Standard name Systematic name Name description Description
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate
Visualize the interactome of PDR3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.134 0.22 0.40
Endosome 0.148 0.08 NaN
Mito 0.067 0.22 0.36
Nucleus 0.497 0.20 0.13
SpindlePole 0.060 NaN 0.09
Vac/Vac Memb 0.208 0.38 0.07

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 166

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PDR3 2 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 13 2 13 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter genetic 3 2 3 Dosage Rescue, Dosage Rescue, Synthetic Growth Defect
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter regulation 3 3 2 beta-galactosidase reporter gene assay evidence, DNAse footprinting evidence, northern blot evidence
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network regulation 3 3 2 beta-galactosidase reporter gene assay evidence, chromatin immunoprecipitation-chip evidence, DNAse footprinting evidence
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter regulation 3 2 2 DNAse footprinting evidence, northern blot evidence, northern blot evidence
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 2 2 Positive Genetic, Phenotypic Enhancement
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 2 1 2 Negative Genetic, Negative Genetic
MSC7 YHR039C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 2 1 2 Negative Genetic, Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response regulation 1 1 1 beta-galactosidase reporter gene assay evidence
MET14 YKL001C Adenylylsulfate kinase regulation 1 1 1 DNA to cDNA expression microarray evidence
LDB7 YBL006C Component of the RSC chromatin remodeling complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
OSI1 YKL071W NADH-dependent aldehyde reductase regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 1 1 1 Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
KAP123 YER110C Karyopherin beta genetic 1 1 1 Synthetic Growth Defect
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Phenotypic Enhancement
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains physical 1 1 1 Two-hybrid
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Phenotypic Enhancement
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-Western
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Rescue
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Two-hybrid
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Phenotypic Enhancement
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes physical 1 1 1 Two-hybrid
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA genetic 1 1 1 Phenotypic Enhancement
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Two-hybrid
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Phenotypic Enhancement
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Phenotypic Enhancement
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Synthetic Rescue
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Synthetic Growth Defect
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
ARA1 YBR149W NADP+ dependent arabinose dehydrogenase physical 1 1 1 Affinity Capture-MS
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) physical 1 1 1 Two-hybrid
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Positive Genetic
HOS3 YPL116W Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Negative Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
GAL1 YBR020W Galactokinase genetic 1 1 1 Negative Genetic
GTS1 YGL181W Protein involved in Arf3p regulation and in transcription regulation genetic 1 1 1 Negative Genetic
CDC19 YAL038W Pyruvate kinase genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
OXA1 YER154W Mitochondrial inner membrane insertase genetic 1 1 1 Synthetic Growth Defect
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response physical 1 1 1 Co-fractionation
ATX1 YNL259C Cytosolic copper metallochaperone genetic 1 1 1 Negative Genetic
MRPL11 YDL202W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
AHK1 YDL073W Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway genetic 1 1 1 Negative Genetic
CWH43 YCR017C GPI lipid remodelase genetic 1 1 1 Phenotypic Enhancement
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-Western
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-Western
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Two-hybrid
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Rescue
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Phenotypic Suppression
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Phenotypic Suppression
POA1 YBR022W Phosphatase that is highly specific for ADP-ribose 1''-phosphate genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Synthetic Growth Defect
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Phenotypic Enhancement
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Phenotypic Enhancement
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Phenotypic Enhancement
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Phenotypic Enhancement
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Phenotypic Enhancement
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Phenotypic Enhancement
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Phenotypic Enhancement
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Phenotypic Enhancement
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Synthetic Growth Defect
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Phenotypic Enhancement
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Positive Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Negative Genetic
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Synthetic Growth Defect
YMR321C YMR321C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Synthetic Growth Defect
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Phenotypic Enhancement
DPL1 YDR294C Dihydrosphingosine phosphate lyase genetic 1 1 1 Phenotypic Enhancement
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Phenotypic Enhancement
GMC1 YDR506C Protein involved in meiotic progression genetic 1 1 1 Negative Genetic
MRX20 YFR045W Putative mitochondrial transport protein genetic 1 1 1 Negative Genetic