Standard name Systematic name Name description Description
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription
Visualize the interactome of RLF2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 45

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 1590

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RLF2 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ASF1 YJL115W Nucleosome assembly factor genetic 20 6 18 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
HIR1 YBL008W Subunit of the HIR complex genetic 15 4 12 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement
RTT106 YNL206C Histone chaperone genetic 13 5 12 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) physical 10 4 10 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex
HHT1 YBR010W Histone H3 physical 8 3 8 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 8 2 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p physical 7 3 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
HIR3 YJR140C Subunit of the HIR complex genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 genetic 7 3 4 Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 7 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 6 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 6 5 4 Synthetic Growth Defect, Positive Genetic, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression
HHF1 YBR009C Histone H4 physical 5 3 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
HHT2 YNL031C Histone H3 physical 5 3 5 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 5 3 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Dosage Lethality, Dosage Lethality
HHT1 YBR010W Histone H3 genetic 5 3 3 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
HHT2 YNL031C Histone H3 genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 4 2 4 Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 4 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 4 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR physical 4 3 1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 3 2 3 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
GCN2 YDR283C Protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 3 3 2 Biochemical Activity, FRET, Co-localization
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 3 2 Dosage Rescue, Synthetic Growth Defect, Positive Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 3 2 2 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
HHF2 YNL030W Histone H4 physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 2 2 Negative Genetic, Synthetic Lethality
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RAD24 YER173W Checkpoint protein genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 2 2 2 Synthetic Rescue, Positive Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 1 2 Biochemical Activity, Biochemical Activity
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 2 Negative Genetic, Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 2 1 2 Negative Genetic, Negative Genetic
KAP122 YGL016W Karyopherin beta genetic 2 1 2 Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 2 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 2 Negative Genetic, Negative Genetic
YPS7 YDR349C Putative GPI-anchored aspartic protease genetic 2 1 2 Negative Genetic, Negative Genetic
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 2 1 2 Negative Genetic, Negative Genetic
YFL051C YFL051C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
EFM1 YHL039W Lysine methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 2 1 2 Negative Genetic, Negative Genetic
CDC21 YOR074C Thymidylate synthase genetic 2 1 2 Dosage Rescue, Dosage Rescue
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 2 Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 2 Negative Genetic, Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
HHF2 YNL030W Histone H4 genetic 2 2 1 Dosage Growth Defect, Synthetic Rescue
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 2 2 1 Affinity Capture-Western, Two-hybrid
SLK19 YOR195W Kinetochore-associated protein physical 2 2 1 PCA, Two-hybrid
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
BIK1 YCL029C Microtubule-associated protein physical 2 2 1 PCA, Two-hybrid
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 2 1 1 Positive Genetic, Positive Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 2 1 1 Negative Genetic, Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation physical 1 1 1 Two-hybrid
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Positive Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Phenotypic Enhancement
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Rescue
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 FRET
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
IPI3 YNL182C Component of the Rix1 complex and pre-replicative complexes (pre-RCs) physical 1 1 1 Two-hybrid
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Phenotypic Enhancement
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 1 1 1 Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 1 1 1 Phenotypic Enhancement
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Two-hybrid
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Synthetic Rescue
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Phenotypic Suppression
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Suppression
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Positive Genetic
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Rescue
NRD1 YNL251C RNA-binding subunit of Nrd1 complex genetic 1 1 1 Negative Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Enhancement
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis physical 1 1 1 Two-hybrid
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 1 1 1 Phenotypic Suppression
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Phenotypic Enhancement
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone physical 1 1 1 Two-hybrid
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Phenotypic Enhancement
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
GYP6 YJL044C GTPase-activating protein (GAP) for yeast Rab family member Ypt6p genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Positive Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Phenotypic Enhancement
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Growth Defect
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 1 1 1 Positive Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Phenotypic Enhancement
ETP1 YHL010C Protein of unknown function required for growth on ethanol physical 1 1 1 Two-hybrid
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Phenotypic Suppression
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Lethality
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Positive Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Phenotypic Enhancement
BUD9 YGR041W Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
GAL3 YDR009W Transcriptional regulator genetic 1 1 1 Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Growth Defect
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Synthetic Growth Defect
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Two-hybrid
RTT106 YNL206C Histone chaperone physical 1 1 1 Reconstituted Complex
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 1 1 1 Two-hybrid
SPC25 YER018C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
SPO12 YHR152W Nucleolar protein of unknown function physical 1 1 1 Two-hybrid
YSW1 YBR148W Protein required for normal prospore membrane formation physical 1 1 1 Two-hybrid
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor physical 1 1 1 Two-hybrid
YHL009W-A YHL009W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Two-hybrid
YKL050C YKL050C Protein of unknown function physical 1 1 1 Two-hybrid
YKL050C YKL050C Protein of unknown function genetic 1 1 1 Negative Genetic
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Two-hybrid
SEG2 YKL105C Eisosome component physical 1 1 1 Two-hybrid
SPA2 YLL021W Component of the polarisome physical 1 1 1 Two-hybrid
SVL3 YPL032C Protein of unknown function physical 1 1 1 Two-hybrid
YPR148C YPR148C Protein of unknown function physical 1 1 1 Two-hybrid
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Synthetic Rescue
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Phenotypic Suppression
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
VHR1 YIL056W Transcriptional activator genetic 1 1 1 Negative Genetic
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Negative Genetic
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 1 1 1 Synthetic Growth Defect
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Positive Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
YAE1 YJR067C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
YBL008W-A YBL008W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
YLL053C YLL053C Putative protein genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
YMR030W-A YMR030W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Negative Genetic
YOR381W-A YOR381W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
SSH4 YKL124W Specificity factor required for Rsp5p-dependent ubiquitination genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Synthetic Growth Defect
SWT1 YOR166C RNA endoribonuclease involved in perinuclear mRNP quality control genetic 1 1 1 Positive Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Synthetic Growth Defect
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Two-hybrid
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Positive Genetic
GZF3 YJL110C GATA zinc finger protein physical 1 1 1 Two-hybrid
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Phenotypic Suppression
ACA1 YER045C ATF/CREB family basic leucine zipper (bZIP) transcription factor physical 1 1 1 Two-hybrid
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Phenotypic Suppression
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Synthetic Growth Defect
DOC1 YGL240W Processivity factor genetic 1 1 1 Synthetic Growth Defect
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Synthetic Growth Defect
MIF2 YKL089W Centromeric CDEIII region binding protein physical 1 1 1 Two-hybrid
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Dosage Rescue
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Synthetic Growth Defect
ORC3 YLL004W Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Synthetic Growth Defect
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 1 1 1 Two-hybrid
MKC7 YDR144C GPI-anchored aspartyl protease genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex physical 1 1 1 Two-hybrid
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Phenotypic Enhancement
ORC5 YNL261W Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Positive Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Phenotypic Suppression
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Positive Genetic
BUG1 YDL099W Cis-golgi localized protein involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
FMP27 YLR454W Protein with structural similarity to lipid transport protein Vps13p physical 1 1 1 Two-hybrid
PAC1 YOR269W Regulator of dynein, involved in intracellular transport physical 1 1 1 Two-hybrid
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Positive Genetic
PDR10 YOR328W ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Negative Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p physical 1 1 1 Two-hybrid
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Phenotypic Enhancement
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Two-hybrid
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
PEX22 YAL055W Putative peroxisomal membrane protein genetic 1 1 1 Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Synthetic Growth Defect
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
FCY22 YER060W-A Putative purine-cytosine permease genetic 1 1 1 Negative Genetic
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Positive Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
HST2 YPL015C Cytoplasmic NAD(+)-dependent protein deacetylase genetic 1 1 1 Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Positive Genetic