Standard name Systematic name Name description Description
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
Visualize the interactome of SRB7
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.245 0.074 0.344
Nucleolus 0.155 0.141 0.180
Nucleus 0.910 0.793 0.836
Vac/Vac Memb NaN 0.081 NaN

GFP localization & abundance

GFP localization GFP abundance
nucleus 1390

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SRB7 2 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 18 5 14 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Co-purification, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex physical 11 4 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Co-purification, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
MED4 YOR174W Subunit of the RNA polymerase II mediator complex physical 7 4 6 Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Co-purification, Co-purification, Two-hybrid
SRB4 YER022W Subunit of the RNA polymerase II mediator complex physical 6 2 6 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex physical 6 2 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
MED8 YBR193C Subunit of the RNA polymerase II mediator complex physical 4 3 4 Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
MED6 YHR058C Subunit of the RNA polymerase II mediator complex physical 4 4 3 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Co-purification
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex physical 3 3 3 Two-hybrid, Co-purification, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
MED1 YPR070W Subunit of the RNA polymerase II mediator complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex physical 3 2 3 Two-hybrid, Affinity Capture-MS, Two-hybrid
NUT1 YGL151W Component of the RNA polymerase II mediator complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TUP1 YCR084C General repressor of transcription in complex with Cyc8p physical 3 3 2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes physical 2 2 2 Affinity Capture-Western, PCA
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 2 2 1 PCA, Affinity Capture-Western
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
SWI6 YLR182W Transcription cofactor genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Synthetic Growth Defect
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex physical 1 1 1 Two-hybrid
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-Western
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Lethality
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-Western
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Synthetic Lethality
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Affinity Capture-MS
GAL3 YDR009W Transcriptional regulator genetic 1 1 1 Dosage Rescue
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
MET16 YPR167C 3'-phosphoadenylsulfate reductase genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
FZF1 YGL254W Transcription factor involved in sulfite metabolism genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
IKS1 YJL057C Protein kinase of unknown cellular role physical 1 1 1 Reconstituted Complex
LAM6 YLR072W Sterol transporter that transfers sterols between membranes genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Lethality
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
SSN3 YPL042C Component of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-Western
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) physical 1 1 1 Two-hybrid
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Phenotypic Enhancement
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
TRR2 YHR106W Mitochondrial thioredoxin reductase genetic 1 1 1 Negative Genetic
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
SRP40 YKR092C Nucleolar serine-rich protein genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase genetic 1 1 1 Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
YNL146W YNL146W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor physical 1 1 1 Two-hybrid
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes physical 1 1 1 Two-hybrid
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 1 1 1 Synthetic Rescue
BNR1 YIL159W Formin physical 1 1 1 Two-hybrid
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
DSF2 YBR007C Deletion suppressor of mpt5 mutation genetic 1 1 1 Negative Genetic
DAD4 YDR320C-A Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex physical 1 1 1 Two-hybrid
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Positive Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PTM1 YKL039W Protein of unknown function genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
DIA1 YMR316W Protein of unknown function genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 1 1 1 Negative Genetic
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Negative Genetic
FSF1 YOR271C Putative protein genetic 1 1 1 Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 1 1 1 Negative Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
APA2 YDR530C Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
ATG22 YCL038C Vacuolar integral membrane protein required for efflux of amino acids genetic 1 1 1 Negative Genetic
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
SAY1 YGR263C Sterol deacetylase genetic 1 1 1 Negative Genetic