MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
15 |
4 |
12 |
Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
14 |
4 |
11 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
CSM3 |
YMR048W |
Replication fork associated factor |
physical |
13 |
4 |
10 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
12 |
4 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
10 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
10 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
9 |
4 |
7 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
9 |
4 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Synthetic Lethality |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
7 |
4 |
6 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic, Negative Genetic |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
7 |
4 |
6 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression |
HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
7 |
3 |
6 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
7 |
2 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic |
DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
6 |
2 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
6 |
3 |
5 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
6 |
3 |
5 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
5 |
4 |
4 |
Synthetic Rescue, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect |
CDC45 |
YLR103C |
DNA replication initiation factor |
physical |
5 |
3 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
5 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
4 |
4 |
4 |
Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Phenotypic Suppression |
NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
4 |
3 |
4 |
Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue |
CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality |
IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic |
TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
4 |
3 |
3 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue |
MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
physical |
4 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
3 |
3 |
Positive Genetic, Synthetic Growth Defect, Phenotypic Enhancement |
RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
3 |
3 |
3 |
Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression |
MAK3 |
YPR051W |
Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
3 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Rescue, Negative Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
KRE28 |
YDR532C |
Subunit of a kinetochore-microtubule binding complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Lethality, Negative Genetic |
MAK31 |
YCR020C-A |
Non-catalytic subunit of N-terminal acetyltransferase of the NatC type |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
physical |
3 |
1 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
TOP2 |
YNL088W |
Topoisomerase II |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect |
TOP1 |
YOL006C |
Topoisomerase I |
physical |
3 |
2 |
2 |
Two-hybrid, Affinity Capture-Western, Affinity Capture-Western |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Dosage Lethality |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
MCM6 |
YGL201C |
Protein involved in DNA replication |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
SIR1 |
YKR101W |
Protein involved in silencing at mating-type loci HML and HMR |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Rescue |
RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Lethality |
TIF2 |
YJL138C |
Translation initiation factor eIF4A |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SMC3 |
YJL074C |
Subunit of the multiprotein cohesin complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
ACE2 |
YLR131C |
Transcription factor required for septum destruction after cytokinesis |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
KAP122 |
YGL016W |
Karyopherin beta |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ATG27 |
YJL178C |
Type I membrane protein involved in autophagy and the Cvt pathway |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HXK2 |
YGL253W |
Hexokinase isoenzyme 2 |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ROG1 |
YGL144C |
Lipase with specificity for monoacylglycerol |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NUP100 |
YKL068W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
INP51 |
YIL002C |
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GLO4 |
YOR040W |
Mitochondrial glyoxalase II |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
JIP4 |
YDR475C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DAP2 |
YHR028C |
Dipeptidyl aminopeptidase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RBK1 |
YCR036W |
Ribokinase, phosphorylates ribose to ribose-5-phosphate |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HMI1 |
YOL095C |
Mitochondrial inner membrane localized ATP-dependent DNA helicase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RBH2 |
YJR030C |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
IES4 |
YOR189W |
Component of the INO80 chromatiin remodeling complex |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Synthetic Lethality |
NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
EPL1 |
YFL024C |
Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
NAT1 |
YDL040C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
HHT1 |
YBR010W |
Histone H3 |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
NPT1 |
YOR209C |
Nicotinate phosphoribosyltransferase |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT20 |
YOL148C |
Subunit of the SAGA transcriptional regulatory complex |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
STB5 |
YHR178W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CIN5 |
YOR028C |
Basic leucine zipper (bZIP) transcription factor of the yAP-1 family |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CST6 |
YIL036W |
Basic leucine zipper (bZIP) transcription factor from ATF/CREB family |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
TUP1 |
YCR084C |
General repressor of transcription in complex with Cyc8p |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
OPI1 |
YHL020C |
Transcriptional regulator of a variety of genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
SWI6 |
YLR182W |
Transcription cofactor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RVB2 |
YPL235W |
ATP-dependent DNA helicase, also known as reptin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
genetic |
1 |
1 |
1 |
Positive Genetic |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
DED1 |
YOR204W |
ATP-dependent DEAD-box RNA helicase with strand-annealing activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPS4B |
YHR203C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Positive Genetic |
CIA2 |
YHR122W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MAK10 |
YEL053C |
Non-catalytic subunit of the NatC N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CSE2 |
YNR010W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IMG2 |
YCR071C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
LCD1 |
YDR499W |
Essential protein required for the DNA integrity checkpoint pathways |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
genetic |
1 |
1 |
1 |
Positive Genetic |
NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PDA1 |
YER178W |
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IDH2 |
YOR136W |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Positive Genetic |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ILV1 |
YER086W |
Threonine deaminase, catalyzes first step in isoleucine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSL1 |
YIR009W |
U2B component of U2 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
HFI1 |
YPL254W |
Adaptor protein required for structural integrity of the SAGA complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOA1 |
YOR194C |
TFIIA large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MKS1 |
YNL076W |
Pleiotropic negative transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Negative Genetic |
GUF1 |
YLR289W |
Mitochondrial matrix GTPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CAT5 |
YOR125C |
Protein required for ubiquinone (Coenzyme Q) biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUL1 |
YMR275C |
Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
1 |
1 |
1 |
Negative Genetic |
FPK1 |
YNR047W |
Ser/Thr protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWM1 |
YDR260C |
Subunit of the anaphase-promoting complex (APC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCR2 |
YNL199C |
Transcriptional activator of genes involved in glycolysis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Positive Genetic |
SIR3 |
YLR442C |
Silencing protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Positive Genetic |
INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
LDB17 |
YDL146W |
Protein involved in the regulation of endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC26 |
YFR036W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLB1 |
YGR108W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SWD2 |
YKL018W |
Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IES2 |
YNL215W |
Protein that associates with the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOS3 |
YPL116W |
Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HOP2 |
YGL033W |
Meiosis-specific protein that localizes to chromosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM3 |
YEL032W |
Protein involved in DNA replication |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CBF2 |
YGR140W |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MOB1 |
YIL106W |
Component of the mitotic exit network |
genetic |
1 |
1 |
1 |
Negative Genetic |
BAG7 |
YOR134W |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Positive Genetic |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMC5 |
YIL027C |
Member of conserved ER transmembrane complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
INP53 |
YOR109W |
Polyphosphatidylinositol phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TAP42 |
YMR028W |
Essential protein involved in the TOR signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATP10 |
YLR393W |
Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CPR7 |
YJR032W |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
physical |
1 |
1 |
1 |
Two-hybrid |
WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
VAC17 |
YCL063W |
Phosphoprotein involved in vacuole inheritance |
genetic |
1 |
1 |
1 |
Negative Genetic |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
YRA2 |
YKL214C |
Member of the REF (RNA and export factor binding proteins) family |
genetic |
1 |
1 |
1 |
Negative Genetic |
YCR050C |
YCR050C |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TPK2 |
YPL203W |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
TTI2 |
YJR136C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPP1 |
YMR156C |
DNA 3'-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
TSC13 |
YDL015C |
Enoyl reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRP1 |
YDR007W |
Phosphoribosylanthranilate isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPC1 |
YBR183W |
Alkaline ceramidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERV29 |
YGR284C |
Protein localized to COPII-coated vesicles |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
1 |
1 |
1 |
Positive Genetic |
RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ARO8 |
YGL202W |
Aromatic aminotransferase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Positive Genetic |
HAM1 |
YJR069C |
Nucleoside triphosphate pyrophosphohydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LYS20 |
YDL182W |
Homocitrate synthase isozyme and functions in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUF4 |
YGL014W |
Member of the PUF protein family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
IMP21 |
YIL154C |
Transcriptional activator involved in maintenance of ion homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MGR1 |
YCL044C |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERV2 |
YPR037C |
Flavin-linked sulfhydryl oxidase localized to the ER lumen |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Positive Genetic |
TIR4 |
YOR009W |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL24A |
YGL031C |
Ribosomal 60S subunit protein L24A |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL43A |
YPR043W |
Ribosomal 60S subunit protein L43A |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
physical |
1 |
1 |
1 |
Two-hybrid |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DGR2 |
YKL121W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
CYT1 |
YOR065W |
Cytochrome c1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
SGO1 |
YOR073W |
Component of the spindle checkpoint |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
LIP1 |
YMR298W |
Ceramide synthase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
TED1 |
YIL039W |
GPI-glycan remodelase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIF2 |
YLR453C |
Protein that binds to the Rap1p C-terminus |
genetic |
1 |
1 |
1 |
Negative Genetic |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
COX12 |
YLR038C |
Subunit VIb of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWS2 |
YNL081C |
Putative mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT21 |
YMR179W |
Protein with a role in transcriptional silencing |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GPM3 |
YOL056W |
Nonfunctional homolog of Gpm1p phosphoglycerate mutase |
genetic |
1 |
1 |
1 |
Negative Genetic |
OAZ1 |
YPL052W |
Regulator of ornithine decarboxylase Spe1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
MDM35 |
YKL053C-A |
Mitochondrial intermembrane space protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
IRC15 |
YPL017C |
Microtubule associated protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
LAS21 |
YJL062W |
Mannose-ethanolamine phosphotransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PER1 |
YCR044C |
Protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Positive Genetic |
GAS4 |
YOL132W |
1,3-beta-glucanosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRX19 |
YDL183C |
Protein that may form an active mitochondrial KHE system |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT105 |
YER104W |
Chaperone for Replication Protein A complex (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NIT2 |
YJL126W |
Nit protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
1 |
1 |
1 |
Negative Genetic |