YOR1 |
YGR281W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
8 |
3 |
8 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression |
SNQ2 |
YDR011W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
5 |
3 |
5 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect |
PDR5 |
YOR153W |
Plasma membrane ATP-binding cassette (ABC) transporter |
physical |
5 |
2 |
4 |
Two-hybrid, PCA, PCA, PCA, PCA |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
4 |
3 |
4 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
PDR1 |
YGL013C |
Transcription factor that regulates the pleiotropic drug response |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect |
SNQ2 |
YDR011W |
Plasma membrane ATP-binding cassette (ABC) transporter |
physical |
4 |
2 |
2 |
Co-fractionation, PCA, PCA, PCA |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
3 |
2 |
3 |
Affinity Capture-RNA, Affinity Capture-MS, Affinity Capture-RNA |
PDR3 |
YBL005W |
Transcriptional activator of the pleiotropic drug resistance network |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Synthetic Growth Defect |
PDR3 |
YBL005W |
Transcriptional activator of the pleiotropic drug resistance network |
regulation |
3 |
3 |
2 |
beta-galactosidase reporter gene assay evidence, DNAse footprinting evidence, northern blot evidence |
PDR12 |
YPL058C |
Plasma membrane ATP-binding cassette (ABC) transporter |
physical |
3 |
1 |
2 |
PCA, PCA, PCA |
YOL075C |
YOL075C |
Putative ABC transporter |
physical |
3 |
1 |
1 |
PCA, PCA, PCA |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
PDR1 |
YGL013C |
Transcription factor that regulates the pleiotropic drug response |
regulation |
2 |
2 |
2 |
beta-galactosidase reporter gene assay evidence, northern blot evidence |
ERG6 |
YML008C |
Delta(24)-sterol C-methyltransferase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
SCP160 |
YJL080C |
Essential RNA-binding G protein effector of mating response pathway |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-MS |
PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
physical |
2 |
2 |
2 |
Co-fractionation, PCA |
ZRT1 |
YGL255W |
High-affinity zinc transporter of the plasma membrane |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Negative Genetic |
RSB1 |
YOR049C |
Sphingoid long-chain base (LCB) efflux transporter |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
SIT4 |
YDL047W |
Ceramide-activated, type 2A-related serine-threonine phosphatase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
TPO1 |
YLL028W |
Polyamine transporter of the major facilitator superfamily |
physical |
2 |
1 |
2 |
PCA, PCA |
YML053C |
YML053C |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DSE2 |
YHR143W |
Daughter cell-specific secreted protein with similarity to glucanases |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ZRT1 |
YGL255W |
High-affinity zinc transporter of the plasma membrane |
physical |
2 |
2 |
1 |
Affinity Capture-Western, PCA |
NCR1 |
YPL006W |
Vacuolar membrane protein involved with Npc2p in sterol trafficking |
physical |
2 |
2 |
1 |
Affinity Capture-Western, PCA |
GEP3 |
YOR205C |
Protein required for mitochondrial ribosome small subunit biogenesis |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
AIM41 |
YOR215C |
Protein of unknown function |
physical |
2 |
1 |
1 |
PCA, PCA |
SEO1 |
YAL067C |
Putative permease |
physical |
2 |
1 |
1 |
PCA, PCA |
SMF2 |
YHR050W |
Divalent metal ion transporter involved in manganese homeostasis |
physical |
2 |
1 |
1 |
PCA, PCA |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
physical |
2 |
1 |
1 |
PCA, PCA |
MCH5 |
YOR306C |
Plasma membrane riboflavin transporter |
physical |
2 |
1 |
1 |
PCA, PCA |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MET32 |
YDR253C |
Zinc-finger DNA-binding transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MET4 |
YNL103W |
Leucine-zipper transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CYC8 |
YBR112C |
General transcriptional co-repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT6 |
YGR116W |
Nucleosome remodeling protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TUP1 |
YCR084C |
General repressor of transcription in complex with Cyc8p |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
FUN12 |
YAL035W |
Translation initiation factor eIF5B |
physical |
1 |
1 |
1 |
PCA |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
APL2 |
YKL135C |
Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FLC2 |
YAL053W |
Putative calcium channel involved in calcium release under hypotonic |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LAP2 |
YNL045W |
Leucyl aminopeptidase yscIV with epoxide hydrolase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
FET4 |
YMR319C |
Low-affinity Fe(II) transporter of the plasma membrane |
physical |
1 |
1 |
1 |
Co-fractionation |
GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIP5 |
YPL265W |
Dicarboxylic amino acid permease |
physical |
1 |
1 |
1 |
PCA |
HXT7 |
YDR342C |
High-affinity glucose transporter |
physical |
1 |
1 |
1 |
Co-fractionation |
HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
physical |
1 |
1 |
1 |
PCA |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FZO1 |
YBR179C |
Mitofusin, protein involved in mitochondrial outer membrane fusion |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HXT5 |
YHR096C |
Hexose transporter with moderate affinity for glucose |
physical |
1 |
1 |
1 |
PCA |
LEM3 |
YNL323W |
Membrane protein of the plasma membrane and ER |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
genetic |
1 |
1 |
1 |
Dosage Rescue |
CSM3 |
YMR048W |
Replication fork associated factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ITT1 |
YML068W |
Protein that modulates the efficiency of translation termination |
genetic |
1 |
1 |
1 |
Negative Genetic |
AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ELO3 |
YLR372W |
Elongase |
physical |
1 |
1 |
1 |
PCA |
OST2 |
YOR103C |
Epsilon subunit of the oligosaccharyltransferase complex |
physical |
1 |
1 |
1 |
PCA |
ECM27 |
YJR106W |
Protein involved in calcium homeostasis and exit from quiescence |
physical |
1 |
1 |
1 |
Two-hybrid |
HKR1 |
YDR420W |
Mucin family member that functions as an osmosensor in the HOG pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
PRY3 |
YJL078C |
GPI-anchored cell wall protein involved in export of sterols |
physical |
1 |
1 |
1 |
Two-hybrid |
RAX2 |
YLR084C |
Protein required for the maintenance of bud site selection |
physical |
1 |
1 |
1 |
Two-hybrid |
TMS1 |
YDR105C |
Vacuolar membrane protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
YAP3 |
YHL009C |
Basic leucine zipper (bZIP) transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
UTP10 |
YJL109C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Two-hybrid |
PTR2 |
YKR093W |
Integral membrane peptide transporter |
physical |
1 |
1 |
1 |
Co-fractionation |
YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Co-fractionation |
SUR7 |
YML052W |
Plasma membrane protein, component of eisosomes |
physical |
1 |
1 |
1 |
Co-fractionation |
SUR7 |
YML052W |
Plasma membrane protein, component of eisosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR266W |
YGR266W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Co-fractionation |
PMT1 |
YDL095W |
Protein O-mannosyltransferase of the ER membrane |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SDS23 |
YGL056C |
Protein involved in cell separation during budding |
physical |
1 |
1 |
1 |
PCA |
TPO2 |
YGR138C |
Polyamine transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
PCA |
QDR2 |
YIL121W |
Plasma membrane transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
PCA |
SFK1 |
YKL051W |
Protein that regulates phospholipid asymmetry at plasma membrane |
physical |
1 |
1 |
1 |
PCA |
SFK1 |
YKL051W |
Protein that regulates phospholipid asymmetry at plasma membrane |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
URN1 |
YPR152C |
Protein of unknown function containing WW and FF domains |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RAS2 |
YNL098C |
GTP-binding protein |
physical |
1 |
1 |
1 |
PCA |
RTN1 |
YDR233C |
Reticulon protein |
physical |
1 |
1 |
1 |
PCA |
SER1 |
YOR184W |
3-phosphoserine aminotransferase |
physical |
1 |
1 |
1 |
PCA |
TMN3 |
YER113C |
Protein with a role in cellular adhesion and filamentous growth |
physical |
1 |
1 |
1 |
PCA |
YGR026W |
YGR026W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
POM33 |
YLL023C |
Transmembrane nucleoporin |
physical |
1 |
1 |
1 |
PCA |
YND1 |
YER005W |
Apyrase with wide substrate specificity |
physical |
1 |
1 |
1 |
PCA |
YNL208W |
YNL208W |
Protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
TMA108 |
YIL137C |
Ribosome-associated, nascent chain binding factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL16A |
YIL133C |
Ribosomal 60S subunit protein L16A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TMA46 |
YOR091W |
Protein of unknown function that associates with translating ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
SND2 |
YLR065C |
Protein involved in SRP-independent targeting of substrates to the ER |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SND3 |
YBR106W |
Involved in SRP-independent protein targeting to the ER |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SBH1 |
YER087C-B |
Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) |
physical |
1 |
1 |
1 |
Two-hybrid |
SPA2 |
YLL021W |
Component of the polarisome |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SCS3 |
YGL126W |
Protein required for normal ER membrane biosynthesis in response to ER |
physical |
1 |
1 |
1 |
PCA |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SBA1 |
YKL117W |
Co-chaperone that binds and regulates Hsp90 family chaperones |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS1 |
YKR001C |
Dynamin-like GTPase required for vacuolar sorting |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YPT7 |
YML001W |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YPT32 |
YGL210W |
Rab family GTPase involved in the exocytic pathway |
genetic |
1 |
1 |
1 |
Dosage Rescue |
YPT31 |
YER031C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
SSM4 |
YIL030C |
Membrane-embedded ubiquitin-protein ligase and retrotranslocase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RKM2 |
YDR198C |
Ribosomal protein lysine methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDR524C-B |
YDR524C-B |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNK1 |
YKL067W |
Nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPL9B |
YNL067W |
Ribosomal 60S subunit protein L9B |
genetic |
1 |
1 |
1 |
Negative Genetic |
OTU1 |
YFL044C |
Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p |
physical |
1 |
1 |
1 |
Two-hybrid |
NRT1 |
YOR071C |
High-affinity nicotinamide riboside transporter |
physical |
1 |
1 |
1 |
Two-hybrid |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
physical |
1 |
1 |
1 |
Biochemical Activity |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HOT13 |
YKL084W |
Zinc-binding mitochondrial intermembrane space (IMS) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CRG1 |
YHR209W |
S-AdoMet-dependent methyltransferase involved in lipid homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HNM1 |
YGL077C |
Plasma membrane transporter for choline, ethanolamine, and carnitine |
physical |
1 |
1 |
1 |
PCA |
FUN26 |
YAL022C |
High affinity, broad selectivity, nucleoside/nucleobase transporter |
physical |
1 |
1 |
1 |
PCA |
MRH1 |
YDR033W |
Protein that localizes primarily to the plasma membrane |
physical |
1 |
1 |
1 |
Co-fractionation |
NCE102 |
YPR149W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Co-fractionation |
PDR10 |
YOR328W |
ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PDR15 |
YDR406W |
Plasma membrane ATP binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
COX10 |
YPL172C |
Heme A:farnesyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FMP45 |
YDL222C |
Integral membrane protein localized to mitochondria |
physical |
1 |
1 |
1 |
PCA |
HXT1 |
YHR094C |
Low-affinity glucose transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
PCA |
COS1 |
YNL336W |
Endosomal protein involved in turnover of plasma membrane proteins |
physical |
1 |
1 |
1 |
PCA |
CCW12 |
YLR110C |
Cell wall mannoprotein |
physical |
1 |
1 |
1 |
PCA |
EMA19 |
YLR050C |
Integral ER membrane protein involved in protein sorting |
physical |
1 |
1 |
1 |
PCA |
DPL1 |
YDR294C |
Dihydrosphingosine phosphate lyase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
GPI1 |
YGR216C |
Membrane protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDR16 |
YNL231C |
Phosphatidylinositol transfer protein (PITP) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |