Standard name Systematic name Name description Description
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion Mitofusin, protein involved in mitochondrial outer membrane fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; activity regulated by ubiquitylation at conserved lysine residues and by deubiquitylases Ubp2p and Ubp12p
Visualize the interactome of FZO1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.064 NaN 0.118
Mito 0.831 0.886 0.774
Vac/Vac Memb 0.192 0.137 0.105
Cytoplasm NaN NaN 0.052
Peroxisome NaN NaN 0.115

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 1010

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
FZO1 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 9 4 8 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex physical 5 2 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
MDV1 YJL112W Peripheral protein of cytosolic face of mitochondrial outer membrane genetic 5 2 4 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 5 1 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
UGO1 YDR470C Outer membrane component of the mitochondrial fusion machinery physical 5 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation
NUM1 YDR150W Protein required for nuclear migration genetic 4 3 3 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 4 3 2 Negative Genetic, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex genetic 3 3 3 Dosage Rescue, Synthetic Rescue, Synthetic Growth Defect
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Co-fractionation
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 3 3 2 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance genetic 3 2 2 Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 2 Synthetic Haploinsufficiency, Negative Genetic
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
UBP2 YOR124C Ubiquitin-specific protease regulation 2 1 2 qualitative western immunoblotting evidence, qualitative western immunoblotting evidence
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
UPS1 YLR193C Phosphatidic acid transfer protein genetic 2 1 2 Negative Genetic, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
YPT11 YNL304W Rab GTPase genetic 2 2 1 Dosage Rescue, Synthetic Lethality
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RSP5 YER125W NEDD4 family E3 ubiquitin ligase regulation 1 1 1 qualitative western immunoblotting evidence
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation regulation 1 1 1 qualitative western immunoblotting evidence
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex regulation 1 1 1 qualitative western immunoblotting evidence
UBP12 YJL197W Ubiquitin-specific protease regulation 1 1 1 qualitative western immunoblotting evidence
AIM25 YJR100C Mitochondria protein of unknown function genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation physical 1 1 1 Affinity Capture-Western
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Positive Genetic
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex genetic 1 1 1 Synthetic Rescue
PEX7 YDR142C Peroxisomal signal receptor for peroxisomal matrix proteins physical 1 1 1 Affinity Capture-MS
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
PRR1 YKL116C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
UBP12 YJL197W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-Western
UBP2 YOR124C Ubiquitin-specific protease physical 1 1 1 Affinity Capture-Western
UBP2 YOR124C Ubiquitin-specific protease genetic 1 1 1 Dosage Rescue
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
TOM6 YOR045W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Reconstituted Complex
PEX14 YGL153W Central component of the peroxisomal importomer complex physical 1 1 1 Affinity Capture-Western
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs physical 1 1 1 Affinity Capture-Western
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
OXA1 YER154W Mitochondrial inner membrane insertase genetic 1 1 1 Synthetic Growth Defect
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Synthetic Rescue
MDM36 YPR083W Mitochondrial protein genetic 1 1 1 Phenotypic Suppression
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Positive Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
KAR5 YMR065W Protein required for nuclear membrane fusion during karyogamy genetic 1 1 1 Positive Genetic
MGR3 YMR115W Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Positive Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Positive Genetic
SDH5 YOL071W Protein required for flavinylation of Sdh1p genetic 1 1 1 Positive Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Synthetic Rescue
SAL1 YNL083W ADP/ATP transporter genetic 1 1 1 Dosage Rescue
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Positive Genetic
YHP1 YDR451C Homeobox transcriptional repressor genetic 1 1 1 Positive Genetic
SHE10 YGL228W Protein involved in outer spore wall assembly genetic 1 1 1 Positive Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Positive Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Positive Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
NNF1 YJR112W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
HYM1 YKL189W Component of the RAM signaling network genetic 1 1 1 Negative Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Negative Genetic
YDL218W YDL218W Putative protein of unknown function genetic 1 1 1 Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
YDR109C YDR109C D-ribulokinase genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
INM2 YDR287W Inositol monophosphatase genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YGR050C YGR050C Protein of unknown function genetic 1 1 1 Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
IGO2 YHR132W-A Protein required for initiation of G0 program genetic 1 1 1 Negative Genetic
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Negative Genetic
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B genetic 1 1 1 Negative Genetic
SFC1 YJR095W Mitochondrial succinate-fumarate transporter genetic 1 1 1 Negative Genetic
URA8 YJR103W Minor CTP synthase isozyme (see also URA7) genetic 1 1 1 Negative Genetic
JHD2 YJR119C JmjC domain family histone demethylase genetic 1 1 1 Negative Genetic
RSF2 YJR127C Zinc-finger protein genetic 1 1 1 Negative Genetic
STR2 YJR130C Cystathionine gamma-synthase, converts cysteine into cystathionine genetic 1 1 1 Negative Genetic
XPT1 YJR133W Xanthine-guanine phosphoribosyl transferase genetic 1 1 1 Negative Genetic
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
MRP8 YKL142W Protein of unknown function genetic 1 1 1 Negative Genetic
TFS1 YLR178C Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p) genetic 1 1 1 Negative Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
YLR456W YLR456W Protein of unknown function genetic 1 1 1 Negative Genetic
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
YMR099C YMR099C Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase) genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
RPL1A YPL220W Ribosomal 60S subunit protein L1A genetic 1 1 1 Negative Genetic
YPR097W YPR097W Protein that contains a PX domain and binds phosphoinositides genetic 1 1 1 Negative Genetic
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Phenotypic Suppression
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Dosage Rescue
EFM1 YHL039W Lysine methyltransferase genetic 1 1 1 Negative Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Positive Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-Western
ELO3 YLR372W Elongase genetic 1 1 1 Positive Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Negative Genetic
FMP42 YMR221C Putative protein of unknown function genetic 1 1 1 Negative Genetic
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase genetic 1 1 1 Positive Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 1 1 1 Positive Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Positive Genetic
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis genetic 1 1 1 Negative Genetic
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 1 1 1 Phenotypic Suppression
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Positive Genetic
ABM1 YJR108W Protein of unknown function genetic 1 1 1 Negative Genetic
DGR2 YKL121W Protein of unknown function genetic 1 1 1 Negative Genetic
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 1 1 1 Positive Genetic
FRM2 YCL026C-A Type II nitroreductase, using NADH as reductant genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
DPL1 YDR294C Dihydrosphingosine phosphate lyase genetic 1 1 1 Positive Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
FMP30 YPL103C Protein with a role in maintaining mitochondrial morphology genetic 1 1 1 Phenotypic Enhancement