Standard name Systematic name Name description Description
PUS4 YNL292W Pseudouridine synthase Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
Visualize the interactome of PUS4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.744 0.875 0.885
Mito 0.403 0.174 NaN
Nucleus NaN NaN 0.067

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 3990

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PUS4 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1095 (yUMP synthetase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TAN1 YGL232W Putative tRNA acetyltransferase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PUS1 YPL212C tRNA:pseudouridine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
TRM1 YDR120C tRNA methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
ZRC1 YMR243C Vacuolar membrane zinc transporter genetic 2 1 2 Negative Genetic, Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 1 2 Negative Genetic, Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 2 1 2 Negative Genetic, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 2 1 2 Negative Genetic, Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 2 1 2 Negative Genetic, Negative Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 2 1 2 Negative Genetic, Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones physical 2 2 1 Reconstituted Complex, Two-hybrid
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUS4 YNL292W Pseudouridine synthase physical 1 1 1 Affinity Capture-MS
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Affinity Capture-MS
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
SHC1 YER096W Sporulation-specific activator of Chs3p (chitin synthase III) genetic 1 1 1 Negative Genetic
VFA1 YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting genetic 1 1 1 Negative Genetic
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase genetic 1 1 1 Dosage Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
DIA4 YHR011W Probable mitochondrial seryl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
HXT10 YFL011W Hexose transporter genetic 1 1 1 Negative Genetic
AGE1 YDR524C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Positive Genetic