GLN1 |
YPR035W |
Glutamine synthetase (GS) |
physical |
5 |
4 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Biochemical Activity |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
physical |
3 |
2 |
3 |
Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex |
GPX2 |
YBR244W |
Phospholipid hydroperoxide glutathione peroxidase |
genetic |
3 |
1 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
GPX1 |
YKL026C |
Phospholipid hydroperoxide glutathione peroxidase |
genetic |
3 |
1 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
physical |
3 |
3 |
2 |
Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western |
MXR1 |
YER042W |
Methionine-S-sulfoxide reductase |
physical |
3 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
AHP1 |
YLR109W |
Thiol-specific peroxiredoxin |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
YBP1 |
YBR216C |
Protein involved in cellular response to oxidative stress |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
DAK1 |
YML070W |
Dihydroxyacetone kinase |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MIA40 |
YKL195W |
Import and assembly protein in mitochondrial intermembrane space |
physical |
2 |
2 |
1 |
Protein-peptide, Affinity Capture-Western |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ISU1 |
YPL135W |
Conserved protein of the mitochondrial matrix |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RPH1 |
YER169W |
JmjC domain-containing histone demethylase |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
DED1 |
YOR204W |
ATP-dependent DEAD-box RNA helicase with strand-annealing activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMG1 |
YLR186W |
Methyltransferase for rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
physical |
1 |
1 |
1 |
Two-hybrid |
HOM6 |
YJR139C |
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADE17 |
YMR120C |
Enzyme of 'de novo' purine biosynthesis |
physical |
1 |
1 |
1 |
PCA |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG11 |
YHR007C |
Lanosterol 14-alpha-demethylase |
physical |
1 |
1 |
1 |
PCA |
FIG1 |
YBR040W |
Integral membrane protein required for efficient mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CAD1 |
YDR423C |
AP-1-like basic leucine zipper (bZIP) transcriptional activator |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HRD3 |
YLR207W |
ER membrane protein that plays a central role in ERAD |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NGR1 |
YBR212W |
RNA binding protein that negatively regulates growth rate |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HYR1 |
YIR037W |
Glutathione peroxidase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
YBL029C-A |
YBL029C-A |
Protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
RFS1 |
YBR052C |
Protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
PEX11 |
YOL147C |
Peroxisomal protein required for medium-chain fatty acid oxidation |
physical |
1 |
1 |
1 |
PCA |
PDR12 |
YPL058C |
Plasma membrane ATP-binding cassette (ABC) transporter |
physical |
1 |
1 |
1 |
PCA |
TPO3 |
YPR156C |
Polyamine transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
PCA |
YLR345W |
YLR345W |
Similar to 6-phosphofructo-2-kinase enzymes |
physical |
1 |
1 |
1 |
Two-hybrid |
TFA1 |
YKL028W |
TFIIE large subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PTR3 |
YFR029W |
Component of the SPS plasma membrane amino acid sensor system |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PTR3 |
YFR029W |
Component of the SPS plasma membrane amino acid sensor system |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PDI1 |
YCL043C |
Protein disulfide isomerase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
THI3 |
YDL080C |
Regulatory protein that binds Pdc2p and Thi2p transcription factors |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
IAH1 |
YOR126C |
Isoamyl acetate-hydrolyzing esterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDA1 |
YER178W |
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
TAT2 |
YOL020W |
High affinity tryptophan and tyrosine permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
TSA2 |
YDR453C |
Stress inducible cytoplasmic thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PRX1 |
YBL064C |
Mitochondrial peroxiredoxin with thioredoxin peroxidase activity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMD2 |
YLR275W |
Core Sm protein Sm D2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Negative Genetic |
LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNU56 |
YDR240C |
Component of U1 snRNP required for mRNA splicing via spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAD3 |
YLR316C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS16B |
YDL083C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRG1 |
YDR065W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSM28 |
YDR494W |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
LPD1 |
YFL018C |
Dihydrolipoamide dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
POT1 |
YIL160C |
3-ketoacyl-CoA thiolase with broad chain length specificity |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRK1 |
YJL129C |
Component of the Trk1p-Trk2p potassium transport system |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRN2 |
YLR119W |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM21 |
YNL294C |
pH sensor molecule, component of the RIM101 pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSY1 |
YDR160W |
Component of the SPS plasma membrane amino acid sensor system |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SSY5 |
YJL156C |
Serine protease of SPS plasma membrane amino acid sensor system |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NRT1 |
YOR071C |
High-affinity nicotinamide riboside transporter |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
GUP1 |
YGL084C |
Plasma membrane protein involved in remodeling GPI anchors |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG24 |
YNL280C |
C-14 sterol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALO1 |
YML086C |
D-Arabinono-1,4-lactone oxidase |
physical |
1 |
1 |
1 |
PCA |
COQ4 |
YDR204W |
Protein with a role in ubiquinone (Coenzyme Q) biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GRX2 |
YDR513W |
Cytoplasmic glutaredoxin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ERG12 |
YMR208W |
Mevalonate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIT2 |
YDR402C |
N-formyltyrosine oxidase |
genetic |
1 |
1 |
1 |
Positive Genetic |