| HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
25 |
6 |
21 |
Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western, Biochemical Activity, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
7 |
5 |
7 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, FRET, Affinity Capture-MS, Co-crystal Structure |
| STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression |
| DOT5 |
YIL010W |
Nuclear thiol peroxidase |
physical |
3 |
2 |
2 |
Two-hybrid, Reconstituted Complex, Two-hybrid |
| CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence |
| NPL6 |
YMR091C |
Component of the RSC chromatin remodeling complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
2 |
2 |
Synthetic Haploinsufficiency, Synthetic Lethality |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
| CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
physical |
2 |
2 |
2 |
Reconstituted Complex, Two-hybrid |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| STB5 |
YHR178W |
Transcription factor |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PPT1 |
YGR123C |
Protein serine/threonine phosphatase |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| BRX1 |
YOL077C |
Nucleolar protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| HAS1 |
YMR290C |
ATP-dependent RNA helicase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| GUS1 |
YGL245W |
Glutamyl-tRNA synthetase (GluRS) |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| HCA4 |
YJL033W |
DEAD box RNA helicase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| NPL3 |
YDR432W |
RNA-binding protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| PUS4 |
YNL292W |
Pseudouridine synthase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MAL12 |
YGR292W |
Maltase (alpha-D-glucosidase) |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RSA4 |
YCR072C |
Ribosomal large subunit (60S) assembly factor |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RGC1 |
YPR115W |
Putative regulator of the Fps1p glycerol channel |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| DIM1 |
YPL266W |
Essential 18S rRNA dimethylase (dimethyladenosine transferase) |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| CMS1 |
YLR003C |
Putative subunit of the 90S preribosome processome complex |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| NOB1 |
YOR056C |
Protein involved in proteasomal and 40S ribosomal subunit biogenesis |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| PYC1 |
YGL062W |
Pyruvate carboxylase isoform |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| AAT2 |
YLR027C |
Cytosolic aspartate aminotransferase involved in nitrogen metabolism |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| LAF1 |
YMR102C |
Sterol-binding beta-propeller protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| EMI2 |
YDR516C |
Hexokinase expressed during growth with low glucose levels |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| LYS1 |
YIR034C |
Saccharopine dehydrogenase (NAD+, L-lysine-forming) |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RNR1 |
YER070W |
Major isoform of large subunit of ribonucleotide-diphosphate reductase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MDH3 |
YDL078C |
Peroxisomal malate dehydrogenase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| JJJ1 |
YNL227C |
Co-chaperone that stimulates the ATPase activity of Ssa1p |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MVP1 |
YMR004W |
Protein required for sorting proteins to the vacuole |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MLS1 |
YNL117W |
Malate synthase, enzyme of the glyoxylate cycle |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MAP1 |
YLR244C |
Methionine aminopeptidase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| HTD2 |
YHR067W |
Mitochondrial 3-hydroxyacyl-thioester dehydratase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RIM8 |
YGL045W |
Protein involved in proteolytic activation of Rim101p |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| YCR016W |
YCR016W |
Putative protein of unknown function |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| SLM5 |
YCR024C |
Mitochondrial asparaginyl-tRNA synthetase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| YDL177C |
YDL177C |
Putative protein of unknown function |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| TRM1 |
YDR120C |
tRNA methyltransferase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| UTP7 |
YER082C |
Nucleolar protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| UTP25 |
YIL091C |
Nucleolar protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| SKA1 |
YKL023W |
SKI complex-associated protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| UTP30 |
YKR060W |
Subunit of U3-containing 90S preribosome complex |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| SDO1 |
YLR022C |
Guanine nucleotide exchange factor (GEF) for Ria1p |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| SUB1 |
YMR039C |
Transcriptional regulator |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| UBP10 |
YNL186W |
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| YLH47 |
YPR125W |
Mitochondrial inner membrane protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MEF1 |
YLR069C |
Mitochondrial elongation factor involved in translational elongation |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| ADE12 |
YNL220W |
Adenylosuccinate synthase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MSE1 |
YOL033W |
Mitochondrial glutamyl-tRNA synthetase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| NPT1 |
YOR209C |
Nicotinate phosphoribosyltransferase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RDS2 |
YPL133C |
Transcription factor involved in regulating gluconeogenesis |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| IDP3 |
YNL009W |
Peroxisomal NADP-dependent isocitrate dehydrogenase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RPL36A |
YMR194W |
Ribosomal 60S subunit protein L36A |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| DGR2 |
YKL121W |
Protein of unknown function |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| MPD1 |
YOR288C |
Member of the protein disulfide isomerase (PDI) family |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| PCS60 |
YBR222C |
Oxalyl-CoA synthetase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| AST2 |
YER101C |
Lipid raft associated protein |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| ALG9 |
YNL219C |
Mannosyltransferase, involved in N-linked glycosylation |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| FEN2 |
YCR028C |
Plasma membrane H+-pantothenate symporter |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| RIB2 |
YOL066C |
Bifunctional DRAP deaminase tRNA:pseudouridine synthase |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SUA7 |
YPR086W |
Transcription factor TFIIB |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED6 |
YHR058C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CKA1 |
YIL035C |
Alpha catalytic subunit of casein kinase 2 (CK2) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| NOG1 |
YPL093W |
Putative GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP16 |
YER002W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPF1 |
YHR088W |
Protein involved in assembly and export of the large ribosomal subunit |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| NOP9 |
YJL010C |
Essential subunit of U3-containing 90S preribosome |
physical |
1 |
1 |
1 |
Two-hybrid |
| HOL1 |
YNR055C |
Putative transporter in the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PLB1 |
YMR008C |
Phospholipase B (lysophospholipase) involved in lipid metabolism |
physical |
1 |
1 |
1 |
Two-hybrid |
| RGT2 |
YDL138W |
Plasma membrane high glucose sensor that regulates glucose transport |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NUG1 |
YER006W |
GTPase that associates with nuclear 60S pre-ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBP3 |
YGL078C |
RNA-Dependent ATPase, member of DExD/H-box family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GCD11 |
YER025W |
Gamma subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
physical |
1 |
1 |
1 |
Two-hybrid |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
physical |
1 |
1 |
1 |
Two-hybrid |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| LHP1 |
YDL051W |
RNA binding protein required for maturation of tRNA and U6 snRNA |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| EFT2 |
YDR385W |
Elongation factor 2 (EF-2), also encoded by EFT1 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARO1 |
YDR127W |
Pentafunctional arom protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CAF40 |
YNL288W |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CNS1 |
YBR155W |
TPR-containing co-chaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
| EMP24 |
YGL200C |
Component of the p24 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ECM29 |
YHL030W |
Scaffold protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL1 |
YDR116C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MAM33 |
YIL070C |
Acidic protein of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APM1 |
YPL259C |
Mu1-like medium subunit of the AP-1 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PDB1 |
YBR221C |
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| IDH2 |
YOR136W |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MDS3 |
YGL197W |
Putative component of the TOR regulatory pathway |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| REF2 |
YDR195W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL23A |
YBL087C |
Ribosomal 60S subunit protein L23A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
physical |
1 |
1 |
1 |
Two-hybrid |
| HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
physical |
1 |
1 |
1 |
Two-hybrid |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAV1 |
YJR033C |
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HSE1 |
YHL002W |
Subunit of the endosomal Vps27p-Hse1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CIR2 |
YOR356W |
Putative ortholog of human ETF-dH |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPH1 |
YPR160W |
Glycogen phosphorylase required for the mobilization of glycogen |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ADR1 |
YDR216W |
Carbon source-responsive zinc-finger transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
| IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IDH1 |
YNL037C |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRB1 |
YEL060C |
Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CNB1 |
YKL190W |
Calcineurin B |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| POR1 |
YNL055C |
Mitochondrial porin (voltage-dependent anion channel) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FYV10 |
YIL097W |
Subunit of GID complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ATG11 |
YPR049C |
Adapter protein for pexophagy and the Cvt targeting pathway |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APT1 |
YML022W |
Adenine phosphoribosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GPA2 |
YER020W |
Nucleotide binding alpha subunit of the heterotrimeric G protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RNQ1 |
YCL028W |
[PIN(+)] prion |
physical |
1 |
1 |
1 |
Two-hybrid |
| HMF1 |
YER057C |
Member of the p14.5 protein family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LSB1 |
YGR136W |
Negative regulator of actin nucleation-promoting factor activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ADH4 |
YGL256W |
Alcohol dehydrogenase isoenzyme type IV |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC37 |
YDR168W |
Essential Hsp90p co-chaperone |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
physical |
1 |
1 |
1 |
Two-hybrid |
| CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KSS1 |
YGR040W |
Mitogen-activated protein kinase (MAPK) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PGM1 |
YKL127W |
Phosphoglucomutase, minor isoform |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| EAP1 |
YKL204W |
eIF4E-associated protein, competes with eIF4G for binding to eIF4E |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PPZ1 |
YML016C |
Serine/threonine protein phosphatase Z, isoform of Ppz2p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MDH3 |
YDL078C |
Peroxisomal malate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APE3 |
YBR286W |
Vacuolar aminopeptidase Y |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GEP4 |
YHR100C |
Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AFT1 |
YGL071W |
Transcription factor involved in iron utilization and homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LST7 |
YGR057C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRP8 |
YKL142W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PCL2 |
YDL127W |
Cyclin, interacts with cyclin-dependent kinase Pho85p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MMR1 |
YLR190W |
Phosphorylated protein of the mitochondrial outer membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PEX21 |
YGR239C |
Peroxin required for peroxisomal matrix protein targeting |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KTI12 |
YKL110C |
Protein that plays a role in modification of tRNA wobble nucleosides |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GPN2 |
YOR262W |
Putative GTPase with a specific role in RNA pol II and polIII biogenes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PRR1 |
YKL116C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX13 |
YLR191W |
Peroxisomal importomer complex component |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS4A |
YJR145C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RSC30 |
YHR056C |
Component of the RSC chromatin remodeling complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ARP5 |
YNL059C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ALF1 |
YNL148C |
Alpha-tubulin folding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CTK2 |
YJL006C |
Beta subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HOP2 |
YGL033W |
Meiosis-specific protein that localizes to chromosomes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MYO3 |
YKL129C |
One of two type I myosins |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PHO80 |
YOL001W |
Cyclin |
physical |
1 |
1 |
1 |
Two-hybrid |
| PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERV41 |
YML067C |
Protein localized to COPII-coated vesicles |
physical |
1 |
1 |
1 |
Two-hybrid |
| ERV41 |
YML067C |
Protein localized to COPII-coated vesicles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MKC7 |
YDR144C |
GPI-anchored aspartyl protease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KAR2 |
YJL034W |
ATPase involved in protein import into the ER |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HAP4 |
YKL109W |
Transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GAP1 |
YKR039W |
General amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RBL2 |
YOR265W |
Protein involved in microtubule morphogenesis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CAD1 |
YDR423C |
AP-1-like basic leucine zipper (bZIP) transcriptional activator |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GTS1 |
YGL181W |
Protein involved in Arf3p regulation and in transcription regulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HCH1 |
YNL281W |
Heat shock protein regulator |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| GAD1 |
YMR250W |
Glutamate decarboxylase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BCH1 |
YMR237W |
Member of the ChAPs family (Chs5p-Arf1p-binding proteins) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PDR5 |
YOR153W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CCH1 |
YGR217W |
Voltage-gated high-affinity calcium channel |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HSV2 |
YGR223C |
Phosphatidylinositol 3,5-bisphosphate-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PXA1 |
YPL147W |
Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p |
physical |
1 |
1 |
1 |
PCA |
| MID1 |
YNL291C |
Stretch-activated Ca2+-permeable cation channel |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ERF2 |
YLR246W |
Subunit of a palmitoyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MON2 |
YNL297C |
Protein with a role in endocytosis and vacuole integrity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FOX2 |
YKR009C |
3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| EUC1 |
YMR111C |
Sequence-specific DNA binding protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| MIT1 |
YEL007W |
Transcriptional regulator of pseudohyphal growth |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SAC7 |
YDR389W |
GTPase activating protein (GAP) for Rho1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GTA1 |
YEL043W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GEF1 |
YJR040W |
Voltage-gated chloride channel |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CST26 |
YBR042C |
Acyltransferase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| BSC6 |
YOL137W |
Protein of unknown function with 8 putative transmembrane segments |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GDA1 |
YEL042W |
Guanosine diphosphatase located in the Golgi |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KEX1 |
YGL203C |
Cell death protease essential for hypochlorite-induced apoptosis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BDH1 |
YAL060W |
NAD-dependent (R,R)-butanediol dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PHR1 |
YOR386W |
DNA photolyase involved in photoreactivation |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| COQ10 |
YOL008W |
Coenzyme Q (ubiquinone) binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LYS4 |
YDR234W |
Homoaconitase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PUF4 |
YGL014W |
Member of the PUF protein family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RIM8 |
YGL045W |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IMP21 |
YIL154C |
Transcriptional activator involved in maintenance of ion homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CYB5 |
YNL111C |
Cytochrome b5 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CWP2 |
YKL096W-A |
Covalently linked cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SRO77 |
YBL106C |
Protein with roles in exocytosis and cation homeostasis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YGL140C |
YGL140C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| URA8 |
YJR103W |
Minor CTP synthase isozyme (see also URA7) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
physical |
1 |
1 |
1 |
Two-hybrid |
| TAH1 |
YCR060W |
Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) |
physical |
1 |
1 |
1 |
Two-hybrid |
| SRB4 |
YER022W |
Subunit of the RNA polymerase II mediator complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| YBL055C |
YBL055C |
3'-->5' exonuclease and endonuclease with a possible role in apoptosis |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YGR026W |
YGR026W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TOM71 |
YHR117W |
Mitochondrial outer membrane protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TES1 |
YJR019C |
Peroxisomal acyl-CoA thioesterase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| STM1 |
YLR150W |
Protein required for optimal translation under nutrient stress |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SLZ1 |
YNL196C |
Sporulation-specific protein with a leucine zipper motif |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
physical |
1 |
1 |
1 |
Two-hybrid |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YKR104W |
YKR104W |
Putative transporter of the MRP subfamily |
physical |
1 |
1 |
1 |
PCA |
| YKR104W |
YKR104W |
Putative transporter of the MRP subfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTR1 |
YJR049C |
ATP-NADH kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SYG1 |
YIL047C |
Plasma membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEC28 |
YIL076W |
Epsilon-COP subunit of the coatomer |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YIL165C |
YIL165C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ZAP1 |
YJL056C |
Zinc-regulated transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TIF2 |
YJL138C |
Translation initiation factor eIF4A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YJR056C |
YJR056C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SBA1 |
YKL117W |
Co-chaperone that binds and regulates Hsp90 family chaperones |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SHS1 |
YDL225W |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SNF11 |
YDR073W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| STB3 |
YDR169C |
Ribosomal RNA processing element (RRPE)-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPR28 |
YDR218C |
Sporulation-specific homolog of the CDC3/10/11/12 family of genes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SWA2 |
YDR320C |
Auxilin-like protein involved in vesicular transport |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SIP1 |
YDR422C |
One of three alternate beta-subunits of the Snf1p kinase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YDR514C |
YDR514C |
Protein of unknown function that localizes to mitochondria |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VAB2 |
YEL005C |
Subunit of the BLOC-1 complex involved in endosomal maturation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TCA17 |
YEL048C |
Component of transport protein particle (TRAPP) complex II |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YER121W |
YER121W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SWP82 |
YFL049W |
Member of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ZRT1 |
YGL255W |
High-affinity zinc transporter of the plasma membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UGA1 |
YGR019W |
Gamma-aminobutyrate (GABA) transaminase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YGR079W |
YGR079W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YGR122W |
YGR122W |
Protein that may be involved in pH regulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VSB1 |
YGR125W |
Vacuolar membrane protein required for uptake and storage of arginine |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMY2 |
YBR172C |
GYF domain protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VAC17 |
YCL063W |
Phosphoprotein involved in vacuole inheritance |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEG2 |
YKL105C |
Eisosome component |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YKL107W |
YKL107W |
NADH-dependent aldehyde reductase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSH4 |
YKL124W |
Specificity factor required for Rsp5p-dependent ubiquitination |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SHE2 |
YKL130C |
RNA-binding protein that binds specific mRNAs and interacts with She3p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SIS2 |
YKR072C |
Negative regulatory subunit of protein phosphatase 1 (Ppz1p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YLR031W |
YLR031W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SNX3 |
YOR357C |
Sorting nexin for late-Golgi enzymes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YPL077C |
YPL077C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SGT1 |
YOR057W |
Cochaperone protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI1 |
YPL016W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSH1 |
YBR283C |
Subunit of the Ssh1 translocon complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDH9 |
YJL045W |
Minor succinate dehydrogenase isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR084W |
YJR084W |
Protein that forms a complex with Thp3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRK2 |
YKR050W |
Component of the Trk1p-Trk2p potassium transport system |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URA5 |
YML106W |
Major orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STB4 |
YMR019W |
Putative transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPR147C |
YPR147C |
Bifunctional triacylglycerol lipase and short chain ester hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHE4 |
YOR035C |
Protein containing a UCS (UNC-45/CRO1/SHE4) domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STH1 |
YIL126W |
ATPase component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DTR1 |
YBR180W |
Putative dityrosine transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PMU1 |
YKL128C |
Putative phosphomutase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AQY3 |
YFL054C |
Putative channel-like protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RIM21 |
YNL294C |
pH sensor molecule, component of the RIM101 pathway |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MUB1 |
YMR100W |
MYND domain-containing protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RTR1 |
YER139C |
Dual specificity protein phosphatase |
physical |
1 |
1 |
1 |
Two-hybrid |
| RTR1 |
YER139C |
Dual specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DOS2 |
YDR068W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL26B |
YGR034W |
Ribosomal 60S subunit protein L26B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARV1 |
YLR242C |
Cortical ER protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HUT1 |
YPL244C |
Protein with a role in UDP-galactose transport to the Golgi lumen |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DGR2 |
YKL121W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PAU8 |
YAL068C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIB2 |
YGL023C |
Phosphatidylinositol 3-phosphate binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LOA1 |
YPR139C |
Lysophosphatidic acid acyltransferase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| DAP2 |
YHR028C |
Dipeptidyl aminopeptidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NMD4 |
YLR363C |
Protein that may be involved in nonsense-mediated mRNA decay |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ECM7 |
YLR443W |
Putative integral membrane protein with a role in calcium uptake |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GIS1 |
YDR096W |
Histone demethylase and transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| COQ2 |
YNR041C |
Para hydroxybenzoate polyprenyl transferase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HXT3 |
YDR345C |
Low affinity glucose transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
Two-hybrid |
| HXT3 |
YDR345C |
Low affinity glucose transporter of the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HXT4 |
YHR092C |
High-affinity glucose transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CEM1 |
YER061C |
Mitochondrial beta-keto-acyl synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| COX23 |
YHR116W |
Protein that functions in mitochondrial copper homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FAA3 |
YIL009W |
Long chain fatty acyl-CoA synthetase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| OAC1 |
YKL120W |
Mitochondrial inner membrane transporter |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CCW12 |
YLR110C |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MTC2 |
YKL098W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ASP3-2 |
YLR157C |
Cell-wall L-asparaginase II involved in asparagine catabolism |
physical |
1 |
1 |
1 |
Two-hybrid |
| DIT1 |
YDR403W |
Sporulation-specific enzyme required for spore wall maturation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SAM50 |
YNL026W |
Component of the Sorting and Assembly Machinery (SAM) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| AVT5 |
YBL089W |
Putative transporter |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KHA1 |
YJL094C |
Putative K+/H+ antiporter |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CYT2 |
YKL087C |
Cytochrome c1 heme lyase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AFG1 |
YEL052W |
Protein that may act as a chaperone for cytochrome c oxidase subunits |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AIM19 |
YIL087C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ALD3 |
YMR169C |
Cytoplasmic aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL24B |
YGR148C |
Ribosomal 60S subunit protein L24B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NMA111 |
YNL123W |
Serine protease and general molecular chaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MMM1 |
YLL006W |
ER integral membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NFT1 |
YKR103W |
Putative transporter of the MRP subfamily |
physical |
1 |
1 |
1 |
PCA |
| MPM1 |
YJL066C |
Mitochondrial intermembrane space protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MFA1 |
YDR461W |
Mating pheromone a-factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL37B |
YDR500C |
Ribosomal 60S subunit protein L37B |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS21B |
YJL136C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS28A |
YOR167C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCI50 |
YKL133C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPM1 |
YDR435C |
Carboxyl methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AAT1 |
YKL106W |
Mitochondrial aspartate aminotransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RTC6 |
YPL183W-A |
Protein involved in translation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRM6 |
YML047C |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RIM9 |
YMR063W |
Plasma membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MTC6 |
YHR151C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| OAF3 |
YKR064W |
Putative transcriptional repressor with Zn(2)-Cys(6) finger |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAU4 |
YLR461W |
Member of the seripauperin multigene family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
