 Affinity Capture-MS
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 Affinity Capture-MS
PGM1 YKL127W Phosphoglucomutase, minor isoform physical 1 1 1 Affinity Capture-MS
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
MPM1 YJL066C Mitochondrial intermembrane space protein of unknown function physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
RPL9B YNL067W Ribosomal 60S subunit protein L9B physical 1 1 1 Affinity Capture-MS
VAR1 Q0140 Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
MRX3 YBL095W Protein that associates with mitochondrial ribosome physical 1 1 1 Affinity Capture-MS
TRP5 YGL026C Tryptophan synthase physical 1 1 1 Affinity Capture-MS
RLI1 YDR091C Essential Fe-S protein physical 1 1 1 Affinity Capture-MS
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins physical 1 1 1 Affinity Capture-MS
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SPS2 YDR522C Protein expressed during sporulation physical 1 1 1 Affinity Capture-MS
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
TIM50 YPL063W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
PGC1 YPL206C Phosphatidylglycerol phospholipase C physical 1 1 1 Affinity Capture-MS
VID22 YLR373C G-quadruplex (G4) DNA binding protein physical 1 1 1 Affinity Capture-MS
MNN5 YJL186W Alpha-1,2-mannosyltransferase physical 1 1 1 Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex physical 1 1 1 Affinity Capture-MS
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-MS
RSR1 YGR152C Ras-type GTPase physical 1 1 1 Affinity Capture-MS
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 1 1 1 Affinity Capture-MS
SEC17 YBL050W Alpha-SNAP cochaperone physical 1 1 1 Affinity Capture-MS
NCA2 YPR155C Protein that regulates expression of Fo-F1 ATP synthase subunits physical 1 1 1 Affinity Capture-MS
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
MSC7 YHR039C Protein of unknown function physical 1 1 1 Affinity Capture-MS
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) physical 1 1 1 Affinity Capture-MS
TMA19 YKL056C Protein that associates with ribosomes physical 1 1 1 Affinity Capture-MS
NDT80 YHR124W Meiosis-specific transcription factor physical 1 1 1 Affinity Capture-MS
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
VPS29 YHR012W Subunit of the membrane-associated retromer complex physical 1 1 1 Affinity Capture-MS
PNP1 YLR209C Purine nucleoside phosphorylase physical 1 1 1 Affinity Capture-MS
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) physical 1 1 1 Affinity Capture-MS
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
YHR020W YHR020W Prolyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Affinity Capture-MS
SPN1 YPR133C Protein involved in RNA polymerase II transcription physical 1 1 1 Affinity Capture-MS
RAI1 YGL246C Nuclear decapping endonuclease physical 1 1 1 Affinity Capture-MS
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Affinity Capture-MS
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
NTE1 YML059C Serine esterase physical 1 1 1 Affinity Capture-MS
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex physical 1 1 1 Affinity Capture-MS
NUM1 YDR150W Protein required for nuclear migration physical 1 1 1 Affinity Capture-MS
YMC2 YBR104W Putative mitochondrial inner membrane transporter physical 1 1 1 Affinity Capture-MS
MSR1 YHR091C Mitochondrial arginyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
MRX9 YDL027C Protein that associates with mitochondrial ribosome physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
YBR287W YBR287W Protein of unknown function physical 1 1 1 Affinity Capture-MS
YPK9 YOR291W Vacuolar protein with a possible role in sequestering heavy metals physical 1 1 1 Affinity Capture-MS
PRM4 YPL156C Pheromone-regulated protein proposed to be involved in mating physical 1 1 1 Affinity Capture-MS
PSR2 YLR019W Putative plasma membrane phosphatase physical 1 1 1 Affinity Capture-MS
MRP13 YGR084C Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Affinity Capture-MS
THI6 YPL214C Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase physical 1 1 1 Affinity Capture-MS
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase physical 1 1 1 Affinity Capture-MS
SOL2 YCR073W-A Protein with a possible role in tRNA export physical 1 1 1 Affinity Capture-MS
STE23 YLR389C Metalloprotease physical 1 1 1 Affinity Capture-MS
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
YIL108W YIL108W Putative metalloendopeptidase physical 1 1 1 Affinity Capture-MS
UTP7 YER082C Nucleolar protein physical 1 1 1 Affinity Capture-MS
MRX15 YNR040W Membrane-associated mitoribosome receptor physical 1 1 1 Affinity Capture-MS
VPS64 YDR200C Protein required for cytoplasm to vacuole targeting of proteins physical 1 1 1 Affinity Capture-MS
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Enhancement
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
MMF1 YIL051C Mitochondrial protein required for transamination of isoleucine genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Lethality
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport genetic 1 1 1 Negative Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
STB4 YMR019W Putative transcription factor genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Phenotypic Suppression
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 1 1 1 Phenotypic Suppression
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Phenotypic Enhancement
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
YEN1 YER041W Holliday junction resolvase genetic 1 1 1 Phenotypic Suppression
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
HSL7 YBR133C Protein arginine N-methyltransferase physical 1 1 1 Affinity Capture-MS
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
MAP2 YBL091C Methionine aminopeptidase physical 1 1 1 Affinity Capture-MS
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-MS
CYS3 YAL012W Cystathionine gamma-lyase physical 1 1 1 Affinity Capture-MS
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family physical 1 1 1 Affinity Capture-MS
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 1 1 1 Affinity Capture-MS
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
ECM11 YDR446W Meiosis-specific protein genetic 1 1 1 Phenotypic Suppression
ADP1 YCR011C Putative ATP-dependent permease of the ABC transporter family physical 1 1 1 Affinity Capture-MS
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes physical 1 1 1 Affinity Capture-MS
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
EMP47 YFL048C Integral membrane component of ER-derived COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
DFG5 YMR238W Putative mannosidase physical 1 1 1 Affinity Capture-MS
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Affinity Capture-MS
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription physical 1 1 1 Affinity Capture-MS
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase physical 1 1 1 Affinity Capture-MS
GPI17 YDR434W Transmembrane protein physical 1 1 1 Affinity Capture-MS
CDA1 YLR307W Chitin deacetylase physical 1 1 1 Affinity Capture-MS
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
COQ4 YDR204W Protein with a role in ubiquinone (Coenzyme Q) biosynthesis physical 1 1 1 Affinity Capture-MS
COA1 YIL157C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
ERG4 YGL012W C-24(28) sterol reductase physical 1 1 1 Affinity Capture-MS
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway physical 1 1 1 Affinity Capture-MS
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
AIM9 YER080W Protein of unknown function physical 1 1 1 Affinity Capture-MS
FMT1 YBL013W Methionyl-tRNA formyltransferase genetic 1 1 1 Positive Genetic