Standard name Systematic name Name description Description
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS
Visualize the interactome of SEN1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.935 0.901 0.881
Mito NaN 0.156 0.256

GFP localization & abundance

GFP localization GFP abundance
nucleus 125

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SEN1 12 0 0 0 1

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 14 4 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 8 4 7 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 8 2 6 Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 8 4 4 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) physical 6 3 5 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 6 4 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 6 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 5 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
RRP6 YOR001W Nuclear exosome exonuclease component genetic 4 3 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) physical 4 2 3 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid
CTF4 YPR135W Chromatin-associated protein genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RAD2 YGR258C Single-stranded DNA endonuclease physical 4 2 3 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex genetic 3 3 2 Dosage Rescue, Phenotypic Suppression, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
REF2 YDR195W RNA-binding protein genetic 3 3 1 Dosage Rescue, Phenotypic Suppression, Synthetic Lethality
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 2 Negative Genetic, Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 2 2 2 Positive Genetic, Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 1 2 Biochemical Activity, Biochemical Activity
RAD51 YER095W Strand exchange protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 2 1 Positive Genetic, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 1 1 Negative Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 1 1 Negative Genetic, Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 1 Negative Genetic, Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 2 1 1 Negative Genetic, Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 2 1 1 Positive Genetic, Positive Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 2 1 1 Negative Genetic, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 1 Negative Genetic, Negative Genetic
CMD1 YBR109C Calmodulin genetic 2 1 1 Negative Genetic, Negative Genetic
PRP4 YPR178W Splicing factor genetic 2 1 1 Positive Genetic, Positive Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase genetic 2 1 1 Negative Genetic, Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 2 1 1 Negative Genetic, Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 2 1 1 Negative Genetic, Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 2 1 1 Negative Genetic, Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 2 1 1 Negative Genetic, Negative Genetic
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex genetic 2 1 1 Negative Genetic, Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 2 1 1 Negative Genetic, Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 2 1 1 Negative Genetic, Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
USE1 YGL098W Essential SNARE protein localized to the ER genetic 2 1 1 Negative Genetic, Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 2 1 1 Negative Genetic, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 2 1 1 Negative Genetic, Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 2 1 1 Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 1 1 Negative Genetic, Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 2 1 1 Negative Genetic, Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 2 1 1 Negative Genetic, Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 2 1 1 Negative Genetic, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 1 1 Negative Genetic, Negative Genetic
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p genetic 2 1 1 Negative Genetic, Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 2 1 1 Positive Genetic, Positive Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 2 1 1 Negative Genetic, Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 2 1 1 Negative Genetic, Negative Genetic
MCM3 YEL032W Protein involved in DNA replication physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 2 1 1 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 2 1 1 Negative Genetic, Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 2 1 1 Negative Genetic, Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 2 1 1 Negative Genetic, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Negative Genetic, Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 2 1 1 Negative Genetic, Negative Genetic
ENT4 YLL038C Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 2 1 1 Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
ARO7 YPR060C Chorismate mutase genetic 2 1 1 Negative Genetic, Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 2 1 1 Negative Genetic, Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 1 1 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 1 Negative Genetic, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DAL82 YNL314W Positive regulator of allophanate inducible genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ZAP1 YJL056C Zinc-regulated transcription factor regulation 1 1 1 northern blot evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Positive Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Positive Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Affinity Capture-MS
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-Western
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-Western
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-Western
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Positive Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p physical 1 1 1 Affinity Capture-MS
ERB1 YMR049C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-RNA
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Positive Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Negative Genetic
NAF1 YNL124W RNA-binding protein required for the assembly of box H/ACA snoRNPs genetic 1 1 1 Positive Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
RRP43 YCR035C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPC17 YJL011C RNA polymerase III subunit C17 genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Negative Genetic
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Synthetic Growth Defect
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Positive Genetic
CFT1 YDR301W RNA-binding subunit of the mRNA cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BDF1 YLR399C BET family transcriptional regulator physical 1 1 1 Two-hybrid
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Two-hybrid
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CDC45 YLR103C DNA replication initiation factor physical 1 1 1 Affinity Capture-Western
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Positive Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Rescue
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-Western
ECM1 YAL059W Pre-ribosomal factor involved in 60S ribosomal protein subunit export genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 genetic 1 1 1 Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Affinity Capture-Western
MCM6 YGL201C Protein involved in DNA replication physical 1 1 1 Affinity Capture-Western
MRPL13 YKR006C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 1 1 1 Affinity Capture-Western
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
HTA1 YDR225W Histone H2A genetic 1 1 1 Positive Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Affinity Capture-Western
NAB6 YML117W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
IMP4 YNL075W Component of the SSU processome physical 1 1 1 Affinity Capture-MS
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Negative Genetic
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Synthetic Lethality
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family physical 1 1 1 Reconstituted Complex
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Positive Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Negative Genetic
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
SLU7 YDR088C RNA splicing factor physical 1 1 1 Two-hybrid
YPR148C YPR148C Protein of unknown function physical 1 1 1 Two-hybrid
SMD3 YLR147C Core Sm protein Sm D3 physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Two-hybrid
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Positive Genetic
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-RNA
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Affinity Capture-RNA
TMA19 YKL056C Protein that associates with ribosomes physical 1 1 1 Affinity Capture-RNA
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme physical 1 1 1 Affinity Capture-RNA
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Two-hybrid
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease physical 1 1 1 Affinity Capture-MS
YME2 YMR302C Integral inner mitochondrial membrane protein genetic 1 1 1 Positive Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Synthetic Lethality
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Synthetic Lethality
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Positive Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Positive Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
SOF1 YLL011W Protein required for biogenesis of 40S (small) ribosomal subunit genetic 1 1 1 Positive Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Positive Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Positive Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
UFD4 YKL010C Ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Positive Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Positive Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Negative Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
UTP18 YJL069C Small-subunit processome protein involved in pre-18S rRNA maturation genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
UTP13 YLR222C Nucleolar protein genetic 1 1 1 Negative Genetic
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Negative Genetic
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Negative Genetic
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
YBL036C YBL036C Putative non-specific single-domain racemase genetic 1 1 1 Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
YCR023C YCR023C Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 1 1 1 Negative Genetic
TOH1 YJL171C GPI-anchored cell wall protein of unknown function genetic 1 1 1 Negative Genetic
TIF1 YKR059W Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 1 1 1 Negative Genetic
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 1 1 1 Negative Genetic
TRS33 YOR115C Core component of TRAPP complexes I, II and IV genetic 1 1 1 Negative Genetic
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 1 1 1 Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Negative Genetic
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
YBR196C-A YBR196C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Negative Genetic
YCR099C YCR099C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VTC1 YER072W Regulatory subunit of the vacuolar transporter chaperone (VTC) complex genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
YMR001C-A YMR001C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL193W YNL193W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SKP2 YNL311C F-box protein of unknown function genetic 1 1 1 Negative Genetic
SNF12 YNR023W 73 kDa subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Phenotypic Enhancement
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Growth Defect
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) physical 1 1 1 Affinity Capture-MS
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
AIM17 YHL021C Protein of unknown function genetic 1 1 1 Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform physical 1 1 1 Two-hybrid
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
AHP1 YLR109W Thiol-specific peroxiredoxin physical 1 1 1 Affinity Capture-RNA
CDC53 YDL132W Cullin genetic 1 1 1 Positive Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Affinity Capture-RNA
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Two-hybrid
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Positive Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
NUP49 YGL172W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Two-hybrid
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Suppression
CTF4 YPR135W Chromatin-associated protein physical 1 1 1 Affinity Capture-Western
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Affinity Capture-MS
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Negative Genetic
MDH2 YOL126C Cytoplasmic malate dehydrogenase genetic 1 1 1 Positive Genetic
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Positive Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Positive Genetic
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis physical 1 1 1 Two-hybrid
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Lethality
ECM11 YDR446W Meiosis-specific protein physical 1 1 1 Two-hybrid
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Positive Genetic
DSL1 YNL258C Peripheral membrane protein needed for Golgi-to-ER retrograde traffic genetic 1 1 1 Negative Genetic
ARH1 YDR376W Oxidoreductase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Negative Genetic
GNA1 YFL017C Glucosamine-6-phosphate acetyltransferase genetic 1 1 1 Negative Genetic
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Affinity Capture-Western
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
IRC6 YFR043C Clathrin coat accessory factor genetic 1 1 1 Positive Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-RNA
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-RNA
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Positive Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Positive Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Positive Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease physical 1 1 1 Affinity Capture-MS
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Positive Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Positive Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Negative Genetic
RAD2 YGR258C Single-stranded DNA endonuclease genetic 1 1 1 Synthetic Growth Defect
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
MEI4 YER044C-A Meiosis-specific protein involved in forming DSBs genetic 1 1 1 Negative Genetic
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Phenotypic Suppression
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Phenotypic Suppression
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
NVJ1 YHR195W Nuclear envelope protein genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 physical 1 1 1 Affinity Capture-RNA
MDM1 YML104C PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 1 1 1 Affinity Capture-Western
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
JHD2 YJR119C JmjC domain family histone demethylase genetic 1 1 1 Synthetic Rescue
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Negative Genetic
RPS31 YLR167W Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin physical 1 1 1 Affinity Capture-RNA
HSK3 YKL138C-A Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Positive Genetic
NPY1 YGL067W NADH diphosphatase (pyrophosphatase) genetic 1 1 1 Negative Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 1 1 1 Negative Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Synthetic Lethality
PEX32 YBR168W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
RPL4B YDR012W Ribosomal 60S subunit protein L4B physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-RNA
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Negative Genetic
LCL1 YPL056C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MSK1 YNL073W Mitochondrial lysine-tRNA synthetase physical 1 1 1 Two-hybrid
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
ENA1 YDR040C P-type ATPase sodium pump genetic 1 1 1 Synthetic Rescue
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA genetic 1 1 1 Negative Genetic
CCW12 YLR110C Cell wall mannoprotein physical 1 1 1 Affinity Capture-RNA
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
HPT1 YDR399W Dimeric hypoxanthine-guanine phosphoribosyltransferase genetic 1 1 1 Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Negative Genetic
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Negative Genetic
IML2 YJL082W Protein required for clearance of inclusion bodies genetic 1 1 1 Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Negative Genetic
LIH1 YJR107W Putative lipase genetic 1 1 1 Positive Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Positive Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
MAL32 YBR299W Maltase (alpha-D-glucosidase) genetic 1 1 1 Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
MTQ1 YNL063W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
MRX8 YDR336W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
REX3 YLR107W RNA exonuclease genetic 1 1 1 Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 1 1 1 Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Negative Genetic
SAY1 YGR263C Sterol deacetylase genetic 1 1 1 Negative Genetic
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic
RRT15 YLR162W-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
MIN3 YMR182W-A Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic