Standard name Systematic name Name description Description
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
Visualize the interactome of SRB8
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 1730

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SRB8 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SSN3 YPL042C Component of the RNA polymerase II mediator complex physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 4 3 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 3 2 2 Synthetic Rescue, Dosage Lethality, Dosage Lethality
HTZ1 YOL012C Histone variant H2AZ genetic 3 2 2 Negative Genetic, Phenotypic Suppression, Phenotypic Suppression
GET1 YGL020C Subunit of the GET complex genetic 3 2 2 Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MED1 YPR070W Subunit of the RNA polymerase II mediator complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
STP22 YCL008C Component of the ESCRT-I complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS28 YPL065W Component of the ESCRT-I complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ECM30 YLR436C Protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
AHC2 YCR082W Component of the ADA histone acetyltransferase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPC2 YML055W Subunit of signal peptidase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CWP1 YKL096W Cell wall mannoprotein that localizes to birth scars of daughter cells regulation 1 1 1 DNA to cDNA expression microarray evidence
YGP1 YNL160W Cell wall-related secretory glycoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
CIP1 YPL014W Cyclin-dependent kinase inhibitor regulation 1 1 1 DNA to cDNA expression microarray evidence
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase regulation 1 1 1 DNA to cDNA expression microarray evidence
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase regulation 1 1 1 DNA to cDNA expression microarray evidence
GLK1 YCL040W Glucokinase regulation 1 1 1 DNA to cDNA expression microarray evidence
GAD1 YMR250W Glutamate decarboxylase regulation 1 1 1 DNA to cDNA expression microarray evidence
SPI1 YER150W GPI-anchored cell wall protein involved in weak acid resistance regulation 1 1 1 DNA to cDNA expression microarray evidence
YRF1-4 YLR466W Helicase encoded by the Y' element of subtelomeric regions regulation 1 1 1 DNA to cDNA expression microarray evidence
YRF1-6 YNL339C Helicase encoded by the Y' element of subtelomeric regions regulation 1 1 1 DNA to cDNA expression microarray evidence
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane regulation 1 1 1 DNA to cDNA expression microarray evidence
GRE1 YPL223C Hydrophilin essential in desiccation-rehydration process regulation 1 1 1 DNA to cDNA expression microarray evidence
PTR2 YKR093W Integral membrane peptide transporter regulation 1 1 1 DNA to cDNA expression microarray evidence
TSL1 YML100W Large subunit of trehalose 6-phosphate synthase/phosphatase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
FIT3 YOR383C Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation regulation 1 1 1 DNA to cDNA expression microarray evidence
MDM35 YKL053C-A Mitochondrial intermembrane space protein regulation 1 1 1 DNA to cDNA expression microarray evidence
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) regulation 1 1 1 DNA to cDNA expression microarray evidence
MRP17 YKL003C Mitochondrial ribosomal protein of the small subunit regulation 1 1 1 DNA to cDNA expression microarray evidence
DDR2 YOL052C-A Multi-stress response protein regulation 1 1 1 DNA to cDNA expression microarray evidence
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization regulation 1 1 1 DNA to cDNA expression microarray evidence
MCH5 YOR306C Plasma membrane riboflavin transporter regulation 1 1 1 DNA to cDNA expression microarray evidence
TPO4 YOR273C Polyamine transporter of the major facilitator superfamily regulation 1 1 1 DNA to cDNA expression microarray evidence
YFL067W YFL067W Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR297W YLR297W Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
PXL1 YKR090W Protein that localizes to sites of polarized growth regulation 1 1 1 DNA to cDNA expression microarray evidence
TIR2 YOR010C Putative cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
NNR2 YKL151C Widely-conserved NADHX dehydratase regulation 1 1 1 DNA to cDNA expression microarray evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Positive Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Growth Defect
NPL6 YMR091C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SRB4 YER022W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Rescue
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Positive Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Rescue
MED2 YDL005C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Positive Genetic
PRP21 YJL203W Subunit of the SF3a splicing factor complex physical 1 1 1 Two-hybrid
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Suppression
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Phenotypic Suppression
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Co-purification
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Positive Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Synthetic Rescue
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Phenotypic Suppression
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Phenotypic Suppression
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 1 1 1 Negative Genetic
UBP2 YOR124C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
TMA20 YER007C-A Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Negative Genetic
VPS70 YJR126C Protein of unknown function involved in vacuolar protein sorting genetic 1 1 1 Negative Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Positive Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Phenotypic Suppression
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Rescue
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Positive Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Positive Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Negative Genetic
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-Western
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Negative Genetic
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Affinity Capture-MS
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Positive Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Rescue
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Synthetic Growth Defect
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Phenotypic Suppression
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Positive Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Phenotypic Suppression
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
PLC1 YPL268W Phospholipase C genetic 1 1 1 Phenotypic Suppression
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Synthetic Rescue
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Negative Genetic
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes physical 1 1 1 PCA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Synthetic Rescue
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Phenotypic Enhancement
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Negative Genetic
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
HAM1 YJR069C Nucleoside triphosphate pyrophosphohydrolase genetic 1 1 1 Phenotypic Suppression
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Positive Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Phenotypic Suppression
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Phenotypic Suppression
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Synthetic Growth Defect
RTT106 YNL206C Histone chaperone genetic 1 1 1 Positive Genetic
SET5 YHR207C Methyltransferase involved in methylation of histone H4 Lys5, -8, -12 genetic 1 1 1 Positive Genetic
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network physical 1 1 1 Affinity Capture-Western
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network genetic 1 1 1 Phenotypic Enhancement
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Negative Genetic