| TRK2 |
YKR050W |
Component of the Trk1p-Trk2p potassium transport system |
genetic |
28 |
7 |
25 |
Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic |
| TOK1 |
YJL093C |
Outward-rectifier potassium channel of the plasma membrane |
genetic |
4 |
4 |
3 |
Dosage Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect |
| SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
4 |
4 |
1 |
Dosage Lethality, Phenotypic Enhancement, Synthetic Rescue, Dosage Rescue |
| SIS2 |
YKR072C |
Negative regulatory subunit of protein phosphatase 1 (Ppz1p) |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Synthetic Rescue, Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
3 |
1 |
3 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| PPZ2 |
YDR436W |
Serine/threonine protein phosphatase Z, isoform of Ppz1p |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
| PPZ1 |
YML016C |
Serine/threonine protein phosphatase Z, isoform of Ppz2p |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
| HXT3 |
YDR345C |
Low affinity glucose transporter of the major facilitator superfamily |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| HXT1 |
YHR094C |
Low-affinity glucose transporter of the major facilitator superfamily |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Suppression |
| PRM6 |
YML047C |
Potassium transporter that mediates K+ influx |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Suppression |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
| PTK2 |
YJR059W |
Serine/threonine protein kinase |
genetic |
2 |
2 |
1 |
Dosage Lethality, Dosage Rescue |
| VHC1 |
YBR235W |
Vacuolar membrane cation-chloride cotransporter (CCC) |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Synthetic Growth Defect |
| ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
| SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
| HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| STP3 |
YLR375W |
Zinc-finger protein of unknown function |
genetic |
2 |
1 |
1 |
Synthetic Rescue, Synthetic Rescue |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AXL2 |
YIL140W |
Integral plasma membrane protein |
physical |
1 |
1 |
1 |
PCA |
| PEX19 |
YDL065C |
Chaperone and import receptor for newly-synthesized class I PMPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| APL3 |
YBL037W |
Alpha-adaptin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BDF1 |
YLR399C |
BET family transcriptional regulator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| ENO1 |
YGR254W |
Enolase I, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Protein-RNA |
| GCN1 |
YGL195W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ILV1 |
YER086W |
Threonine deaminase, catalyzes first step in isoleucine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BZZ1 |
YHR114W |
SH3 domain protein implicated in regulating actin polymerization |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| NAT1 |
YDL040C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| IST2 |
YBR086C |
Cortical ER protein involved in ER-plasma membrane (PM) tethering |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MNL1 |
YHR204W |
Alpha-1,2-specific exomannosidase of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| OYE2 |
YHR179W |
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OYE3 |
YPL171C |
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEF3 |
YNL014W |
Translational elongation factor EF-3 |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
| BUD32 |
YGR262C |
Protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
| HOG1 |
YLR113W |
Mitogen-activated protein kinase involved in osmoregulation |
physical |
1 |
1 |
1 |
Co-localization |
| ADE17 |
YMR120C |
Enzyme of 'de novo' purine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ISU1 |
YPL135W |
Conserved protein of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LHS1 |
YKL073W |
Molecular chaperone of the endoplasmic reticulum lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP13 |
YNL175C |
Nucleolar protein found in preribosomal complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PPZ1 |
YML016C |
Serine/threonine protein phosphatase Z, isoform of Ppz2p |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| GAL2 |
YLR081W |
Galactose permease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| GTR1 |
YML121W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LST7 |
YGR057C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
| MRP8 |
YKL142W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MGL2 |
YMR210W |
Monoacylglycerol and triacylglycerol lipase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BLI1 |
YKL061W |
Subunit of the BLOC-1 complex involved in endosomal maturation |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CST6 |
YIL036W |
Basic leucine zipper (bZIP) transcription factor from ATF/CREB family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRK1 |
YIL095W |
Ser/Thr protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| ERG25 |
YGR060W |
C-4 methyl sterol oxidase |
physical |
1 |
1 |
1 |
PCA |
| ERV14 |
YGL054C |
COPII-coated vesicle protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AQR1 |
YNL065W |
Plasma membrane transporter of the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLO8 |
YER109C |
Transcription factor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PET127 |
YOR017W |
Protein with a role in 5'-end processing of mitochondrial RNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVT6 |
YER119C |
Vacuolar aspartate and glutamate exporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAM17 |
YKR065C |
Constituent of the TIM23 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MXR1 |
YER042W |
Methionine-S-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIO1 |
YOR119C |
Serine kinase involved in cell cycle regulation and rDNA integrity |
physical |
1 |
1 |
1 |
Two-hybrid |
| PYK2 |
YOR347C |
Pyruvate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EXP1 |
YDL121C |
A cargo receptor protein for Pma1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HYR1 |
YIR037W |
Glutathione peroxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FPR2 |
YDR519W |
Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GRX4 |
YER174C |
Glutathione-dependent oxidoreductase and glutathione S-transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMP46 |
YKR049C |
Putative redox protein containing a thioredoxin fold |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IDP1 |
YDL066W |
Mitochondrial NADP-specific isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EFM6 |
YNL024C |
Putative S-adenosylmethionine-dependent lysine methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NHA1 |
YLR138W |
Na+/H+ antiporter |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SPO14 |
YKR031C |
Phospholipase D |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDR3 |
YBL005W |
Transcriptional activator of the pleiotropic drug resistance network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BAP2 |
YBR068C |
High-affinity leucine permease |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| HAL1 |
YPR005C |
Cytoplasmic protein involved in halotolerance |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| KHA1 |
YJL094C |
Putative K+/H+ antiporter |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FSH3 |
YOR280C |
Putative serine hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIC27 |
YNL100W |
Component of the MICOS complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GMC2 |
YLR445W |
Protein involved in meiotic crossing over |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMP3 |
YDR276C |
Small plasma membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| GMC1 |
YDR506C |
Protein involved in meiotic progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTK1 |
YKL198C |
Putative serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| MNT3 |
YIL014W |
Alpha-1,3-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS30A |
YLR287C-A |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VOA1 |
YGR106C |
ER protein that functions in assembly of the V0 sector of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| UBP8 |
YMR223W |
Ubiquitin-specific protease component of the SAGA acetylation complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YPI1 |
YFR003C |
Regulatory subunit of the type I protein phosphatase (PP1) Glc7p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| VNX1 |
YNL321W |
Calcium/H+ antiporter localized to the endoplasmic reticulum membrane |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YET1 |
YKL065C |
Endoplasmic reticulum transmembrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YCR016W |
YCR016W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YFL051C |
YFL051C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBP2 |
YGL060W |
Central kinetochore associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMR1 |
YHL035C |
Vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YNL046W |
YNL046W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPT53 |
YNL093W |
Stress-induced Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSR3 |
YOR006C |
Protein required for 20S pre-rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPR078C |
YPR078C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPR148C |
YPR148C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM23 |
YPL021W |
Non-essential protein of unconfirmed function |
genetic |
1 |
1 |
1 |
Negative Genetic |
