Standard name Systematic name Name description Description
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
Visualize the interactome of ADE16
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.968 1.0 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 7700

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ADE16 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0570 (inosine monophosphate cyclohydrolase), r_0912 (phosphoribosylaminoimidazolecarboxamide formyltransferase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis genetic 9 4 7 Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis physical 2 2 2 Affinity Capture-MS, PCA
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 2 2 2 Negative Genetic, Positive Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
CMD1 YBR109C Calmodulin genetic 2 2 1 Positive Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
SLX1 YBR228W Endonuclease involved in DNA recombination and repair physical 1 1 1 Affinity Capture-MS
SOL1 YNR034W Protein with a possible role in tRNA export physical 1 1 1 Affinity Capture-MS
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
SOL2 YCR073W-A Protein with a possible role in tRNA export physical 1 1 1 Affinity Capture-MS
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 1 1 1 PCA
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme physical 1 1 1 PCA
LSP1 YPL004C Eisosome core component physical 1 1 1 PCA
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 PCA
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Affinity Capture-MS
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
PMU1 YKL128C Putative phosphomutase genetic 1 1 1 Dosage Rescue
ADE4 YMR300C Phosphoribosylpyrophosphate amidotransferase (PRPPAT) genetic 1 1 1 Dosage Lethality
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
ASN2 YGR124W Asparagine synthetase genetic 1 1 1 Positive Genetic
ATP4 YPL078C Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SOR1 YJR159W Sorbitol dehydrogenase genetic 1 1 1 Negative Genetic
NNT1 YLR285W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Synthetic Rescue
PHO13 YDL236W Conserved phosphatase acting as a metabolite repair enzyme genetic 1 1 1 Synthetic Rescue
PFY1 YOR122C Profilin genetic 1 1 1 Synthetic Growth Defect
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Synthetic Rescue
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Positive Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Positive Genetic
RRP45 YDR280W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
UTP7 YER082C Nucleolar protein genetic 1 1 1 Positive Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Positive Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Positive Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Positive Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Positive Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Positive Genetic
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Positive Genetic
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Positive Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Positive Genetic
ADH5 YBR145W Alcohol dehydrogenase isoenzyme V genetic 1 1 1 Positive Genetic
MIC12 YBR262C Component of the MICOS complex genetic 1 1 1 Positive Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Positive Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Positive Genetic
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
CWC21 YDR482C Protein involved in RNA splicing by the spliceosome genetic 1 1 1 Positive Genetic
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Positive Genetic
MIL1 YFL034W Predicted lipase genetic 1 1 1 Positive Genetic
ZNF1 YFL052W Zinc cluster transcription factor that regulates respiratory growth genetic 1 1 1 Positive Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
CNN1 YFR046C Kinetochore protein genetic 1 1 1 Positive Genetic
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Positive Genetic
YGR016W YGR016W Putative protein of unknown function genetic 1 1 1 Positive Genetic
GPC1 YGR149W Glycerophosphocholine acyltransferase (GPCAT) genetic 1 1 1 Positive Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Positive Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic
LNP1 YHR192W Lunapark family member involved in ER network formation genetic 1 1 1 Positive Genetic
AIM46 YHR199C Protein of unknown function genetic 1 1 1 Positive Genetic
YIL014C-A YIL014C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
YJL107C YJL107C Putative protein of unknown function genetic 1 1 1 Positive Genetic
TMH11 YJR085C Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Positive Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Positive Genetic
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Positive Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Positive Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Positive Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
YMR084W YMR084W Putative protein of unknown function genetic 1 1 1 Positive Genetic
LEU4 YNL104C Alpha-isopropylmalate synthase (2-isopropylmalate synthase) genetic 1 1 1 Positive Genetic
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth genetic 1 1 1 Positive Genetic
YOR034C-A YOR034C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Positive Genetic
PCL8 YPL219W Cyclin genetic 1 1 1 Positive Genetic
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Negative Genetic
IRR1 YIL026C Subunit of the cohesin complex genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
UBA1 YKL210W Ubiquitin activating enzyme (E1) genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
PRP39 YML046W U1 snRNP protein involved in splicing genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
IDI1 YPL117C Isopentenyl diphosphate:dimethylallyl diphosphate isomerase genetic 1 1 1 Negative Genetic
PRP46 YPL151C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
SRP68 YPL243W Core component of the signal recognition particle (SRP) complex genetic 1 1 1 Negative Genetic
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Negative Genetic
RRP15 YPR143W Nucleolar protein genetic 1 1 1 Negative Genetic
JIP5 YPR169W Protein required for biogenesis of the large ribosomal subunit genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 1 1 1 Negative Genetic
GDT1 YBR187W Calcium and manganese transporter with higher affinity for Ca2+ genetic 1 1 1 Negative Genetic
YCL001W-B YCL001W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase genetic 1 1 1 Negative Genetic
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p genetic 1 1 1 Negative Genetic
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
RSM24 YDR175C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
SDH6 YDR379C-A Mitochondrial protein involved in assembly of succinate dehydrogenase genetic 1 1 1 Negative Genetic
RPH1 YER169W JmjC domain-containing histone demethylase genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
SKG1 YKR100C Transmembrane protein with a role in cell wall polymer composition genetic 1 1 1 Negative Genetic
VBA5 YKR105C Plasma membrane protein of the Major Facilitator Superfamily (MFS) genetic 1 1 1 Negative Genetic
FLO1 YAR050W Lectin-like protein involved in flocculation genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
MRX8 YDR336W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
RGD3 YHR182W GTPase activating protein (GAP) for Rho3p, involved in cell polarity g genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PPM2 YOL141W AdoMet-dependent tRNA methyltransferase genetic 1 1 1 Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
VBA1 YMR088C Permease of basic amino acids in the vacuolar membrane genetic 1 1 1 Negative Genetic
ICY1 YMR195W Protein of unknown function genetic 1 1 1 Negative Genetic
DSS1 YMR287C 3'-5' exoribonuclease genetic 1 1 1 Negative Genetic
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Negative Genetic
RRG9 YNL213C Protein of unknown function genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TIR2 YOR010C Putative cell wall mannoprotein genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic