MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
physical |
27 |
7 |
22 |
Co-localization, Co-localization, Co-fractionation, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
CDC45 |
YLR103C |
DNA replication initiation factor |
physical |
25 |
5 |
19 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western |
MCM3 |
YEL032W |
Protein involved in DNA replication |
physical |
18 |
5 |
14 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Co-localization, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
MCM6 |
YGL201C |
Protein involved in DNA replication |
physical |
17 |
6 |
13 |
Co-localization, Co-fractionation, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
physical |
16 |
3 |
14 |
Affinity Capture-Western, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
physical |
16 |
5 |
10 |
Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-purification, Reconstituted Complex, Co-localization |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
12 |
6 |
12 |
Affinity Capture-Western, Co-localization, Co-fractionation, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
TAH11 |
YJR046W |
DNA replication licensing factor |
physical |
12 |
2 |
10 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
10 |
4 |
10 |
Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
physical |
9 |
4 |
6 |
Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western |
PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
8 |
2 |
8 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
8 |
6 |
7 |
Co-localization, Co-fractionation, Co-purification, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
physical |
8 |
3 |
6 |
Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-fractionation, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
7 |
4 |
5 |
Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement |
PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
6 |
2 |
6 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
6 |
4 |
5 |
Phenotypic Enhancement, Synthetic Rescue, Dosage Growth Defect, Negative Genetic, Negative Genetic, Synthetic Rescue |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
physical |
6 |
3 |
5 |
Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
genetic |
6 |
4 |
4 |
Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Growth Defect |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
5 |
1 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
physical |
5 |
3 |
3 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
SLD2 |
YKL108W |
Single-stranded DNA origin-binding and annealing protein |
physical |
5 |
2 |
3 |
Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
5 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
physical |
4 |
3 |
4 |
Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
CSM3 |
YMR048W |
Replication fork associated factor |
physical |
4 |
1 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
4 |
4 |
3 |
Dosage Lethality, Synthetic Lethality, Phenotypic Enhancement, Dosage Growth Defect |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
4 |
3 |
3 |
Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic, Negative Genetic |
DIA2 |
YOR080W |
Origin-binding F-box protein |
physical |
4 |
3 |
3 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
4 |
3 |
3 |
Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
4 |
3 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
4 |
3 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS |
HTB1 |
YDR224C |
Histone H2B |
physical |
4 |
3 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS |
HHT1 |
YBR010W |
Histone H3 |
physical |
4 |
3 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
4 |
3 |
2 |
Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
4 |
2 |
2 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
physical |
3 |
3 |
3 |
Co-fractionation, Affinity Capture-Western, Reconstituted Complex |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
PSF3 |
YOL146W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
3 |
2 |
3 |
Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
physical |
3 |
1 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
HHF1 |
YBR009C |
Histone H4 |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
HTA1 |
YDR225W |
Histone H2A |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
HTA2 |
YBL003C |
Histone H2A |
physical |
3 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
MCM2 |
YBL023C |
Protein involved in DNA replication |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
DPB11 |
YJL090C |
DNA replication initiation protein |
physical |
3 |
2 |
2 |
Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
HTB2 |
YBL002W |
Histone H2B |
physical |
3 |
3 |
1 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS |
HHT2 |
YNL031C |
Histone H3 |
physical |
3 |
3 |
1 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS |
IPI3 |
YNL182C |
Component of the Rix1 complex and pre-replicative complexes (pre-RCs) |
physical |
3 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-Western, Co-fractionation |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Enhancement |
CTF4 |
YPR135W |
Chromatin-associated protein |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
physical |
2 |
1 |
2 |
Reconstituted Complex, Reconstituted Complex |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
physical |
2 |
1 |
2 |
Reconstituted Complex, Reconstituted Complex |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
SWI5 |
YDR146C |
Transcription factor that recruits Mediator and Swi/Snf complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HHF2 |
YNL030W |
Histone H4 |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-MS |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Phenotypic Enhancement |
CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
physical |
2 |
2 |
1 |
Two-hybrid, Reconstituted Complex |
BMH2 |
YDR099W |
14-3-3 protein, minor isoform |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IMG1 |
YCR046C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PEP3 |
YLR148W |
Component of CORVET membrane tethering complex |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
VMA13 |
YPR036W |
Subunit H of the V1 peripheral membrane domain of V-ATPase |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
SKN1 |
YGR143W |
Protein involved in sphingolipid biosynthesis |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PDS1 |
YDR113C |
Securin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
BUD23 |
YCR047C |
Ribosome biogenesis factor |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
IPI1 |
YHR085W |
Component of the Rix1 complex and possibly pre-replicative complexes |
physical |
1 |
1 |
1 |
Co-fractionation |
ADH1 |
YOL086C |
Alcohol dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
GCD7 |
YLR291C |
Beta subunit of translation initiation factor eIF2B |
physical |
1 |
1 |
1 |
Two-hybrid |
HAT1 |
YPL001W |
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HAT1 |
YPL001W |
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ENO2 |
YHR174W |
Enolase II, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MAL12 |
YGR292W |
Maltase (alpha-D-glucosidase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MBP1 |
YDL056W |
Transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
GLT1 |
YDL171C |
NAD(+)-dependent glutamate synthase (GOGAT) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOC3 |
YLR002C |
Subunit of a nuclear complex with Noc2p and pre-replicative complexes |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPL150W |
YPL150W |
Protein kinase of unknown cellular role |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRP3 |
YDR473C |
Splicing factor |
physical |
1 |
1 |
1 |
Two-hybrid |
PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Two-hybrid |
POC4 |
YPL144W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRI1 |
YIR008C |
Subunit of DNA primase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIX1 |
YHR197W |
Component of the Rix1 complex and possibly pre-replicative complexes |
physical |
1 |
1 |
1 |
Co-fractionation |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
physical |
1 |
1 |
1 |
Two-hybrid |
POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YEF3 |
YLR249W |
Translation elongation factor 3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PUF4 |
YGL014W |
Member of the PUF protein family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
TFC6 |
YDR362C |
Subunit of RNA polymerase III transcription initiation factor complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TRA1 |
YHR099W |
Subunit of SAGA and NuA4 histone acetyltransferase complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT5 |
YML010W |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UFD1 |
YGR048W |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS17A |
YML024W |
Ribosomal protein 51 (rp51) of the small (40s) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL25 |
YOL127W |
Ribosomal 60S subunit protein L25 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS14A |
YCR031C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM8 |
YGL045W |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM101 |
YHL027W |
Cys2His2 zinc-finger transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MCR1 |
YKL150W |
Mitochondrial NADH-cytochrome b5 reductase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RAD2 |
YGR258C |
Single-stranded DNA endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PDR15 |
YDR406W |
Plasma membrane ATP binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RDS2 |
YPL133C |
Transcription factor involved in regulating gluconeogenesis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
YHP1 |
YDR451C |
Homeobox transcriptional repressor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SSM4 |
YIL030C |
Membrane-embedded ubiquitin-protein ligase and retrotranslocase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIP18 |
YMR175W |
Phospholipid-binding hydrophilin |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL8B |
YLL045C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
1 |
1 |
1 |
Positive Genetic |
VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NMT1 |
YLR195C |
N-myristoyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT6 |
YGR116W |
Nucleosome remodeling protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWC3 |
YAL011W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS27B |
YHR021C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO86 |
YJL117W |
Endoplasmic reticulum (ER) resident protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJL163C |
YJL163C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPT6 |
YLR262C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO1 |
YNL012W |
Meiosis-specific prospore protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MNE1 |
YOR350C |
Protein involved in splicing Group I aI5-beta intron from COX1 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
MXR1 |
YER042W |
Methionine-S-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJL136W-A |
YJL136W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMA2 |
YML066C |
Meiosis-specific prospore membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL36A |
YMR194W |
Ribosomal 60S subunit protein L36A |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RNH1 |
YMR234W |
Ribonuclease H1 |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
genetic |
1 |
1 |
1 |
Positive Genetic |
MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRN2 |
YLR119W |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM21 |
YNL294C |
pH sensor molecule, component of the RIM101 pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACE2 |
YLR131C |
Transcription factor required for septum destruction after cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
KIN1 |
YDR122W |
S/T protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
KIN2 |
YLR096W |
S/T protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
KSS1 |
YGR040W |
Mitogen-activated protein kinase (MAPK) |
physical |
1 |
1 |
1 |
Biochemical Activity |
MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
physical |
1 |
1 |
1 |
Biochemical Activity |
IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
physical |
1 |
1 |
1 |
Biochemical Activity |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAK1 |
YFL029C |
Cyclin-dependent kinase-activating kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
CHL1 |
YPL008W |
Probable DNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
DAL81 |
YIR023W |
Positive regulator of genes in multiple nitrogen degradation pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC19 |
YAL038W |
Pyruvate kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ETT1 |
YOR051C |
Nuclear protein that inhibits replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
FAF1 |
YIL019W |
Protein required for pre-rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
IDS2 |
YJL146W |
Protein involved in modulation of Ime2p activity during meiosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
AIM39 |
YOL053W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
DFG16 |
YOR030W |
Probable multiple transmembrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAD1 |
YDL045C |
Flavin adenine dinucleotide (FAD) synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
AGA1 |
YNR044W |
Anchorage subunit of a-agglutinin of a-cells |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIT2 |
YDR402C |
N-formyltyrosine oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |